STAT1 (signal transducer and activator of transcription 1)

2003-02-01  

Identity

HGNC
LOCATION
2q32.2
LOCUSID
ALIAS
CANDF7,IMD31A,IMD31B,IMD31C,ISGF-3,STAT91
FUSION GENES

Other Information

Locus ID:

NCBI: 6772
MIM: 600555
HGNC: 11362
Ensembl: ENSG00000115415

Variants:

dbSNP: 6772
ClinVar: 6772
TCGA: ENSG00000115415
COSMIC: STAT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115415ENST00000361099P42224
ENSG00000115415ENST00000392322P42224
ENSG00000115415ENST00000392323J3KPM9
ENSG00000115415ENST00000409465P42224
ENSG00000115415ENST00000415035H7BZ88
ENSG00000115415ENST00000423282H7BZB5
ENSG00000115415ENST00000423282Q67C41
ENSG00000115415ENST00000424722E7EPD2
ENSG00000115415ENST00000432058E9PH66
ENSG00000115415ENST00000452281D2KFR9
ENSG00000115415ENST00000454414E7ENM1
ENSG00000115415ENST00000540176D2KFR9

Expression (GTEx)

0
100
200
300
400
500
600

Pathways

PathwaySourceExternal ID
Toll-like receptor signaling pathwayKEGGko04620
Jak-STAT signaling pathwayKEGGko04630
Pancreatic cancerKEGGko05212
Toll-like receptor signaling pathwayKEGGhsa04620
Jak-STAT signaling pathwayKEGGhsa04630
Pathways in cancerKEGGhsa05200
Pancreatic cancerKEGGhsa05212
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
LeishmaniasisKEGGko05140
LeishmaniasisKEGGhsa05140
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
MeaslesKEGGko05162
MeaslesKEGGhsa05162
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Hepatitis BKEGGhsa05161
Prolactin signaling pathwayKEGGhsa04917
Prolactin signaling pathwayKEGGko04917
Inflammatory bowel disease (IBD)KEGGhsa05321
Inflammatory bowel disease (IBD)KEGGko05321
Thyroid hormone signaling pathwayKEGGhsa04919
JAK-STAT signalingKEGGhsa_M00684
JAK-STAT signalingKEGGM00684
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by FGFR in diseaseREACTOMER-HSA-1226099
Signaling by FGFR1 in diseaseREACTOMER-HSA-5655302
FGFR1 mutant receptor activationREACTOMER-HSA-1839124
Signaling by cytosolic FGFR1 fusion mutantsREACTOMER-HSA-1839117
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733
Regulation of IFNA signalingREACTOMER-HSA-912694
Interferon gamma signalingREACTOMER-HSA-877300
Regulation of IFNG signalingREACTOMER-HSA-877312
Antiviral mechanism by IFN-stimulated genesREACTOMER-HSA-1169410
ISG15 antiviral mechanismREACTOMER-HSA-1169408
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-6 signalingREACTOMER-HSA-1059683
Growth hormone receptor signalingREACTOMER-HSA-982772
Signal TransductionREACTOMER-HSA-162582
Signaling by PDGFREACTOMER-HSA-186797
Downstream signal transductionREACTOMER-HSA-186763
Signaling by SCF-KITREACTOMER-HSA-1433557
AGE-RAGE signaling pathway in diabetic complicationsKEGGko04933
AGE-RAGE signaling pathway in diabetic complicationsKEGGhsa04933
Interleukin-6 family signalingREACTOMER-HSA-6783589
Th1 and Th2 cell differentiationKEGGko04658
Th1 and Th2 cell differentiationKEGGhsa04658
Th17 cell differentiationKEGGko04659
Th17 cell differentiationKEGGhsa04659
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA134992438CAMK1DGenePathwayassociated
PA24684AKT1GenePathwayassociated
PA24685AKT2GenePathwayassociated
PA24686AKT3GenePathwayassociated
PA248NFKB1GenePathwayassociated
PA26048CAMK1GenePathwayassociated
PA26049CAMK1GGenePathwayassociated
PA27749ELK1GenePathwayassociated
PA28212FOSGenePathwayassociated
PA283MAPK8GenePathwayassociated
PA296RELAGenePathwayassociated
PA29988JAK1GenePathwayassociated
PA30006JUNGenePathwayassociated
PA30616MAPK1GenePathwayassociated
PA30622MAPK3GenePathwayassociated
PA31353MYCGenePathwayassociated
PA31600NFKB2GenePathwayassociated
PA33285PIAS1GenePathwayassociated26111151
PA337STAT3GenePathwayassociated
PA33759PRKCAGenePathwayassociated
PA33761PRKCBGenePathwayassociated
PA33766PRKCGGenePathwayassociated
PA338STAT5AGenePathwayassociated
PA36042SP1GenePathwayassociated
PA36184STAT2GenePathwayassociated
PA36185STAT4GenePathwayassociated
PA36186STAT5BGenePathwayassociated
PA90CAMK2AGenePathwayassociated
PA91CAMK2BGenePathwayassociated
PA92CAMK2DGenePathwayassociated
PA93CAMK2GGenePathwayassociated

References

Pubmed IDYearTitleCitations
220250542011Transcriptional regulation of macrophage polarization: enabling diversity with identity.607
125902592003Impaired response to interferon-alpha/beta and lethal viral disease in human STAT1 deficiency.246
217271882011Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis.227
217146432011STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis.194
175963012007Severe acute respiratory syndrome coronavirus ORF6 antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/Golgi membrane.168
146573532003IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms.142
156502192005Inhibition of interferon signaling by the New York 99 strain and Kunjin subtype of West Nile virus involves blockage of STAT1 and STAT2 activation by nonstructural proteins.134
165717252006Role of STAT3 in type I interferon responses. Negative regulation of STAT1-dependent inflammatory gene activation.124
123887092002Nipah virus V protein evades alpha and gamma interferons by preventing STAT1 and STAT2 activation and nuclear accumulation.123
179283502007Ebola virus VP24 proteins inhibit the interaction of NPI-1 subfamily karyopherin alpha proteins with activated STAT1.118

Citation

Dessen P

STAT1 (signal transducer and activator of transcription 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/437/stat1