| NAB2 (12q13.3) / STAT6 (12q13.3) | STAT6 (12q13.3) / ADGRL2 (1p31.1) | STAT6 (12q13.3) / CTTN (11q13.3) |
|
STAT6 (12q13.3) / IFITM2 (11p15.5) | STAT6 (12q13.3) / NAB2 (12q13.3) | STAT6 (12q13.3) / PALLD (4q32.3) |
|
STAT6 (12q13.3) / SH3KBP1 (Xp22.12) | STAT6 (12q13.3) / STAT6 (12q13.3) | STAT6 12q13.3 / NAB2 12q13.3 |
|
| Nomenclature |
HGNC (Hugo) | STAT6 11368 |
| Cards |
Entrez_Gene (NCBI) | STAT6 signal transducer and activator of transcription 6 |
Aliases | D12S1644; IL-4-STAT; STAT6B; STAT6C |
GeneCards (Weizmann) | STAT6 |
Ensembl hg19 (Hinxton) | ENSG00000166888 [Gene_View] |
Ensembl hg38 (Hinxton) | ENSG00000166888 [Gene_View]  ENSG00000166888 [Sequence] chr12:57095410-57111362 [Contig_View] STAT6 [Vega] |
ICGC DataPortal | ENSG00000166888 |
TCGA cBioPortal | STAT6 |
AceView (NCBI) | STAT6 |
Genatlas (Paris) | STAT6 |
SOURCE (Princeton) | STAT6 |
Genetics Home Reference (NIH) | STAT6 |
| Genomic and cartography |
GoldenPath hg38 (UCSC) | STAT6 - chr12:57095410-57111362 - 12q13.3 [Description] (hg38-Dec_2013) |
GoldenPath hg19 (UCSC) | STAT6 - 12q13.3 [Description] (hg19-Feb_2009) |
GoldenPath | STAT6 - 12q13.3 [CytoView hg19] STAT6 - 12q13.3 [CytoView hg38] |
ImmunoBase | ENSG00000166888 |
genome Data Viewer NCBI | STAT6 [Mapview hg19] |
OMIM | 601512 |
| Gene and transcription |
Genbank (Entrez) | AB103088 AB103089 AI082533 AK290431 AK291044 |
RefSeq transcript (Entrez) | NM_001178078 NM_001178079 NM_001178080 NM_001178081 NM_003153 |
RefSeq genomic (Entrez) | |
Consensus coding sequences : CCDS (NCBI) | STAT6 |
Alternative Splicing Gallery | ENSG00000166888 |
Gene Expression | STAT6 [ NCBI-GEO ] STAT6 [ EBI - ARRAY_EXPRESS ]
STAT6 [ SEEK ] STAT6 [ MEM ] |
Gene Expression Viewer (FireBrowse) | STAT6 [ Firebrowse - Broad ] |
Genevisible | Expression of STAT6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]   |
BioGPS (Tissue expression) | 6778 |
GTEX Portal (Tissue expression) | STAT6 |
Human Protein Atlas | ENSG00000166888-STAT6 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
UniProt/SwissProt | P42226 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
NextProt | P42226 [Sequence] [Exons] [Medical] [Publications] |
With graphics : InterPro | P42226 |
Splice isoforms : SwissVar | P42226 |
PhosPhoSitePlus | P42226 |
Domaine pattern : Prosite (Expaxy) | SH2 (PS50001) |
Domains : Interpro (EBI) | p53-like_TF_DNA-bd SH2 SH2_dom_sf STAT STAT6_C STAT6_SH2 STAT_N_sf STAT_TF_alpha STAT_TF_coiled-coil STAT_TF_DNA-bd STAT_TF_DNA-bd_N STAT_TF_prot_interaction |
Domain families : Pfam (Sanger) | SH2 (PF00017) STAT6_C (PF14596) STAT_alpha (PF01017) STAT_bind (PF02864) STAT_int (PF02865) |
Domain families : Pfam (NCBI) | pfam00017 pfam14596 pfam01017 pfam02864 pfam02865 |
Domain families : Smart (EMBL) | SH2 (SM00252) STAT_int (SM00964) |
Conserved Domain (NCBI) | STAT6 |
Blocks (Seattle) | STAT6 |
PDB (RSDB) | 1OJ5 4Y5U 4Y5W 5D39 5NWM 5NWX |
PDB Europe | 1OJ5 4Y5U 4Y5W 5D39 5NWM 5NWX |
PDB (PDBSum) | 1OJ5 4Y5U 4Y5W 5D39 5NWM 5NWX |
PDB (IMB) | 1OJ5 4Y5U 4Y5W 5D39 5NWM 5NWX |
Structural Biology KnowledgeBase | 1OJ5 4Y5U 4Y5W 5D39 5NWM 5NWX |
SCOP (Structural Classification of Proteins) | 1OJ5 4Y5U 4Y5W 5D39 5NWM 5NWX |
CATH (Classification of proteins structures) | 1OJ5 4Y5U 4Y5W 5D39 5NWM 5NWX |
Superfamily | P42226 |
Human Protein Atlas [tissue] | ENSG00000166888-STAT6 [tissue] |
Peptide Atlas | P42226 |
HPRD | 03302 |
IPI | IPI00030782 IPI01012094 IPI01011669 IPI01025306 IPI01025670 IPI01025044 IPI01025337 IPI01025731 IPI01026080 IPI01025551 IPI01025849 IPI01026170 IPI01026273 IPI01024711 IPI01025087 IPI00792907 |
| Protein Interaction databases |
DIP (DOE-UCLA) | P42226 |
IntAct (EBI) | P42226 |
BioGRID | STAT6 |
STRING (EMBL) | STAT6 |
ZODIAC | STAT6 |
| Ontologies - Pathways |
QuickGO | P42226 |
Ontology : AmiGO | chromatin RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity protein binding nucleoplasm nucleoplasm cytosol cytosol regulation of transcription by RNA polymerase II defense response signal transduction receptor signaling pathway via JAK-STAT cytokine-mediated signaling pathway cytokine-mediated signaling pathway protein phosphatase binding positive regulation of type I interferon production interleukin-4-mediated signaling pathway regulation of cell population proliferation identical protein binding response to peptide hormone positive regulation of transcription by RNA polymerase II growth hormone receptor signaling pathway via JAK-STAT positive regulation of cold-induced thermogenesis |
Ontology : EGO-EBI | chromatin RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity protein binding nucleoplasm nucleoplasm cytosol cytosol regulation of transcription by RNA polymerase II defense response signal transduction receptor signaling pathway via JAK-STAT cytokine-mediated signaling pathway cytokine-mediated signaling pathway protein phosphatase binding positive regulation of type I interferon production interleukin-4-mediated signaling pathway regulation of cell population proliferation identical protein binding response to peptide hormone positive regulation of transcription by RNA polymerase II growth hormone receptor signaling pathway via JAK-STAT positive regulation of cold-induced thermogenesis |
Pathways : BIOCARTA | IL 4 signaling pathway [Genes] |
Pathways : KEGG | Jak-STAT signaling pathway Hepatitis B Inflammatory bowel disease (IBD) |
NDEx Network | STAT6 |
Atlas of Cancer Signalling Network | STAT6 |
Wikipedia pathways | STAT6 |
| Orthology - Evolution |
OrthoDB | 6778 |
GeneTree (enSembl) | ENSG00000166888 |
Phylogenetic Trees/Animal Genes : TreeFam | STAT6 |
HOGENOM | P42226 |
Homologs : HomoloGene | STAT6 |
Homology/Alignments : Family Browser (UCSC) | STAT6 |
| Gene fusions - Rearrangements |
Fusion : Mitelman | NAB2/STAT6 [12q13.3/12q13.3]   |
| |
Fusion : Quiver | STAT6 |
| Polymorphisms : SNP and Copy number variants |
NCBI Variation Viewer | STAT6 [hg38] |
dbVar | STAT6 |
ClinVar | STAT6 |
Monarch | STAT6 |
1000_Genomes | STAT6 |
Exome Variant Server | STAT6 |
GNOMAD Browser | ENSG00000166888 |
Varsome Browser | STAT6 |
Genomic Variants (DGV) | STAT6 [DGVbeta] |
DECIPHER | STAT6 [patients] [syndromes] [variants] [genes] |
CONAN: Copy Number Analysis | STAT6 |
| Mutations |
ICGC Data Portal | STAT6 |
TCGA Data Portal | STAT6 |
Broad Tumor Portal | STAT6 |
OASIS Portal | STAT6 [ Somatic mutations - Copy number] |
Cancer Gene: Census | STAT6 |
Somatic Mutations in Cancer : COSMIC | STAT6 [overview] [genome browser] [tissue] [distribution] |
Somatic Mutations in Cancer : COSMIC3D | STAT6 |
Mutations and Diseases : HGMD | STAT6 |
LOVD (Leiden Open Variation Database) | Whole genome datasets |
LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
BioMuta | search STAT6 |
DgiDB (Drug Gene Interaction Database) | STAT6 |
DoCM (Curated mutations) | STAT6 (select the gene name) |
CIViC (Clinical Interpretations of Variants in Cancer) | STAT6 (select a term) |
intoGen | STAT6 |
Cancer3D | STAT6(select the gene name) |
Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
---|
OMIM | 601512 |
Orphanet | 3735 |
DisGeNET | STAT6 |
Medgen | STAT6 |
Genetic Testing Registry | STAT6
|
NextProt | P42226 [Medical] |
GENETests | STAT6 |
Target Validation | STAT6 |
Huge Navigator |
STAT6 [HugePedia] |
ClinGen | STAT6 |
| Clinical trials, drugs, therapy |
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MyCancerGenome | STAT6 |
Protein Interactions : CTD | |
Pharm GKB Gene | PA339 |
Pharos | P42226 |
Clinical trial | STAT6 |
| Miscellaneous |
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canSAR (ICR) | STAT6 (select the gene name) |
Harmonizome | STAT6 |
DataMed Index | STAT6 |
| Probes |
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| Litterature |
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PubMed | 340 Pubmed reference(s) in Entrez |
GeneRIFs | Gene References Into Functions (Entrez) |
EVEX | STAT6 |