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SAT1 (spermidine/spermine N1-acetyltransferase 1)

Identity

Alias_namesSAT
spermidine/spermine N1-acetyltransferase
Alias_symbol (synonym)SSAT
Other aliasDC21
KFSD
KFSDX
SSAT-1
HGNC (Hugo) SAT1
LocusID (NCBI) 6303
Atlas_Id 45929
Location Xp22.11  [Link to chromosome band Xp22]
Location_base_pair Starts at 23783158 and ends at 23786223 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FYCO1 (3p21.31) / SAT1 (Xp22.11)MPHOSPH8 (13q12.11) / SAT1 (Xp22.11)SAT1 (Xp22.11) / ANKH (5p15.2)
SAT1 (Xp22.11) / CTTN (11q13.3)SAT1 (Xp22.11) / FNDC3B (3q26.31)SAT1 (Xp22.11) / MPHOSPH8 (13q12.11)
SAT1 (Xp22.11) / SAT1 (Xp22.11)SAT1 (Xp22.11) / SERPINE1 (7q22.1)SAT1 Xp22.11 / CTTN 11q13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SAT1   10540
Cards
Entrez_Gene (NCBI)SAT1  6303  spermidine/spermine N1-acetyltransferase 1
AliasesDC21; KFSD; KFSDX; SAT; 
SSAT; SSAT-1
GeneCards (Weizmann)SAT1
Ensembl hg19 (Hinxton)ENSG00000130066 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000130066 [Gene_View]  chrX:23783158-23786223 [Contig_View]  SAT1 [Vega]
ICGC DataPortalENSG00000130066
TCGA cBioPortalSAT1
AceView (NCBI)SAT1
Genatlas (Paris)SAT1
WikiGenes6303
SOURCE (Princeton)SAT1
Genetics Home Reference (NIH)SAT1
Genomic and cartography
GoldenPath hg38 (UCSC)SAT1  -     chrX:23783158-23786223 +  Xp22.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SAT1  -     Xp22.11   [Description]    (hg19-Feb_2009)
EnsemblSAT1 - Xp22.11 [CytoView hg19]  SAT1 - Xp22.11 [CytoView hg38]
Mapping of homologs : NCBISAT1 [Mapview hg19]  SAT1 [Mapview hg38]
OMIM308800   313020   
Gene and transcription
Genbank (Entrez)AF251292 AK310078 AK310094 AK312162 AK315888
RefSeq transcript (Entrez)NM_002970
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SAT1
Cluster EST : UnigeneHs.28491 [ NCBI ]
CGAP (NCI)Hs.28491
Alternative Splicing GalleryENSG00000130066
Gene ExpressionSAT1 [ NCBI-GEO ]   SAT1 [ EBI - ARRAY_EXPRESS ]   SAT1 [ SEEK ]   SAT1 [ MEM ]
Gene Expression Viewer (FireBrowse)SAT1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6303
GTEX Portal (Tissue expression)SAT1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP21673   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP21673  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP21673
Splice isoforms : SwissVarP21673
PhosPhoSitePlusP21673
Domaine pattern : Prosite (Expaxy)GNAT (PS51186)   
Domains : Interpro (EBI)Acyl_CoA_acyltransferase    GNAT_dom    SAT1   
Domain families : Pfam (Sanger)Acetyltransf_1 (PF00583)   
Domain families : Pfam (NCBI)pfam00583   
Conserved Domain (NCBI)SAT1
DMDM Disease mutations6303
Blocks (Seattle)SAT1
PDB (SRS)2B3U    2B3V    2B4B    2B4D    2B58    2B5G    2F5I    2FXF    2G3T    2JEV   
PDB (PDBSum)2B3U    2B3V    2B4B    2B4D    2B58    2B5G    2F5I    2FXF    2G3T    2JEV   
PDB (IMB)2B3U    2B3V    2B4B    2B4D    2B58    2B5G    2F5I    2FXF    2G3T    2JEV   
PDB (RSDB)2B3U    2B3V    2B4B    2B4D    2B58    2B5G    2F5I    2FXF    2G3T    2JEV   
Structural Biology KnowledgeBase2B3U    2B3V    2B4B    2B4D    2B58    2B5G    2F5I    2FXF    2G3T    2JEV   
SCOP (Structural Classification of Proteins)2B3U    2B3V    2B4B    2B4D    2B58    2B5G    2F5I    2FXF    2G3T    2JEV   
CATH (Classification of proteins structures)2B3U    2B3V    2B4B    2B4D    2B58    2B5G    2F5I    2FXF    2G3T    2JEV   
SuperfamilyP21673
Human Protein AtlasENSG00000130066
Peptide AtlasP21673
HPRD02431
IPIIPI00009889   IPI00385876   IPI00644879   IPI00641408   
Protein Interaction databases
DIP (DOE-UCLA)P21673
IntAct (EBI)P21673
FunCoupENSG00000130066
BioGRIDSAT1
STRING (EMBL)SAT1
ZODIACSAT1
Ontologies - Pathways
QuickGOP21673
Ontology : AmiGOangiogenesis  diamine N-acetyltransferase activity  diamine N-acetyltransferase activity  protein binding  intracellular  cytosol  cytosol  polyamine biosynthetic process  putrescine catabolic process  spermidine binding  spermidine acetylation  regulation of cell proliferation  spermine catabolic process  
Ontology : EGO-EBIangiogenesis  diamine N-acetyltransferase activity  diamine N-acetyltransferase activity  protein binding  intracellular  cytosol  cytosol  polyamine biosynthetic process  putrescine catabolic process  spermidine binding  spermidine acetylation  regulation of cell proliferation  spermine catabolic process  
Pathways : KEGGArginine and proline metabolism   
NDEx NetworkSAT1
Atlas of Cancer Signalling NetworkSAT1
Wikipedia pathwaysSAT1
Orthology - Evolution
OrthoDB6303
GeneTree (enSembl)ENSG00000130066
Phylogenetic Trees/Animal Genes : TreeFamSAT1
HOVERGENP21673
HOGENOMP21673
Homologs : HomoloGeneSAT1
Homology/Alignments : Family Browser (UCSC)SAT1
Gene fusions - Rearrangements
Fusion : MitelmanSAT1/CTTN [Xp22.11/11q13.3]  
Fusion: TCGASAT1 Xp22.11 CTTN 11q13.3 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSAT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SAT1
dbVarSAT1
ClinVarSAT1
1000_GenomesSAT1 
Exome Variant ServerSAT1
ExAC (Exome Aggregation Consortium)SAT1 (select the gene name)
Genetic variants : HAPMAP6303
Genomic Variants (DGV)SAT1 [DGVbeta]
DECIPHERSAT1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSAT1 
Mutations
ICGC Data PortalSAT1 
TCGA Data PortalSAT1 
Broad Tumor PortalSAT1
OASIS PortalSAT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSAT1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSAT1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SAT1
DgiDB (Drug Gene Interaction Database)SAT1
DoCM (Curated mutations)SAT1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SAT1 (select a term)
intoGenSAT1
Cancer3DSAT1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM308800    313020   
Orphanet2192   
MedgenSAT1
Genetic Testing Registry SAT1
NextProtP21673 [Medical]
TSGene6303
GENETestsSAT1
Target ValidationSAT1
Huge Navigator SAT1 [HugePedia]
snp3D : Map Gene to Disease6303
BioCentury BCIQSAT1
ClinGenSAT1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6303
Chemical/Pharm GKB GenePA162402389
Clinical trialSAT1
Miscellaneous
canSAR (ICR)SAT1 (select the gene name)
Probes
Litterature
PubMed79 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSAT1
EVEXSAT1
GoPubMedSAT1
iHOPSAT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:54:25 CEST 2017

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