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SIX3 (SIX homeobox 3)

Identity

Other namesHPE2
HGNC (Hugo) SIX3
LocusID (NCBI) 6496
Location 2p21
Location_base_pair Starts at 45169037 and ends at 45173216 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SIX3   10889
Cards
Entrez_Gene (NCBI)SIX3  6496  SIX homeobox 3
GeneCards (Weizmann)SIX3
Ensembl (Hinxton)ENSG00000138083 [Gene_View]  chr2:45169037-45173216 [Contig_View]  SIX3 [Vega]
ICGC DataPortalENSG00000138083
AceView (NCBI)SIX3
Genatlas (Paris)SIX3
WikiGenes6496
SOURCE (Princeton)NM_005413
Genomic and cartography
GoldenPath (UCSC)SIX3  -  2p21   chr2:45169037-45173216 +  2p21   [Description]    (hg19-Feb_2009)
EnsemblSIX3 - 2p21 [CytoView]
Mapping of homologs : NCBISIX3 [Mapview]
OMIM157170   269160   603714   
Gene and transcription
Genbank (Entrez)AJ012611 AL162671 BC030289 BC153026 BF569811
RefSeq transcript (Entrez)NM_005413
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NG_016222 NT_022184 NW_001838769 NW_004929300
Consensus coding sequences : CCDS (NCBI)SIX3
Cluster EST : UnigeneHs.567336 [ NCBI ]
CGAP (NCI)Hs.567336
Alternative Splicing : Fast-db (Paris)GSHG0016425
Alternative Splicing GalleryENSG00000138083
Gene ExpressionSIX3 [ NCBI-GEO ]     SIX3 [ SEEK ]   SIX3 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95343 (Uniprot)
NextProtO95343  [Medical]
With graphics : InterProO95343
Splice isoforms : SwissVarO95343 (Swissvar)
Domaine pattern : Prosite (Expaxy)HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox_dom    Homeodomain-like   
Related proteins : CluSTrO95343
Domain families : Pfam (Sanger)Homeobox (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
DMDM Disease mutations6496
Blocks (Seattle)O95343
Human Protein AtlasENSG00000138083
Peptide AtlasO95343
HPRD04756
IPIIPI00030013   
Protein Interaction databases
DIP (DOE-UCLA)O95343
IntAct (EBI)O95343
FunCoupENSG00000138083
BioGRIDSIX3
InParanoidO95343
Interologous Interaction database O95343
IntegromeDBSIX3
STRING (EMBL)SIX3
Ontologies - Pathways
Ontology : AmiGORNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity  nucleus  transcription from RNA polymerase II promoter  protein import into nucleus  brain development  visual perception  diencephalon development  telencephalon development  forebrain anterior/posterior pattern specification  negative regulation of Wnt signaling pathway  sequence-specific DNA binding  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  circadian behavior  lens induction in camera-type eye  
Ontology : EGO-EBIRNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity  nucleus  transcription from RNA polymerase II promoter  protein import into nucleus  brain development  visual perception  diencephalon development  telencephalon development  forebrain anterior/posterior pattern specification  negative regulation of Wnt signaling pathway  sequence-specific DNA binding  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  circadian behavior  lens induction in camera-type eye  
Protein Interaction DatabaseSIX3
Wikipedia pathwaysSIX3
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)SIX3
SNP (GeneSNP Utah)SIX3
SNP : HGBaseSIX3
Genetic variants : HAPMAPSIX3
1000_GenomesSIX3 
ICGC programENSG00000138083 
CONAN: Copy Number AnalysisSIX3 
Somatic Mutations in Cancer : COSMICSIX3 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Mutations and Diseases : HGMDSIX3
OMIM157170    269160    603714   
MedgenSIX3
GENETestsSIX3
Disease Genetic AssociationSIX3
Huge Navigator SIX3 [HugePedia]  SIX3 [HugeCancerGEM]
Genomic VariantsSIX3  SIX3 [DGVbeta]
Exome VariantSIX3
dbVarSIX3
ClinVarSIX3
snp3D : Map Gene to Disease6496
General knowledge
Homologs : HomoloGeneSIX3
Homology/Alignments : Family Browser (UCSC)SIX3
Phylogenetic Trees/Animal Genes : TreeFamSIX3
Chemical/Protein Interactions : CTD6496
Chemical/Pharm GKB GenePA35789
Clinical trialSIX3
Cancer Resource (Charite)ENSG00000138083
Other databases
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
CoreMineSIX3
iHOPSIX3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 13 13:16:34 CEST 2014

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