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SKAP2 (src kinase associated phosphoprotein 2)

Identity

Alias_namesSCAP2
src family associated phosphoprotein 2
Alias_symbol (synonym)RA70
SKAP-HOM
SKAP55R
SAPS
Other aliasPRAP
HGNC (Hugo) SKAP2
LocusID (NCBI) 8935
Atlas_Id 50165
Location 7p15.2  [Link to chromosome band 7p15]
Location_base_pair Starts at 26667062 and ends at 26857723 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ATG7 (3p25.3) / SKAP2 (7p15.2)HNRNPDL (4q21.22) / SKAP2 (7p15.2)SKAP2 (7p15.2) / INPP4B (4q31.21)
SKAP2 (7p15.2) / SNX10 (7p15.2)SNHG6 (8q13.1) / SKAP2 (7p15.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SKAP2   15687
Cards
Entrez_Gene (NCBI)SKAP2  8935  src kinase associated phosphoprotein 2
AliasesPRAP; RA70; SAPS; SCAP2; 
SKAP-HOM; SKAP55R
GeneCards (Weizmann)SKAP2
Ensembl hg19 (Hinxton)ENSG00000005020 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000005020 [Gene_View]  chr7:26667062-26857723 [Contig_View]  SKAP2 [Vega]
ICGC DataPortalENSG00000005020
TCGA cBioPortalSKAP2
AceView (NCBI)SKAP2
Genatlas (Paris)SKAP2
WikiGenes8935
SOURCE (Princeton)SKAP2
Genetics Home Reference (NIH)SKAP2
Genomic and cartography
GoldenPath hg38 (UCSC)SKAP2  -     chr7:26667062-26857723 -  7p15.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SKAP2  -     7p15.2   [Description]    (hg19-Feb_2009)
EnsemblSKAP2 - 7p15.2 [CytoView hg19]  SKAP2 - 7p15.2 [CytoView hg38]
Mapping of homologs : NCBISKAP2 [Mapview hg19]  SKAP2 [Mapview hg38]
OMIM605215   
Gene and transcription
Genbank (Entrez)AB014486 AF051323 AF072166 AF174049 AJ004886
RefSeq transcript (Entrez)NM_001303468 NM_003930
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SKAP2
Cluster EST : UnigeneHs.675700 [ NCBI ]
CGAP (NCI)Hs.675700
Alternative Splicing GalleryENSG00000005020
Gene ExpressionSKAP2 [ NCBI-GEO ]   SKAP2 [ EBI - ARRAY_EXPRESS ]   SKAP2 [ SEEK ]   SKAP2 [ MEM ]
Gene Expression Viewer (FireBrowse)SKAP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8935
GTEX Portal (Tissue expression)SKAP2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75563   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75563  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75563
Splice isoforms : SwissVarO75563
PhosPhoSitePlusO75563
Domaine pattern : Prosite (Expaxy)PH_DOMAIN (PS50003)    SH3 (PS50002)   
Domains : Interpro (EBI)PH_dom-like    PH_domain    SH3_domain   
Domain families : Pfam (Sanger)PH (PF00169)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam00169    pfam00018   
Domain families : Smart (EMBL)PH (SM00233)  SH3 (SM00326)  
Conserved Domain (NCBI)SKAP2
DMDM Disease mutations8935
Blocks (Seattle)SKAP2
PDB (SRS)3OMH   
PDB (PDBSum)3OMH   
PDB (IMB)3OMH   
PDB (RSDB)3OMH   
Structural Biology KnowledgeBase3OMH   
SCOP (Structural Classification of Proteins)3OMH   
CATH (Classification of proteins structures)3OMH   
SuperfamilyO75563
Human Protein AtlasENSG00000005020
Peptide AtlasO75563
HPRD05558
IPIIPI00022508   IPI00917559   IPI01009715   
Protein Interaction databases
DIP (DOE-UCLA)O75563
IntAct (EBI)O75563
FunCoupENSG00000005020
BioGRIDSKAP2
STRING (EMBL)SKAP2
ZODIACSKAP2
Ontologies - Pathways
QuickGOO75563
Ontology : AmiGOimmune response-activating signal transduction  SH3/SH2 adaptor activity  protein binding  cytoplasm  cytosol  plasma membrane  protein complex assembly  signal transduction  negative regulation of cell proliferation  positive regulation of signal transduction  B cell activation  
Ontology : EGO-EBIimmune response-activating signal transduction  SH3/SH2 adaptor activity  protein binding  cytoplasm  cytosol  plasma membrane  protein complex assembly  signal transduction  negative regulation of cell proliferation  positive regulation of signal transduction  B cell activation  
NDEx NetworkSKAP2
Atlas of Cancer Signalling NetworkSKAP2
Wikipedia pathwaysSKAP2
Orthology - Evolution
OrthoDB8935
GeneTree (enSembl)ENSG00000005020
Phylogenetic Trees/Animal Genes : TreeFamSKAP2
HOVERGENO75563
HOGENOMO75563
Homologs : HomoloGeneSKAP2
Homology/Alignments : Family Browser (UCSC)SKAP2
Gene fusions - Rearrangements
Fusion : MitelmanSKAP2/SNX10 [7p15.2/7p15.2]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSKAP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SKAP2
dbVarSKAP2
ClinVarSKAP2
1000_GenomesSKAP2 
Exome Variant ServerSKAP2
ExAC (Exome Aggregation Consortium)SKAP2 (select the gene name)
Genetic variants : HAPMAP8935
Genomic Variants (DGV)SKAP2 [DGVbeta]
DECIPHERSKAP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSKAP2 
Mutations
ICGC Data PortalSKAP2 
TCGA Data PortalSKAP2 
Broad Tumor PortalSKAP2
OASIS PortalSKAP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSKAP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSKAP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SKAP2
DgiDB (Drug Gene Interaction Database)SKAP2
DoCM (Curated mutations)SKAP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SKAP2 (select a term)
intoGenSKAP2
Cancer3DSKAP2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605215   
Orphanet
MedgenSKAP2
Genetic Testing Registry SKAP2
NextProtO75563 [Medical]
TSGene8935
GENETestsSKAP2
Huge Navigator SKAP2 [HugePedia]
snp3D : Map Gene to Disease8935
BioCentury BCIQSKAP2
ClinGenSKAP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8935
Chemical/Pharm GKB GenePA162403393
Clinical trialSKAP2
Miscellaneous
canSAR (ICR)SKAP2 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSKAP2
EVEXSKAP2
GoPubMedSKAP2
iHOPSKAP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:37:19 CEST 2017

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