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ST6GAL1 (ST6 beta-galactosamide alpha-2,6-sialyltranferase 1)

Identity

Alias_namesSIAT1
sialyltransferase 1 (beta-galactoside alpha-2,6-sialytransferase)
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Other aliasST6GalI
ST6N
HGNC (Hugo) ST6GAL1
LocusID (NCBI) 6480
Atlas_Id 42295
Location 3q27.3  [Link to chromosome band 3q27]
Location_base_pair Starts at 186739665 and ends at 186796341 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
GRN (17q21.31) / ST6GAL1 (3q27.3)LPP-AS2 (3q27.3) / ST6GAL1 (3q27.3)LPP (3q28) / ST6GAL1 (3q27.3)
MRPS34 (16p13.3) / ST6GAL1 (3q27.3)SREK1 (5q12.3) / ST6GAL1 (3q27.3)ST6GAL1 (3q27.3) / BCL6 (3q27.3)
ST6GAL1 (3q27.3) / KNG1 (3q27.3)ST6GAL1 (3q27.3) / ST6GAL1 (3q27.3)ST6GAL1 (3q27.3) / TBCCD1 (3q27.3)
ST6GAL1 (3q27.3) / WHSC1 (4p16.3)UBE2R2 (9p13.3) / ST6GAL1 (3q27.3)LPP 3q28 / ST6GAL1 3q27.3
SREK1 5q12.3 / ST6GAL1 3q27.3ST6GAL1 3q27.3 / KNG1 3q27.3ST6GAL1 3q27.3 / TBCCD1 3q27.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(3;3)(q27;q27) ST6GAL1/BCL6::del(3)(q27q27) ST6GAL1/BCL6


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)ST6GAL1   10860
Cards
Entrez_Gene (NCBI)ST6GAL1  6480  ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
AliasesSIAT1; ST6GalI; ST6N
GeneCards (Weizmann)ST6GAL1
Ensembl hg19 (Hinxton)ENSG00000073849 [Gene_View]  chr3:186739665-186796341 [Contig_View]  ST6GAL1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000073849 [Gene_View]  chr3:186739665-186796341 [Contig_View]  ST6GAL1 [Vega]
ICGC DataPortalENSG00000073849
TCGA cBioPortalST6GAL1
AceView (NCBI)ST6GAL1
Genatlas (Paris)ST6GAL1
WikiGenes6480
SOURCE (Princeton)ST6GAL1
Genetics Home Reference (NIH)ST6GAL1
Genomic and cartography
GoldenPath hg19 (UCSC)ST6GAL1  -     chr3:186739665-186796341 +  3q27.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ST6GAL1  -     3q27.3   [Description]    (hg38-Dec_2013)
EnsemblST6GAL1 - 3q27.3 [CytoView hg19]  ST6GAL1 - 3q27.3 [CytoView hg38]
Mapping of homologs : NCBIST6GAL1 [Mapview hg19]  ST6GAL1 [Mapview hg38]
OMIM109675   
Gene and transcription
Genbank (Entrez)A17362 A23699 AF007133 AK128726 AK292879
RefSeq transcript (Entrez)NM_003032 NM_173216 NM_173217
RefSeq genomic (Entrez)NC_000003 NC_018914 NT_005612 NW_004929311
Consensus coding sequences : CCDS (NCBI)ST6GAL1
Cluster EST : UnigeneHs.207459 [ NCBI ]
CGAP (NCI)Hs.207459
Alternative Splicing GalleryENSG00000073849
Gene ExpressionST6GAL1 [ NCBI-GEO ]   ST6GAL1 [ EBI - ARRAY_EXPRESS ]   ST6GAL1 [ SEEK ]   ST6GAL1 [ MEM ]
Gene Expression Viewer (FireBrowse)ST6GAL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6480
GTEX Portal (Tissue expression)ST6GAL1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP15907   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP15907  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP15907
Splice isoforms : SwissVarP15907
Catalytic activity : Enzyme2.4.99.1 [ Enzyme-Expasy ]   2.4.99.12.4.99.1 [ IntEnz-EBI ]   2.4.99.1 [ BRENDA ]   2.4.99.1 [ KEGG ]   
PhosPhoSitePlusP15907
Domains : Interpro (EBI)Glyco_trans_29    Sialyl_trans   
Domain families : Pfam (Sanger)Glyco_transf_29 (PF00777)   
Domain families : Pfam (NCBI)pfam00777   
Conserved Domain (NCBI)ST6GAL1
DMDM Disease mutations6480
Blocks (Seattle)ST6GAL1
PDB (SRS)4JS1    4JS2   
PDB (PDBSum)4JS1    4JS2   
PDB (IMB)4JS1    4JS2   
PDB (RSDB)4JS1    4JS2   
Structural Biology KnowledgeBase4JS1    4JS2   
SCOP (Structural Classification of Proteins)4JS1    4JS2   
CATH (Classification of proteins structures)4JS1    4JS2   
SuperfamilyP15907
Human Protein AtlasENSG00000073849
Peptide AtlasP15907
HPRD00184
IPIIPI00013887   IPI00376240   IPI00925201   IPI00924988   IPI00924805   IPI00924563   IPI00927798   IPI00927588   IPI00927347   IPI00927060   IPI00926833   IPI00926637   IPI00926861   IPI00926557   
Protein Interaction databases
DIP (DOE-UCLA)P15907
IntAct (EBI)P15907
FunCoupENSG00000073849
BioGRIDST6GAL1
STRING (EMBL)ST6GAL1
ZODIACST6GAL1
Ontologies - Pathways
QuickGOP15907
Ontology : AmiGOGolgi trans cisterna  Golgi membrane  beta-galactoside alpha-2,6-sialyltransferase activity  beta-galactoside alpha-2,6-sialyltransferase activity  protein binding  endoplasmic reticulum  Golgi medial cisterna  N-acetylneuraminate metabolic process  humoral immune response  sialyltransferase activity  oligosaccharide metabolic process  O-glycan processing  protein N-linked glycosylation via asparagine  integral component of Golgi membrane  Golgi cisterna membrane  positive regulation of mononuclear cell proliferation  response to ethanol  negative regulation of chemotaxis  extracellular exosome  sialylation  regulation of substrate adhesion-dependent cell spreading  protein sialylation  negative regulation of macrophage apoptotic process  
Ontology : EGO-EBIGolgi trans cisterna  Golgi membrane  beta-galactoside alpha-2,6-sialyltransferase activity  beta-galactoside alpha-2,6-sialyltransferase activity  protein binding  endoplasmic reticulum  Golgi medial cisterna  N-acetylneuraminate metabolic process  humoral immune response  sialyltransferase activity  oligosaccharide metabolic process  O-glycan processing  protein N-linked glycosylation via asparagine  integral component of Golgi membrane  Golgi cisterna membrane  positive regulation of mononuclear cell proliferation  response to ethanol  negative regulation of chemotaxis  extracellular exosome  sialylation  regulation of substrate adhesion-dependent cell spreading  protein sialylation  negative regulation of macrophage apoptotic process  
Pathways : KEGGN-Glycan biosynthesis    Other types of O-glycan biosynthesis   
NDEx NetworkST6GAL1
Atlas of Cancer Signalling NetworkST6GAL1
Wikipedia pathwaysST6GAL1
Orthology - Evolution
OrthoDB6480
GeneTree (enSembl)ENSG00000073849
Phylogenetic Trees/Animal Genes : TreeFamST6GAL1
HOVERGENP15907
HOGENOMP15907
Homologs : HomoloGeneST6GAL1
Homology/Alignments : Family Browser (UCSC)ST6GAL1
Gene fusions - Rearrangements
Fusion : MitelmanLPP/ST6GAL1 [3q28/3q27.3]  [t(3;3)(q27;q28)]  
Fusion : MitelmanSREK1/ST6GAL1 [5q12.3/3q27.3]  [t(3;5)(q27;q12)]  
Fusion : MitelmanST6GAL1/BCL6 [3q27.3/3q27.3]  [t(3;3)(q27;q27)]  
Fusion : MitelmanST6GAL1/KNG1 [3q27.3/3q27.3]  [t(3;3)(q27;q27)]  
Fusion : MitelmanST6GAL1/TBCCD1 [3q27.3/3q27.3]  [t(3;3)(q27;q27)]  
Fusion : MitelmanST6GAL1/WHSC1 [3q27.3/4p16.3]  [t(3;4)(q27;p16)]  
Fusion: TCGALPP 3q28 ST6GAL1 3q27.3 LUSC
Fusion: TCGASREK1 5q12.3 ST6GAL1 3q27.3 LUSC
Fusion: TCGAST6GAL1 3q27.3 KNG1 3q27.3 LUAD
Fusion: TCGAST6GAL1 3q27.3 TBCCD1 3q27.3 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerST6GAL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ST6GAL1
dbVarST6GAL1
ClinVarST6GAL1
1000_GenomesST6GAL1 
Exome Variant ServerST6GAL1
ExAC (Exome Aggregation Consortium)ST6GAL1 (select the gene name)
Genetic variants : HAPMAP6480
Genomic Variants (DGV)ST6GAL1 [DGVbeta]
DECIPHER (Syndromes)3:186739665-186796341  ENSG00000073849
CONAN: Copy Number AnalysisST6GAL1 
Mutations
ICGC Data PortalST6GAL1 
TCGA Data PortalST6GAL1 
Broad Tumor PortalST6GAL1
OASIS PortalST6GAL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICST6GAL1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDST6GAL1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ST6GAL1
DgiDB (Drug Gene Interaction Database)ST6GAL1
DoCM (Curated mutations)ST6GAL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ST6GAL1 (select a term)
intoGenST6GAL1
Cancer3DST6GAL1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM109675   
Orphanet
MedgenST6GAL1
Genetic Testing Registry ST6GAL1
NextProtP15907 [Medical]
TSGene6480
GENETestsST6GAL1
Huge Navigator ST6GAL1 [HugePedia]
snp3D : Map Gene to Disease6480
BioCentury BCIQST6GAL1
ClinGenST6GAL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6480
Chemical/Pharm GKB GenePA35762
Clinical trialST6GAL1
Miscellaneous
canSAR (ICR)ST6GAL1 (select the gene name)
Probes
Litterature
PubMed76 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineST6GAL1
EVEXST6GAL1
GoPubMedST6GAL1
iHOPST6GAL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:21:07 CEST 2017

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