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STAT6 (signal transducer and activator of transcription 6, interleukin-4 induced)

Identity

Other namesD12S1644
IL-4-STAT
STAT6B
STAT6C
HGNC (Hugo) STAT6
LocusID (NCBI) 6778
Location 12q13.3
Location_base_pair Starts at 57489187 and ends at 57505196 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias 11q23ChildAMLID1615

Other Solid tumors implicated (Data extracted from papers in the Atlas)

Solid Tumors AmeloblastomID5945

External links

Nomenclature
HGNC (Hugo)STAT6   11368
Cards
Entrez_Gene (NCBI)STAT6  6778  signal transducer and activator of transcription 6, interleukin-4 induced
GeneCards (Weizmann)STAT6
Ensembl hg19 (Hinxton)ENSG00000166888 [Gene_View]  chr12:57489187-57505196 [Contig_View]  STAT6 [Vega]
Ensembl hg38 (Hinxton)ENSG00000166888 [Gene_View]  chr12:57489187-57505196 [Contig_View]  STAT6 [Vega]
ICGC DataPortalENSG00000166888
cBioPortalSTAT6
AceView (NCBI)STAT6
Genatlas (Paris)STAT6
WikiGenes6778
SOURCE (Princeton)STAT6
Genomic and cartography
GoldenPath hg19 (UCSC)STAT6  -     chr12:57489187-57505196 -  12q13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)STAT6  -     12q13.3   [Description]    (hg38-Dec_2013)
EnsemblSTAT6 - 12q13.3 [CytoView hg19]  STAT6 - 12q13.3 [CytoView hg38]
Mapping of homologs : NCBISTAT6 [Mapview hg19]  STAT6 [Mapview hg38]
OMIM601512   
Gene and transcription
Genbank (Entrez)AB103088 AB103089 AI082533 AK290431 AK291044
RefSeq transcript (Entrez)NM_001178078 NM_001178079 NM_001178080 NM_001178081 NM_003153
RefSeq genomic (Entrez)AC_000144 NC_000012 NC_018923 NG_021272 NT_029419 NW_001838059 NW_004929384
Consensus coding sequences : CCDS (NCBI)STAT6
Cluster EST : UnigeneHs.524518 [ NCBI ]
CGAP (NCI)Hs.524518
Alternative Splicing : Fast-db (Paris)GSHG0007567
Alternative Splicing GalleryENSG00000166888
Gene ExpressionSTAT6 [ NCBI-GEO ]     STAT6 [ SEEK ]   STAT6 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP42226 (Uniprot)
NextProtP42226  [Medical]
With graphics : InterProP42226
Splice isoforms : SwissVarP42226 (Swissvar)
Domaine pattern : Prosite (Expaxy)SH2 (PS50001)   
Domains : Interpro (EBI)EF-hand-dom_pair    p53-like_TF_DNA-bd    SH2    STAT    STAT6_C    STAT_TF_alpha    STAT_TF_coiled-coil    STAT_TF_DNA-bd    STAT_TF_DNA-bd_sub    STAT_TF_prot_interaction   
Related proteins : CluSTrP42226
Domain families : Pfam (Sanger)SH2 (PF00017)    STAT6_C (PF14596)    STAT_alpha (PF01017)    STAT_bind (PF02864)    STAT_int (PF02865)   
Domain families : Pfam (NCBI)pfam00017    pfam14596    pfam01017    pfam02864    pfam02865   
Domain families : Smart (EMBL)SH2 (SM00252)  STAT_int (SM00964)  
DMDM Disease mutations6778
Blocks (Seattle)P42226
PDB (SRS)1OJ5   
PDB (PDBSum)1OJ5   
PDB (IMB)1OJ5   
PDB (RSDB)1OJ5   
Human Protein AtlasENSG00000166888
Peptide AtlasP42226
HPRD03302
IPIIPI00030782   IPI01012094   IPI01011669   IPI01025306   IPI01025670   IPI01025044   IPI01025337   IPI01025731   IPI01026080   IPI01025551   IPI01025849   IPI01026170   IPI01026273   IPI01024711   IPI01025087   IPI00792907   
Protein Interaction databases
DIP (DOE-UCLA)P42226
IntAct (EBI)P42226
FunCoupENSG00000166888
BioGRIDSTAT6
IntegromeDBSTAT6
STRING (EMBL)STAT6
Ontologies - Pathways
QuickGOP42226
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  nuclear chromatin  RNA polymerase II core promoter sequence-specific DNA binding  T-helper 1 cell lineage commitment  negative regulation of type 2 immune response  sequence-specific DNA binding transcription factor activity  signal transducer activity  calcium ion binding  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  cytosol  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  signal transduction  protein phosphatase binding  positive regulation of type I interferon production  mammary gland epithelial cell proliferation  interleukin-4-mediated signaling pathway  regulation of cell proliferation  identical protein binding  innate immune response  membrane raft  positive regulation of transcription from RNA polymerase II promoter  positive regulation of isotype switching to IgE isotypes  mammary gland morphogenesis  cellular response to hydrogen peroxide  cellular response to reactive nitrogen species  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  nuclear chromatin  RNA polymerase II core promoter sequence-specific DNA binding  T-helper 1 cell lineage commitment  negative regulation of type 2 immune response  sequence-specific DNA binding transcription factor activity  signal transducer activity  calcium ion binding  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  cytosol  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  signal transduction  protein phosphatase binding  positive regulation of type I interferon production  mammary gland epithelial cell proliferation  interleukin-4-mediated signaling pathway  regulation of cell proliferation  identical protein binding  innate immune response  membrane raft  positive regulation of transcription from RNA polymerase II promoter  positive regulation of isotype switching to IgE isotypes  mammary gland morphogenesis  cellular response to hydrogen peroxide  cellular response to reactive nitrogen species  
Pathways : BIOCARTAIL 4 signaling pathway [Genes]   
Pathways : KEGGJak-STAT signaling pathway    Hepatitis B    Inflammatory bowel disease (IBD)   
Protein Interaction DatabaseSTAT6
DoCM (Curated mutations)STAT6
Wikipedia pathwaysSTAT6
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerSTAT6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STAT6
dbVarSTAT6
ClinVarSTAT6
1000_GenomesSTAT6 
Exome Variant ServerSTAT6
SNP (GeneSNP Utah)STAT6
SNP : HGBaseSTAT6
Genetic variants : HAPMAPSTAT6
Genomic VariantsSTAT6  STAT6 [DGVbeta]
Mutations
ICGC Data PortalENSG00000166888 
Somatic Mutations in Cancer : COSMICSTAT6 
CONAN: Copy Number AnalysisSTAT6 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)12:57489187-57505196
Mutations and Diseases : HGMDSTAT6
OMIM601512   
MedgenSTAT6
NextProtP42226 [Medical]
GENETestsSTAT6
Disease Genetic AssociationSTAT6
Huge Navigator STAT6 [HugePedia]  STAT6 [HugeCancerGEM]
snp3D : Map Gene to Disease6778
DGIdb (Drug Gene Interaction db)STAT6
General knowledge
Homologs : HomoloGeneSTAT6
Homology/Alignments : Family Browser (UCSC)STAT6
Phylogenetic Trees/Animal Genes : TreeFamSTAT6
Chemical/Protein Interactions : CTD6778
Chemical/Pharm GKB GenePA339
Clinical trialSTAT6
Cancer Resource (Charite)ENSG00000166888
Other databases
Probes
Litterature
PubMed242 Pubmed reference(s) in Entrez
CoreMineSTAT6
GoPubMedSTAT6
iHOPSTAT6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sun Dec 21 01:45:52 CET 2014
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