SH3GLB1 (SH3 domain containing GRB2 like, endophilin B1)

2007-02-01  

Identity

HGNC
LOCATION
1p22.3
LOCUSID
ALIAS
Bif-1,CGI-61,PPP1R70,dJ612B15.2
FUSION GENES

Other Information

Locus ID:

NCBI: 51100
MIM: 609287
HGNC: 10833
Ensembl: ENSG00000097033

Variants:

dbSNP: 51100
ClinVar: 51100
TCGA: ENSG00000097033
COSMIC: SH3GLB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000097033ENST00000370558Q9Y371
ENSG00000097033ENST00000370558A0A140VJU5
ENSG00000097033ENST00000482504Q9Y371
ENSG00000097033ENST00000535010Q9Y371
ENSG00000097033ENST00000616170A0A087WW40

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
167635572006Endophilin BAR domain drives membrane curvature by two newly identified structure-based mechanisms.119
154521442004Endophilin B1 is required for the maintenance of mitochondrial morphology.90
162275882005Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis.77
210685422011Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy.57
201599672010GSK-3beta promotes cell survival by modulating Bif-1-dependent autophagy and cell death.34
190744402009Endophilin B1/Bif-1 stimulates BAX activation independently from its capacity to produce large scale membrane morphological rearrangements.30
234294962013Prognostic significance of autophagy-related protein expression in resected pancreatic ductal adenocarcinoma.28
188335852008Down-regulation of Bax-interacting factor-1 in colorectal adenocarcinoma.26
169167192006Decreased expression of tumour suppressor Bax-interacting factor-1 (Bif-1), a Bax activator, in gastric carcinomas.24
198055442009Bax activates endophilin B1 oligomerization and lipid membrane vesiculation.19

Citation

Dessen P

SH3GLB1 (SH3 domain containing GRB2 like, endophilin B1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43859/sh3glb1