Atlas of Genetics and Cytogenetics in Oncology and Haematology

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RPS6KB2 (ribosomal protein S6 kinase B2)

Identity

Alias_namesribosomal protein S6 kinase
Alias_symbol (synonym)p70S6Kb
P70-BETA
STK14B
KLS
Other aliasP70-beta
P70-beta-1
P70-beta-2
S6K-beta2
S6K2
S6KB
S6KI(2)
S6Kbeta
SRK
p70(S6K)-beta
HGNC (Hugo) RPS6KB2
LocusID (NCBI) 6199
Atlas_Id 42169
Location 11q13.2  [Link to chromosome band 11q13]
Location_base_pair Starts at 67428464 and ends at 67435408 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RPS6KB2 (11q13.2) / C10orf54 (10q22.1)RPS6KB2 (11q13.2) / KDM2A (11q13.2)RPS6KB2 (11q13.2) / PAAF1 (11q13.4)
RPS6KB2 (11q13.2) / PCNX3 (11q13.1)RPS6KB2 11q13.2 / C10orf54 10q22.1RPS6KB2 11q13.2 / PAAF1 11q13.4
RPS6KB2 11q13.2 / PCNXL3 11q13.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  RPS6KB2/PAAF1 (11q13)

External links

Nomenclature
HGNC (Hugo)RPS6KB2   10437
Cards
Entrez_Gene (NCBI)RPS6KB2  6199  ribosomal protein S6 kinase B2
AliasesKLS; P70-beta; P70-beta-1; P70-beta-2; 
S6K-beta2; S6K2; S6KB; S6KI(2); S6Kbeta; SRK; STK14B; p70(S6K)-beta; p70S6Kb
GeneCards (Weizmann)RPS6KB2
Ensembl hg19 (Hinxton)ENSG00000175634 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000175634 [Gene_View]  ENSG00000175634 [Sequence]  chr11:67428464-67435408 [Contig_View]  RPS6KB2 [Vega]
ICGC DataPortalENSG00000175634
TCGA cBioPortalRPS6KB2
AceView (NCBI)RPS6KB2
Genatlas (Paris)RPS6KB2
WikiGenes6199
SOURCE (Princeton)RPS6KB2
Genetics Home Reference (NIH)RPS6KB2
Genomic and cartography
GoldenPath hg38 (UCSC)RPS6KB2  -     chr11:67428464-67435408 +  11q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)RPS6KB2  -     11q13.2   [Description]    (hg19-Feb_2009)
GoldenPathRPS6KB2 - 11q13.2 [CytoView hg19]  RPS6KB2 - 11q13.2 [CytoView hg38]
ImmunoBaseENSG00000175634
Mapping of homologs : NCBIRPS6KB2 [Mapview hg19]  RPS6KB2 [Mapview hg38]
OMIM608939   
Gene and transcription
Genbank (Entrez)AB016869 AB019245 AB208827 AF076931 AF099739
RefSeq transcript (Entrez)NM_001007071 NM_003952
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)RPS6KB2
Cluster EST : UnigeneHs.534345 [ NCBI ]
CGAP (NCI)Hs.534345
Alternative Splicing GalleryENSG00000175634
Gene ExpressionRPS6KB2 [ NCBI-GEO ]   RPS6KB2 [ EBI - ARRAY_EXPRESS ]   RPS6KB2 [ SEEK ]   RPS6KB2 [ MEM ]
Gene Expression Viewer (FireBrowse)RPS6KB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6199
GTEX Portal (Tissue expression)RPS6KB2
Human Protein AtlasENSG00000175634-RPS6KB2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UBS0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UBS0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UBS0
Splice isoforms : SwissVarQ9UBS0
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ9UBS0
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)AGC-kinase_C    Kinase-like_dom_sf    Pkinase_C    Prot_kinase_dom    Protein_kinase_ATP_BS    Ribosomal_S6_kinase    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)    Pkinase_C (PF00433)   
Domain families : Pfam (NCBI)pfam00069    pfam00433   
Domain families : Smart (EMBL)S_TK_X (SM00133)  S_TKc (SM00220)  
Conserved Domain (NCBI)RPS6KB2
DMDM Disease mutations6199
Blocks (Seattle)RPS6KB2
SuperfamilyQ9UBS0
Human Protein Atlas [tissue]ENSG00000175634-RPS6KB2 [tissue]
Peptide AtlasQ9UBS0
HPRD10203
IPIIPI00217069   IPI00555772   IPI01025384   IPI00974340   IPI00982155   IPI00981724   IPI00981120   
Protein Interaction databases
DIP (DOE-UCLA)Q9UBS0
IntAct (EBI)Q9UBS0
FunCoupENSG00000175634
BioGRIDRPS6KB2
STRING (EMBL)RPS6KB2
ZODIACRPS6KB2
Ontologies - Pathways
QuickGOQ9UBS0
Ontology : AmiGOprotein kinase activity  protein serine/threonine kinase activity  ribosomal protein S6 kinase activity  ATP binding  nucleus  nucleoplasm  cytoplasm  translation  protein phosphorylation  signal transduction  intracellular signal transduction  peptide binding  protein kinase B signaling  positive regulation of translational initiation  positive regulation of translational initiation  
Ontology : EGO-EBIprotein kinase activity  protein serine/threonine kinase activity  ribosomal protein S6 kinase activity  ATP binding  nucleus  nucleoplasm  cytoplasm  translation  protein phosphorylation  signal transduction  intracellular signal transduction  peptide binding  protein kinase B signaling  positive regulation of translational initiation  positive regulation of translational initiation  
Pathways : KEGGErbB signaling pathway    HIF-1 signaling pathway    mTOR signaling pathway    PI3K-Akt signaling pathway    TGF-beta signaling pathway    Fc gamma R-mediated phagocytosis    Insulin signaling pathway    Proteoglycans in cancer    Acute myeloid leukemia   
NDEx NetworkRPS6KB2
Atlas of Cancer Signalling NetworkRPS6KB2
Wikipedia pathwaysRPS6KB2
Orthology - Evolution
OrthoDB6199
GeneTree (enSembl)ENSG00000175634
Phylogenetic Trees/Animal Genes : TreeFamRPS6KB2
HOGENOMQ9UBS0
Homologs : HomoloGeneRPS6KB2
Homology/Alignments : Family Browser (UCSC)RPS6KB2
Gene fusions - Rearrangements
Fusion : MitelmanRPS6KB2/C10orf54 [11q13.2/10q22.1]  
Fusion : MitelmanRPS6KB2/PAAF1 [11q13.2/11q13.4]  [t(11;11)(q13;q13)]  
Fusion : MitelmanRPS6KB2/PCNXL3 [11q13.2/11q13.1]  [t(11;11)(q13;q13)]  
Fusion PortalRPS6KB2 11q13.2 C10orf54 10q22.1 BRCA
Fusion PortalRPS6KB2 11q13.2 PAAF1 11q13.4 BRCA
Fusion PortalRPS6KB2 11q13.2 PCNXL3 11q13.1 HNSC
Fusion : QuiverRPS6KB2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRPS6KB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RPS6KB2
dbVarRPS6KB2
ClinVarRPS6KB2
1000_GenomesRPS6KB2 
Exome Variant ServerRPS6KB2
ExAC (Exome Aggregation Consortium)ENSG00000175634
GNOMAD BrowserENSG00000175634
Varsome BrowserRPS6KB2
Genetic variants : HAPMAP6199
Genomic Variants (DGV)RPS6KB2 [DGVbeta]
DECIPHERRPS6KB2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisRPS6KB2 
Mutations
ICGC Data PortalRPS6KB2 
TCGA Data PortalRPS6KB2 
Broad Tumor PortalRPS6KB2
OASIS PortalRPS6KB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRPS6KB2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRPS6KB2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RPS6KB2
DgiDB (Drug Gene Interaction Database)RPS6KB2
DoCM (Curated mutations)RPS6KB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RPS6KB2 (select a term)
intoGenRPS6KB2
Cancer3DRPS6KB2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608939   
Orphanet
DisGeNETRPS6KB2
MedgenRPS6KB2
Genetic Testing Registry RPS6KB2
NextProtQ9UBS0 [Medical]
TSGene6199
GENETestsRPS6KB2
Target ValidationRPS6KB2
Huge Navigator RPS6KB2 [HugePedia]
snp3D : Map Gene to Disease6199
BioCentury BCIQRPS6KB2
ClinGenRPS6KB2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6199
Chemical/Pharm GKB GenePA34852
Clinical trialRPS6KB2
Miscellaneous
canSAR (ICR)RPS6KB2 (select the gene name)
DataMed IndexRPS6KB2
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRPS6KB2
EVEXRPS6KB2
GoPubMedRPS6KB2
iHOPRPS6KB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 7 18:15:58 CEST 2019
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