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SIK2 (salt inducible kinase 2)

Identity

Alias_namesSNF1LK2
SNF1-like kinase 2
Alias_symbol (synonym)KIAA0781
QIK
DKFZp434K1115
LOH11CR1I
Other aliasSIK-2
HGNC (Hugo) SIK2
LocusID (NCBI) 23235
Atlas_Id 43497
Location 11q23.1  [Link to chromosome band 11q23]
Location_base_pair Starts at 111473115 and ends at 111597641 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ALG9 (11q23.1) / SIK2 (11q23.1)SIK2 (11q23.1) / ATXN1 (6p22.3)SIK2 (11q23.1) / JAK2 (9p24.1)
SIK2 (11q23.1) / MEGF11 (15q22.31)SIK2 (11q23.1) / RAB6A (11q13.4)SIK2 (11q23.1) / SIK2 (11q23.1)
THUMPD1 (16p12.3) / SIK2 (11q23.1)SIK2 11q23.1 / JAK2 9p24.1SIK2 11q23.1 / MEGF11 15q22.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SIK2   21680
Cards
Entrez_Gene (NCBI)SIK2  23235  salt inducible kinase 2
AliasesLOH11CR1I; QIK; SIK-2; SNF1LK2
GeneCards (Weizmann)SIK2
Ensembl hg19 (Hinxton)ENSG00000170145 [Gene_View]  chr11:111473115-111597641 [Contig_View]  SIK2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000170145 [Gene_View]  chr11:111473115-111597641 [Contig_View]  SIK2 [Vega]
ICGC DataPortalENSG00000170145
TCGA cBioPortalSIK2
AceView (NCBI)SIK2
Genatlas (Paris)SIK2
WikiGenes23235
SOURCE (Princeton)SIK2
Genetics Home Reference (NIH)SIK2
Genomic and cartography
GoldenPath hg19 (UCSC)SIK2  -     chr11:111473115-111597641 +  11q23.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SIK2  -     11q23.1   [Description]    (hg38-Dec_2013)
EnsemblSIK2 - 11q23.1 [CytoView hg19]  SIK2 - 11q23.1 [CytoView hg38]
Mapping of homologs : NCBISIK2 [Mapview hg19]  SIK2 [Mapview hg38]
OMIM608973   
Gene and transcription
Genbank (Entrez)AB018324 AB084424 AB096248 AK000396 AK096463
RefSeq transcript (Entrez)NM_015191
RefSeq genomic (Entrez)NC_000011 NC_018922 NT_033899 NW_004929381
Consensus coding sequences : CCDS (NCBI)SIK2
Cluster EST : UnigeneHs.269128 [ NCBI ]
CGAP (NCI)Hs.269128
Alternative Splicing GalleryENSG00000170145
Gene ExpressionSIK2 [ NCBI-GEO ]   SIK2 [ EBI - ARRAY_EXPRESS ]   SIK2 [ SEEK ]   SIK2 [ MEM ]
Gene Expression Viewer (FireBrowse)SIK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23235
GTEX Portal (Tissue expression)SIK2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H0K1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H0K1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H0K1
Splice isoforms : SwissVarQ9H0K1
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ9H0K1
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    UBA (PS50030)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS    Ser/Thr_kinase_SIK1/2    UBA   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)SIK2
DMDM Disease mutations23235
Blocks (Seattle)SIK2
SuperfamilyQ9H0K1
Human Protein AtlasENSG00000170145
Peptide AtlasQ9H0K1
HPRD12348
IPIIPI00465291   
Protein Interaction databases
DIP (DOE-UCLA)Q9H0K1
IntAct (EBI)Q9H0K1
FunCoupENSG00000170145
BioGRIDSIK2
STRING (EMBL)SIK2
ZODIACSIK2
Ontologies - Pathways
QuickGOQ9H0K1
Ontology : AmiGOmagnesium ion binding  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytoplasm  protein phosphorylation  cellular response to hormone stimulus  intracellular signal transduction  regulation of insulin receptor signaling pathway  protein autophosphorylation  
Ontology : EGO-EBImagnesium ion binding  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytoplasm  protein phosphorylation  cellular response to hormone stimulus  intracellular signal transduction  regulation of insulin receptor signaling pathway  protein autophosphorylation  
NDEx NetworkSIK2
Atlas of Cancer Signalling NetworkSIK2
Wikipedia pathwaysSIK2
Orthology - Evolution
OrthoDB23235
GeneTree (enSembl)ENSG00000170145
Phylogenetic Trees/Animal Genes : TreeFamSIK2
HOVERGENQ9H0K1
HOGENOMQ9H0K1
Homologs : HomoloGeneSIK2
Homology/Alignments : Family Browser (UCSC)SIK2
Gene fusions - Rearrangements
Fusion : MitelmanSIK2/JAK2 [11q23.1/9p24.1]  
Fusion : MitelmanSIK2/MEGF11 [11q23.1/15q22.31]  [t(11;15)(q23;q22)]  
Fusion: TCGASIK2 11q23.1 JAK2 9p24.1 BRCA
Fusion: TCGASIK2 11q23.1 MEGF11 15q22.31 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSIK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SIK2
dbVarSIK2
ClinVarSIK2
1000_GenomesSIK2 
Exome Variant ServerSIK2
ExAC (Exome Aggregation Consortium)SIK2 (select the gene name)
Genetic variants : HAPMAP23235
Genomic Variants (DGV)SIK2 [DGVbeta]
DECIPHER (Syndromes)11:111473115-111597641  ENSG00000170145
CONAN: Copy Number AnalysisSIK2 
Mutations
ICGC Data PortalSIK2 
TCGA Data PortalSIK2 
Broad Tumor PortalSIK2
OASIS PortalSIK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSIK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSIK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SIK2
DgiDB (Drug Gene Interaction Database)SIK2
DoCM (Curated mutations)SIK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SIK2 (select a term)
intoGenSIK2
Cancer3DSIK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608973   
Orphanet
MedgenSIK2
Genetic Testing Registry SIK2
NextProtQ9H0K1 [Medical]
TSGene23235
GENETestsSIK2
Huge Navigator SIK2 [HugePedia]
snp3D : Map Gene to Disease23235
BioCentury BCIQSIK2
ClinGenSIK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23235
Chemical/Pharm GKB GenePA164725750
Clinical trialSIK2
Miscellaneous
canSAR (ICR)SIK2 (select the gene name)
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSIK2
EVEXSIK2
GoPubMedSIK2
iHOPSIK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:27:17 CET 2017

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