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SGPL1 (sphingosine-1-phosphate lyase 1)

Identity

Alias_symbol (synonym)SPL
Other aliasNPHS14
S1PL
HGNC (Hugo) SGPL1
LocusID (NCBI) 8879
Atlas_Id 45944
Location 10q22.1  [Link to chromosome band 10q22]
Location_base_pair Starts at 70815948 and ends at 70881175 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SGPL1 (10q22.1) / ADAMTS14 (10q22.1)SGPL1 (10q22.1) / BTBD9 (6p21.2)SGPL1 (10q22.1) / FKBP15 (9q32)
SGPL1 (10q22.1) / USP39 (2p11.2)SRGN (10q22.1) / SGPL1 (10q22.1)SGPL1 10q22.1 / BTBD9 6p21.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;10)(p21;q22) SGPL1/BTBD9

External links

Nomenclature
HGNC (Hugo)SGPL1   10817
Cards
Entrez_Gene (NCBI)SGPL1  8879  sphingosine-1-phosphate lyase 1
AliasesNPHS14; S1PL; SPL
GeneCards (Weizmann)SGPL1
Ensembl hg19 (Hinxton)ENSG00000166224 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166224 [Gene_View]  ENSG00000166224 [Sequence]  chr10:70815948-70881175 [Contig_View]  SGPL1 [Vega]
ICGC DataPortalENSG00000166224
TCGA cBioPortalSGPL1
AceView (NCBI)SGPL1
Genatlas (Paris)SGPL1
WikiGenes8879
SOURCE (Princeton)SGPL1
Genetics Home Reference (NIH)SGPL1
Genomic and cartography
GoldenPath hg38 (UCSC)SGPL1  -     chr10:70815948-70881175 +  10q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SGPL1  -     10q22.1   [Description]    (hg19-Feb_2009)
EnsemblSGPL1 - 10q22.1 [CytoView hg19]  SGPL1 - 10q22.1 [CytoView hg38]
Mapping of homologs : NCBISGPL1 [Mapview hg19]  SGPL1 [Mapview hg38]
OMIM603729   617575   
Gene and transcription
Genbank (Entrez)AB033078 AF144638 AJ011304 AK023873 AK308610
RefSeq transcript (Entrez)NM_003901
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SGPL1
Cluster EST : UnigeneHs.499984 [ NCBI ]
CGAP (NCI)Hs.499984
Alternative Splicing GalleryENSG00000166224
Gene ExpressionSGPL1 [ NCBI-GEO ]   SGPL1 [ EBI - ARRAY_EXPRESS ]   SGPL1 [ SEEK ]   SGPL1 [ MEM ]
Gene Expression Viewer (FireBrowse)SGPL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8879
GTEX Portal (Tissue expression)SGPL1
Human Protein AtlasENSG00000166224-SGPL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95470   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95470  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95470
Splice isoforms : SwissVarO95470
PhosPhoSitePlusO95470
Domains : Interpro (EBI)PyrdxlP-dep_de-COase    PyrdxlP-dep_Trfase    PyrdxlP-dep_Trfase_major_sub1   
Domain families : Pfam (Sanger)Pyridoxal_deC (PF00282)   
Domain families : Pfam (NCBI)pfam00282   
Conserved Domain (NCBI)SGPL1
DMDM Disease mutations8879
Blocks (Seattle)SGPL1
PDB (SRS)4Q6R   
PDB (PDBSum)4Q6R   
PDB (IMB)4Q6R   
PDB (RSDB)4Q6R   
Structural Biology KnowledgeBase4Q6R   
SCOP (Structural Classification of Proteins)4Q6R   
CATH (Classification of proteins structures)4Q6R   
SuperfamilyO95470
Human Protein Atlas [tissue]ENSG00000166224-SGPL1 [tissue]
Peptide AtlasO95470
HPRD07224
IPIIPI00099463   IPI00647291   IPI00639821   
Protein Interaction databases
DIP (DOE-UCLA)O95470
IntAct (EBI)O95470
FunCoupENSG00000166224
BioGRIDSGPL1
STRING (EMBL)SGPL1
ZODIACSGPL1
Ontologies - Pathways
QuickGOO95470
Ontology : AmiGOluteinization  vasculogenesis  kidney development  protein binding  endoplasmic reticulum  endoplasmic reticulum membrane  fatty acid metabolic process  ceramide metabolic process  spermatogenesis  sphinganine-1-phosphate aldolase activity  sphinganine-1-phosphate aldolase activity  sphinganine-1-phosphate aldolase activity  sphinganine-1-phosphate aldolase activity  androgen metabolic process  estrogen metabolic process  post-embryonic development  fibroblast migration  carboxy-lyase activity  hemopoiesis  sphingolipid biosynthetic process  sphingolipid catabolic process  sphingolipid catabolic process  sphingolipid catabolic process  pyridoxal phosphate binding  integral component of endoplasmic reticulum membrane  Leydig cell differentiation  regulation of multicellular organism growth  platelet-derived growth factor receptor signaling pathway  skeletal system morphogenesis  palate development  face morphogenesis  apoptotic signaling pathway  
Ontology : EGO-EBIluteinization  vasculogenesis  kidney development  protein binding  endoplasmic reticulum  endoplasmic reticulum membrane  fatty acid metabolic process  ceramide metabolic process  spermatogenesis  sphinganine-1-phosphate aldolase activity  sphinganine-1-phosphate aldolase activity  sphinganine-1-phosphate aldolase activity  sphinganine-1-phosphate aldolase activity  androgen metabolic process  estrogen metabolic process  post-embryonic development  fibroblast migration  carboxy-lyase activity  hemopoiesis  sphingolipid biosynthetic process  sphingolipid catabolic process  sphingolipid catabolic process  sphingolipid catabolic process  pyridoxal phosphate binding  integral component of endoplasmic reticulum membrane  Leydig cell differentiation  regulation of multicellular organism growth  platelet-derived growth factor receptor signaling pathway  skeletal system morphogenesis  palate development  face morphogenesis  apoptotic signaling pathway  
Pathways : KEGGSphingolipid metabolism   
NDEx NetworkSGPL1
Atlas of Cancer Signalling NetworkSGPL1
Wikipedia pathwaysSGPL1
Orthology - Evolution
OrthoDB8879
GeneTree (enSembl)ENSG00000166224
Phylogenetic Trees/Animal Genes : TreeFamSGPL1
HOVERGENO95470
HOGENOMO95470
Homologs : HomoloGeneSGPL1
Homology/Alignments : Family Browser (UCSC)SGPL1
Gene fusions - Rearrangements
Fusion : MitelmanSGPL1/BTBD9 [10q22.1/6p21.2]  
Fusion PortalSGPL1 10q22.1 BTBD9 6p21.2 PRAD
Fusion : QuiverSGPL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSGPL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SGPL1
dbVarSGPL1
ClinVarSGPL1
1000_GenomesSGPL1 
Exome Variant ServerSGPL1
ExAC (Exome Aggregation Consortium)ENSG00000166224
GNOMAD BrowserENSG00000166224
Genetic variants : HAPMAP8879
Genomic Variants (DGV)SGPL1 [DGVbeta]
DECIPHERSGPL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSGPL1 
Mutations
ICGC Data PortalSGPL1 
TCGA Data PortalSGPL1 
Broad Tumor PortalSGPL1
OASIS PortalSGPL1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDSGPL1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SGPL1
DgiDB (Drug Gene Interaction Database)SGPL1
DoCM (Curated mutations)SGPL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SGPL1 (select a term)
intoGenSGPL1
Cancer3DSGPL1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603729    617575   
Orphanet
DisGeNETSGPL1
MedgenSGPL1
Genetic Testing Registry SGPL1
NextProtO95470 [Medical]
TSGene8879
GENETestsSGPL1
Target ValidationSGPL1
Huge Navigator SGPL1 [HugePedia]
snp3D : Map Gene to Disease8879
BioCentury BCIQSGPL1
ClinGenSGPL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8879
Chemical/Pharm GKB GenePA35725
Clinical trialSGPL1
Miscellaneous
canSAR (ICR)SGPL1 (select the gene name)
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSGPL1
EVEXSGPL1
GoPubMedSGPL1
iHOPSGPL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 22 16:49:24 CEST 2018
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