SMC2 (structural maintenance of chromosomes 2)

2007-11-01  

Identity

HGNC
LOCATION
9q31.1
LOCUSID
ALIAS
CAP-E,CAPE,SMC-2,SMC2L1
FUSION GENES

Other Information

Locus ID:

NCBI: 10592
MIM: 605576
HGNC: 14011
Ensembl: ENSG00000136824

Variants:

dbSNP: 10592
ClinVar: 10592
TCGA: ENSG00000136824
COSMIC: SMC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136824ENST00000286398O95347
ENSG00000136824ENST00000286398A0A024R158
ENSG00000136824ENST00000374787O95347
ENSG00000136824ENST00000374787A0A024R158
ENSG00000136824ENST00000374793O95347
ENSG00000136824ENST00000374793A0A024R158
ENSG00000136824ENST00000440179Q5T821
ENSG00000136824ENST00000493955A0A0C4DGE5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic ProphaseREACTOMER-HSA-68875
Condensation of Prophase ChromosomesREACTOMER-HSA-2299718
Mitotic PrometaphaseREACTOMER-HSA-68877
Condensation of Prometaphase ChromosomesREACTOMER-HSA-2514853

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
174883352007Condensin mutations and abnormal chromosomal structures in pyothorax-associated lymphoma.19
230957422012Human SMC2 protein, a core subunit of human condensin complex, is a novel transcriptional target of the WNT signaling pathway and a new therapeutic target.19
245531212014Inactivation of SMC2 shows a synergistic lethal response in MYCN-amplified neuroblastoma cells.14
211944742010Streptavidin-Binding Peptide (SBP)-tagged SMC2 allows single-step affinity fluorescence, blotting or purification of the condensin complex.8
244839902014Mutational and expressional analysis of SMC2 gene in gastric and colorectal cancers with microsatellite instability.5
264910212015Structural Basis for Dimer Formation of Human Condensin Structural Maintenance of Chromosome Proteins and Its Implications for Single-stranded DNA Recognition.4
307947212019Potential functional variants in SMC2 and TP53 in the AURORA pathway genes and risk of pancreatic cancer.3
208235282010Cloning, expression, crystallization and preliminary X-ray crystallographic analysis of a human condensin SMC2 hinge domain with short coiled coils.2

Citation

Dessen P

SMC2 (structural maintenance of chromosomes 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-11-01

Online version: http://atlasgeneticsoncology.org/gene/49801/smc2