RPS6KB2 (ribosomal protein S6 kinase B2)

2003-02-01 Affiliation

Identity

HGNC

RPS6KB2

LOCATION

11q13.2

LOCUSID

6199

ALIAS

KLS,P70-beta,P70-beta-1,P70-beta-2,S6K-beta2,S6K2,S6KB,S6KI(2),S6Kbeta,SRK,STK14B,p70(S6K)-beta,p70S6Kb

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6199
MIM: 608939
HGNC: 10437
Ensembl: ENSG00000175634

Variants:

dbSNP: 6199
ClinVar: 6199
TCGA: ENSG00000175634
COSMIC: RPS6KB2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000175634	ENST00000312629	Q9UBS0
ENSG00000175634	ENST00000420069	E9PIP7
ENSG00000175634	ENST00000524934	E9PQF6
ENSG00000175634	ENST00000525996	R4GN47
ENSG00000175634	ENST00000528964	Q9UBS0
ENSG00000175634	ENST00000556575	G3V2F1

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
ErbB signaling pathway	KEGG	ko04012
Autophagy - animal	KEGG	ko04140
mTOR signaling pathway	KEGG	ko04150
TGF-beta signaling pathway	KEGG	ko04350
Insulin signaling pathway	KEGG	ko04910
Acute myeloid leukemia	KEGG	ko05221
ErbB signaling pathway	KEGG	hsa04012
Autophagy - animal	KEGG	hsa04140
mTOR signaling pathway	KEGG	hsa04150
TGF-beta signaling pathway	KEGG	hsa04350
Insulin signaling pathway	KEGG	hsa04910
Acute myeloid leukemia	KEGG	hsa05221
Fc gamma R-mediated phagocytosis	KEGG	ko04666
Fc gamma R-mediated phagocytosis	KEGG	hsa04666
PI3K-Akt signaling pathway	KEGG	hsa04151
PI3K-Akt signaling pathway	KEGG	ko04151
HIF-1 signaling pathway	KEGG	hsa04066
Proteoglycans in cancer	KEGG	hsa05205
Proteoglycans in cancer	KEGG	ko05205
AMPK signaling pathway	KEGG	hsa04152
AMPK signaling pathway	KEGG	ko04152
Choline metabolism in cancer	KEGG	hsa05231
Choline metabolism in cancer	KEGG	ko05231
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
PI3K/AKT Signaling in Cancer	REACTOME	R-HSA-2219528
Constitutive Signaling by AKT1 E17K in Cancer	REACTOME	R-HSA-5674400
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Signaling by the B Cell Receptor (BCR)	REACTOME	R-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)	REACTOME	R-HSA-1168372
PIP3 activates AKT signaling	REACTOME	R-HSA-1257604
AKT phosphorylates targets in the nucleus	REACTOME	R-HSA-198693
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
Role of LAT2/NTAL/LAB on calcium mobilization	REACTOME	R-HSA-2730905
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
GAB1 signalosome	REACTOME	R-HSA-180292
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
PI3K/AKT activation	REACTOME	R-HSA-198203
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by SCF-KIT	REACTOME	R-HSA-1433557
Insulin resistance	KEGG	hsa04931
Longevity regulating pathway	KEGG	hsa04211
Longevity regulating pathway - multiple species	KEGG	ko04213
Longevity regulating pathway - multiple species	KEGG	hsa04213
EGFR tyrosine kinase inhibitor resistance	KEGG	ko01521
Endocrine resistance	KEGG	ko01522
EGFR tyrosine kinase inhibitor resistance	KEGG	hsa01521
Endocrine resistance	KEGG	hsa01522
Breast cancer	KEGG	ko05224
Breast cancer	KEGG	hsa05224
Apelin signaling pathway	KEGG	hsa04371

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
20932932	2011	Functions and regulation of the 70kDa ribosomal S6 kinases.	112
12875979	2003	Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease.	107
24469061	2015	MicroRNA-193a-3p and -5p suppress the metastasis of human non-small-cell lung cancer by downregulating the ERBB4/PIK3R3/mTOR/S6K2 signaling pathway.	99
15051500	2004	Interferon-gamma engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein.	32
24131622	2013	The mTOR effectors 4EBP1 and S6K2 are frequently coexpressed, and associated with a poor prognosis and endocrine resistance in breast cancer: a retrospective study including patients from the randomised Stockholm tamoxifen trials.	29
20953835	2011	Clinical potential of the mTOR targets S6K1 and S6K2 in breast cancer.	26
21035469	2011	Genetic variation in RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 and risk of colon or rectal cancer.	23
21035469	2011	Genetic variation in RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 and risk of colon or rectal cancer.	23
20308064	2010	Involvement of heterogeneous ribonucleoprotein F in the regulation of cell proliferation via the mammalian target of rapamycin/S6 kinase 2 pathway.	22
12529391	2003	Protein kinase C phosphorylates ribosomal protein S6 kinase betaII and regulates its subcellular localization.	21

Citation

Dessen P

RPS6KB2 (ribosomal protein S6 kinase B2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42169/rps6kb2