Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

SH3GLB1 (SH3 domain containing GRB2 like, endophilin B1)

Identity

Alias_namesregulatory subunit 70
Alias_symbol (synonym)CGI-61
KIAA0491
Bif-1
PPP1R70
Other aliasdJ612B15.2
HGNC (Hugo) SH3GLB1
LocusID (NCBI) 51100
Atlas_Id 43859
Location 1p22.3  [Link to chromosome band 1p22]
Location_base_pair Starts at 86704570 and ends at 86748184 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MFSD14B (9q22.32) / SH3GLB1 (1p22.3)SH3GLB1 (1p22.3) / CSNK2A1 (20p13)SH3GLB1 (1p22.3) / HSP90AB1 (6p21.1)
SYT12 (11q13.2) / SH3GLB1 (1p22.3)TRIM66 (11p15.4) / SH3GLB1 (1p22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SH3GLB1   10833
Cards
Entrez_Gene (NCBI)SH3GLB1  51100  SH3 domain containing GRB2 like, endophilin B1
AliasesBif-1; CGI-61; PPP1R70; dJ612B15.2
GeneCards (Weizmann)SH3GLB1
Ensembl hg19 (Hinxton)ENSG00000097033 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000097033 [Gene_View]  chr1:86704570-86748184 [Contig_View]  SH3GLB1 [Vega]
ICGC DataPortalENSG00000097033
TCGA cBioPortalSH3GLB1
AceView (NCBI)SH3GLB1
Genatlas (Paris)SH3GLB1
WikiGenes51100
SOURCE (Princeton)SH3GLB1
Genetics Home Reference (NIH)SH3GLB1
Genomic and cartography
GoldenPath hg38 (UCSC)SH3GLB1  -     chr1:86704570-86748184 +  1p22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SH3GLB1  -     1p22.3   [Description]    (hg19-Feb_2009)
EnsemblSH3GLB1 - 1p22.3 [CytoView hg19]  SH3GLB1 - 1p22.3 [CytoView hg38]
Mapping of homologs : NCBISH3GLB1 [Mapview hg19]  SH3GLB1 [Mapview hg38]
OMIM609287   
Gene and transcription
Genbank (Entrez)AB007960 AF151819 AF257318 AF263293 AF350371
RefSeq transcript (Entrez)NM_001206651 NM_001206652 NM_001206653 NM_016009
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SH3GLB1
Cluster EST : UnigeneHs.136309 [ NCBI ]
CGAP (NCI)Hs.136309
Alternative Splicing GalleryENSG00000097033
Gene ExpressionSH3GLB1 [ NCBI-GEO ]   SH3GLB1 [ EBI - ARRAY_EXPRESS ]   SH3GLB1 [ SEEK ]   SH3GLB1 [ MEM ]
Gene Expression Viewer (FireBrowse)SH3GLB1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51100
GTEX Portal (Tissue expression)SH3GLB1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y371   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y371  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y371
Splice isoforms : SwissVarQ9Y371
PhosPhoSitePlusQ9Y371
Domaine pattern : Prosite (Expaxy)BAR (PS51021)    SH3 (PS50002)   
Domains : Interpro (EBI)AH/BAR-dom    BAR_dom    SH3_domain   
Domain families : Pfam (Sanger)BAR (PF03114)    SH3_9 (PF14604)   
Domain families : Pfam (NCBI)pfam03114    pfam14604   
Domain families : Smart (EMBL)BAR (SM00721)  SH3 (SM00326)  
Conserved Domain (NCBI)SH3GLB1
DMDM Disease mutations51100
Blocks (Seattle)SH3GLB1
SuperfamilyQ9Y371
Human Protein AtlasENSG00000097033
Peptide AtlasQ9Y371
HPRD15333
IPIIPI00006558   IPI00022824   IPI01018062   IPI01014107   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y371
IntAct (EBI)Q9Y371
FunCoupENSG00000097033
BioGRIDSH3GLB1
STRING (EMBL)SH3GLB1
ZODIACSH3GLB1
Ontologies - Pathways
QuickGOQ9Y371
Ontology : AmiGOGolgi membrane  autophagosome membrane  protein binding  cytoplasm  mitochondrial outer membrane  cytosol  autophagy  apoptotic process  lipid binding  positive regulation of autophagy  regulation of macroautophagy  midbody  cytoplasmic vesicle  regulation of protein stability  positive regulation of protein oligomerization  regulation of cytokinesis  receptor catabolic process  cellular response to amino acid starvation  cellular response to glucose starvation  identical protein binding  protein homodimerization activity  cadherin binding  autophagic cell death  protein oligomerization  extracellular exosome  membrane fission  positive regulation of membrane tubulation  protein localization to vacuolar membrane  positive regulation of protein targeting to mitochondrion  positive regulation of autophagosome assembly  
Ontology : EGO-EBIGolgi membrane  autophagosome membrane  protein binding  cytoplasm  mitochondrial outer membrane  cytosol  autophagy  apoptotic process  lipid binding  positive regulation of autophagy  regulation of macroautophagy  midbody  cytoplasmic vesicle  regulation of protein stability  positive regulation of protein oligomerization  regulation of cytokinesis  receptor catabolic process  cellular response to amino acid starvation  cellular response to glucose starvation  identical protein binding  protein homodimerization activity  cadherin binding  autophagic cell death  protein oligomerization  extracellular exosome  membrane fission  positive regulation of membrane tubulation  protein localization to vacuolar membrane  positive regulation of protein targeting to mitochondrion  positive regulation of autophagosome assembly  
Pathways : BIOCARTACBL mediated ligand-induced downregulation of EGF receptors [Genes]   
Pathways : KEGGEndocytosis   
NDEx NetworkSH3GLB1
Atlas of Cancer Signalling NetworkSH3GLB1
Wikipedia pathwaysSH3GLB1
Orthology - Evolution
OrthoDB51100
GeneTree (enSembl)ENSG00000097033
Phylogenetic Trees/Animal Genes : TreeFamSH3GLB1
HOVERGENQ9Y371
HOGENOMQ9Y371
Homologs : HomoloGeneSH3GLB1
Homology/Alignments : Family Browser (UCSC)SH3GLB1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSH3GLB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SH3GLB1
dbVarSH3GLB1
ClinVarSH3GLB1
1000_GenomesSH3GLB1 
Exome Variant ServerSH3GLB1
ExAC (Exome Aggregation Consortium)SH3GLB1 (select the gene name)
Genetic variants : HAPMAP51100
Genomic Variants (DGV)SH3GLB1 [DGVbeta]
DECIPHERSH3GLB1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSH3GLB1 
Mutations
ICGC Data PortalSH3GLB1 
TCGA Data PortalSH3GLB1 
Broad Tumor PortalSH3GLB1
OASIS PortalSH3GLB1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSH3GLB1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSH3GLB1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SH3GLB1
DgiDB (Drug Gene Interaction Database)SH3GLB1
DoCM (Curated mutations)SH3GLB1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SH3GLB1 (select a term)
intoGenSH3GLB1
Cancer3DSH3GLB1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609287   
Orphanet
MedgenSH3GLB1
Genetic Testing Registry SH3GLB1
NextProtQ9Y371 [Medical]
TSGene51100
GENETestsSH3GLB1
Huge Navigator SH3GLB1 [HugePedia]
snp3D : Map Gene to Disease51100
BioCentury BCIQSH3GLB1
ClinGenSH3GLB1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51100
Chemical/Pharm GKB GenePA35739
Clinical trialSH3GLB1
Miscellaneous
canSAR (ICR)SH3GLB1 (select the gene name)
Probes
Litterature
PubMed62 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSH3GLB1
EVEXSH3GLB1
GoPubMedSH3GLB1
iHOPSH3GLB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:37:04 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.