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SRPK1 (SRSF protein kinase 1)

Identity

Alias_namesSFRS protein kinase 1
Alias_symbol (synonym)SFRSK1
Other alias
HGNC (Hugo) SRPK1
LocusID (NCBI) 6732
Atlas_Id 43505
Location 6p21.31  [Link to chromosome band 6p21]
Location_base_pair Starts at 35833034 and ends at 35921180 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HDDC2 (6q22.31) / SRPK1 (6p21.31)SRPK1 (6p21.31) / ANKRD42 (11q14.1)SRPK1 (6p21.31) / CEP57L1 (6q21)
SRPK1 (6p21.31) / DDAH1 (1p22.3)SRPK1 (6p21.31) / SRPK1 (6p21.31)SRPK1 (6p21.31) / TJP2 (9q21.11)
UBR2 (6p21.1) / SRPK1 (6p21.31)SRPK1 6p21.31 / ANKRD42 11q14.1SRPK1 6p21.31 / CEP57L1 6q21
SRPK1 6p21.31 / DDAH1 1p22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  t(1;6)(p22;p21) SRPK1/DDAH1
UBR2/SRPK1 (6p21)
t(6;6)(p21;q21) SRPK1/CEP57L1
t(6;11)(p21;q14) SRPK1/ANKRD42


External links

Nomenclature
HGNC (Hugo)SRPK1   11305
Cards
Entrez_Gene (NCBI)SRPK1  6732  SRSF protein kinase 1
AliasesSFRSK1
GeneCards (Weizmann)SRPK1
Ensembl hg19 (Hinxton)ENSG00000096063 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000096063 [Gene_View]  ENSG00000096063 [Sequence]  chr6:35833034-35921180 [Contig_View]  SRPK1 [Vega]
ICGC DataPortalENSG00000096063
TCGA cBioPortalSRPK1
AceView (NCBI)SRPK1
Genatlas (Paris)SRPK1
WikiGenes6732
SOURCE (Princeton)SRPK1
Genetics Home Reference (NIH)SRPK1
Genomic and cartography
GoldenPath hg38 (UCSC)SRPK1  -     chr6:35833034-35921180 -  6p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SRPK1  -     6p21.31   [Description]    (hg19-Feb_2009)
EnsemblSRPK1 - 6p21.31 [CytoView hg19]  SRPK1 - 6p21.31 [CytoView hg38]
Mapping of homologs : NCBISRPK1 [Mapview hg19]  SRPK1 [Mapview hg38]
OMIM601939   
Gene and transcription
Genbank (Entrez)AJ318054 AK292277 AK299591 AK312712 AL117648
RefSeq transcript (Entrez)NM_003137
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SRPK1
Cluster EST : UnigeneHs.443861 [ NCBI ]
CGAP (NCI)Hs.443861
Alternative Splicing GalleryENSG00000096063
Gene ExpressionSRPK1 [ NCBI-GEO ]   SRPK1 [ EBI - ARRAY_EXPRESS ]   SRPK1 [ SEEK ]   SRPK1 [ MEM ]
Gene Expression Viewer (FireBrowse)SRPK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6732
GTEX Portal (Tissue expression)SRPK1
Human Protein AtlasENSG00000096063-SRPK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96SB4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96SB4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96SB4
Splice isoforms : SwissVarQ96SB4
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ96SB4
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)SRPK1
DMDM Disease mutations6732
Blocks (Seattle)SRPK1
PDB (SRS)1WAK    1WBP    3BEG    4WUA    5MXX    5MY8   
PDB (PDBSum)1WAK    1WBP    3BEG    4WUA    5MXX    5MY8   
PDB (IMB)1WAK    1WBP    3BEG    4WUA    5MXX    5MY8   
PDB (RSDB)1WAK    1WBP    3BEG    4WUA    5MXX    5MY8   
Structural Biology KnowledgeBase1WAK    1WBP    3BEG    4WUA    5MXX    5MY8   
SCOP (Structural Classification of Proteins)1WAK    1WBP    3BEG    4WUA    5MXX    5MY8   
CATH (Classification of proteins structures)1WAK    1WBP    3BEG    4WUA    5MXX    5MY8   
SuperfamilyQ96SB4
Human Protein Atlas [tissue]ENSG00000096063-SRPK1 [tissue]
Peptide AtlasQ96SB4
HPRD15992
IPIIPI00412344   IPI00914014   IPI00964681   IPI00966190   IPI00290439   IPI00968125   IPI00969086   IPI00966821   IPI00967873   
Protein Interaction databases
DIP (DOE-UCLA)Q96SB4
IntAct (EBI)Q96SB4
FunCoupENSG00000096063
BioGRIDSRPK1
STRING (EMBL)SRPK1
ZODIACSRPK1
Ontologies - Pathways
QuickGOQ96SB4
Ontology : AmiGOspliceosomal complex assembly  magnesium ion binding  RNA binding  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleus  cytoplasm  cytoplasm  endoplasmic reticulum  cytosol  plasma membrane  protein phosphorylation  chromosome segregation  RNA splicing  regulation of gene expression  viral process  nuclear matrix  sperm chromatin condensation  intracellular signal transduction  intracellular signal transduction  positive regulation of viral genome replication  negative regulation of viral genome replication  innate immune response  regulation of mRNA splicing, via spliceosome  regulation of mRNA processing  regulation of mRNA processing  
Ontology : EGO-EBIspliceosomal complex assembly  magnesium ion binding  RNA binding  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleus  cytoplasm  cytoplasm  endoplasmic reticulum  cytosol  plasma membrane  protein phosphorylation  chromosome segregation  RNA splicing  regulation of gene expression  viral process  nuclear matrix  sperm chromatin condensation  intracellular signal transduction  intracellular signal transduction  positive regulation of viral genome replication  negative regulation of viral genome replication  innate immune response  regulation of mRNA splicing, via spliceosome  regulation of mRNA processing  regulation of mRNA processing  
Pathways : KEGGHerpes simplex infection   
NDEx NetworkSRPK1
Atlas of Cancer Signalling NetworkSRPK1
Wikipedia pathwaysSRPK1
Orthology - Evolution
OrthoDB6732
GeneTree (enSembl)ENSG00000096063
Phylogenetic Trees/Animal Genes : TreeFamSRPK1
HOVERGENQ96SB4
HOGENOMQ96SB4
Homologs : HomoloGeneSRPK1
Homology/Alignments : Family Browser (UCSC)SRPK1
Gene fusions - Rearrangements
Fusion : MitelmanSRPK1/ANKRD42 [6p21.31/11q14.1]  
Fusion : MitelmanSRPK1/CEP57L1 [6p21.31/6q21]  [t(6;6)(p21;q21)]  
Fusion : MitelmanSRPK1/DDAH1 [6p21.31/1p22.3]  [t(1;6)(p22;p21)]  
Fusion : MitelmanUBR2/SRPK1 [6p21.1/6p21.31]  [t(6;6)(p21;p21)]  
Fusion PortalSRPK1 6p21.31 ANKRD42 11q14.1 BRCA
Fusion PortalSRPK1 6p21.31 CEP57L1 6q21 LUSC
Fusion PortalSRPK1 6p21.31 DDAH1 1p22.3 BRCA
Fusion : QuiverSRPK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSRPK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SRPK1
dbVarSRPK1
ClinVarSRPK1
1000_GenomesSRPK1 
Exome Variant ServerSRPK1
ExAC (Exome Aggregation Consortium)ENSG00000096063
GNOMAD BrowserENSG00000096063
Varsome BrowserSRPK1
Genetic variants : HAPMAP6732
Genomic Variants (DGV)SRPK1 [DGVbeta]
DECIPHERSRPK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSRPK1 
Mutations
ICGC Data PortalSRPK1 
TCGA Data PortalSRPK1 
Broad Tumor PortalSRPK1
OASIS PortalSRPK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSRPK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSRPK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SRPK1
DgiDB (Drug Gene Interaction Database)SRPK1
DoCM (Curated mutations)SRPK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SRPK1 (select a term)
intoGenSRPK1
Cancer3DSRPK1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601939   
Orphanet
DisGeNETSRPK1
MedgenSRPK1
Genetic Testing Registry SRPK1
NextProtQ96SB4 [Medical]
TSGene6732
GENETestsSRPK1
Target ValidationSRPK1
Huge Navigator SRPK1 [HugePedia]
snp3D : Map Gene to Disease6732
BioCentury BCIQSRPK1
ClinGenSRPK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6732
Chemical/Pharm GKB GenePA36129
Clinical trialSRPK1
Miscellaneous
canSAR (ICR)SRPK1 (select the gene name)
Probes
Litterature
PubMed118 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSRPK1
EVEXSRPK1
GoPubMedSRPK1
iHOPSRPK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:41:56 CET 2018

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