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STAT1 (signal transducer and activator of transcription 1, 91kDa)

Identity

Other namesCANDF7
ISGF-3
STAT91
HGNC (Hugo) STAT1
LocusID (NCBI) 6772
Location 2q32.2
Location_base_pair Starts at 191833762 and ends at 191878976 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias 11q23ChildAMLID1615

External links

Nomenclature
HGNC (Hugo)STAT1   11362
Cards
Entrez_Gene (NCBI)STAT1  6772  signal transducer and activator of transcription 1, 91kDa
GeneCards (Weizmann)STAT1
Ensembl (Hinxton)ENSG00000115415 [Gene_View]  chr2:191833762-191878976 [Contig_View]  STAT1 [Vega]
ICGC DataPortalENSG00000115415
AceView (NCBI)STAT1
Genatlas (Paris)STAT1
WikiGenes6772
SOURCE (Princeton)NM_007315 NM_139266
Genomic and cartography
GoldenPath (UCSC)STAT1  -  2q32.2   chr2:191833762-191878976 -  2q32.2   [Description]    (hg19-Feb_2009)
EnsemblSTAT1 - 2q32.2 [CytoView]
Mapping of homologs : NCBISTAT1 [Mapview]
OMIM209950   600555   613796   614162   
Gene and transcription
Genbank (Entrez)AI992149 AK096686 AK225853 AK292604 AK315002
RefSeq transcript (Entrez)NM_007315 NM_139266
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NG_008294 NT_005403 NW_001838863 NW_004929305
Consensus coding sequences : CCDS (NCBI)STAT1
Cluster EST : UnigeneHs.743244 [ NCBI ]
CGAP (NCI)Hs.743244
Alternative Splicing : Fast-db (Paris)GSHG0018230
Alternative Splicing GalleryENSG00000115415
Gene ExpressionSTAT1 [ NCBI-GEO ]     STAT1 [ SEEK ]   STAT1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP42224 (Uniprot)
NextProtP42224  [Medical]
With graphics : InterProP42224
Splice isoforms : SwissVarP42224 (Swissvar)
Domaine pattern : Prosite (Expaxy)SH2 (PS50001)   
Domains : Interpro (EBI)EF-hand-dom_pair    p53-like_TF_DNA-bd    SH2    STAT    STAT1_TAZ2-bd_C    STAT_TF_alpha    STAT_TF_coiled-coil    STAT_TF_DNA-bd    STAT_TF_DNA-bd_sub    STAT_TF_prot_interaction   
Related proteins : CluSTrP42224
Domain families : Pfam (Sanger)SH2 (PF00017)    STAT1_TAZ2bind (PF12162)    STAT_alpha (PF01017)    STAT_bind (PF02864)    STAT_int (PF02865)   
Domain families : Pfam (NCBI)pfam00017    pfam12162    pfam01017    pfam02864    pfam02865   
Domain families : Smart (EMBL)SH2 (SM00252)  STAT_int (SM00964)  
DMDM Disease mutations6772
Blocks (Seattle)P42224
PDB (SRS)1BF5    1YVL    2KA6   
PDB (PDBSum)1BF5    1YVL    2KA6   
PDB (IMB)1BF5    1YVL    2KA6   
PDB (RSDB)1BF5    1YVL    2KA6   
Human Protein AtlasENSG00000115415
Peptide AtlasP42224
HPRD02777
IPIIPI00030781   IPI00218188   IPI01015490   IPI00795482   IPI00797149   IPI00915952   IPI00915841   IPI00916196   IPI00916067   IPI00916320   
Protein Interaction databases
DIP (DOE-UCLA)P42224
IntAct (EBI)P42224
FunCoupENSG00000115415
BioGRIDSTAT1
InParanoidP42224
Interologous Interaction database P42224
IntegromeDBSTAT1
STRING (EMBL)STAT1
Ontologies - Pathways
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  nuclear chromatin  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II core promoter sequence-specific DNA binding  RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity  negative regulation of endothelial cell proliferation  positive regulation of mesenchymal cell proliferation  negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  double-stranded DNA binding  sequence-specific DNA binding transcription factor activity  sequence-specific DNA binding transcription factor activity  signal transducer activity  tumor necrosis factor receptor binding  calcium ion binding  protein binding  nucleus  nucleoplasm  nucleolus  nucleolus  cytoplasm  cytosol  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  apoptotic process  JAK-STAT cascade  response to nutrient  blood circulation  response to mechanical stimulus  viral process  negative regulation of angiogenesis  cytokine-mediated signaling pathway  enzyme binding  axon  dendrite  lipopolysaccharide-mediated signaling pathway  CCR5 chemokine receptor binding  cellular response to insulin stimulus  tumor necrosis factor-mediated signaling pathway  response to cytokine  negative regulation of macrophage fusion  cellular response to interferon-beta  response to drug  response to hydrogen peroxide  identical protein binding  protein homodimerization activity  regulation of apoptotic process  negative regulation of I-kappaB kinase/NF-kappaB signaling  response to exogenous dsRNA  response to peptide hormone  endothelial cell migration  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  positive regulation of smooth muscle cell proliferation  response to cAMP  defense response to virus  interferon-gamma-mediated signaling pathway  interferon-gamma-mediated signaling pathway  interferon-gamma-mediated signaling pathway  regulation of interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  type I interferon signaling pathway  regulation of type I interferon-mediated signaling pathway  JAK-STAT cascade involved in growth hormone signaling pathway  renal tubule development  metanephric mesenchymal cell proliferation involved in metanephros development  metanephric mesenchymal cell differentiation  negative regulation of metanephric nephron tubule epithelial cell differentiation  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  nuclear chromatin  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II core promoter sequence-specific DNA binding  RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity  negative regulation of endothelial cell proliferation  positive regulation of mesenchymal cell proliferation  negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  double-stranded DNA binding  sequence-specific DNA binding transcription factor activity  sequence-specific DNA binding transcription factor activity  signal transducer activity  tumor necrosis factor receptor binding  calcium ion binding  protein binding  nucleus  nucleoplasm  nucleolus  nucleolus  cytoplasm  cytosol  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  apoptotic process  JAK-STAT cascade  response to nutrient  blood circulation  response to mechanical stimulus  viral process  negative regulation of angiogenesis  cytokine-mediated signaling pathway  enzyme binding  axon  dendrite  lipopolysaccharide-mediated signaling pathway  CCR5 chemokine receptor binding  cellular response to insulin stimulus  tumor necrosis factor-mediated signaling pathway  response to cytokine  negative regulation of macrophage fusion  cellular response to interferon-beta  response to drug  response to hydrogen peroxide  identical protein binding  protein homodimerization activity  regulation of apoptotic process  negative regulation of I-kappaB kinase/NF-kappaB signaling  response to exogenous dsRNA  response to peptide hormone  endothelial cell migration  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  positive regulation of smooth muscle cell proliferation  response to cAMP  defense response to virus  interferon-gamma-mediated signaling pathway  interferon-gamma-mediated signaling pathway  interferon-gamma-mediated signaling pathway  regulation of interferon-gamma-mediated signaling pathway  type I interferon signaling pathway  type I interferon signaling pathway  regulation of type I interferon-mediated signaling pathway  JAK-STAT cascade involved in growth hormone signaling pathway  renal tubule development  metanephric mesenchymal cell proliferation involved in metanephros development  metanephric mesenchymal cell differentiation  negative regulation of metanephric nephron tubule epithelial cell differentiation  
Pathways : BIOCARTAInhibition of Cellular Proliferation by Gleevec [Genes]    IFN alpha signaling pathway [Genes]    p38 MAPK Signaling Pathway [Genes]    Bioactive Peptide Induced Signaling Pathway [Genes]    Apoptotic Signaling in Response to DNA Damage [Genes]    IL22 Soluble Receptor Signaling [Genes]    TPO Signaling Pathway [Genes]    EGF Signaling Pathway [Genes]    MAPKinase Signaling Pathway [Genes]    PDGF Signaling Pathway [Genes]    IFN gamma signaling pathway [Genes]    IL-10 Anti-inflammatory Signaling Pathway [Genes]   
Pathways : KEGGChemokine signaling pathway    Osteoclast differentiation    Toll-like receptor signaling pathway    Jak-STAT signaling pathway    Prolactin signaling pathway    Thyroid hormone signaling pathway    Leishmaniasis    Toxoplasmosis    Tuberculosis    Hepatitis C    Hepatitis B    Measles    Influenza A    Herpes simplex infection    Pathways in cancer    Pancreatic cancer    Inflammatory bowel disease (IBD)   
Protein Interaction DatabaseSTAT1
Wikipedia pathwaysSTAT1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)STAT1
SNP (GeneSNP Utah)STAT1
SNP : HGBaseSTAT1
Genetic variants : HAPMAPSTAT1
1000_GenomesSTAT1 
ICGC programENSG00000115415 
CONAN: Copy Number AnalysisSTAT1 
Somatic Mutations in Cancer : COSMICSTAT1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
Mutations and Diseases : HGMDSTAT1
OMIM209950    600555    613796    614162   
MedgenSTAT1
GENETestsSTAT1
Disease Genetic AssociationSTAT1
Huge Navigator STAT1 [HugePedia]  STAT1 [HugeCancerGEM]
Genomic VariantsSTAT1  STAT1 [DGVbeta]
Exome VariantSTAT1
dbVarSTAT1
ClinVarSTAT1
snp3D : Map Gene to Disease6772
General knowledge
Homologs : HomoloGeneSTAT1
Homology/Alignments : Family Browser (UCSC)STAT1
Phylogenetic Trees/Animal Genes : TreeFamSTAT1
Chemical/Protein Interactions : CTD6772
Chemical/Pharm GKB GenePA36183
Clinical trialSTAT1
Cancer Resource (Charite)ENSG00000115415
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineSTAT1
iHOPSTAT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 13 13:19:31 CEST 2014

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