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STAT6 (signal transducer and activator of transcription 6)

Identity

Alias_namessignal transducer and activator of transcription 6
Alias_symbol (synonym)D12S1644
IL-4-STAT
Other aliasSTAT6B
STAT6C
HGNC (Hugo) STAT6
LocusID (NCBI) 6778
Atlas_Id 42432
Location 12q13.3  [Link to chromosome band 12q13]
Location_base_pair Starts at 57095405 and ends at 57111413 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)		NAB2 (12q13.3) / STAT6 (12q13.3)STAT6 (12q13.3) / ADGRL2 (1p31.1)STAT6 (12q13.3) / CTTN (11q13.3)
STAT6 (12q13.3) / IFITM2 (11p15.5)STAT6 (12q13.3) / NAB2 (12q13.3)STAT6 (12q13.3) / PALLD (4q32.3)
STAT6 (12q13.3) / SH3KBP1 (Xp22.12)STAT6 (12q13.3) / STAT6 (12q13.3)NAB2 12q13.3 / STAT6 12q13.3
STAT6 12q13.3 / NAB2 12q13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]
  Chronic myelogenous leukaemia (CML)
B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma
Primary mediastinal B-cell lymphoma (PMBL)

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Soft tissue tumors: an overview

External links

Nomenclature
HGNC (Hugo)STAT6   11368
Cards
Entrez_Gene (NCBI)STAT6  6778  signal transducer and activator of transcription 6
AliasesD12S1644; IL-4-STAT; STAT6B; STAT6C
GeneCards (Weizmann)STAT6
Ensembl hg19 (Hinxton)ENSG00000166888 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166888 [Gene_View]  chr12:57095405-57111413 [Contig_View]  STAT6 [Vega]
ICGC DataPortalENSG00000166888
TCGA cBioPortalSTAT6
AceView (NCBI)STAT6
Genatlas (Paris)STAT6
WikiGenes6778
SOURCE (Princeton)STAT6
Genetics Home Reference (NIH)STAT6
Genomic and cartography
GoldenPath hg38 (UCSC)STAT6  -     chr12:57095405-57111413 -  12q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)STAT6  -     12q13.3   [Description]    (hg19-Feb_2009)
EnsemblSTAT6 - 12q13.3 [CytoView hg19]  STAT6 - 12q13.3 [CytoView hg38]
Mapping of homologs : NCBISTAT6 [Mapview hg19]  STAT6 [Mapview hg38]
OMIM601512   
Gene and transcription
Genbank (Entrez)AB103088 AB103089 AI082533 AK290431 AK291044
RefSeq transcript (Entrez)NM_001178078 NM_001178079 NM_001178080 NM_001178081 NM_003153
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)STAT6
Cluster EST : UnigeneHs.524518 [ NCBI ]
CGAP (NCI)Hs.524518
Alternative Splicing GalleryENSG00000166888
Gene ExpressionSTAT6 [ NCBI-GEO ]   STAT6 [ EBI - ARRAY_EXPRESS ]   STAT6 [ SEEK ]   STAT6 [ MEM ]
Gene Expression Viewer (FireBrowse)STAT6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6778
GTEX Portal (Tissue expression)STAT6
Protein : pattern, domain, 3D structure
UniProt/SwissProtP42226   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP42226  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP42226
Splice isoforms : SwissVarP42226
PhosPhoSitePlusP42226
Domaine pattern : Prosite (Expaxy)SH2 (PS50001)   
Domains : Interpro (EBI)EF-hand-dom_pair    p53-like_TF_DNA-bd    SH2    STAT    STAT6_C    STAT_TF_alpha    STAT_TF_coiled-coil    STAT_TF_DNA-bd    STAT_TF_DNA-bd_sub    STAT_TF_prot_interaction   
Domain families : Pfam (Sanger)SH2 (PF00017)    STAT6_C (PF14596)    STAT_alpha (PF01017)    STAT_bind (PF02864)    STAT_int (PF02865)   
Domain families : Pfam (NCBI)pfam00017    pfam14596    pfam01017    pfam02864    pfam02865   
Domain families : Smart (EMBL)SH2 (SM00252)  STAT_int (SM00964)  
Conserved Domain (NCBI)STAT6
DMDM Disease mutations6778
Blocks (Seattle)STAT6
PDB (SRS)1OJ5    4Y5U    4Y5W    5D39   
PDB (PDBSum)1OJ5    4Y5U    4Y5W    5D39   
PDB (IMB)1OJ5    4Y5U    4Y5W    5D39   
PDB (RSDB)1OJ5    4Y5U    4Y5W    5D39   
Structural Biology KnowledgeBase1OJ5    4Y5U    4Y5W    5D39   
SCOP (Structural Classification of Proteins)1OJ5    4Y5U    4Y5W    5D39   
CATH (Classification of proteins structures)1OJ5    4Y5U    4Y5W    5D39   
SuperfamilyP42226
Human Protein AtlasENSG00000166888
Peptide AtlasP42226
HPRD03302
IPIIPI00030782   IPI01012094   IPI01011669   IPI01025306   IPI01025670   IPI01025044   IPI01025337   IPI01025731   IPI01026080   IPI01025551   IPI01025849   IPI01026170   IPI01026273   IPI01024711   IPI01025087   IPI00792907   
Protein Interaction databases
DIP (DOE-UCLA)P42226
IntAct (EBI)P42226
FunCoupENSG00000166888
BioGRIDSTAT6
STRING (EMBL)STAT6
ZODIACSTAT6
Ontologies - Pathways
QuickGOP42226
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  nuclear chromatin  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II core promoter sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  T-helper 1 cell lineage commitment  negative regulation of type 2 immune response  transcription factor activity, sequence-specific DNA binding  signal transducer activity  protein binding  nucleoplasm  nucleoplasm  cytosol  cytosol  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  signal transduction  protein phosphatase binding  nuclear membrane  positive regulation of type I interferon production  mammary gland epithelial cell proliferation  interleukin-4-mediated signaling pathway  regulation of cell proliferation  identical protein binding  membrane raft  positive regulation of transcription from RNA polymerase II promoter  positive regulation of isotype switching to IgE isotypes  mammary gland morphogenesis  cellular response to hydrogen peroxide  cellular response to reactive nitrogen species  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  nuclear chromatin  RNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II core promoter sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  T-helper 1 cell lineage commitment  negative regulation of type 2 immune response  transcription factor activity, sequence-specific DNA binding  signal transducer activity  protein binding  nucleoplasm  nucleoplasm  cytosol  cytosol  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  signal transduction  protein phosphatase binding  nuclear membrane  positive regulation of type I interferon production  mammary gland epithelial cell proliferation  interleukin-4-mediated signaling pathway  regulation of cell proliferation  identical protein binding  membrane raft  positive regulation of transcription from RNA polymerase II promoter  positive regulation of isotype switching to IgE isotypes  mammary gland morphogenesis  cellular response to hydrogen peroxide  cellular response to reactive nitrogen species  
Pathways : BIOCARTAIL 4 signaling pathway [Genes]   
Pathways : KEGGJak-STAT signaling pathway    Hepatitis B    Inflammatory bowel disease (IBD)   
NDEx NetworkSTAT6
Atlas of Cancer Signalling NetworkSTAT6
Wikipedia pathwaysSTAT6
Orthology - Evolution
OrthoDB6778
GeneTree (enSembl)ENSG00000166888
Phylogenetic Trees/Animal Genes : TreeFamSTAT6
HOVERGENP42226
HOGENOMP42226
Homologs : HomoloGeneSTAT6
Homology/Alignments : Family Browser (UCSC)STAT6
Gene fusions - Rearrangements
Fusion : MitelmanNAB2/STAT6 [12q13.3/12q13.3]  [inv(12)(q13q13)]  [t(12;12)(q13;q13)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTAT6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STAT6
dbVarSTAT6
ClinVarSTAT6
1000_GenomesSTAT6 
Exome Variant ServerSTAT6
ExAC (Exome Aggregation Consortium)STAT6 (select the gene name)
Genetic variants : HAPMAP6778
Genomic Variants (DGV)STAT6 [DGVbeta]
DECIPHERSTAT6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSTAT6 
Mutations
ICGC Data PortalSTAT6 
TCGA Data PortalSTAT6 
Broad Tumor PortalSTAT6
OASIS PortalSTAT6 [ Somatic mutations - Copy number]
Cancer Gene: CensusSTAT6 
Somatic Mutations in Cancer : COSMICSTAT6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSTAT6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch STAT6
DgiDB (Drug Gene Interaction Database)STAT6
DoCM (Curated mutations)STAT6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)STAT6 (select a term)
intoGenSTAT6
Cancer3DSTAT6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601512   
Orphanet3735   
MedgenSTAT6
Genetic Testing Registry STAT6
NextProtP42226 [Medical]
TSGene6778
GENETestsSTAT6
Target ValidationSTAT6
Huge Navigator STAT6 [HugePedia]
snp3D : Map Gene to Disease6778
BioCentury BCIQSTAT6
ClinGenSTAT6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6778
Chemical/Pharm GKB GenePA339
Clinical trialSTAT6
Miscellaneous
canSAR (ICR)STAT6 (select the gene name)
Probes
Litterature
PubMed288 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSTAT6
EVEXSTAT6
GoPubMedSTAT6
iHOPSTAT6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:15:56 CEST 2017
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