SLC39A2 (solute carrier family 39 member 2)

2009-03-01  

Identity

HGNC
SLC39A2
LOCATION
14q11.2
LOCUSID
29986
ALIAS
6A1,ETI-1,ZIP-2,ZIP2

Other Information

Locus ID:

NCBI: 29986
MIM: 612166
HGNC: 17127
Ensembl: ENSG00000165794

Variants:

dbSNP: 29986
ClinVar: 29986
TCGA: ENSG00000165794
COSMIC: SLC39A2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165794ENST00000298681Q9NP94
ENSG00000165794ENST00000554422Q9NP94

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Metal ion SLC transportersREACTOMER-HSA-425410
Zinc transportersREACTOMER-HSA-435354
Zinc influx into cells by the SLC39 gene familyREACTOMER-HSA-442380

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
175506122007hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands.40
186766802008Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.32
196921682010Genetic susceptibility to distinct bladder cancer subphenotypes.25
182790332008Zinc supplementation in the elderly reduces spontaneous inflammatory cytokine release and restores T cell functions.23
249360572014ZIP2 protein, a zinc transporter, is associated with keratinocyte differentiation.13
196251762009PTEN identified as important risk factor of chronic obstructive pulmonary disease.12
283456602017Zinc deficiency and low enterocyte zinc transporter expression in human patients with autism related mutations in SHANK3.11
183280052008A novel Zip2 Gln/Arg/Leu codon 2 polymorphism is associated with carotid artery disease in aging.5
183280052008A novel Zip2 Gln/Arg/Leu codon 2 polymorphism is associated with carotid artery disease in aging.5
191701962009Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.5

Citation

Dessen P

SLC39A2 (solute carrier family 39 member 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50696/slc39a2