Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SIX3 (SIX homeobox 3)

Identity

Other namesHPE2
HGNC (Hugo) SIX3
LocusID (NCBI) 6496
Location 2p21
Location_base_pair Starts at 45169037 and ends at 45173216 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SIX3   10889
Entrez_Gene (NCBI)SIX3  6496  SIX homeobox 3
Cards
GeneCards (Weizmann)SIX3
Ensembl (Hinxton)ENSG00000138083 [Gene_View]  chr2:45169037-45173216 [Contig_View]  SIX3 [Vega]
AceView (NCBI)SIX3
Genatlas (Paris)SIX3
SOURCE (Stanford)NM_005413
Genomic and cartography
GoldenPath (UCSC)SIX3  -  2p21   chr2:45169037-45173216 +  2p21   [Description]    (hg19-Feb_2009)
EnsemblSIX3 - 2p21 [CytoView]
Mapping of homologs : NCBISIX3 [Mapview]
OMIM157170   269160   603714   
Gene and transcription
Genbank (Entrez)AJ012611 AL162671 BC030289 BC153026 BF569811
RefSeq transcript (SRS)NM_005413
RefSeq transcript (Entrez)NM_005413
RefSeq genomic (SRS)AC_000134 NC_000002 NC_018913 NG_016222 NT_022184 NW_001838769 NW_004078005
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NG_016222 NT_022184 NW_001838769 NW_004078005
Consensus coding sequences : CCDS (NCBI)SIX3
Cluster EST : UnigeneHs.567336 [ SRS ] Hs.567336 [ NCBI ]
CGAP (NCI)Hs.567336
Alternative Splicing : Fast-db (Paris)GSHG0016425
Alternative Splicing GalleryENSG00000138083
Gene ExpressionSIX3 [ NCBI-GEO ]   SIX3 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95343 (SRS) O95343 (Uniprot)
NextProtO95343
With graphics : InterProO95343
Splice isoforms : SwissVarO95343(Swissvar)
Domaine pattern : Prosite (SRS)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (SRS)Homeodomain    Homeodomain-like   
Domains : Interpro (EBI)Homeodomain    Homeodomain-like   
Related proteins : CluSTrO95343
Domain families : Pfam (SRS)Homeobox (PF00046)   
Domain families : Pfam (Sanger)Homeobox (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
DMDM6496
Blocks (Seattle)O95343
Human Protein AtlasENSG00000138083
HPRD04756
IPIIPI00030013   
Protein Interaction databases
DIP (DOE-UCLA)O95343
IntAct (EBI)O95343
FunCoupENSG00000138083
REACTOMESIX3
Protein Interaction Database6496
BioGRIDSIX3
InParanoidO95343
Interologous Interaction database O95343
IntegromeDBSIX3
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)SIX3
SNP (GeneSNP Utah)SIX3
SNP : HGBaseSIX3
Genetic variants : HAPMAPSIX3
Somatic Mutations in Cancer : COSMICSIX3 
CONAN: Copy Number AnalysisSIX3 
Mutations and Diseases : HGMDSIX3
OMIM157170    269160    603714   
GENETests157170    269160    603714   
Disease Genetic AssociationSIX3
Huge Navigator SIX3 [HugePedia]  SIX3 [HugeCancerGEM]
Genomic VariantsSIX3  SIX3 [DGVbeta]
snp3D : Map Gene to Disease6496
General knowledge
Homologs : HomoloGeneSIX3
Homology/Alignments : Family Browser (UCSC)SIX3
Phylogenetic Trees/Animal Genes : TreeFamSIX3
Chemical/Protein Interactions : CTD6496
Chemical/Pharm GKB GenePA35789
Clinical trialSIX3
Cancer Resource (Charite)ENSG00000138083
Ontology : AmiGORNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity  nucleus  protein import into nucleus  brain development  visual perception  diencephalon development  telencephalon development  forebrain anterior/posterior pattern specification  negative regulation of Wnt receptor signaling pathway  sequence-specific DNA binding  negative regulation of transcription, DNA-dependent  positive regulation of transcription from RNA polymerase II promoter  circadian behavior  lens induction in camera-type eye  
Ontology : EGO-EBIRNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity  nucleus  protein import into nucleus  brain development  visual perception  diencephalon development  telencephalon development  forebrain anterior/posterior pattern specification  negative regulation of Wnt receptor signaling pathway  sequence-specific DNA binding  negative regulation of transcription, DNA-dependent  positive regulation of transcription from RNA polymerase II promoter  circadian behavior  lens induction in camera-type eye  
Other databases
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
PubGeneSIX3
iHOPSIX3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:24:21 CEST 2013
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