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SMURF2 (SMAD specific E3 ubiquitin protein ligase 2)

Identity

Other alias-
HGNC (Hugo) SMURF2
LocusID (NCBI) 64750
Atlas_Id 42342
Location 17q23.3  [Link to chromosome band 17q23]
Location_base_pair Starts at 64544617 and ends at 64662268 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CEP95 (17q23.3) / SMURF2 (17q23.3)ERN1 (17q23.3) / SMURF2 (17q23.3)SMURF2 (17q23.3) / IKZF3 (17q12)
SMURF2 (17q23.3) / LRRC37A3 (17q24.1)SMURF2 (17q23.3) / NGFR (17q21.33)SMURF2 (17q23.3) / SAE1 (19q13.32)
SMURF2 (17q23.3) / SMURF2 (17q23.3)SND1 (7q32.1) / SMURF2 (17q23.3)SMURF2 17q23.3 / IKZF3 17q12
SMURF2 17q23.3 / LRRC37A3 17q24.1SMURF2 17q23.3 / NGFR 17q21.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SMURF2   16809
Cards
Entrez_Gene (NCBI)SMURF2  64750  SMAD specific E3 ubiquitin protein ligase 2
Aliases
GeneCards (Weizmann)SMURF2
Ensembl hg19 (Hinxton)ENSG00000108854 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108854 [Gene_View]  chr17:64544617-64662268 [Contig_View]  SMURF2 [Vega]
ICGC DataPortalENSG00000108854
TCGA cBioPortalSMURF2
AceView (NCBI)SMURF2
Genatlas (Paris)SMURF2
WikiGenes64750
SOURCE (Princeton)SMURF2
Genetics Home Reference (NIH)SMURF2
Genomic and cartography
GoldenPath hg38 (UCSC)SMURF2  -     chr17:64544617-64662268 -  17q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SMURF2  -     17q23.3   [Description]    (hg19-Feb_2009)
EnsemblSMURF2 - 17q23.3 [CytoView hg19]  SMURF2 - 17q23.3 [CytoView hg38]
Mapping of homologs : NCBISMURF2 [Mapview hg19]  SMURF2 [Mapview hg38]
OMIM605532   
Gene and transcription
Genbank (Entrez)AF301463 AF310676 AK002019 AY014180 BC009527
RefSeq transcript (Entrez)NM_022739
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SMURF2
Cluster EST : UnigeneHs.515011 [ NCBI ]
CGAP (NCI)Hs.515011
Alternative Splicing GalleryENSG00000108854
Gene ExpressionSMURF2 [ NCBI-GEO ]   SMURF2 [ EBI - ARRAY_EXPRESS ]   SMURF2 [ SEEK ]   SMURF2 [ MEM ]
Gene Expression Viewer (FireBrowse)SMURF2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64750
GTEX Portal (Tissue expression)SMURF2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HAU4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HAU4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HAU4
Splice isoforms : SwissVarQ9HAU4
PhosPhoSitePlusQ9HAU4
Domaine pattern : Prosite (Expaxy)C2 (PS50004)    HECT (PS50237)    WW_DOMAIN_1 (PS01159)    WW_DOMAIN_2 (PS50020)   
Domains : Interpro (EBI)C2_dom    HECT_dom    WW_dom   
Domain families : Pfam (Sanger)C2 (PF00168)    HECT (PF00632)    WW (PF00397)   
Domain families : Pfam (NCBI)pfam00168    pfam00632    pfam00397   
Domain families : Smart (EMBL)C2 (SM00239)  HECTc (SM00119)  WW (SM00456)  
Conserved Domain (NCBI)SMURF2
DMDM Disease mutations64750
Blocks (Seattle)SMURF2
PDB (SRS)1ZVD    2DJY    2JQZ    2KXQ    2LTZ   
PDB (PDBSum)1ZVD    2DJY    2JQZ    2KXQ    2LTZ   
PDB (IMB)1ZVD    2DJY    2JQZ    2KXQ    2LTZ   
PDB (RSDB)1ZVD    2DJY    2JQZ    2KXQ    2LTZ   
Structural Biology KnowledgeBase1ZVD    2DJY    2JQZ    2KXQ    2LTZ   
SCOP (Structural Classification of Proteins)1ZVD    2DJY    2JQZ    2KXQ    2LTZ   
CATH (Classification of proteins structures)1ZVD    2DJY    2JQZ    2KXQ    2LTZ   
SuperfamilyQ9HAU4
Human Protein AtlasENSG00000108854
Peptide AtlasQ9HAU4
HPRD06901
IPIIPI00329664   
Protein Interaction databases
DIP (DOE-UCLA)Q9HAU4
IntAct (EBI)Q9HAU4
FunCoupENSG00000108854
BioGRIDSMURF2
STRING (EMBL)SMURF2
ZODIACSMURF2
Ontologies - Pathways
QuickGOQ9HAU4
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  ubiquitin ligase complex  protein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  transforming growth factor beta receptor binding  protein binding  nucleus  nucleoplasm  cytosol  plasma membrane  ubiquitin-dependent protein catabolic process  protein deubiquitination  nuclear speck  regulation of transforming growth factor beta receptor signaling pathway  BMP signaling pathway  negative regulation of transforming growth factor beta receptor signaling pathway  negative regulation of transforming growth factor beta receptor signaling pathway  ubiquitin-dependent SMAD protein catabolic process  identical protein binding  membrane raft  negative regulation of transcription, DNA-templated  SMAD binding  Wnt signaling pathway, planar cell polarity pathway  ubiquitin protein ligase activity  positive regulation of canonical Wnt signaling pathway  positive regulation of trophoblast cell migration  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  ubiquitin ligase complex  protein polyubiquitination  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  transforming growth factor beta receptor binding  protein binding  nucleus  nucleoplasm  cytosol  plasma membrane  ubiquitin-dependent protein catabolic process  protein deubiquitination  nuclear speck  regulation of transforming growth factor beta receptor signaling pathway  BMP signaling pathway  negative regulation of transforming growth factor beta receptor signaling pathway  negative regulation of transforming growth factor beta receptor signaling pathway  ubiquitin-dependent SMAD protein catabolic process  identical protein binding  membrane raft  negative regulation of transcription, DNA-templated  SMAD binding  Wnt signaling pathway, planar cell polarity pathway  ubiquitin protein ligase activity  positive regulation of canonical Wnt signaling pathway  positive regulation of trophoblast cell migration  
Pathways : BIOCARTAEstrogen-responsive protein Efp controls cell cycle and breast tumors growth [Genes]   
Pathways : KEGGUbiquitin mediated proteolysis    Endocytosis    TGF-beta signaling pathway   
NDEx NetworkSMURF2
Atlas of Cancer Signalling NetworkSMURF2
Wikipedia pathwaysSMURF2
Orthology - Evolution
OrthoDB64750
GeneTree (enSembl)ENSG00000108854
Phylogenetic Trees/Animal Genes : TreeFamSMURF2
HOVERGENQ9HAU4
HOGENOMQ9HAU4
Homologs : HomoloGeneSMURF2
Homology/Alignments : Family Browser (UCSC)SMURF2
Gene fusions - Rearrangements
Fusion : MitelmanSMURF2/LRRC37A3 [17q23.3/17q24.1]  
Fusion : MitelmanSMURF2/NGFR [17q23.3/17q21.33]  [t(17;17)(q21;q24)]  
Fusion: TCGASMURF2 17q23.3 IKZF3 17q12 BRCA
Fusion: TCGASMURF2 17q23.3 LRRC37A3 17q24.1 LUAD
Fusion: TCGASMURF2 17q23.3 NGFR 17q21.33 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSMURF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SMURF2
dbVarSMURF2
ClinVarSMURF2
1000_GenomesSMURF2 
Exome Variant ServerSMURF2
ExAC (Exome Aggregation Consortium)SMURF2 (select the gene name)
Genetic variants : HAPMAP64750
Genomic Variants (DGV)SMURF2 [DGVbeta]
DECIPHERSMURF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSMURF2 
Mutations
ICGC Data PortalSMURF2 
TCGA Data PortalSMURF2 
Broad Tumor PortalSMURF2
OASIS PortalSMURF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSMURF2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSMURF2
intOGen PortalSMURF2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SMURF2
DgiDB (Drug Gene Interaction Database)SMURF2
DoCM (Curated mutations)SMURF2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SMURF2 (select a term)
intoGenSMURF2
Cancer3DSMURF2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605532   
Orphanet
MedgenSMURF2
Genetic Testing Registry SMURF2
NextProtQ9HAU4 [Medical]
TSGene64750
GENETestsSMURF2
Target ValidationSMURF2
Huge Navigator SMURF2 [HugePedia]
snp3D : Map Gene to Disease64750
BioCentury BCIQSMURF2
ClinGenSMURF2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64750
Chemical/Pharm GKB GenePA134985524
Clinical trialSMURF2
Miscellaneous
canSAR (ICR)SMURF2 (select the gene name)
Probes
Litterature
PubMed103 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSMURF2
EVEXSMURF2
GoPubMedSMURF2
iHOPSMURF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:56:37 CEST 2017

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