Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

SLC22A6 (solute carrier family 22 member 6)

Identity

Alias_namessolute carrier family 22 (organic anion transporter)
Alias_symbol (synonym)ROAT1
PAHT
OAT1
Other aliasHOAT1
HGNC (Hugo) SLC22A6
LocusID (NCBI) 9356
Atlas_Id 47691
Location 11q12.3  [Link to chromosome band 11q12]
Location_base_pair Starts at 62976597 and ends at 62985023 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SLC22A6   10970
Cards
Entrez_Gene (NCBI)SLC22A6  9356  solute carrier family 22 member 6
AliasesHOAT1; OAT1; PAHT; ROAT1
GeneCards (Weizmann)SLC22A6
Ensembl hg19 (Hinxton)ENSG00000197901 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000197901 [Gene_View]  chr11:62976597-62985023 [Contig_View]  SLC22A6 [Vega]
ICGC DataPortalENSG00000197901
TCGA cBioPortalSLC22A6
AceView (NCBI)SLC22A6
Genatlas (Paris)SLC22A6
WikiGenes9356
SOURCE (Princeton)SLC22A6
Genetics Home Reference (NIH)SLC22A6
Genomic and cartography
GoldenPath hg38 (UCSC)SLC22A6  -     chr11:62976597-62985023 -  11q12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SLC22A6  -     11q12.3   [Description]    (hg19-Feb_2009)
EnsemblSLC22A6 - 11q12.3 [CytoView hg19]  SLC22A6 - 11q12.3 [CytoView hg38]
Mapping of homologs : NCBISLC22A6 [Mapview hg19]  SLC22A6 [Mapview hg38]
OMIM607582   
Gene and transcription
Genbank (Entrez)AB009697 AB009698 AF057039 AF097490 AF104038
RefSeq transcript (Entrez)NM_004790 NM_153276 NM_153277 NM_153278 NM_153279
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SLC22A6
Cluster EST : UnigeneHs.369252 [ NCBI ]
CGAP (NCI)Hs.369252
Alternative Splicing GalleryENSG00000197901
Gene ExpressionSLC22A6 [ NCBI-GEO ]   SLC22A6 [ EBI - ARRAY_EXPRESS ]   SLC22A6 [ SEEK ]   SLC22A6 [ MEM ]
Gene Expression Viewer (FireBrowse)SLC22A6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9356
GTEX Portal (Tissue expression)SLC22A6
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ4U2R8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ4U2R8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ4U2R8
Splice isoforms : SwissVarQ4U2R8
PhosPhoSitePlusQ4U2R8
Domaine pattern : Prosite (Expaxy)MFS (PS50850)   
Domains : Interpro (EBI)MFS_dom    MFS_sugar_transport-like    Orgcat_transp/SVOP   
Domain families : Pfam (Sanger)Sugar_tr (PF00083)   
Domain families : Pfam (NCBI)pfam00083   
Conserved Domain (NCBI)SLC22A6
DMDM Disease mutations9356
Blocks (Seattle)SLC22A6
SuperfamilyQ4U2R8
Human Protein AtlasENSG00000197901
Peptide AtlasQ4U2R8
HPRD12125
IPIIPI00006296   IPI00654872   IPI00645624   IPI00011035   IPI00871594   IPI00909473   IPI01014667   
Protein Interaction databases
DIP (DOE-UCLA)Q4U2R8
IntAct (EBI)Q4U2R8
FunCoupENSG00000197901
BioGRIDSLC22A6
STRING (EMBL)SLC22A6
ZODIACSLC22A6
Ontologies - Pathways
QuickGOQ4U2R8
Ontology : AmiGOinorganic anion exchanger activity  protein binding  plasma membrane  integral component of plasma membrane  caveola  organic anion transmembrane transporter activity  organic anion transmembrane transporter activity  urate transmembrane transporter activity  anion:anion antiporter activity  sodium-independent organic anion transmembrane transporter activity  inorganic anion transport  organic anion transport  organic anion transport  alpha-ketoglutarate transport  urate transport  basolateral plasma membrane  chloride ion binding  response to methotrexate  protein homodimerization activity  protein complex  sodium-independent organic anion transport  protein homooligomerization  extracellular exosome  renal tubular secretion  renal tubular secretion  anion transmembrane transport  organic acid transmembrane transport  
Ontology : EGO-EBIinorganic anion exchanger activity  protein binding  plasma membrane  integral component of plasma membrane  caveola  organic anion transmembrane transporter activity  organic anion transmembrane transporter activity  urate transmembrane transporter activity  anion:anion antiporter activity  sodium-independent organic anion transmembrane transporter activity  inorganic anion transport  organic anion transport  organic anion transport  alpha-ketoglutarate transport  urate transport  basolateral plasma membrane  chloride ion binding  response to methotrexate  protein homodimerization activity  protein complex  sodium-independent organic anion transport  protein homooligomerization  extracellular exosome  renal tubular secretion  renal tubular secretion  anion transmembrane transport  organic acid transmembrane transport  
NDEx NetworkSLC22A6
Atlas of Cancer Signalling NetworkSLC22A6
Wikipedia pathwaysSLC22A6
Orthology - Evolution
OrthoDB9356
GeneTree (enSembl)ENSG00000197901
Phylogenetic Trees/Animal Genes : TreeFamSLC22A6
HOVERGENQ4U2R8
HOGENOMQ4U2R8
Homologs : HomoloGeneSLC22A6
Homology/Alignments : Family Browser (UCSC)SLC22A6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLC22A6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLC22A6
dbVarSLC22A6
ClinVarSLC22A6
1000_GenomesSLC22A6 
Exome Variant ServerSLC22A6
ExAC (Exome Aggregation Consortium)SLC22A6 (select the gene name)
Genetic variants : HAPMAP9356
Genomic Variants (DGV)SLC22A6 [DGVbeta]
DECIPHERSLC22A6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSLC22A6 
Mutations
ICGC Data PortalSLC22A6 
TCGA Data PortalSLC22A6 
Broad Tumor PortalSLC22A6
OASIS PortalSLC22A6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLC22A6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSLC22A6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SLC22A6
DgiDB (Drug Gene Interaction Database)SLC22A6
DoCM (Curated mutations)SLC22A6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLC22A6 (select a term)
intoGenSLC22A6
Cancer3DSLC22A6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607582   
Orphanet
MedgenSLC22A6
Genetic Testing Registry SLC22A6
NextProtQ4U2R8 [Medical]
TSGene9356
GENETestsSLC22A6
Target ValidationSLC22A6
Huge Navigator SLC22A6 [HugePedia]
snp3D : Map Gene to Disease9356
BioCentury BCIQSLC22A6
ClinGenSLC22A6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9356
Chemical/Pharm GKB GenePA388
Clinical trialSLC22A6
Miscellaneous
canSAR (ICR)SLC22A6 (select the gene name)
Probes
Litterature
PubMed62 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSLC22A6
EVEXSLC22A6
GoPubMedSLC22A6
iHOPSLC22A6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:55:51 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.