Atlas of Genetics and Cytogenetics in Oncology and Haematology


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SLCO1B3 (solute carrier organic anion transporter family member 1B3)

Identity

Alias_namesSLC21A8
solute carrier family 21 (organic anion transporter), member 8
solute carrier organic anion transporter family, member 1B3
Alias_symbol (synonym)OATP8
OATP1B3
HGNC (Hugo) SLCO1B3
LocusID (NCBI) 28234
Atlas_Id 46289
Location 12p12.2  [Link to chromosome band 12p12]
Location_base_pair Starts at 20963638 and ends at 21069843 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PAX5 (9p13.2) / SLCO1B3 (12p12.2)SLCO1B3 (12p12.2) / SLCO1B7 (12p12.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  dic(9;12)(p13;p12) PAX5/SLCO1B3


External links

Nomenclature
HGNC (Hugo)SLCO1B3   10961
Cards
Entrez_Gene (NCBI)SLCO1B3  28234  solute carrier organic anion transporter family member 1B3
AliasesHBLRR; LST-2; LST-3TM13; LST3; 
OATP-8; OATP1B3; OATP8; SLC21A8
GeneCards (Weizmann)SLCO1B3
Ensembl hg19 (Hinxton)ENSG00000111700 [Gene_View]  chr12:20963638-21069843 [Contig_View]  SLCO1B3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000111700 [Gene_View]  chr12:20963638-21069843 [Contig_View]  SLCO1B3 [Vega]
ICGC DataPortalENSG00000111700
TCGA cBioPortalSLCO1B3
AceView (NCBI)SLCO1B3
Genatlas (Paris)SLCO1B3
WikiGenes28234
SOURCE (Princeton)SLCO1B3
Genetics Home Reference (NIH)SLCO1B3
Genomic and cartography
GoldenPath hg19 (UCSC)SLCO1B3  -     chr12:20963638-21069843 +  12p12.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SLCO1B3  -     12p12.2   [Description]    (hg38-Dec_2013)
EnsemblSLCO1B3 - 12p12.2 [CytoView hg19]  SLCO1B3 - 12p12.2 [CytoView hg38]
Mapping of homologs : NCBISLCO1B3 [Mapview hg19]  SLCO1B3 [Mapview hg38]
OMIM237450   605495   
Gene and transcription
Genbank (Entrez)AB669023 AF187815 AJ251506 AK055874 AY342017
RefSeq transcript (Entrez)NM_019844
RefSeq genomic (Entrez)NC_000012 NC_018923 NG_032071 NT_009714 NW_004929383
Consensus coding sequences : CCDS (NCBI)SLCO1B3
Cluster EST : UnigeneHs.504966 [ NCBI ]
CGAP (NCI)Hs.504966
Alternative Splicing GalleryENSG00000111700
Gene ExpressionSLCO1B3 [ NCBI-GEO ]   SLCO1B3 [ EBI - ARRAY_EXPRESS ]   SLCO1B3 [ SEEK ]   SLCO1B3 [ MEM ]
Gene Expression Viewer (FireBrowse)SLCO1B3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)28234
GTEX Portal (Tissue expression)SLCO1B3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NPD5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NPD5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NPD5
Splice isoforms : SwissVarQ9NPD5
PhosPhoSitePlusQ9NPD5
Domaine pattern : Prosite (Expaxy)KAZAL_2 (PS51465)    MFS (PS50850)   
Domains : Interpro (EBI)Kazal_dom    MFS_dom    OA_transporter   
Domain families : Pfam (Sanger)Kazal_2 (PF07648)    OATP (PF03137)   
Domain families : Pfam (NCBI)pfam07648    pfam03137   
Domain families : Smart (EMBL)KAZAL (SM00280)  
Conserved Domain (NCBI)SLCO1B3
DMDM Disease mutations28234
Blocks (Seattle)SLCO1B3
SuperfamilyQ9NPD5
Human Protein AtlasENSG00000111700
Peptide AtlasQ9NPD5
HPRD12021
IPIIPI00902630   
Protein Interaction databases
DIP (DOE-UCLA)Q9NPD5
IntAct (EBI)Q9NPD5
FunCoupENSG00000111700
BioGRIDSLCO1B3
STRING (EMBL)SLCO1B3
ZODIACSLCO1B3
Ontologies - Pathways
QuickGOQ9NPD5
Ontology : AmiGOplasma membrane  integral component of plasma membrane  bile acid metabolic process  organic anion transmembrane transporter activity  bile acid transmembrane transporter activity  bile acid transmembrane transporter activity  sodium-independent organic anion transmembrane transporter activity  organic anion transport  bile acid and bile salt transport  basolateral plasma membrane  sodium-independent organic anion transport  sodium-independent organic anion transport  
Ontology : EGO-EBIplasma membrane  integral component of plasma membrane  bile acid metabolic process  organic anion transmembrane transporter activity  bile acid transmembrane transporter activity  bile acid transmembrane transporter activity  sodium-independent organic anion transmembrane transporter activity  organic anion transport  bile acid and bile salt transport  basolateral plasma membrane  sodium-independent organic anion transport  sodium-independent organic anion transport  
Pathways : KEGGBile secretion   
NDEx NetworkSLCO1B3
Atlas of Cancer Signalling NetworkSLCO1B3
Wikipedia pathwaysSLCO1B3
Orthology - Evolution
OrthoDB28234
GeneTree (enSembl)ENSG00000111700
Phylogenetic Trees/Animal Genes : TreeFamSLCO1B3
HOVERGENQ9NPD5
HOGENOMQ9NPD5
Homologs : HomoloGeneSLCO1B3
Homology/Alignments : Family Browser (UCSC)SLCO1B3
Gene fusions - Rearrangements
Fusion : MitelmanPAX5/SLCO1B3 [9p13.2/12p12.2]  [dic(9;12)(p13;p12)]  
Fusion Cancer (Beijing)SLCO1B3 [12p12.2]  -  SLCO1B7 [12p12.2]  [FUSC003252]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSLCO1B3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SLCO1B3
dbVarSLCO1B3
ClinVarSLCO1B3
1000_GenomesSLCO1B3 
Exome Variant ServerSLCO1B3
ExAC (Exome Aggregation Consortium)SLCO1B3 (select the gene name)
Genetic variants : HAPMAP28234
Genomic Variants (DGV)SLCO1B3 [DGVbeta]
DECIPHER (Syndromes)12:20963638-21069843  ENSG00000111700
CONAN: Copy Number AnalysisSLCO1B3 
Mutations
ICGC Data PortalSLCO1B3 
TCGA Data PortalSLCO1B3 
Broad Tumor PortalSLCO1B3
OASIS PortalSLCO1B3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSLCO1B3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSLCO1B3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SLCO1B3
DgiDB (Drug Gene Interaction Database)SLCO1B3
DoCM (Curated mutations)SLCO1B3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SLCO1B3 (select a term)
intoGenSLCO1B3
Cancer3DSLCO1B3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM237450    605495   
Orphanet882   
MedgenSLCO1B3
Genetic Testing Registry SLCO1B3
NextProtQ9NPD5 [Medical]
TSGene28234
GENETestsSLCO1B3
Huge Navigator SLCO1B3 [HugePedia]
snp3D : Map Gene to Disease28234
BioCentury BCIQSLCO1B3
ClinGenSLCO1B3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD28234
Chemical/Pharm GKB GenePA35844
Clinical trialSLCO1B3
Miscellaneous
canSAR (ICR)SLCO1B3 (select the gene name)
Probes
Litterature
PubMed107 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSLCO1B3
EVEXSLCO1B3
GoPubMedSLCO1B3
iHOPSLCO1B3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:51:52 CET 2016

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