SLC36A1 (solute carrier family 36 member 1)

2008-07-01  

Identity

HGNC
SLC36A1
LOCATION
5q33.1
LOCUSID
206358
ALIAS
Dct1,LYAAT1,PAT1,TRAMD3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 206358
MIM: 606561
HGNC: 18761
Ensembl: ENSG00000123643

Variants:

dbSNP: 206358
ClinVar: 206358
TCGA: ENSG00000123643
COSMIC: SLC36A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123643ENST00000243389Q7Z2H8
ENSG00000123643ENST00000429484Q7Z2H8
ENSG00000123643ENST00000517628H0YB60
ENSG00000123643ENST00000517945E5RG64
ENSG00000123643ENST00000519829E5RI40
ENSG00000123643ENST00000520111E5RHG5
ENSG00000123643ENST00000520701Q7Z2H8
ENSG00000123643ENST00000521925E7EW39
ENSG00000123643ENST00000522185H0YBS2
ENSG00000123643ENST00000616007Q7Z2H8

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Protein digestion and absorptionKEGGko04974
Protein digestion and absorptionKEGGhsa04974
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Amino acid transport across the plasma membraneREACTOMER-HSA-352230
Proton-coupled neutral amino acid transportersREACTOMER-HSA-428559

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
204986352010Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation.58
225741972012Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes.55
125277232003Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2.37
155210112004H+/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat.30
190749662009Taurine uptake across the human intestinal brush-border membrane is via two transporters: H+-coupled PAT1 (SLC36A1) and Na+- and Cl(-)-dependent TauT (SLC6A6).23
170505372006PAT1a modulates intracellular transport and processing of amyloid precursor protein (APP), APLP1, and APLP2.16
195497852009Identification of a disulfide bridge essential for transport function of the human proton-coupled amino acid transporter hPAT1.11
157543242005Indirect regulation of the intestinal H+-coupled amino acid transporter hPAT1 (SLC36A1).9
182303302008Mutational analysis of histidine residues in the human proton-coupled amino acid transporter PAT1.8
193585712009The orally active antihyperglycemic drug beta-guanidinopropionic acid is transported by the human proton-coupled amino acid transporter hPAT1.7

Citation

Dessen P

SLC36A1 (solute carrier family 36 member 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-07-01

Online version: http://atlasgeneticsoncology.org/gene/50264/slc36a1