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SIK2 (salt inducible kinase 2)

Identity

Alias (NCBI)LOH11CR1I
QIK
SIK-2
SNF1LK2
HGNC (Hugo) SIK2
HGNC Alias symbKIAA0781
QIK
DKFZp434K1115
LOH11CR1I
HGNC Previous nameSNF1LK2
HGNC Previous nameSNF1-like kinase 2
LocusID (NCBI) 23235
Atlas_Id 43497
Location 11q23.1  [Link to chromosome band 11q23]
Location_base_pair Starts at 111602449 and ends at 111730855 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ALG9 (11q23.1) / SIK2 (11q23.1)SIK2 (11q23.1) / ATXN1 (6p22.3)SIK2 (11q23.1) / JAK2 (9p24.1)
SIK2 (11q23.1) / MEGF11 (15q22.31)SIK2 (11q23.1) / RAB6A (11q13.4)SIK2 (11q23.1) / SIK2 (11q23.1)
THUMPD1 (16p12.3) / SIK2 (11q23.1)SIK2 11q23.1 / JAK2 9p24.1SIK2 11q23.1 / MEGF11 15q22.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(9;11)(p24;q23) SIK2/JAK2
t(11;15)(q23;q22) SIK2/MEGF11


External links

Nomenclature
HGNC (Hugo)SIK2   21680
Cards
Entrez_Gene (NCBI)SIK2  23235  salt inducible kinase 2
AliasesLOH11CR1I; QIK; SIK-2; SNF1LK2
GeneCards (Weizmann)SIK2
Ensembl hg19 (Hinxton)ENSG00000170145 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170145 [Gene_View]  ENSG00000170145 [Sequence]  chr11:111602449-111730855 [Contig_View]  SIK2 [Vega]
ICGC DataPortalENSG00000170145
TCGA cBioPortalSIK2
AceView (NCBI)SIK2
Genatlas (Paris)SIK2
WikiGenes23235
SOURCE (Princeton)SIK2
Genetics Home Reference (NIH)SIK2
Genomic and cartography
GoldenPath hg38 (UCSC)SIK2  -     chr11:111602449-111730855 +  11q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SIK2  -     11q23.1   [Description]    (hg19-Feb_2009)
GoldenPathSIK2 - 11q23.1 [CytoView hg19]  SIK2 - 11q23.1 [CytoView hg38]
ImmunoBaseENSG00000170145
genome Data Viewer NCBISIK2 [Mapview hg19]  
OMIM608973   
Gene and transcription
Genbank (Entrez)AB018324 AB084424 AB096248 AK000396 AK096463
RefSeq transcript (Entrez)NM_015191
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SIK2
Alternative Splicing GalleryENSG00000170145
Gene ExpressionSIK2 [ NCBI-GEO ]   SIK2 [ EBI - ARRAY_EXPRESS ]   SIK2 [ SEEK ]   SIK2 [ MEM ]
Gene Expression Viewer (FireBrowse)SIK2 [ Firebrowse - Broad ]
GenevisibleExpression of SIK2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23235
GTEX Portal (Tissue expression)SIK2
Human Protein AtlasENSG00000170145-SIK2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H0K1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H0K1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H0K1
Splice isoforms : SwissVarQ9H0K1
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9H0K1
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    UBA (PS50030)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS    Ser/Thr_kinase_SIK1/2    SIK    UBA   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)SIK2
DMDM Disease mutations23235
Blocks (Seattle)SIK2
SuperfamilyQ9H0K1
Human Protein Atlas [tissue]ENSG00000170145-SIK2 [tissue]
Peptide AtlasQ9H0K1
HPRD12348
IPIIPI00465291   
Protein Interaction databases
DIP (DOE-UCLA)Q9H0K1
IntAct (EBI)Q9H0K1
FunCoupENSG00000170145
BioGRIDSIK2
STRING (EMBL)SIK2
ZODIACSIK2
Ontologies - Pathways
QuickGOQ9H0K1
Ontology : AmiGOmagnesium ion binding  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytoplasm  protein phosphorylation  protein phosphorylation  intracellular signal transduction  intracellular signal transduction  regulation of insulin receptor signaling pathway  protein autophosphorylation  
Ontology : EGO-EBImagnesium ion binding  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytoplasm  protein phosphorylation  protein phosphorylation  intracellular signal transduction  intracellular signal transduction  regulation of insulin receptor signaling pathway  protein autophosphorylation  
NDEx NetworkSIK2
Atlas of Cancer Signalling NetworkSIK2
Wikipedia pathwaysSIK2
Orthology - Evolution
OrthoDB23235
GeneTree (enSembl)ENSG00000170145
Phylogenetic Trees/Animal Genes : TreeFamSIK2
HOGENOMQ9H0K1
Homologs : HomoloGeneSIK2
Homology/Alignments : Family Browser (UCSC)SIK2
Gene fusions - Rearrangements
Fusion : MitelmanSIK2/JAK2 [11q23.1/9p24.1]  
Fusion : MitelmanSIK2/MEGF11 [11q23.1/15q22.31]  
Fusion PortalSIK2 11q23.1 JAK2 9p24.1 BRCA
Fusion PortalSIK2 11q23.1 MEGF11 15q22.31 LGG
Fusion : QuiverSIK2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSIK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SIK2
dbVarSIK2
ClinVarSIK2
MonarchSIK2
1000_GenomesSIK2 
Exome Variant ServerSIK2
GNOMAD BrowserENSG00000170145
Varsome BrowserSIK2
Genetic variants : HAPMAP23235
Genomic Variants (DGV)SIK2 [DGVbeta]
DECIPHERSIK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSIK2 
Mutations
ICGC Data PortalSIK2 
TCGA Data PortalSIK2 
Broad Tumor PortalSIK2
OASIS PortalSIK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSIK2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSIK2
Mutations and Diseases : HGMDSIK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SIK2
DgiDB (Drug Gene Interaction Database)SIK2
DoCM (Curated mutations)SIK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SIK2 (select a term)
intoGenSIK2
Cancer3DSIK2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608973   
Orphanet
DisGeNETSIK2
MedgenSIK2
Genetic Testing Registry SIK2
NextProtQ9H0K1 [Medical]
TSGene23235
GENETestsSIK2
Target ValidationSIK2
Huge Navigator SIK2 [HugePedia]
snp3D : Map Gene to Disease23235
BioCentury BCIQSIK2
ClinGenSIK2
Clinical trials, drugs, therapy
Protein Interactions : CTD23235
Pharm GKB GenePA164725750
Clinical trialSIK2
Miscellaneous
canSAR (ICR)SIK2 (select the gene name)
HarmonizomeSIK2
DataMed IndexSIK2
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSIK2
EVEXSIK2
GoPubMedSIK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:32:27 CEST 2020

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