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STAT1 (signal transducer and activator of transcription 1)

Identity

Alias (NCBI)CANDF7
IMD31A
IMD31B
IMD31C
ISGF-3
STAT91
HGNC (Hugo) STAT1
HGNC Alias symbSTAT91
ISGF-3
HGNC Alias nametranscription factor ISGF-3 components p91/p84
HGNC Previous namesignal transducer and activator of transcription 1, 91kD
 signal transducer and activator of transcription 1, 91kDa
LocusID (NCBI) 6772
Atlas_Id 437
Location 2q32.2  [Link to chromosome band 2q32]
Location_base_pair Starts at 190975537 and ends at 191014250 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MRPS5 (2q11.1) / STAT1 (2q32.2)STAT1 (2q32.2) / PPP3R1 (2p14)STAT1 (2q32.2) / STAT1 (2q32.2)
STAT1 (2q32.2) / STAT4 (2q32.2)STAT3 (17q21.2) / STAT1 (2q32.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]
  Chronic myelogenous leukaemia (CML)
del(4)(q12q12) FIP1L1/PDGFRA
t(3;5)(p21;q32) RBM6/CSF1R


External links

 

Nomenclature
HGNC (Hugo)STAT1   11362
LRG (Locus Reference Genomic)LRG_111
Cards
Entrez_Gene (NCBI)STAT1    signal transducer and activator of transcription 1
AliasesCANDF7; IMD31A; IMD31B; IMD31C; 
ISGF-3; STAT91
GeneCards (Weizmann)STAT1
Ensembl hg19 (Hinxton)ENSG00000115415 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115415 [Gene_View]  ENSG00000115415 [Sequence]  chr2:190975537-191014250 [Contig_View]  STAT1 [Vega]
ICGC DataPortalENSG00000115415
TCGA cBioPortalSTAT1
AceView (NCBI)STAT1
Genatlas (Paris)STAT1
SOURCE (Princeton)STAT1
Genetics Home Reference (NIH)STAT1
Genomic and cartography
GoldenPath hg38 (UCSC)STAT1  -     chr2:190975537-191014250 -  2q32.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)STAT1  -     2q32.2   [Description]    (hg19-Feb_2009)
GoldenPathSTAT1 - 2q32.2 [CytoView hg19]  STAT1 - 2q32.2 [CytoView hg38]
ImmunoBaseENSG00000115415
Genome Data Viewer NCBISTAT1 [Mapview hg19]  
OMIM600555   613796   614162   614892   
Gene and transcription
Genbank (Entrez)AI992149 AK096686 AK225853 AK292604 AK315002
RefSeq transcript (Entrez)NM_001384880 NM_001384881 NM_001384882 NM_001384883 NM_001384884 NM_001384885 NM_001384886 NM_001384887 NM_001384888 NM_001384889 NM_001384890 NM_001384891 NM_007315 NM_139266
Consensus coding sequences : CCDS (NCBI)STAT1
Gene ExpressionSTAT1 [ NCBI-GEO ]   STAT1 [ EBI - ARRAY_EXPRESS ]   STAT1 [ SEEK ]   STAT1 [ MEM ]
Gene Expression Viewer (FireBrowse)STAT1 [ Firebrowse - Broad ]
GenevisibleExpression of STAT1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6772
GTEX Portal (Tissue expression)STAT1
Human Protein AtlasENSG00000115415-STAT1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP42224   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP42224  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP42224
PhosPhoSitePlusP42224
Domaine pattern : Prosite (Expaxy)SH2 (PS50001)   
Domains : Interpro (EBI)p53-like_TF_DNA-bd    SH2    SH2_dom_sf    STAT    STAT1_C_sf    STAT1_SH2    STAT1_TAZ2-bd_C    STAT_N_sf    STAT_TF_alpha    STAT_TF_coiled-coil    STAT_TF_DNA-bd    STAT_TF_DNA-bd_N    STAT_TF_prot_interaction   
Domain families : Pfam (Sanger)SH2 (PF00017)    STAT1_TAZ2bind (PF12162)    STAT_alpha (PF01017)    STAT_bind (PF02864)    STAT_int (PF02865)   
Domain families : Pfam (NCBI)pfam00017    pfam12162    pfam01017    pfam02864    pfam02865   
Domain families : Smart (EMBL)STAT_int (SM00964)  
Conserved Domain (NCBI)STAT1
PDB (RSDB)1BF5    1YVL    2KA6    3WWT   
PDB Europe1BF5    1YVL    2KA6    3WWT   
PDB (PDBSum)1BF5    1YVL    2KA6    3WWT   
PDB (IMB)1BF5    1YVL    2KA6    3WWT   
Structural Biology KnowledgeBase1BF5    1YVL    2KA6    3WWT   
SCOP (Structural Classification of Proteins)1BF5    1YVL    2KA6    3WWT   
CATH (Classification of proteins structures)1BF5    1YVL    2KA6    3WWT   
SuperfamilyP42224
AlphaFold pdb e-kbP42224   
Human Protein Atlas [tissue]ENSG00000115415-STAT1 [tissue]
HPRD02777
Protein Interaction databases
DIP (DOE-UCLA)P42224
IntAct (EBI)P42224
BioGRIDSTAT1
STRING (EMBL)STAT1
ZODIACSTAT1
Ontologies - Pathways
QuickGOP42224
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  chromatin  chromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II core promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  negative regulation of endothelial cell proliferation  positive regulation of mesenchymal cell proliferation  positive regulation of defense response to virus by host  positive regulation of defense response to virus by host  negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  double-stranded DNA binding  DNA-binding transcription factor activity  tumor necrosis factor receptor binding  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  nucleolus  cytoplasm  cytosol  cytosol  defense response  positive regulation of transcription of Notch receptor target  receptor signaling pathway via JAK-STAT  receptor signaling pathway via JAK-STAT  response to nutrient  blood circulation  response to mechanical stimulus  macrophage derived foam cell differentiation  negative regulation of angiogenesis  nuclear receptor binding  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  enzyme binding  axon  dendrite  CCR5 chemokine receptor binding  positive regulation of interferon-alpha production  cellular response to insulin stimulus  protein-containing complex  tumor necrosis factor-mediated signaling pathway  response to cytokine  histone acetyltransferase binding  response to interferon-beta  cellular response to interferon-beta  interleukin-9-mediated signaling pathway  interleukin-21-mediated signaling pathway  regulation of cell population proliferation  histone binding  response to drug  response to hydrogen peroxide  identical protein binding  protein homodimerization activity  regulation of apoptotic process  negative regulation of I-kappaB kinase/NF-kappaB signaling  response to peptide hormone  response to peptide hormone  endothelial cell migration  ubiquitin-like protein ligase binding  cadherin binding  positive regulation of erythrocyte differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  negative regulation by virus of viral protein levels in host cell  perinuclear region of cytoplasm  positive regulation of smooth muscle cell proliferation  response to cAMP  defense response to virus  protein phosphatase 2A binding  positive regulation of nitric-oxide synthase biosynthetic process  interferon-gamma-mediated signaling pathway  interferon-gamma-mediated signaling pathway  interferon-gamma-mediated signaling pathway  interferon-gamma-mediated signaling pathway  regulation of interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  type I interferon signaling pathway  type I interferon signaling pathway  type I interferon signaling pathway  renal tubule development  interleukin-6-mediated signaling pathway  interleukin-27-mediated signaling pathway  interleukin-27-mediated signaling pathway  interleukin-35-mediated signaling pathway  cellular response to interferon-gamma  cellular response to organic cyclic compound  metanephric mesenchymal cell proliferation involved in metanephros development  metanephric mesenchymal cell differentiation  negative regulation of metanephric nephron tubule epithelial cell differentiation  DNA-binding transcription factor binding  promoter-specific chromatin binding  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  chromatin  chromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II core promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  negative regulation of endothelial cell proliferation  positive regulation of mesenchymal cell proliferation  positive regulation of defense response to virus by host  positive regulation of defense response to virus by host  negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  double-stranded DNA binding  DNA-binding transcription factor activity  tumor necrosis factor receptor binding  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  nucleolus  cytoplasm  cytosol  cytosol  defense response  positive regulation of transcription of Notch receptor target  receptor signaling pathway via JAK-STAT  receptor signaling pathway via JAK-STAT  response to nutrient  blood circulation  response to mechanical stimulus  macrophage derived foam cell differentiation  negative regulation of angiogenesis  nuclear receptor binding  cytokine-mediated signaling pathway  cytokine-mediated signaling pathway  enzyme binding  axon  dendrite  CCR5 chemokine receptor binding  positive regulation of interferon-alpha production  cellular response to insulin stimulus  protein-containing complex  tumor necrosis factor-mediated signaling pathway  response to cytokine  histone acetyltransferase binding  response to interferon-beta  cellular response to interferon-beta  interleukin-9-mediated signaling pathway  interleukin-21-mediated signaling pathway  regulation of cell population proliferation  histone binding  response to drug  response to hydrogen peroxide  identical protein binding  protein homodimerization activity  regulation of apoptotic process  negative regulation of I-kappaB kinase/NF-kappaB signaling  response to peptide hormone  response to peptide hormone  endothelial cell migration  ubiquitin-like protein ligase binding  cadherin binding  positive regulation of erythrocyte differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  negative regulation by virus of viral protein levels in host cell  perinuclear region of cytoplasm  positive regulation of smooth muscle cell proliferation  response to cAMP  defense response to virus  protein phosphatase 2A binding  positive regulation of nitric-oxide synthase biosynthetic process  interferon-gamma-mediated signaling pathway  interferon-gamma-mediated signaling pathway  interferon-gamma-mediated signaling pathway  interferon-gamma-mediated signaling pathway  regulation of interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  type I interferon signaling pathway  type I interferon signaling pathway  type I interferon signaling pathway  renal tubule development  interleukin-6-mediated signaling pathway  interleukin-27-mediated signaling pathway  interleukin-27-mediated signaling pathway  interleukin-35-mediated signaling pathway  cellular response to interferon-gamma  cellular response to organic cyclic compound  metanephric mesenchymal cell proliferation involved in metanephros development  metanephric mesenchymal cell differentiation  negative regulation of metanephric nephron tubule epithelial cell differentiation  DNA-binding transcription factor binding  promoter-specific chromatin binding  
Pathways : BIOCARTAInhibition of Cellular Proliferation by Gleevec [Genes]    IFN alpha signaling pathway [Genes]    p38 MAPK Signaling Pathway [Genes]    Bioactive Peptide Induced Signaling Pathway [Genes]    Apoptotic Signaling in Response to DNA Damage [Genes]    IL22 Soluble Receptor Signaling Pathway [Genes]    TPO Signaling Pathway [Genes]    EGF Signaling Pathway [Genes]    MAPKinase Signaling Pathway [Genes]    PDGF Signaling Pathway [Genes]    IFN gamma signaling pathway [Genes]    IL-10 Anti-inflammatory Signaling Pathway [Genes]   
Pathways : KEGGChemokine signaling pathway    Osteoclast differentiation    Toll-like receptor signaling pathway    Jak-STAT signaling pathway    Prolactin signaling pathway    Thyroid hormone signaling pathway    Leishmaniasis    Toxoplasmosis    Tuberculosis    Hepatitis C    Hepatitis B    Measles    Influenza A    Herpes simplex infection    Pathways in cancer    Pancreatic cancer    Inflammatory bowel disease (IBD)   
NDEx NetworkSTAT1
Atlas of Cancer Signalling NetworkSTAT1
Wikipedia pathwaysSTAT1
Orthology - Evolution
OrthoDB6772
GeneTree (enSembl)ENSG00000115415
Phylogenetic Trees/Animal Genes : TreeFamSTAT1
Homologs : HomoloGeneSTAT1
Homology/Alignments : Family Browser (UCSC)STAT1
Gene fusions - Rearrangements
Fusion : QuiverSTAT1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTAT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STAT1
dbVarSTAT1
ClinVarSTAT1
MonarchSTAT1
1000_GenomesSTAT1 
Exome Variant ServerSTAT1
GNOMAD BrowserENSG00000115415
Varsome BrowserSTAT1
ACMGSTAT1 variants
VarityP42224
Genomic Variants (DGV)STAT1 [DGVbeta]
DECIPHERSTAT1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSTAT1 
Mutations
ICGC Data PortalSTAT1 
TCGA Data PortalSTAT1 
Broad Tumor PortalSTAT1
OASIS PortalSTAT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTAT1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSTAT1
Mutations and Diseases : HGMDSTAT1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSTAT1
DgiDB (Drug Gene Interaction Database)STAT1
DoCM (Curated mutations)STAT1
CIViC (Clinical Interpretations of Variants in Cancer)STAT1
Cancer3DSTAT1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600555    613796    614162    614892   
Orphanet21679    22628    22602   
DisGeNETSTAT1
MedgenSTAT1
Genetic Testing Registry STAT1
NextProtP42224 [Medical]
GENETestsSTAT1
Target ValidationSTAT1
Huge Navigator STAT1 [HugePedia]
ClinGenSTAT1 (curated)
Clinical trials, drugs, therapy
MyCancerGenomeSTAT1
Protein Interactions : CTDSTAT1
Pharm GKB GenePA36183
Pharm GKB PathwaysPA162356267   PA166126086   
PharosP42224
Clinical trialSTAT1
Miscellaneous
canSAR (ICR)STAT1
HarmonizomeSTAT1
DataMed IndexSTAT1
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSTAT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:33:32 CEST 2021

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