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SLC6A2 (solute carrier family 6 member 2)

Identity

Alias_namesNET1
NAT1
SLC6A5
solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
solute carrier family 6 (neurotransmitter transporter), member 2
Alias_symbol (synonym)NET
Other alias
HGNC (Hugo) SLC6A2
LocusID (NCBI) 6530
Atlas_Id 46297
Location 16q12.2  [Link to chromosome band 16q12]
Location_base_pair Starts at 55690352 and ends at 55737700 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PPAN (19p13.2) / SLC6A2 (16q12.2)VPS35 (16q11.2) / SLC6A2 (16q12.2)VPS35 16q11.2 / SLC6A2 16q12.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SLC6A2   11048
Cards
Entrez_Gene (NCBI)SLC6A2  6530  solute carrier family 6 member 2
AliasesNAT1; NET; NET1; SLC6A5
GeneCards (Weizmann)SLC6A2
Ensembl hg19 (Hinxton)ENSG00000103546 [Gene_View]  chr16:55690352-55737700 [Contig_View]  SLC6A2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000103546 [Gene_View]  chr16:55690352-55737700 [Contig_View]  SLC6A2 [Vega]
ICGC DataPortalENSG00000103546
TCGA cBioPortalSLC6A2
AceView (NCBI)SLC6A2
Genatlas (Paris)SLC6A2
WikiGenes6530
SOURCE (Princeton)SLC6A2
Genetics Home Reference (NIH)SLC6A2
Genomic and cartography
GoldenPath hg19 (UCSC)SLC6A2  -     chr16:55690352-55737700 +  16q12.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SLC6A2  -     16q12.2   [Description]    (hg38-Dec_2013)
EnsemblSLC6A2 - 16q12.2 [CytoView hg19]  SLC6A2 - 16q12.2 [CytoView hg38]
Mapping of homologs : NCBISLC6A2 [Mapview hg19]  SLC6A2 [Mapview hg38]
OMIM163970   604715   
Gene and transcription
Genbank (Entrez)AB022846 AB022847 AK301811 AK310410 AK312793
RefSeq transcript (Entrez)NM_001043 NM_001172501 NM_001172502 NM_001172504
RefSeq genomic (Entrez)NC_000016 NC_018927 NG_016969 NT_010498 NW_004929402
Consensus coding sequences : CCDS (NCBI)SLC6A2
Cluster EST : UnigeneHs.78036 [ NCBI ]
CGAP (NCI)Hs.78036
Alternative Splicing GalleryENSG00000103546
Gene ExpressionSLC6A2 [ NCBI-GEO ]   SLC6A2 [ EBI - ARRAY_EXPRESS ]   SLC6A2 [ SEEK ]   SLC6A2 [ MEM ]
Gene Expression Viewer (FireBrowse)SLC6A2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6530
GTEX Portal (Tissue expression)SLC6A2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP23975   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP23975  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP23975
Splice isoforms : SwissVarP23975
PhosPhoSitePlusP23975
Domaine pattern : Prosite (Expaxy)NA_NEUROTRAN_SYMP_1 (PS00610)    NA_NEUROTRAN_SYMP_2 (PS00754)    NA_NEUROTRAN_SYMP_3 (PS50267)   
Domains : Interpro (EBI)Na/ntran_symport    Na/ntran_symport_noradrenaline   
Domain families : Pfam (Sanger)SNF (PF00209)   
Domain families : Pfam (NCBI)pfam00209   
Conserved Domain (NCBI)SLC6A2
DMDM Disease mutations6530
Blocks (Seattle)SLC6A2
SuperfamilyP23975
Human Protein AtlasENSG00000103546
Peptide AtlasP23975
HPRD01232
IPIIPI00743489   IPI00642795   IPI00465438   
Protein Interaction databases
DIP (DOE-UCLA)P23975
IntAct (EBI)P23975
FunCoupENSG00000103546
BioGRIDSLC6A2
STRING (EMBL)SLC6A2
ZODIACSLC6A2
Ontologies - Pathways
QuickGOP23975
Ontology : AmiGOdopamine:sodium symporter activity  norepinephrine:sodium symporter activity  protein binding  plasma membrane  integral component of plasma membrane  transport  synaptic transmission  monoamine transmembrane transporter activity  monoamine transport  norepinephrine transport  membrane  neuron projection  metal ion binding  response to pain  dopamine uptake involved in synaptic transmission  transmembrane transport  
Ontology : EGO-EBIdopamine:sodium symporter activity  norepinephrine:sodium symporter activity  protein binding  plasma membrane  integral component of plasma membrane  transport  synaptic transmission  monoamine transmembrane transporter activity  monoamine transport  norepinephrine transport  membrane  neuron projection  metal ion binding  response to pain  dopamine uptake involved in synaptic transmission  transmembrane transport  
NDEx NetworkSLC6A2
Atlas of Cancer Signalling NetworkSLC6A2
Wikipedia pathwaysSLC6A2
Orthology - Evolution
OrthoDB6530
GeneTree (enSembl)ENSG00000103546
Phylogenetic Trees/Animal Genes : TreeFamSLC6A2
HOVERGENP23975
HOGENOMP23975
Homologs : HomoloGeneSLC6A2
Homology/Alignments : Family Browser (UCSC)SLC6A2
Gene fusions - Rearrangements
Fusion : MitelmanVPS35/SLC6A2 [16q11.2/16q12.2]  [t(16;16)(q11;q12)]  
Fusion: TCGAVPS35 16q11.2 SLC6A2 16q12.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLC6A2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLC6A2
dbVarSLC6A2
ClinVarSLC6A2
1000_GenomesSLC6A2 
Exome Variant ServerSLC6A2
ExAC (Exome Aggregation Consortium)SLC6A2 (select the gene name)
Genetic variants : HAPMAP6530
Genomic Variants (DGV)SLC6A2 [DGVbeta]
DECIPHER (Syndromes)16:55690352-55737700  ENSG00000103546
CONAN: Copy Number AnalysisSLC6A2 
Mutations
ICGC Data PortalSLC6A2 
TCGA Data PortalSLC6A2 
Broad Tumor PortalSLC6A2
OASIS PortalSLC6A2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLC6A2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSLC6A2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SLC6A2
DgiDB (Drug Gene Interaction Database)SLC6A2
DoCM (Curated mutations)SLC6A2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLC6A2 (select a term)
intoGenSLC6A2
Cancer3DSLC6A2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM163970    604715   
Orphanet23453   
MedgenSLC6A2
Genetic Testing Registry SLC6A2
NextProtP23975 [Medical]
TSGene6530
GENETestsSLC6A2
Huge Navigator SLC6A2 [HugePedia]
snp3D : Map Gene to Disease6530
BioCentury BCIQSLC6A2
ClinGenSLC6A2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6530
Chemical/Pharm GKB GenePA310
Clinical trialSLC6A2
Miscellaneous
canSAR (ICR)SLC6A2 (select the gene name)
Probes
Litterature
PubMed183 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSLC6A2
EVEXSLC6A2
GoPubMedSLC6A2
iHOPSLC6A2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:19:54 CEST 2017

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