STAT6 (signal transducer and activator of transcription 6, interleukin-4 induced)

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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret
Donations are also welcome

STAT6 (signal transducer and activator of transcription 6, interleukin-4 induced)

Identity

Other names	D12S1644
	IL-4-STAT
	STAT6B
	STAT6C
HGNC (Hugo)	STAT6
LocusID (NCBI)	6778
Location	12q13.3
Location_base_pair	Starts at 57489187 and ends at 57505196 bp from pter ( according to hg19-Feb_2009)
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

DNA/RNA

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias

11q23ChildAMLID1615

Other Solid tumors implicated (Data extracted from papers in the Atlas)

Solid Tumors

AmeloblastomID5945

External links

	Nomenclature
HGNC (Hugo)	STAT6 11368
	Cards
Entrez_Gene (NCBI)	STAT6 6778 signal transducer and activator of transcription 6, interleukin-4 induced
GeneCards (Weizmann)	STAT6
Ensembl hg19 (Hinxton)	ENSG00000166888 [Gene_View] chr12:57489187-57505196 [Contig_View] STAT6 [Vega]
Ensembl hg38 (Hinxton)	ENSG00000166888 [Gene_View] chr12:57489187-57505196 [Contig_View] STAT6 [Vega]
ICGC DataPortal	ENSG00000166888
cBioPortal	STAT6
AceView (NCBI)	STAT6
Genatlas (Paris)	STAT6
WikiGenes	6778
SOURCE (Princeton)	STAT6
	Genomic and cartography
GoldenPath hg19 (UCSC)	STAT6 - chr12:57489187-57505196 - 12q13.3 [Description] (hg19-Feb_2009)
GoldenPath hg38 (UCSC)	STAT6 - 12q13.3 [Description] (hg38-Dec_2013)
Ensembl	STAT6 - 12q13.3 [CytoView hg19] STAT6 - 12q13.3 [CytoView hg38]
Mapping of homologs : NCBI	STAT6 [Mapview hg19] STAT6 [Mapview hg38]
OMIM	601512
	Gene and transcription
Genbank (Entrez)	AB103088 AB103089 AI082533 AK290431 AK291044
RefSeq transcript (Entrez)	NM_001178078 NM_001178079 NM_001178080 NM_001178081 NM_003153
RefSeq genomic (Entrez)	AC_000144 NC_000012 NC_018923 NG_021272 NT_029419 NW_001838059 NW_004929384
Consensus coding sequences : CCDS (NCBI)	STAT6
Cluster EST : Unigene	Hs.524518 [ NCBI ]
CGAP (NCI)	Hs.524518
Alternative Splicing : Fast-db (Paris)	GSHG0007567
Alternative Splicing Gallery	ENSG00000166888
Gene Expression	STAT6 [ NCBI-GEO ] STAT6 [ SEEK ] STAT6 [ MEM ]
SOURCE (Princeton)	Expression in : [Normal Tissue Atlas] [carcinoma Classsification] [NCI60]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	P42226 (Uniprot)
NextProt	P42226 [Medical]
With graphics : InterPro	P42226
Splice isoforms : SwissVar	P42226 (Swissvar)
Domaine pattern : Prosite (Expaxy)	SH2 (PS50001)
Domains : Interpro (EBI)	EF-hand-dom_pair p53-like_TF_DNA-bd SH2 STAT STAT6_C STAT_TF_alpha STAT_TF_coiled-coil STAT_TF_DNA-bd STAT_TF_DNA-bd_sub STAT_TF_prot_interaction
Related proteins : CluSTr	P42226
Domain families : Pfam (Sanger)	SH2 (PF00017) STAT6_C (PF14596) STAT_alpha (PF01017) STAT_bind (PF02864) STAT_int (PF02865)
Domain families : Pfam (NCBI)	pfam00017 pfam14596 pfam01017 pfam02864 pfam02865
Domain families : Smart (EMBL)	SH2 (SM00252) STAT_int (SM00964)
DMDM Disease mutations	6778
Blocks (Seattle)	P42226
PDB (SRS)	1OJ5
PDB (PDBSum)	1OJ5
PDB (IMB)	1OJ5
PDB (RSDB)	1OJ5
Human Protein Atlas	ENSG00000166888
Peptide Atlas	P42226
HPRD	03302
IPI	IPI00030782 IPI01012094 IPI01011669 IPI01025306 IPI01025670 IPI01025044 IPI01025337 IPI01025731 IPI01026080 IPI01025551 IPI01025849 IPI01026170 IPI01026273 IPI01024711 IPI01025087 IPI00792907
	Protein Interaction databases
DIP (DOE-UCLA)	P42226
IntAct (EBI)	P42226
FunCoup	ENSG00000166888
BioGRID	STAT6
IntegromeDB	STAT6
STRING (EMBL)	STAT6
	Ontologies - Pathways
QuickGO	P42226
Ontology : AmiGO	negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II core promoter sequence-specific DNA binding T-helper 1 cell lineage commitment negative regulation of type 2 immune response sequence-specific DNA binding transcription factor activity signal transducer activity calcium ion binding protein binding nucleus nucleoplasm nucleolus cytoplasm cytosol transcription, DNA-templated regulation of transcription from RNA polymerase II promoter signal transduction protein phosphatase binding positive regulation of type I interferon production mammary gland epithelial cell proliferation interleukin-4-mediated signaling pathway regulation of cell proliferation identical protein binding innate immune response membrane raft positive regulation of transcription from RNA polymerase II promoter positive regulation of isotype switching to IgE isotypes mammary gland morphogenesis cellular response to hydrogen peroxide cellular response to reactive nitrogen species
Ontology : EGO-EBI	negative regulation of transcription from RNA polymerase II promoter nuclear chromatin RNA polymerase II core promoter sequence-specific DNA binding T-helper 1 cell lineage commitment negative regulation of type 2 immune response sequence-specific DNA binding transcription factor activity signal transducer activity calcium ion binding protein binding nucleus nucleoplasm nucleolus cytoplasm cytosol transcription, DNA-templated regulation of transcription from RNA polymerase II promoter signal transduction protein phosphatase binding positive regulation of type I interferon production mammary gland epithelial cell proliferation interleukin-4-mediated signaling pathway regulation of cell proliferation identical protein binding innate immune response membrane raft positive regulation of transcription from RNA polymerase II promoter positive regulation of isotype switching to IgE isotypes mammary gland morphogenesis cellular response to hydrogen peroxide cellular response to reactive nitrogen species
Pathways : BIOCARTA	IL 4 signaling pathway [Genes]
Pathways : KEGG	Jak-STAT signaling pathway Hepatitis B Inflammatory bowel disease (IBD)
Protein Interaction Database	STAT6
DoCM (Curated mutations)	STAT6
Wikipedia pathways	STAT6
	Gene fusion - rearrangements
	Polymorphisms : SNP, variants
NCBI Variation Viewer	STAT6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)	STAT6
dbVar	STAT6
ClinVar	STAT6
1000_Genomes	STAT6
Exome Variant Server	STAT6
SNP (GeneSNP Utah)	STAT6
SNP : HGBase	STAT6
Genetic variants : HAPMAP	STAT6
Genomic Variants (DGV)	STAT6 [DGVbeta]
	Mutations
ICGC Data Portal	ENSG00000166888
Somatic Mutations in Cancer : COSMIC	STAT6
CONAN: Copy Number Analysis	STAT6
LOVD (Leiden Open Variation Database)	Whole genome datasets
LOVD (Leiden Open Variation Database)	LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)	LOVD 3.0 shared installation
Impact of mutations	[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor]
	Diseases
DECIPHER (Syndromes)	12:57489187-57505196
Mutations and Diseases : HGMD	STAT6
OMIM	601512
Medgen	STAT6
NextProt	P42226 [Medical]
GENETests	STAT6
Disease Genetic Association	STAT6
Huge Navigator	STAT6 [HugePedia] STAT6 [HugeCancerGEM]
snp3D : Map Gene to Disease	6778
DGIdb (Drug Gene Interaction db)	STAT6
	General knowledge
Homologs : HomoloGene	STAT6
Homology/Alignments : Family Browser (UCSC)	STAT6
Phylogenetic Trees/Animal Genes : TreeFam	STAT6
Chemical/Protein Interactions : CTD	6778
Chemical/Pharm GKB Gene	PA339
Clinical trial	STAT6
Cancer Resource (Charite)	ENSG00000166888
	Other databases
	Probes
	Litterature
PubMed	242 Pubmed reference(s) in Entrez
CoreMine	STAT6
GoPubMed	STAT6
iHOP	STAT6

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S

Updated	12-2014	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Feb 14 18:52:20 CET 2015

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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.