SLC1A1 (solute carrier family 1 member 1)

2007-10-01  

Identity

HGNC
LOCATION
9p24.2
LOCUSID
ALIAS
DCBXA,EAAC1,EAAT3,SCZD18
FUSION GENES

Other Information

Locus ID:

NCBI: 6505
MIM: 133550
HGNC: 10939
Ensembl: ENSG00000106688

Variants:

dbSNP: 6505
ClinVar: 6505
TCGA: ENSG00000106688
COSMIC: SLC1A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106688ENST00000262352P43005
ENSG00000106688ENST00000422398H0Y7R2

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Protein digestion and absorptionKEGGko04974
Protein digestion and absorptionKEGGhsa04974
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Release CycleREACTOMER-HSA-112310
Glutamate Neurotransmitter Release CycleREACTOMER-HSA-210500
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164713257Selective serotonin reuptake inhibitorsChemicalClinicalAnnotationassociatedPD22776887
PA447211Obsessive-Compulsive DisorderDiseaseClinicalAnnotationassociatedPD22776887

References

Pubmed IDYearTitleCitations
168188662006Glutamate transporter gene SLC1A1 associated with obsessive-compulsive disorder.90
168188672006Association testing of the positional and functional candidate gene SLC1A1/EAAC1 in early-onset obsessive-compulsive disorder.80
178944182007Association of the SLC1A1 glutamate transporter gene and obsessive-compulsive disorder.59
178944182007Association of the SLC1A1 glutamate transporter gene and obsessive-compulsive disorder.59
157164092005Small-scale molecular motions accomplish glutamate uptake in human glutamate transporters.57
173609172007The glutamate-activated anion conductance in excitatory amino acid transporters is gated independently by the individual subunits.47
193493102009A haplotype containing quantitative trait loci for SLC1A1 gene expression and its association with obsessive-compulsive disorder.47
193493102009A haplotype containing quantitative trait loci for SLC1A1 gene expression and its association with obsessive-compulsive disorder.47
173609162007The glutamate and chloride permeation pathways are colocalized in individual neuronal glutamate transporter subunits.46
191561682009Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.46

Citation

Dessen P

SLC1A1 (solute carrier family 1 member 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-10-01

Online version: http://atlasgeneticsoncology.org/gene/49772/slc1a1