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SLCO1B3 (solute carrier organic anion transporter family, member 1B3)

Identity

Other namesHBLRR
LST-2
LST-3TM13
LST3
OATP-8
OATP1B3
OATP8
SLC21A8
HGNC (Hugo) SLCO1B3
LocusID (NCBI) 28234
Location 12p12.2
Location_base_pair Starts at 20963638 and ends at 21069843 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias 11q23ChildAMLID1615

External links

Nomenclature
HGNC (Hugo)SLCO1B3   10961
Cards
Entrez_Gene (NCBI)SLCO1B3  28234  solute carrier organic anion transporter family, member 1B3
GeneCards (Weizmann)SLCO1B3
Ensembl (Hinxton)ENSG00000111700 [Gene_View]  chr12:20963638-21069843 [Contig_View]  SLCO1B3 [Vega]
ICGC DataPortalENSG00000111700
cBioPortalSLCO1B3
AceView (NCBI)SLCO1B3
Genatlas (Paris)SLCO1B3
WikiGenes28234
SOURCE (Princeton)NM_019844
Genomic and cartography
GoldenPath (UCSC)SLCO1B3  -  12p12.2   chr12:20963638-21069843 +  12p12.2   [Description]    (hg19-Feb_2009)
EnsemblSLCO1B3 - 12p12.2 [CytoView]
Mapping of homologs : NCBISLCO1B3 [Mapview]
OMIM237450   605495   
Gene and transcription
Genbank (Entrez)AF187815 AJ251506 AK055874 AY342017 BC022843
RefSeq transcript (Entrez)NM_019844
RefSeq genomic (Entrez)AC_000144 NC_000012 NC_018923 NG_032071 NT_009714 NW_001838052 NW_004929383
Consensus coding sequences : CCDS (NCBI)SLCO1B3
Cluster EST : UnigeneHs.504966 [ NCBI ]
CGAP (NCI)Hs.504966
Alternative Splicing : Fast-db (Paris)GSHG0006527
Alternative Splicing GalleryENSG00000111700
Gene ExpressionSLCO1B3 [ NCBI-GEO ]     SLCO1B3 [ SEEK ]   SLCO1B3 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NPD5 (Uniprot)
NextProtQ9NPD5  [Medical]
With graphics : InterProQ9NPD5
Splice isoforms : SwissVarQ9NPD5 (Swissvar)
Domaine pattern : Prosite (Expaxy)KAZAL_2 (PS51465)    MFS (PS50850)   
Domains : Interpro (EBI)Kazal_dom [organisation]   MFS_dom [organisation]   MFS_dom_general_subst_transpt [organisation]   OA_transporter [organisation]  
Related proteins : CluSTrQ9NPD5
Domain families : Pfam (Sanger)Kazal_2 (PF07648)    OATP (PF03137)   
Domain families : Pfam (NCBI)pfam07648    pfam03137   
Domain families : Smart (EMBL)KAZAL (SM00280)  
DMDM Disease mutations28234
Blocks (Seattle)Q9NPD5
Human Protein AtlasENSG00000111700 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasQ9NPD5
HPRD12021
IPIIPI00902630   
Protein Interaction databases
DIP (DOE-UCLA)Q9NPD5
IntAct (EBI)Q9NPD5
FunCoupENSG00000111700
BioGRIDSLCO1B3
InParanoidQ9NPD5
Interologous Interaction database Q9NPD5
IntegromeDBSLCO1B3
STRING (EMBL)SLCO1B3
Ontologies - Pathways
Ontology : AmiGOplasma membrane  plasma membrane  integral component of plasma membrane  bile acid metabolic process  organic anion transmembrane transporter activity  organic anion transport  bile acid and bile salt transport  basolateral plasma membrane  sodium-independent organic anion transport  small molecule metabolic process  transmembrane transport  
Ontology : EGO-EBIplasma membrane  plasma membrane  integral component of plasma membrane  bile acid metabolic process  organic anion transmembrane transporter activity  organic anion transport  bile acid and bile salt transport  basolateral plasma membrane  sodium-independent organic anion transport  small molecule metabolic process  transmembrane transport  
Pathways : KEGGBile secretion   
Protein Interaction DatabaseSLCO1B3
Wikipedia pathwaysSLCO1B3
Gene fusion - rearrangments
Rearrangement : TICdbPAX5 [9p13.2]  -  SLCO1B3 [2p23.2]
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)SLCO1B3
snp3D : Map Gene to Disease28234
SNP (GeneSNP Utah)SLCO1B3
SNP : HGBaseSLCO1B3
Genetic variants : HAPMAPSLCO1B3
Exome VariantSLCO1B3
1000_GenomesSLCO1B3 
ICGC programENSG00000111700 
Somatic Mutations in Cancer : COSMICSLCO1B3 
CONAN: Copy Number AnalysisSLCO1B3 
Mutations and Diseases : HGMDSLCO1B3
Mutations and Diseases : intOGenSLCO1B3
Genomic VariantsSLCO1B3  SLCO1B3 [DGVbeta]
dbVarSLCO1B3
ClinVarSLCO1B3
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM237450    605495   
MedgenSLCO1B3
GENETestsSLCO1B3
Disease Genetic AssociationSLCO1B3
Huge Navigator SLCO1B3 [HugePedia]  SLCO1B3 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneSLCO1B3
Homology/Alignments : Family Browser (UCSC)SLCO1B3
Phylogenetic Trees/Animal Genes : TreeFamSLCO1B3
Chemical/Protein Interactions : CTD28234
Chemical/Pharm GKB GenePA35844
Clinical trialSLCO1B3
Cancer Resource (Charite)ENSG00000111700
Other databases
Probes
Litterature
PubMed91 Pubmed reference(s) in Entrez
CoreMineSLCO1B3
iHOPSLCO1B3
OncoSearchSLCO1B3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 17:05:22 CEST 2014

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