Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SEMA3C (semaphorin 3C)

Identity

Alias_namesSEMAE
sema domain
Alias_symbol (synonym)SemE
Other alias
HGNC (Hugo) SEMA3C
LocusID (NCBI) 10512
Atlas_Id 42253
Location 7q21.11  [Link to chromosome band 7q21]
Location_base_pair Starts at 80742536 and ends at 80919351 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FABP4 (8q21.13) / SEMA3C (7q21.11)SEMA3C (7q21.11) / ANAPC7 (12q24.11)SEMA3C (7q21.11) / AUTS2 (7q11.22)
SEMA3C (7q21.11) / CD36 (7q21.11)SEMA3C (7q21.11) / CNTNAP2 (7q35)SEMA3C (7q21.11) / SEMA3C (7q21.11)
SEMA3C 7q21.11 / AUTS2 7q11.22SEMA3C 7q21.11 / CD36 7q21.11SEMA3C 7q21.11 / CNTNAP2 7q35

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(7;7)(q11;q21) SEMA3C/AUTS2
t(7;7)(q21;q21) SEMA3C/CD36
t(7;7)(q21;q35) SEMA3C/CNTNAP2

External links

Nomenclature
HGNC (Hugo)SEMA3C   10725
Cards
Entrez_Gene (NCBI)SEMA3C  10512  semaphorin 3C
AliasesSEMAE; SemE
GeneCards (Weizmann)SEMA3C
Ensembl hg19 (Hinxton)ENSG00000075223 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000075223 [Gene_View]ENSG00000075223 [Sequence]  chr7:80742536-80919351 [Contig_View]  SEMA3C [Vega]
ICGC DataPortalENSG00000075223
TCGA cBioPortalSEMA3C
AceView (NCBI)SEMA3C
Genatlas (Paris)SEMA3C
WikiGenes10512
SOURCE (Princeton)SEMA3C
Genetics Home Reference (NIH)SEMA3C
Genomic and cartography
GoldenPath hg38 (UCSC)SEMA3C  -     chr7:80742536-80919351 -  7q21.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SEMA3C  -     7q21.11   [Description]    (hg19-Feb_2009)
EnsemblSEMA3C - 7q21.11 [CytoView hg19]  SEMA3C - 7q21.11 [CytoView hg38]
Mapping of homologs : NCBISEMA3C [Mapview hg19]  SEMA3C [Mapview hg38]
OMIM602645   
Gene and transcription
Genbank (Entrez)AA853650 AB000220 AF086506 AI491966 AK299322
RefSeq transcript (Entrez)NM_001350120 NM_001350121 NM_006379
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SEMA3C
Cluster EST : UnigeneHs.269109 [ NCBI ]
CGAP (NCI)Hs.269109
Alternative Splicing GalleryENSG00000075223
Gene ExpressionSEMA3C [ NCBI-GEO ]   SEMA3C [ EBI - ARRAY_EXPRESS ]   SEMA3C [ SEEK ]   SEMA3C [ MEM ]
Gene Expression Viewer (FireBrowse)SEMA3C [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10512
GTEX Portal (Tissue expression)SEMA3C
Human Protein AtlasENSG00000075223-SEMA3C [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99985   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99985  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99985
Splice isoforms : SwissVarQ99985
PhosPhoSitePlusQ99985
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    SEMA (PS51004)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig_I-set    Ig_sub    PSI    Semap_dom    Semaphorin    WD40/YVTN_repeat-like_dom   
Domain families : Pfam (Sanger)I-set (PF07679)    Sema (PF01403)   
Domain families : Pfam (NCBI)pfam07679    pfam01403   
Domain families : Smart (EMBL)IG (SM00409)  PSI (SM00423)  Sema (SM00630)  
Conserved Domain (NCBI)SEMA3C
DMDM Disease mutations10512
Blocks (Seattle)SEMA3C
SuperfamilyQ99985
Human Protein Atlas [tissue]ENSG00000075223-SEMA3C [tissue]
Peptide AtlasQ99985
HPRD04034
IPIIPI01014918   IPI01015562   IPI00019209   IPI00925709   IPI00926869   
Protein Interaction databases
DIP (DOE-UCLA)Q99985
IntAct (EBI)Q99985
FunCoupENSG00000075223
BioGRIDSEMA3C
STRING (EMBL)SEMA3C
ZODIACSEMA3C
Ontologies - Pathways
QuickGOQ99985
Ontology : AmiGOneural crest cell migration  somitogenesis  blood vessel remodeling  outflow tract septum morphogenesis  cardiac right ventricle morphogenesis  pulmonary myocardium development  extracellular space  immune response  axon guidance  post-embryonic development  neural tube development  semaphorin receptor binding  neuropilin binding  response to drug  negative chemotaxis  limb bud formation  dichotomous subdivision of terminal units involved in salivary gland branching  extracellular exosome  semaphorin-plexin signaling pathway  cardiac endothelial to mesenchymal transition  positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis  
Ontology : EGO-EBIneural crest cell migration  somitogenesis  blood vessel remodeling  outflow tract septum morphogenesis  cardiac right ventricle morphogenesis  pulmonary myocardium development  extracellular space  immune response  axon guidance  post-embryonic development  neural tube development  semaphorin receptor binding  neuropilin binding  response to drug  negative chemotaxis  limb bud formation  dichotomous subdivision of terminal units involved in salivary gland branching  extracellular exosome  semaphorin-plexin signaling pathway  cardiac endothelial to mesenchymal transition  positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis  
Pathways : KEGGAxon guidance   
NDEx NetworkSEMA3C
Atlas of Cancer Signalling NetworkSEMA3C
Wikipedia pathwaysSEMA3C
Orthology - Evolution
OrthoDB10512
GeneTree (enSembl)ENSG00000075223
Phylogenetic Trees/Animal Genes : TreeFamSEMA3C
HOVERGENQ99985
HOGENOMQ99985
Homologs : HomoloGeneSEMA3C
Homology/Alignments : Family Browser (UCSC)SEMA3C
Gene fusions - Rearrangements
Fusion : MitelmanSEMA3C/AUTS2 [7q21.11/7q11.22]  
Fusion : MitelmanSEMA3C/CD36 [7q21.11/7q21.11]  [t(7;7)(q21;q21)]  
Fusion : MitelmanSEMA3C/CNTNAP2 [7q21.11/7q35]  [t(7;7)(q21;q35)]  
Fusion PortalSEMA3C 7q21.11 AUTS2 7q11.22 BRCA
Fusion PortalSEMA3C 7q21.11 CD36 7q21.11 LUSC
Fusion PortalSEMA3C 7q21.11 CNTNAP2 7q35 BRCA
Fusion : QuiverSEMA3C
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSEMA3C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SEMA3C
dbVarSEMA3C
ClinVarSEMA3C
1000_GenomesSEMA3C 
Exome Variant ServerSEMA3C
ExAC (Exome Aggregation Consortium)ENSG00000075223
GNOMAD BrowserENSG00000075223
Genetic variants : HAPMAP10512
Genomic Variants (DGV)SEMA3C [DGVbeta]
DECIPHERSEMA3C [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSEMA3C 
Mutations
ICGC Data PortalSEMA3C 
TCGA Data PortalSEMA3C 
Broad Tumor PortalSEMA3C
OASIS PortalSEMA3C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSEMA3C  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSEMA3C
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SEMA3C
DgiDB (Drug Gene Interaction Database)SEMA3C
DoCM (Curated mutations)SEMA3C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SEMA3C (select a term)
intoGenSEMA3C
Cancer3DSEMA3C(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602645   
Orphanet647   
DisGeNETSEMA3C
MedgenSEMA3C
Genetic Testing Registry SEMA3C
NextProtQ99985 [Medical]
TSGene10512
GENETestsSEMA3C
Target ValidationSEMA3C
Huge Navigator SEMA3C [HugePedia]
snp3D : Map Gene to Disease10512
BioCentury BCIQSEMA3C
ClinGenSEMA3C
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10512
Chemical/Pharm GKB GenePA35647
Clinical trialSEMA3C
Miscellaneous
canSAR (ICR)SEMA3C (select the gene name)
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSEMA3C
EVEXSEMA3C
GoPubMedSEMA3C
iHOPSEMA3C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jun 21 17:14:08 CEST 2018
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