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SH3GLB1 (SH3 domain containing GRB2 like, endophilin B1)

Identity

Alias (NCBI)Bif-1
CGI-61
PPP1R70
dJ612B15.2
HGNC (Hugo) SH3GLB1
HGNC Alias symbCGI-61
KIAA0491
Bif-1
PPP1R70
HGNC Alias nameprotein phosphatase 1, regulatory subunit 70
HGNC Previous nameSH3-domain, GRB2-like, endophilin B1
LocusID (NCBI) 51100
Atlas_Id 43859
Location 1p22.3  [Link to chromosome band 1p22]
Location_base_pair Starts at 86704576 and ends at 86748184 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MFSD14B (9q22.32) / SH3GLB1 (1p22.3)SH3GLB1 (1p22.3) / CSNK2A1 (20p13)SH3GLB1 (1p22.3) / HSP90AB1 (6p21.1)
SYT12 (11q13.2) / SH3GLB1 (1p22.3)TRIM66 (11p15.4) / SH3GLB1 (1p22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SH3GLB1   10833
Cards
Entrez_Gene (NCBI)SH3GLB1    SH3 domain containing GRB2 like, endophilin B1
AliasesBif-1; CGI-61; PPP1R70; dJ612B15.2
GeneCards (Weizmann)SH3GLB1
Ensembl hg19 (Hinxton)ENSG00000097033 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000097033 [Gene_View]  ENSG00000097033 [Sequence]  chr1:86704576-86748184 [Contig_View]  SH3GLB1 [Vega]
ICGC DataPortalENSG00000097033
TCGA cBioPortalSH3GLB1
AceView (NCBI)SH3GLB1
Genatlas (Paris)SH3GLB1
SOURCE (Princeton)SH3GLB1
Genetics Home Reference (NIH)SH3GLB1
Genomic and cartography
GoldenPath hg38 (UCSC)SH3GLB1  -     chr1:86704576-86748184 +  1p22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SH3GLB1  -     1p22.3   [Description]    (hg19-Feb_2009)
GoldenPathSH3GLB1 - 1p22.3 [CytoView hg19]  SH3GLB1 - 1p22.3 [CytoView hg38]
ImmunoBaseENSG00000097033
Genome Data Viewer NCBISH3GLB1 [Mapview hg19]  
OMIM609287   
Gene and transcription
Genbank (Entrez)AB007960 AF151819 AF257318 AF263293 AF350371
RefSeq transcript (Entrez)NM_001206651 NM_001206652 NM_001206653 NM_016009
Consensus coding sequences : CCDS (NCBI)SH3GLB1
Gene ExpressionSH3GLB1 [ NCBI-GEO ]   SH3GLB1 [ EBI - ARRAY_EXPRESS ]   SH3GLB1 [ SEEK ]   SH3GLB1 [ MEM ]
Gene Expression Viewer (FireBrowse)SH3GLB1 [ Firebrowse - Broad ]
GenevisibleExpression of SH3GLB1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51100
GTEX Portal (Tissue expression)SH3GLB1
Human Protein AtlasENSG00000097033-SH3GLB1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y371   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y371  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y371
PhosPhoSitePlusQ9Y371
Domaine pattern : Prosite (Expaxy)BAR (PS51021)    SH3 (PS50002)   
Domains : Interpro (EBI)AH/BAR_dom_sf    BAR_dom    SH3-like_dom_sf    SH3_domain    SH3GLB1    SH3GLB1_BAR   
Domain families : Pfam (Sanger)BAR (PF03114)    SH3_9 (PF14604)   
Domain families : Pfam (NCBI)pfam03114    pfam14604   
Domain families : Smart (EMBL)BAR (SM00721)  SH3 (SM00326)  
Conserved Domain (NCBI)SH3GLB1
PDB (RSDB)6UP6    6UPN   
PDB Europe6UP6    6UPN   
PDB (PDBSum)6UP6    6UPN   
PDB (IMB)6UP6    6UPN   
Structural Biology KnowledgeBase6UP6    6UPN   
SCOP (Structural Classification of Proteins)6UP6    6UPN   
CATH (Classification of proteins structures)6UP6    6UPN   
SuperfamilyQ9Y371
AlphaFold pdb e-kbQ9Y371   
Human Protein Atlas [tissue]ENSG00000097033-SH3GLB1 [tissue]
HPRD15333
Protein Interaction databases
DIP (DOE-UCLA)Q9Y371
IntAct (EBI)Q9Y371
BioGRIDSH3GLB1
STRING (EMBL)SH3GLB1
ZODIACSH3GLB1
Ontologies - Pathways
QuickGOQ9Y371
Ontology : AmiGOGolgi membrane  autophagosome membrane  protein binding  cytoplasm  mitochondrial outer membrane  cytosol  autophagy  apoptotic process  lipid binding  positive regulation of autophagy  regulation of macroautophagy  midbody  positive regulation of protein-containing complex assembly  cytoplasmic vesicle  regulation of protein stability  regulation of cytokinesis  receptor catabolic process  protein-containing complex  cellular response to amino acid starvation  cellular response to glucose starvation  identical protein binding  protein homodimerization activity  cadherin binding  autophagic cell death  membrane fission  positive regulation of membrane tubulation  protein localization to vacuolar membrane  positive regulation of protein targeting to mitochondrion  positive regulation of autophagosome assembly  
Ontology : EGO-EBIGolgi membrane  autophagosome membrane  protein binding  cytoplasm  mitochondrial outer membrane  cytosol  autophagy  apoptotic process  lipid binding  positive regulation of autophagy  regulation of macroautophagy  midbody  positive regulation of protein-containing complex assembly  cytoplasmic vesicle  regulation of protein stability  regulation of cytokinesis  receptor catabolic process  protein-containing complex  cellular response to amino acid starvation  cellular response to glucose starvation  identical protein binding  protein homodimerization activity  cadherin binding  autophagic cell death  membrane fission  positive regulation of membrane tubulation  protein localization to vacuolar membrane  positive regulation of protein targeting to mitochondrion  positive regulation of autophagosome assembly  
Pathways : BIOCARTACBL mediated ligand-induced downregulation of EGF receptors [Genes]   
Pathways : KEGGEndocytosis   
NDEx NetworkSH3GLB1
Atlas of Cancer Signalling NetworkSH3GLB1
Wikipedia pathwaysSH3GLB1
Orthology - Evolution
OrthoDB51100
GeneTree (enSembl)ENSG00000097033
Phylogenetic Trees/Animal Genes : TreeFamSH3GLB1
Homologs : HomoloGeneSH3GLB1
Homology/Alignments : Family Browser (UCSC)SH3GLB1
Gene fusions - Rearrangements
Fusion : QuiverSH3GLB1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSH3GLB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SH3GLB1
dbVarSH3GLB1
ClinVarSH3GLB1
MonarchSH3GLB1
1000_GenomesSH3GLB1 
Exome Variant ServerSH3GLB1
GNOMAD BrowserENSG00000097033
Varsome BrowserSH3GLB1
ACMGSH3GLB1 variants
VarityQ9Y371
Genomic Variants (DGV)SH3GLB1 [DGVbeta]
DECIPHERSH3GLB1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSH3GLB1 
Mutations
ICGC Data PortalSH3GLB1 
TCGA Data PortalSH3GLB1 
Broad Tumor PortalSH3GLB1
OASIS PortalSH3GLB1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSH3GLB1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSH3GLB1
Mutations and Diseases : HGMDSH3GLB1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSH3GLB1
DgiDB (Drug Gene Interaction Database)SH3GLB1
DoCM (Curated mutations)SH3GLB1
CIViC (Clinical Interpretations of Variants in Cancer)SH3GLB1
Cancer3DSH3GLB1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609287   
Orphanet
DisGeNETSH3GLB1
MedgenSH3GLB1
Genetic Testing Registry SH3GLB1
NextProtQ9Y371 [Medical]
GENETestsSH3GLB1
Target ValidationSH3GLB1
Huge Navigator SH3GLB1 [HugePedia]
ClinGenSH3GLB1
Clinical trials, drugs, therapy
MyCancerGenomeSH3GLB1
Protein Interactions : CTDSH3GLB1
Pharm GKB GenePA35739
PharosQ9Y371
Clinical trialSH3GLB1
Miscellaneous
canSAR (ICR)SH3GLB1
HarmonizomeSH3GLB1
DataMed IndexSH3GLB1
Probes
Litterature
PubMed77 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSH3GLB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:31:01 CEST 2021

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