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SMC2 (structural maintenance of chromosomes 2)

Identity

Alias_namesSMC2L1
SMC2 (structural maintenance of chromosomes 2, yeast)-like 1
SMC2 structural maintenance of chromosomes 2-like 1 (yeast)
Alias_symbol (synonym)hCAP-E
CAP-E
Other aliasCAPE
SMC-2
HGNC (Hugo) SMC2
LocusID (NCBI) 10592
Atlas_Id 49801
Location 9q31.1  [Link to chromosome band 9q31]
Location_base_pair Starts at 106856831 and ends at 106903700 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
KIF3B (20q11.21) / SMC2 (9q31.1)MRAP (21q22.11) / SMC2 (9q31.1)SMC2 (9q31.1) / PGM5 (9q21.11)
SMC2 (9q31.1) / SMC2 (9q31.1)SMC2 9q31.1 / PGM5 9q21.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SMC2   14011
Cards
Entrez_Gene (NCBI)SMC2  10592  structural maintenance of chromosomes 2
AliasesCAP-E; CAPE; SMC-2; SMC2L1
GeneCards (Weizmann)SMC2
Ensembl hg19 (Hinxton)ENSG00000136824 [Gene_View]  chr9:106856831-106903700 [Contig_View]  SMC2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000136824 [Gene_View]  chr9:106856831-106903700 [Contig_View]  SMC2 [Vega]
ICGC DataPortalENSG00000136824
TCGA cBioPortalSMC2
AceView (NCBI)SMC2
Genatlas (Paris)SMC2
WikiGenes10592
SOURCE (Princeton)SMC2
Genetics Home Reference (NIH)SMC2
Genomic and cartography
GoldenPath hg19 (UCSC)SMC2  -     chr9:106856831-106903700 +  9q31.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SMC2  -     9q31.1   [Description]    (hg38-Dec_2013)
EnsemblSMC2 - 9q31.1 [CytoView hg19]  SMC2 - 9q31.1 [CytoView hg38]
Mapping of homologs : NCBISMC2 [Mapview hg19]  SMC2 [Mapview hg38]
OMIM605576   
Gene and transcription
Genbank (Entrez)AF092563 AF113673 AJ420415 AJ420453 AK000955
RefSeq transcript (Entrez)NM_001042550 NM_001042551 NM_001265602 NM_006444
RefSeq genomic (Entrez)NC_000009 NC_018920 NT_008470 NW_004929366
Consensus coding sequences : CCDS (NCBI)SMC2
Cluster EST : UnigeneHs.119023 [ NCBI ]
CGAP (NCI)Hs.119023
Alternative Splicing GalleryENSG00000136824
Gene ExpressionSMC2 [ NCBI-GEO ]   SMC2 [ EBI - ARRAY_EXPRESS ]   SMC2 [ SEEK ]   SMC2 [ MEM ]
Gene Expression Viewer (FireBrowse)SMC2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10592
GTEX Portal (Tissue expression)SMC2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95347   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95347  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95347
Splice isoforms : SwissVarO95347
PhosPhoSitePlusO95347
Domains : Interpro (EBI)P-loop_NTPase    RecF/RecN/SMC_N    SMC    Smc2    SMC_hinge   
Domain families : Pfam (Sanger)SMC_hinge (PF06470)    SMC_N (PF02463)   
Domain families : Pfam (NCBI)pfam06470    pfam02463   
Domain families : Smart (EMBL)SMC_hinge (SM00968)  
Conserved Domain (NCBI)SMC2
DMDM Disease mutations10592
Blocks (Seattle)SMC2
PDB (SRS)4U4P   
PDB (PDBSum)4U4P   
PDB (IMB)4U4P   
PDB (RSDB)4U4P   
Structural Biology KnowledgeBase4U4P   
SCOP (Structural Classification of Proteins)4U4P   
CATH (Classification of proteins structures)4U4P   
SuperfamilyO95347
Human Protein AtlasENSG00000136824
Peptide AtlasO95347
HPRD09277
IPIIPI00007927   IPI00232806   IPI01010977   
Protein Interaction databases
DIP (DOE-UCLA)O95347
IntAct (EBI)O95347
FunCoupENSG00000136824
BioGRIDSMC2
STRING (EMBL)SMC2
ZODIACSMC2
Ontologies - Pathways
QuickGOO95347
Ontology : AmiGOnuclear chromosome  condensed chromosome  condensin complex  protein binding  ATP binding  nucleus  nucleoplasm  nucleolus  cytoplasm  cytosol  mitotic chromosome condensation  meiotic chromosome condensation  meiotic chromosome segregation  protein heterodimerization activity  cell division  kinetochore organization  extracellular exosome  
Ontology : EGO-EBInuclear chromosome  condensed chromosome  condensin complex  protein binding  ATP binding  nucleus  nucleoplasm  nucleolus  cytoplasm  cytosol  mitotic chromosome condensation  meiotic chromosome condensation  meiotic chromosome segregation  protein heterodimerization activity  cell division  kinetochore organization  extracellular exosome  
NDEx NetworkSMC2
Atlas of Cancer Signalling NetworkSMC2
Wikipedia pathwaysSMC2
Orthology - Evolution
OrthoDB10592
GeneTree (enSembl)ENSG00000136824
Phylogenetic Trees/Animal Genes : TreeFamSMC2
HOVERGENO95347
HOGENOMO95347
Homologs : HomoloGeneSMC2
Homology/Alignments : Family Browser (UCSC)SMC2
Gene fusions - Rearrangements
Fusion : MitelmanSMC2/PGM5 [9q31.1/9q21.11]  
Fusion: TCGASMC2 9q31.1 PGM5 9q21.11 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSMC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SMC2
dbVarSMC2
ClinVarSMC2
1000_GenomesSMC2 
Exome Variant ServerSMC2
ExAC (Exome Aggregation Consortium)SMC2 (select the gene name)
Genetic variants : HAPMAP10592
Genomic Variants (DGV)SMC2 [DGVbeta]
DECIPHER (Syndromes)9:106856831-106903700  ENSG00000136824
CONAN: Copy Number AnalysisSMC2 
Mutations
ICGC Data PortalSMC2 
TCGA Data PortalSMC2 
Broad Tumor PortalSMC2
OASIS PortalSMC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSMC2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSMC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SMC2
DgiDB (Drug Gene Interaction Database)SMC2
DoCM (Curated mutations)SMC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SMC2 (select a term)
intoGenSMC2
Cancer3DSMC2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605576   
Orphanet
MedgenSMC2
Genetic Testing Registry SMC2
NextProtO95347 [Medical]
TSGene10592
GENETestsSMC2
Huge Navigator SMC2 [HugePedia]
snp3D : Map Gene to Disease10592
BioCentury BCIQSMC2
ClinGenSMC2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10592
Chemical/Pharm GKB GenePA37833
Clinical trialSMC2
Miscellaneous
canSAR (ICR)SMC2 (select the gene name)
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSMC2
EVEXSMC2
GoPubMedSMC2
iHOPSMC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:28:16 CET 2017

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