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ST6GAL1 (ST6 beta-galactoside alpha-2,6-sialyltransferase 1)

Identity

Alias (NCBI)SIAT1
ST6GalI
ST6N
HGNC (Hugo) ST6GAL1
HGNC Alias nameST6Gal I
HGNC Previous nameSIAT1
HGNC Previous namesialyltransferase 1 (beta-galactoside alpha-2,6-sialytransferase)
 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
LocusID (NCBI) 6480
Atlas_Id 42295
Location 3q27.3  [Link to chromosome band 3q27]
Location_base_pair Starts at 186930526 and ends at 187078553 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GRN (17q21.31) / ST6GAL1 (3q27.3)LPP-AS2 (3q27.3) / ST6GAL1 (3q27.3)LPP (3q28) / ST6GAL1 (3q27.3)
MRPS34 (16p13.3) / ST6GAL1 (3q27.3)SREK1 (5q12.3) / ST6GAL1 (3q27.3)ST6GAL1 (3q27.3) / BCL6 (3q27.3)
ST6GAL1 (3q27.3) / KNG1 (3q27.3)ST6GAL1 (3q27.3) / ST6GAL1 (3q27.3)ST6GAL1 (3q27.3) / TBCCD1 (3q27.3)
ST6GAL1 (3q27.3) / WHSC1 (4p16.3)UBE2R2 (9p13.3) / ST6GAL1 (3q27.3)LPP 3q28 / ST6GAL1 3q27.3
SREK1 5q12.3 / ST6GAL1 3q27.3ST6GAL1 3q27.3 / KNG1 3q27.3ST6GAL1 3q27.3 / TBCCD1 3q27.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(3;3)(q27;q27) ST6GAL1/BCL6::del(3)(q27q27) ST6GAL1/BCL6


External links

 

Nomenclature
HGNC (Hugo)ST6GAL1   10860
Cards
Entrez_Gene (NCBI)ST6GAL1    ST6 beta-galactoside alpha-2,6-sialyltransferase 1
AliasesSIAT1; ST6GalI; ST6N
GeneCards (Weizmann)ST6GAL1
Ensembl hg19 (Hinxton)ENSG00000073849 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000073849 [Gene_View]  ENSG00000073849 [Sequence]  chr3:186930526-187078553 [Contig_View]  ST6GAL1 [Vega]
ICGC DataPortalENSG00000073849
TCGA cBioPortalST6GAL1
AceView (NCBI)ST6GAL1
Genatlas (Paris)ST6GAL1
SOURCE (Princeton)ST6GAL1
Genetics Home Reference (NIH)ST6GAL1
Genomic and cartography
GoldenPath hg38 (UCSC)ST6GAL1  -     chr3:186930526-187078553 +  3q27.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ST6GAL1  -     3q27.3   [Description]    (hg19-Feb_2009)
GoldenPathST6GAL1 - 3q27.3 [CytoView hg19]  ST6GAL1 - 3q27.3 [CytoView hg38]
ImmunoBaseENSG00000073849
Genome Data Viewer NCBIST6GAL1 [Mapview hg19]  
OMIM109675   
Gene and transcription
Genbank (Entrez)A17362 A23699 AF007133 AK128726 AK292879
RefSeq transcript (Entrez)NM_001353916 NM_003032 NM_173216 NM_173217
Consensus coding sequences : CCDS (NCBI)ST6GAL1
Gene ExpressionST6GAL1 [ NCBI-GEO ]   ST6GAL1 [ EBI - ARRAY_EXPRESS ]   ST6GAL1 [ SEEK ]   ST6GAL1 [ MEM ]
Gene Expression Viewer (FireBrowse)ST6GAL1 [ Firebrowse - Broad ]
GenevisibleExpression of ST6GAL1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6480
GTEX Portal (Tissue expression)ST6GAL1
Human Protein AtlasENSG00000073849-ST6GAL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP15907   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP15907  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP15907
PhosPhoSitePlusP15907
Domains : Interpro (EBI)Glyco_trans_29    GT29-like_sf    Sialyl_trans   
Domain families : Pfam (Sanger)Glyco_transf_29 (PF00777)   
Domain families : Pfam (NCBI)pfam00777   
Conserved Domain (NCBI)ST6GAL1
PDB (RSDB)4JS1    4JS2    6QVS    6QVT   
PDB Europe4JS1    4JS2    6QVS    6QVT   
PDB (PDBSum)4JS1    4JS2    6QVS    6QVT   
PDB (IMB)4JS1    4JS2    6QVS    6QVT   
Structural Biology KnowledgeBase4JS1    4JS2    6QVS    6QVT   
SCOP (Structural Classification of Proteins)4JS1    4JS2    6QVS    6QVT   
CATH (Classification of proteins structures)4JS1    4JS2    6QVS    6QVT   
SuperfamilyP15907
AlphaFold pdb e-kbP15907   
Human Protein Atlas [tissue]ENSG00000073849-ST6GAL1 [tissue]
HPRD00184
Protein Interaction databases
DIP (DOE-UCLA)P15907
IntAct (EBI)P15907
BioGRIDST6GAL1
STRING (EMBL)ST6GAL1
ZODIACST6GAL1
Ontologies - Pathways
QuickGOP15907
Ontology : AmiGOGolgi membrane  Golgi membrane  beta-galactoside alpha-2,6-sialyltransferase activity  beta-galactoside alpha-2,6-sialyltransferase activity  protein binding  extracellular region  N-acetylneuraminate metabolic process  humoral immune response  sialyltransferase activity  integral component of membrane  O-glycan processing  protein N-linked glycosylation via asparagine  viral protein processing  Golgi cisterna membrane  protein homodimerization activity  sialylation  
Ontology : EGO-EBIGolgi membrane  Golgi membrane  beta-galactoside alpha-2,6-sialyltransferase activity  beta-galactoside alpha-2,6-sialyltransferase activity  protein binding  extracellular region  N-acetylneuraminate metabolic process  humoral immune response  sialyltransferase activity  integral component of membrane  O-glycan processing  protein N-linked glycosylation via asparagine  viral protein processing  Golgi cisterna membrane  protein homodimerization activity  sialylation  
Pathways : KEGGN-Glycan biosynthesis    Other types of O-glycan biosynthesis   
NDEx NetworkST6GAL1
Atlas of Cancer Signalling NetworkST6GAL1
Wikipedia pathwaysST6GAL1
Orthology - Evolution
OrthoDB6480
GeneTree (enSembl)ENSG00000073849
Phylogenetic Trees/Animal Genes : TreeFamST6GAL1
Homologs : HomoloGeneST6GAL1
Homology/Alignments : Family Browser (UCSC)ST6GAL1
Gene fusions - Rearrangements
Fusion : MitelmanLPP/ST6GAL1 [3q28/3q27.3]  
Fusion : MitelmanSREK1/ST6GAL1 [5q12.3/3q27.3]  
Fusion : MitelmanST6GAL1/BCL6 [3q27.3/3q27.3]  
Fusion : MitelmanST6GAL1/KNG1 [3q27.3/3q27.3]  
Fusion : MitelmanST6GAL1/TBCCD1 [3q27.3/3q27.3]  
Fusion : MitelmanST6GAL1/WHSC1 [3q27.3/4p16.3]  
Fusion : QuiverST6GAL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerST6GAL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ST6GAL1
dbVarST6GAL1
ClinVarST6GAL1
MonarchST6GAL1
1000_GenomesST6GAL1 
Exome Variant ServerST6GAL1
GNOMAD BrowserENSG00000073849
Varsome BrowserST6GAL1
ACMGST6GAL1 variants
VarityP15907
Genomic Variants (DGV)ST6GAL1 [DGVbeta]
DECIPHERST6GAL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisST6GAL1 
Mutations
ICGC Data PortalST6GAL1 
TCGA Data PortalST6GAL1 
Broad Tumor PortalST6GAL1
OASIS PortalST6GAL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICST6GAL1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DST6GAL1
Mutations and Diseases : HGMDST6GAL1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaST6GAL1
DgiDB (Drug Gene Interaction Database)ST6GAL1
DoCM (Curated mutations)ST6GAL1
CIViC (Clinical Interpretations of Variants in Cancer)ST6GAL1
Cancer3DST6GAL1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM109675   
Orphanet
DisGeNETST6GAL1
MedgenST6GAL1
Genetic Testing Registry ST6GAL1
NextProtP15907 [Medical]
GENETestsST6GAL1
Target ValidationST6GAL1
Huge Navigator ST6GAL1 [HugePedia]
ClinGenST6GAL1
Clinical trials, drugs, therapy
MyCancerGenomeST6GAL1
Protein Interactions : CTDST6GAL1
Pharm GKB GenePA35762
PharosP15907
Clinical trialST6GAL1
Miscellaneous
canSAR (ICR)ST6GAL1
HarmonizomeST6GAL1
DataMed IndexST6GAL1
Probes
Litterature
PubMed111 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXST6GAL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:33:26 CEST 2021

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