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SERPINE1 (serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1)

Identity

Other namesPAI
PAI-1
PAI1
PLANH1
HGNC (Hugo) SERPINE1
LocusID (NCBI) 5054
Location 7q22.1
Location_base_pair Starts at 100770370 and ends at 100782547 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SERPINE1   8583
Cards
Entrez_Gene (NCBI)SERPINE1  5054  serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
GeneCards (Weizmann)SERPINE1
Ensembl (Hinxton)ENSG00000106366 [Gene_View]  chr7:100770370-100782547 [Contig_View]  SERPINE1 [Vega]
ICGC DataPortalENSG00000106366
AceView (NCBI)SERPINE1
Genatlas (Paris)SERPINE1
WikiGenes5054
SOURCE (Princeton)NM_000602 NM_001165413
Genomic and cartography
GoldenPath (UCSC)SERPINE1  -  7q22.1   chr7:100770370-100782547 +  7q22.1   [Description]    (hg19-Feb_2009)
EnsemblSERPINE1 - 7q22.1 [CytoView]
Mapping of homologs : NCBISERPINE1 [Mapview]
OMIM173360   613329   
Gene and transcription
Genbank (Entrez)AI752990 AK293248 AK297728 AK298048 AK316225
RefSeq transcript (Entrez)NM_000602 NM_001165413
RefSeq genomic (Entrez)AC_000139 NC_000007 NC_018918 NG_013213 NT_007933 NW_001839067 NW_004929332
Consensus coding sequences : CCDS (NCBI)SERPINE1
Cluster EST : UnigeneHs.741440 [ NCBI ]
CGAP (NCI)Hs.741440
Alternative Splicing : Fast-db (Paris)GSHG0027598
Alternative Splicing GalleryENSG00000106366
Gene ExpressionSERPINE1 [ NCBI-GEO ]     SERPINE1 [ SEEK ]   SERPINE1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05121 (Uniprot)
NextProtP05121  [Medical]
With graphics : InterProP05121
Splice isoforms : SwissVarP05121 (Swissvar)
Domaine pattern : Prosite (Expaxy)SERPIN (PS00284)   
Domains : Interpro (EBI)Serpin_CS    Serpin_dom    Serpin_fam   
Related proteins : CluSTrP05121
Domain families : Pfam (Sanger)Serpin (PF00079)   
Domain families : Pfam (NCBI)pfam00079   
Domain families : Smart (EMBL)SERPIN (SM00093)  
DMDM Disease mutations5054
Blocks (Seattle)P05121
PDB (SRS)1A7C    1B3K    1C5G    1DB2    1DVM    1DVN    1LJ5    1OC0    3CVM    3EOX    3PB1    3Q02    3Q03    3R4L    3UT3    4AQH    4G8O    4G8R    4IC0    9PAI   
PDB (PDBSum)1A7C    1B3K    1C5G    1DB2    1DVM    1DVN    1LJ5    1OC0    3CVM    3EOX    3PB1    3Q02    3Q03    3R4L    3UT3    4AQH    4G8O    4G8R    4IC0    9PAI   
PDB (IMB)1A7C    1B3K    1C5G    1DB2    1DVM    1DVN    1LJ5    1OC0    3CVM    3EOX    3PB1    3Q02    3Q03    3R4L    3UT3    4AQH    4G8O    4G8R    4IC0    9PAI   
PDB (RSDB)1A7C    1B3K    1C5G    1DB2    1DVM    1DVN    1LJ5    1OC0    3CVM    3EOX    3PB1    3Q02    3Q03    3R4L    3UT3    4AQH    4G8O    4G8R    4IC0    9PAI   
Human Protein AtlasENSG00000106366
Peptide AtlasP05121
HPRD01418
IPIIPI00007118   IPI01014079   IPI00926949   
Protein Interaction databases
DIP (DOE-UCLA)P05121
IntAct (EBI)P05121
FunCoupENSG00000106366
BioGRIDSERPINE1
InParanoidP05121
Interologous Interaction database P05121
IntegromeDBSERPINE1
STRING (EMBL)SERPINE1
Ontologies - Pathways
Ontology : AmiGOchronological cell aging  angiogenesis  protease binding  platelet degranulation  serine-type endopeptidase inhibitor activity  receptor binding  protein binding  extracellular region  extracellular region  extracellular space  plasma membrane  transcription, DNA-templated  transcription initiation from RNA polymerase II promoter  transforming growth factor beta receptor signaling pathway  blood coagulation  gene expression  regulation of receptor activity  negative regulation of plasminogen activation  negative regulation of plasminogen activation  negative regulation of endopeptidase activity  negative regulation of smooth muscle cell migration  platelet activation  positive regulation of blood coagulation  negative regulation of blood coagulation  extracellular matrix organization  negative regulation of cell migration  extracellular matrix  platelet alpha granule lumen  positive regulation of interleukin-8 production  negative regulation of cell adhesion mediated by integrin  positive regulation of leukotriene production involved in inflammatory response  regulation of cell proliferation  fibrinolysis  positive regulation of angiogenesis  positive regulation of transcription from RNA polymerase II promoter  positive regulation of receptor-mediated endocytosis  positive regulation of inflammatory response  defense response to Gram-negative bacterium  negative regulation of fibrinolysis  negative regulation of vascular wound healing  negative regulation of wound healing  cellular response to lipopolysaccharide  positive regulation of monocyte chemotaxis  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  negative regulation of smooth muscle cell-matrix adhesion  negative regulation of endothelial cell apoptotic process  
Ontology : EGO-EBIchronological cell aging  angiogenesis  protease binding  platelet degranulation  serine-type endopeptidase inhibitor activity  receptor binding  protein binding  extracellular region  extracellular region  extracellular space  plasma membrane  transcription, DNA-templated  transcription initiation from RNA polymerase II promoter  transforming growth factor beta receptor signaling pathway  blood coagulation  gene expression  regulation of receptor activity  negative regulation of plasminogen activation  negative regulation of plasminogen activation  negative regulation of endopeptidase activity  negative regulation of smooth muscle cell migration  platelet activation  positive regulation of blood coagulation  negative regulation of blood coagulation  extracellular matrix organization  negative regulation of cell migration  extracellular matrix  platelet alpha granule lumen  positive regulation of interleukin-8 production  negative regulation of cell adhesion mediated by integrin  positive regulation of leukotriene production involved in inflammatory response  regulation of cell proliferation  fibrinolysis  positive regulation of angiogenesis  positive regulation of transcription from RNA polymerase II promoter  positive regulation of receptor-mediated endocytosis  positive regulation of inflammatory response  defense response to Gram-negative bacterium  negative regulation of fibrinolysis  negative regulation of vascular wound healing  negative regulation of wound healing  cellular response to lipopolysaccharide  positive regulation of monocyte chemotaxis  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  negative regulation of smooth muscle cell-matrix adhesion  negative regulation of endothelial cell apoptotic process  
Pathways : BIOCARTAFibrinolysis Pathway [Genes]    Platelet Amyloid Precursor Protein Pathway [Genes]   
Pathways : KEGGHIF-1 signaling pathway    p53 signaling pathway    Hippo signaling pathway    Complement and coagulation cascades    Chagas disease (American trypanosomiasis)   
Protein Interaction DatabaseSERPINE1
Wikipedia pathwaysSERPINE1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)SERPINE1
SNP (GeneSNP Utah)SERPINE1
SNP : HGBaseSERPINE1
Genetic variants : HAPMAPSERPINE1
1000_GenomesSERPINE1 
ICGC programENSG00000106366 
CONAN: Copy Number AnalysisSERPINE1 
Somatic Mutations in Cancer : COSMICSERPINE1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Mutations and Diseases : HGMDSERPINE1
OMIM173360    613329   
MedgenSERPINE1
GENETestsSERPINE1
Disease Genetic AssociationSERPINE1
Huge Navigator SERPINE1 [HugePedia]  SERPINE1 [HugeCancerGEM]
Genomic VariantsSERPINE1  SERPINE1 [DGVbeta]
Exome VariantSERPINE1
dbVarSERPINE1
ClinVarSERPINE1
snp3D : Map Gene to Disease5054
General knowledge
Homologs : HomoloGeneSERPINE1
Homology/Alignments : Family Browser (UCSC)SERPINE1
Phylogenetic Trees/Animal Genes : TreeFamSERPINE1
Chemical/Protein Interactions : CTD5054
Chemical/Pharm GKB GenePA261
Clinical trialSERPINE1
Cancer Resource (Charite)ENSG00000106366
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineSERPINE1
iHOPSERPINE1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 13 13:15:48 CEST 2014

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