SLC39A4 (solute carrier family 39 member 4)

2007-02-01 Affiliation

Identity

HGNC

SLC39A4

LOCATION

8q24.3

LOCUSID

55630

ALIAS

AEZ,AWMS2,ZIP4

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 55630
MIM: 607059
HGNC: 17129
Ensembl: ENSG00000147804

Variants:

dbSNP: 55630
ClinVar: 55630
TCGA: ENSG00000147804
COSMIC: SLC39A4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000147804	ENST00000276833	Q6P5W5
ENSG00000147804	ENST00000301305	Q6P5W5
ENSG00000147804	ENST00000526658	E9PQ16

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Mineral absorption	KEGG	ko04978
Mineral absorption	KEGG	hsa04978
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	REACTOME	R-HSA-425366
Metal ion SLC transporters	REACTOME	R-HSA-425410
Zinc transporters	REACTOME	R-HSA-435354
Zinc influx into cells by the SLC39 gene family	REACTOME	R-HSA-442380

References

Pubmed ID	Year	Title	Citations
12032886	2002	A novel member of a zinc transporter family is defective in acrodermatitis enteropathica.	114
12068297	2002	Identification of SLC39A4, a gene involved in acrodermatitis enteropathica.	105
18003899	2007	Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression.	92
17202136	2007	A histidine-rich cluster mediates the ubiquitination and degradation of the human zinc transporter, hZIP4, and protects against zinc cytotoxicity.	63
19755388	2009	Down-regulation of ZIP4 by RNA interference inhibits pancreatic cancer growth and increases the survival of nude mice with pancreatic cancer xenografts.	41
20160059	2010	ZIP4 regulates pancreatic cancer cell growth by activating IL-6/STAT3 pathway through zinc finger transcription factor CREB.	32
20957146	2010	Zip4 (Slc39a4) expression is activated in hepatocellular carcinomas and functions to repress apoptosis, enhance cell cycle and increase migration.	32
23857777	2013	A novel epigenetic CREB-miR-373 axis mediates ZIP4-induced pancreatic cancer growth.	31
21462106	2010	Gastrointestinal factors influencing zinc absorption and homeostasis.	24
23595627	2013	ZIP4 is a novel molecular marker for glioma.	23

Citation

Dessen P

SLC39A4 (solute carrier family 39 member 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/50007/slc39a4