ST6GAL1 (ST6 beta-galactoside alpha-2,6-sialyltransferase 1)

2003-11-01  

Identity

HGNC
LOCATION
3q27.3
LOCUSID
ALIAS
SIAT1,ST6GalI,ST6N
FUSION GENES

Other Information

Locus ID:

NCBI: 6480
MIM: 109675
HGNC: 10860
Ensembl: ENSG00000073849

Variants:

dbSNP: 6480
ClinVar: 6480
TCGA: ENSG00000073849
COSMIC: ST6GAL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000073849ENST00000169298P15907
ENSG00000073849ENST00000416235C9JKG0
ENSG00000073849ENST00000417392C9K0R8
ENSG00000073849ENST00000423451C9J6X5
ENSG00000073849ENST00000427315C9JVK7
ENSG00000073849ENST00000430309C9JTR0
ENSG00000073849ENST00000438590C9JI90
ENSG00000073849ENST00000440338C9JPG6
ENSG00000073849ENST00000442023C9JH16
ENSG00000073849ENST00000446170C9JR47
ENSG00000073849ENST00000448044P15907
ENSG00000073849ENST00000448408C9JFM4
ENSG00000073849ENST00000448449H7C472
ENSG00000073849ENST00000455441C9JAT4
ENSG00000073849ENST00000457772P15907
ENSG00000073849ENST00000458216C9IYS8

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
N-Glycan biosynthesisKEGGko00510
Other types of O-glycan biosynthesisKEGGko00514
N-Glycan biosynthesisKEGGhsa00510
Other types of O-glycan biosynthesisKEGGhsa00514
Metabolic pathwaysKEGGhsa01100
N-glycan biosynthesis, complex typeKEGGhsa_M00075
N-glycan biosynthesis, complex typeKEGGM00075
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinREACTOMER-HSA-446193
Synthesis of substrates in N-glycan biosythesisREACTOMER-HSA-446219
Sialic acid metabolismREACTOMER-HSA-4085001
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
N-glycan antennae elongation in the medial/trans-GolgiREACTOMER-HSA-975576
N-Glycan antennae elongationREACTOMER-HSA-975577
O-linked glycosylationREACTOMER-HSA-5173105
O-linked glycosylation of mucinsREACTOMER-HSA-913709
Termination of O-glycan biosynthesisREACTOMER-HSA-977068

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164781042flucloxacillinChemicalLiterature, MultilinkAnnotationassociated19483685

References

Pubmed IDYearTitleCitations
124993762003The ST6Gal I sialyltransferase selectively modifies N-glycans on CD45 to negatively regulate galectin-1-induced CD45 clustering, phosphatase modulation, and T cell death.64
215509772011Sialylation of the Fas death receptor by ST6Gal-I provides protection against Fas-mediated apoptosis in colon carcinoma cells.63
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
233586842013ST6Gal-I protein expression is upregulated in human epithelial tumors and correlates with stem cell markers in normal tissues and colon cancer cell lines.51
272161782016The Tumor-Associated Glycosyltransferase ST6Gal-I Regulates Stem Cell Transcription Factors and Confers a Cancer Stem Cell Phenotype.41
239993062013The structure of human α-2,6-sialyltransferase reveals the binding mode of complex glycans.33
253446062014β-Galactoside α2,6-sialyltranferase 1 promotes transforming growth factor-β-mediated epithelial-mesenchymal transition.33
219307132011ST6Gal-I regulates macrophage apoptosis via α2-6 sialylation of the TNFR1 death receptor.32
186504472008Proteolytic shedding of ST6Gal-I by BACE1 regulates the glycosylation and function of alpha4beta1 integrins.31
263048312015Glycosyltransferase ST6GAL1 contributes to the regulation of pluripotency in human pluripotent stem cells.23

Citation

Dessen P

ST6GAL1 (ST6 beta-galactoside alpha-2,6-sialyltransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42295/st6gal1