| ACAA2 (18q21.1) / SMG1 (16p12.3) | BPTF (17q24.2) / SMG1 (16p12.3) | KCNC3 (19q13.33) / SMG1 (16p12.3) |
|
SMG1 (16p12.3) / ANO3 (11p14.2) | SMG1 (16p12.3) / ARL6IP1 (16p12.3) | SMG1 (16p12.3) / COMMD1 (2p15) |
|
SMG1 (16p12.3) / CYP2C9 (10q23.33) | SMG1 (16p12.3) / DOCK3 (3p21.2) | SMG1 (16p12.3) / KPNA3 (13q14.2) |
|
SMG1 (16p12.3) / SLC25A3 (12q23.1) | SMG1 16p12.3 / ANO3 11p14.2 |
| Nomenclature |
HGNC (Hugo) | SMG1 30045 |
| Cards |
Entrez_Gene (NCBI) | SMG1 23049 SMG1 nonsense mediated mRNA decay associated PI3K related kinase |
Aliases | 61E3.4; ATX; LIP |
GeneCards (Weizmann) | SMG1 |
Ensembl hg19 (Hinxton) | ENSG00000157106 [Gene_View] |
Ensembl hg38 (Hinxton) | ENSG00000157106 [Gene_View]  ENSG00000157106 [Sequence] chr16:18804853-18926404 [Contig_View] SMG1 [Vega] |
ICGC DataPortal | ENSG00000157106 |
TCGA cBioPortal | SMG1 |
AceView (NCBI) | SMG1 |
Genatlas (Paris) | SMG1 |
WikiGenes | 23049 |
SOURCE (Princeton) | SMG1 |
Genetics Home Reference (NIH) | SMG1 |
| Genomic and cartography |
GoldenPath hg38 (UCSC) | SMG1 - chr16:18804853-18926404 - 16p12.3 [Description] (hg38-Dec_2013) |
GoldenPath hg19 (UCSC) | SMG1 - 16p12.3 [Description] (hg19-Feb_2009) |
GoldenPath | SMG1 - 16p12.3 [CytoView hg19] SMG1 - 16p12.3 [CytoView hg38] |
ImmunoBase | ENSG00000157106 |
Mapping of homologs : NCBI | SMG1 [Mapview hg19] SMG1 [Mapview hg38] |
OMIM | 607032 |
| Gene and transcription |
Genbank (Entrez) | AB007881 AB061371 AF186377 AF395444 AK025794 |
RefSeq transcript (Entrez) | NM_015092 |
RefSeq genomic (Entrez) | |
Consensus coding sequences : CCDS (NCBI) | SMG1 |
Cluster EST : Unigene | Hs.460179 [ NCBI ] |
CGAP (NCI) | Hs.460179 |
Alternative Splicing Gallery | ENSG00000157106 |
Gene Expression | SMG1 [ NCBI-GEO ] SMG1 [ EBI - ARRAY_EXPRESS ]
SMG1 [ SEEK ] SMG1 [ MEM ] |
Gene Expression Viewer (FireBrowse) | SMG1 [ Firebrowse - Broad ] |
SOURCE (Princeton) | Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60] |
Genevestigator | Expression in : [tissues]  [cell-lines]  [cancer]  [perturbations]   |
BioGPS (Tissue expression) | 23049 |
GTEX Portal (Tissue expression) | SMG1 |
Human Protein Atlas | ENSG00000157106-SMG1 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
UniProt/SwissProt | Q96Q15 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
NextProt | Q96Q15 [Sequence] [Exons] [Medical] [Publications] |
With graphics : InterPro | Q96Q15 |
Splice isoforms : SwissVar | Q96Q15 |
Catalytic activity : Enzyme | 2.7.11.1 [ Enzyme-Expasy ] 2.7.11.12.7.11.1 [ IntEnz-EBI ] 2.7.11.1 [ BRENDA ] 2.7.11.1 [ KEGG ] |
PhosPhoSitePlus | Q96Q15 |
Domaine pattern : Prosite (Expaxy) | FAT (PS51189) FATC (PS51190) PI3_4_KINASE_2 (PS00916) PI3_4_KINASE_3 (PS50290) |
Domains : Interpro (EBI) | ARM-type_fold FATC_dom Kinase-like_dom_sf PI3/4_kinase_cat_dom PI3/4_kinase_cat_sf PI3/4_kinase_CS PIK_FAT SMG1 SMG1_N |
Domain families : Pfam (Sanger) | DUF5303 (PF17229) FATC (PF02260) PI3_PI4_kinase (PF00454) SMG1 (PF15785) |
Domain families : Pfam (NCBI) | pfam17229 pfam02260 pfam00454 pfam15785 |
Domain families : Smart (EMBL) | FATC (SM01343) PI3Kc (SM00146) |
Conserved Domain (NCBI) | SMG1 |
DMDM Disease mutations | 23049 |
Blocks (Seattle) | SMG1 |
Superfamily | Q96Q15 |
Human Protein Atlas [tissue] | ENSG00000157106-SMG1 [tissue] |
Peptide Atlas | Q96Q15 |
HPRD | 06123 |
IPI | IPI00939320 IPI00639874 IPI00183368 IPI00640955 IPI00747038 IPI00556369 IPI00978348 |
| Protein Interaction databases |
DIP (DOE-UCLA) | Q96Q15 |
IntAct (EBI) | Q96Q15 |
FunCoup | ENSG00000157106 |
BioGRID | SMG1 |
STRING (EMBL) | SMG1 |
ZODIAC | SMG1 |
| Ontologies - Pathways |
QuickGO | Q96Q15 |
Ontology : AmiGO | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay nuclear-transcribed mRNA catabolic process, nonsense-mediated decay nuclear-transcribed mRNA catabolic process, nonsense-mediated decay nuclear-transcribed mRNA catabolic process, nonsense-mediated decay RNA binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus nucleus nucleoplasm cytoplasm cytosol DNA repair mRNA export from nucleus peptidyl-serine phosphorylation peptidyl-serine phosphorylation regulation of telomere maintenance telomeric DNA binding protein autophosphorylation phosphatidylinositol phosphorylation metal ion binding regulation of response to DNA damage stimulus |
Ontology : EGO-EBI | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay nuclear-transcribed mRNA catabolic process, nonsense-mediated decay nuclear-transcribed mRNA catabolic process, nonsense-mediated decay nuclear-transcribed mRNA catabolic process, nonsense-mediated decay RNA binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein serine/threonine kinase activity protein binding ATP binding nucleus nucleus nucleoplasm cytoplasm cytosol DNA repair mRNA export from nucleus peptidyl-serine phosphorylation peptidyl-serine phosphorylation regulation of telomere maintenance telomeric DNA binding protein autophosphorylation phosphatidylinositol phosphorylation metal ion binding regulation of response to DNA damage stimulus |
Pathways : KEGG | mRNA surveillance pathway |
NDEx Network | SMG1 |
Atlas of Cancer Signalling Network | SMG1 |
Wikipedia pathways | SMG1 |
| Orthology - Evolution |
OrthoDB | 23049 |
GeneTree (enSembl) | ENSG00000157106 |
Phylogenetic Trees/Animal Genes : TreeFam | SMG1 |
HOGENOM | Q96Q15 |
Homologs : HomoloGene | SMG1 |
Homology/Alignments : Family Browser (UCSC) | SMG1 |
| Gene fusions - Rearrangements |
Fusion : Mitelman | SMG1/ANO3 [16p12.3/11p14.2]   |
Fusion Portal | SMG1 16p12.3 ANO3 11p14.2 BRCA |
Fusion : Quiver | SMG1 |
| Polymorphisms : SNP and Copy number variants |
NCBI Variation Viewer | SMG1 [hg38] |
dbSNP Single Nucleotide Polymorphism (NCBI) | SMG1 |
dbVar | SMG1 |
ClinVar | SMG1 |
1000_Genomes | SMG1 |
Exome Variant Server | SMG1 |
ExAC (Exome Aggregation Consortium) | ENSG00000157106 |
GNOMAD Browser | ENSG00000157106 |
Varsome Browser | SMG1 |
Genetic variants : HAPMAP | 23049 |
Genomic Variants (DGV) | SMG1 [DGVbeta] |
DECIPHER | SMG1 [patients] [syndromes] [variants] [genes] |
CONAN: Copy Number Analysis | SMG1 |
| Mutations |
ICGC Data Portal | SMG1 |
TCGA Data Portal | SMG1 |
Broad Tumor Portal | SMG1 |
OASIS Portal | SMG1 [ Somatic mutations - Copy number] |
Somatic Mutations in Cancer : COSMIC | SMG1 [overview] [genome browser] [tissue] [distribution] |
Somatic Mutations in Cancer : COSMIC3D | SMG1 |
Mutations and Diseases : HGMD | SMG1 |
LOVD (Leiden Open Variation Database) | Whole genome datasets |
LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
BioMuta | search SMG1 |
DgiDB (Drug Gene Interaction Database) | SMG1 |
DoCM (Curated mutations) | SMG1 (select the gene name) |
CIViC (Clinical Interpretations of Variants in Cancer) | SMG1 (select a term) |
intoGen | SMG1 |
Cancer3D | SMG1(select the gene name) |
Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
---|
OMIM | 607032 |
Orphanet | |
DisGeNET | SMG1 |
Medgen | SMG1 |
Genetic Testing Registry | SMG1
|
NextProt | Q96Q15 [Medical] |
TSGene | 23049 |
GENETests | SMG1 |
Target Validation | SMG1 |
Huge Navigator |
SMG1 [HugePedia] |
snp3D : Map Gene to Disease | 23049 |
BioCentury BCIQ | SMG1 |
ClinGen | SMG1 |
| Clinical trials, drugs, therapy |
---|
Chemical/Protein Interactions : CTD | 23049 |
Chemical/Pharm GKB Gene | PA164725852 |
Clinical trial | SMG1 |
| Miscellaneous |
---|
canSAR (ICR) | SMG1 (select the gene name) |
DataMed Index | SMG1 |
| Probes |
---|
| Litterature |
---|
PubMed | 64 Pubmed reference(s) in Entrez |
GeneRIFs | Gene References Into Functions (Entrez) |
CoreMine | SMG1 |
EVEX | SMG1 |
GoPubMed | SMG1 |
iHOP | SMG1 |