SEMA3C (semaphorin 3C)

2003-11-01 Affiliation

Identity

HGNC

SEMA3C

LOCATION

7q21.11

LOCUSID

10512

ALIAS

SEMAE,SemE

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10512
MIM: 602645
HGNC: 10725
Ensembl: ENSG00000075223

Variants:

dbSNP: 10512
ClinVar: 10512
TCGA: ENSG00000075223
COSMIC: SEMA3C

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000075223	ENST00000265361	Q99985
ENSG00000075223	ENST00000411788	F2Z2Y0
ENSG00000075223	ENST00000419255	Q99985
ENSG00000075223	ENST00000427167	F2Z2Y0
ENSG00000075223	ENST00000458729	F8WEP9

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Axon guidance	KEGG	ko04360
Axon guidance	KEGG	hsa04360

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA443622	Carcinoma, Non-Small-Cell Lung	Disease	ClinicalAnnotation	associated		PD	22664479
PA450085	irinotecan	Chemical	ClinicalAnnotation	associated		PD	22664479

References

Pubmed ID	Year	Title	Citations
19666519	2009	GATA6 mutations cause human cardiac outflow tract defects by disrupting semaphorin-plexin signaling.	55
17390026	2007	Increased class 3 semaphorin expression modulates the invasive and adhesive properties of prostate cancer cells.	46
25464848	2014	Sema3C promotes the survival and tumorigenicity of glioma stem cells through Rac1 activation.	42
19915008	2010	The cleavage of semaphorin 3C induced by ADAMTS1 promotes cell migration.	40
25808871	2015	Full-Length Semaphorin-3C Is an Inhibitor of Tumor Lymphangiogenesis and Metastasis.	33
25839327	2015	Functional loss of semaphorin 3C and/or semaphorin 3D and their epistatic interaction with ret are critical to Hirschsprung disease liability.	31
12730958	2003	Human malignant glioma cells express semaphorins and their receptors, neuropilins and plexins.	28
26993346	2016	Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease.	28
15077297	2004	Increased prevalence of semaphorin 3C, a repellent of sympathetic nerve fibers, in the synovial tissue of patients with rheumatoid arthritis.	26
22924992	2012	Semaphorin 3C is involved in the progression of gastric cancer.	25

Citation

Dessen P

SEMA3C (semaphorin 3C)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42253/sema3c