SKAP2 (src kinase associated phosphoprotein 2)

2008-07-01  

Identity

HGNC
LOCATION
7p15.2
LOCUSID
ALIAS
PRAP,RA70,SAPS,SCAP2,SKAP-HOM,SKAP55R
FUSION GENES

Other Information

Locus ID:

NCBI: 8935
MIM: 605215
HGNC: 15687
Ensembl: ENSG00000005020

Variants:

dbSNP: 8935
ClinVar: 8935
TCGA: ENSG00000005020
COSMIC: SKAP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000005020ENST00000345317O75563
ENSG00000005020ENST00000432747C9JQ17

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Cell-Cell communicationREACTOMER-HSA-1500931
Signal regulatory protein (SIRP) family interactionsREACTOMER-HSA-391160

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
179521252008Genome-wide DNA copy number analysis in pancreatic cancer using high-density single nucleotide polymorphism arrays.60
151662272004RAFTK/Pyk2 activation is mediated by trans-acting autophosphorylation in a Src-independent manner.43
229763042012Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement.19
128938332003Identification and characterization of a novel Pyk2/related adhesion focal tyrosine kinase-associated protein that inhibits alpha-synuclein phosphorylation.14
217197042011Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrate.13
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
265777012016SKAP2 Promotes Podosome Formation to Facilitate Tumor-Associated Macrophage Infiltration and Metastatic Progression.10
203786052010In silico replication of the genome-wide association results of the Type 1 Diabetes Genetics Consortium.9
258629072015Src kinase-associated phosphoprotein2 expression is associated with poor prognosis in non-small cell lung cancer.6

Citation

Dessen P

SKAP2 (src kinase associated phosphoprotein 2)

Atlas Genet Cytogenet Oncol Haematol. 2008-07-01

Online version: http://atlasgeneticsoncology.org/gene/50165/skap2