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ST8SIA4 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4)

Identity

Alias_namesSIAT8D
sialyltransferase 8 (alpha-2, 8-polysialytransferase) D
ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 4
Alias_symbol (synonym)PST
PST1
Other aliasST8SIA-IV
HGNC (Hugo) ST8SIA4
LocusID (NCBI) 7903
Atlas_Id 45830
Location 5q21.1  [Link to chromosome band 5q21]
Location_base_pair Starts at 100806935 and ends at 100903285 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ATP6V1H (8q11.23) / ST8SIA4 (5q21.1)C6orf48 (6p21.33) / ST8SIA4 (5q21.1)CLASP1 (2q14.2) / ST8SIA4 (5q21.1)
ST8SIA4 (5q21.1) / PAM (5q21.1)ATP6V1H 8q11.23 / ST8SIA4 5q21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ST8SIA4   10871
Cards
Entrez_Gene (NCBI)ST8SIA4  7903  ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
AliasesPST; PST1; SIAT8D; ST8SIA-IV
GeneCards (Weizmann)ST8SIA4
Ensembl hg19 (Hinxton)ENSG00000113532 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113532 [Gene_View]  chr5:100806935-100903285 [Contig_View]  ST8SIA4 [Vega]
ICGC DataPortalENSG00000113532
TCGA cBioPortalST8SIA4
AceView (NCBI)ST8SIA4
Genatlas (Paris)ST8SIA4
WikiGenes7903
SOURCE (Princeton)ST8SIA4
Genetics Home Reference (NIH)ST8SIA4
Genomic and cartography
GoldenPath hg38 (UCSC)ST8SIA4  -     chr5:100806935-100903285 -  5q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ST8SIA4  -     5q21.1   [Description]    (hg19-Feb_2009)
EnsemblST8SIA4 - 5q21.1 [CytoView hg19]  ST8SIA4 - 5q21.1 [CytoView hg38]
Mapping of homologs : NCBIST8SIA4 [Mapview hg19]  ST8SIA4 [Mapview hg38]
OMIM602547   
Gene and transcription
Genbank (Entrez)AA836260 AK292872 BC027866 BC040671 BC053657
RefSeq transcript (Entrez)NM_005668 NM_175052
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ST8SIA4
Cluster EST : UnigeneHs.308628 [ NCBI ]
CGAP (NCI)Hs.308628
Alternative Splicing GalleryENSG00000113532
Gene ExpressionST8SIA4 [ NCBI-GEO ]   ST8SIA4 [ EBI - ARRAY_EXPRESS ]   ST8SIA4 [ SEEK ]   ST8SIA4 [ MEM ]
Gene Expression Viewer (FireBrowse)ST8SIA4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7903
GTEX Portal (Tissue expression)ST8SIA4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92187   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92187  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92187
Splice isoforms : SwissVarQ92187
Catalytic activity : Enzyme2.4.99.- [ Enzyme-Expasy ]   2.4.99.-2.4.99.- [ IntEnz-EBI ]   2.4.99.- [ BRENDA ]   2.4.99.- [ KEGG ]   
PhosPhoSitePlusQ92187
Domains : Interpro (EBI)Glyco_trans_29    Sialyl_trans   
Domain families : Pfam (Sanger)Glyco_transf_29 (PF00777)   
Domain families : Pfam (NCBI)pfam00777   
Conserved Domain (NCBI)ST8SIA4
DMDM Disease mutations7903
Blocks (Seattle)ST8SIA4
SuperfamilyQ92187
Human Protein AtlasENSG00000113532
Peptide AtlasQ92187
HPRD03970
IPIIPI00020201   IPI00375304   IPI00974342   
Protein Interaction databases
DIP (DOE-UCLA)Q92187
IntAct (EBI)Q92187
FunCoupENSG00000113532
BioGRIDST8SIA4
STRING (EMBL)ST8SIA4
ZODIACST8SIA4
Ontologies - Pathways
QuickGOQ92187
Ontology : AmiGOGolgi membrane  ganglioside biosynthetic process  alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity  alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity  cellular protein modification process  protein glycosylation  protein glycosylation  N-glycan processing  nervous system development  oligosaccharide metabolic process  integral component of Golgi membrane  sialic acid binding  sialylation  
Ontology : EGO-EBIGolgi membrane  ganglioside biosynthetic process  alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity  alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity  cellular protein modification process  protein glycosylation  protein glycosylation  N-glycan processing  nervous system development  oligosaccharide metabolic process  integral component of Golgi membrane  sialic acid binding  sialylation  
Pathways : BIOCARTASteps in the Glycosylation of Mammalian N-linked Oligosaccarides [Genes]   
NDEx NetworkST8SIA4
Atlas of Cancer Signalling NetworkST8SIA4
Wikipedia pathwaysST8SIA4
Orthology - Evolution
OrthoDB7903
GeneTree (enSembl)ENSG00000113532
Phylogenetic Trees/Animal Genes : TreeFamST8SIA4
HOVERGENQ92187
HOGENOMQ92187
Homologs : HomoloGeneST8SIA4
Homology/Alignments : Family Browser (UCSC)ST8SIA4
Gene fusions - Rearrangements
Fusion : MitelmanATP6V1H/ST8SIA4 [8q11.23/5q21.1]  [t(5;8)(q21;q11)]  
Fusion : MitelmanST8SIA4/PAM [5q21.1/5q21.1]  [t(5;5)(q21;q21)]  
Fusion: TCGAATP6V1H 8q11.23 ST8SIA4 5q21.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerST8SIA4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ST8SIA4
dbVarST8SIA4
ClinVarST8SIA4
1000_GenomesST8SIA4 
Exome Variant ServerST8SIA4
ExAC (Exome Aggregation Consortium)ST8SIA4 (select the gene name)
Genetic variants : HAPMAP7903
Genomic Variants (DGV)ST8SIA4 [DGVbeta]
DECIPHERST8SIA4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisST8SIA4 
Mutations
ICGC Data PortalST8SIA4 
TCGA Data PortalST8SIA4 
Broad Tumor PortalST8SIA4
OASIS PortalST8SIA4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICST8SIA4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDST8SIA4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ST8SIA4
DgiDB (Drug Gene Interaction Database)ST8SIA4
DoCM (Curated mutations)ST8SIA4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ST8SIA4 (select a term)
intoGenST8SIA4
Cancer3DST8SIA4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602547   
Orphanet
MedgenST8SIA4
Genetic Testing Registry ST8SIA4
NextProtQ92187 [Medical]
TSGene7903
GENETestsST8SIA4
Target ValidationST8SIA4
Huge Navigator ST8SIA4 [HugePedia]
snp3D : Map Gene to Disease7903
BioCentury BCIQST8SIA4
ClinGenST8SIA4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7903
Chemical/Pharm GKB GenePA35772
Clinical trialST8SIA4
Miscellaneous
canSAR (ICR)ST8SIA4 (select the gene name)
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineST8SIA4
EVEXST8SIA4
GoPubMedST8SIA4
iHOPST8SIA4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:08:43 CEST 2017

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