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SUPT16H (SPT16 homolog, facilitates chromatin remodeling subunit)

Identity

Alias_namessuppressor of Ty (S.cerevisiae) 16 homolog
suppressor of Ty 16 homolog (S. cerevisiae)
Alias_symbol (synonym)FACT
FACTP140
SPT16/CDC68
FLJ14010
FLJ10857
CDC68
Other aliasSPT16
HGNC (Hugo) SUPT16H
LocusID (NCBI) 11198
Atlas_Id 50177
Location 14q11.2  [Link to chromosome band 14q11]
Location_base_pair Starts at 21351472 and ends at 21384266 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CS (12q13.3) / SUPT16H (14q11.2)KMT2B (19q13.12) / SUPT16H (14q11.2)SUPT16H (14q11.2) / EMP2 (16p13.13)
VPS13C (15q22.2) / SUPT16H (14q11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SUPT16H   11465
Cards
Entrez_Gene (NCBI)SUPT16H  11198  SPT16 homolog, facilitates chromatin remodeling subunit
AliasesCDC68; FACTP140; SPT16; SPT16/CDC68
GeneCards (Weizmann)SUPT16H
Ensembl hg19 (Hinxton)ENSG00000092201 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000092201 [Gene_View]  chr14:21351472-21384266 [Contig_View]  SUPT16H [Vega]
ICGC DataPortalENSG00000092201
TCGA cBioPortalSUPT16H
AceView (NCBI)SUPT16H
Genatlas (Paris)SUPT16H
WikiGenes11198
SOURCE (Princeton)SUPT16H
Genetics Home Reference (NIH)SUPT16H
Genomic and cartography
GoldenPath hg38 (UCSC)SUPT16H  -     chr14:21351472-21384266 -  14q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SUPT16H  -     14q11.2   [Description]    (hg19-Feb_2009)
EnsemblSUPT16H - 14q11.2 [CytoView hg19]  SUPT16H - 14q11.2 [CytoView hg38]
Mapping of homologs : NCBISUPT16H [Mapview hg19]  SUPT16H [Mapview hg38]
OMIM605012   
Gene and transcription
Genbank (Entrez)AF164924 AK001719 AK024072 AK091676 BC000565
RefSeq transcript (Entrez)NM_007192
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SUPT16H
Cluster EST : UnigeneHs.213724 [ NCBI ]
CGAP (NCI)Hs.213724
Alternative Splicing GalleryENSG00000092201
Gene ExpressionSUPT16H [ NCBI-GEO ]   SUPT16H [ EBI - ARRAY_EXPRESS ]   SUPT16H [ SEEK ]   SUPT16H [ MEM ]
Gene Expression Viewer (FireBrowse)SUPT16H [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11198
GTEX Portal (Tissue expression)SUPT16H
Human Protein AtlasENSG00000092201-SUPT16H [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y5B9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y5B9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y5B9
Splice isoforms : SwissVarQ9Y5B9
PhosPhoSitePlusQ9Y5B9
Domains : Interpro (EBI)Creatin/AminoP/Spt16_NTD    DUF1747    EFG_V    FACT-Spt16_Nlobe    FACT_Spt16p    Pept_M24    SPT16   
Domain families : Pfam (Sanger)FACT-Spt16_Nlob (PF14826)    Peptidase_M24 (PF00557)    Rtt106 (PF08512)    SPT16 (PF08644)   
Domain families : Pfam (NCBI)pfam14826    pfam00557    pfam08512    pfam08644   
Domain families : Smart (EMBL)FACT-Spt16_Nlob (SM01285)  Rtt106 (SM01287)  SPT16 (SM01286)  
Conserved Domain (NCBI)SUPT16H
DMDM Disease mutations11198
Blocks (Seattle)SUPT16H
PDB (SRS)4Z2M    4Z2N    5E5B   
PDB (PDBSum)4Z2M    4Z2N    5E5B   
PDB (IMB)4Z2M    4Z2N    5E5B   
PDB (RSDB)4Z2M    4Z2N    5E5B   
Structural Biology KnowledgeBase4Z2M    4Z2N    5E5B   
SCOP (Structural Classification of Proteins)4Z2M    4Z2N    5E5B   
CATH (Classification of proteins structures)4Z2M    4Z2N    5E5B   
SuperfamilyQ9Y5B9
Human Protein Atlas [tissue]ENSG00000092201-SUPT16H [tissue]
Peptide AtlasQ9Y5B9
HPRD16088
IPIIPI00026970   IPI01010863   IPI01025344   IPI00983993   IPI01025697   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y5B9
IntAct (EBI)Q9Y5B9
FunCoupENSG00000092201
BioGRIDSUPT16H
STRING (EMBL)SUPT16H
ZODIACSUPT16H
Ontologies - Pathways
QuickGOQ9Y5B9
Ontology : AmiGORNA binding  protein binding  nucleus  nucleoplasm  chromosome  DNA replication  DNA repair  nucleosome disassembly  transcription from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  nucleosome binding  positive regulation of DNA-templated transcription, elongation  positive regulation of transcription elongation from RNA polymerase II promoter  DNA replication-independent nucleosome organization  FACT complex  histone binding  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBIRNA binding  protein binding  nucleus  nucleoplasm  chromosome  DNA replication  DNA repair  nucleosome disassembly  transcription from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  nucleosome binding  positive regulation of DNA-templated transcription, elongation  positive regulation of transcription elongation from RNA polymerase II promoter  DNA replication-independent nucleosome organization  FACT complex  histone binding  regulation of signal transduction by p53 class mediator  
Pathways : BIOCARTAControl of Gene Expression by Vitamin D Receptor [Genes]   
NDEx NetworkSUPT16H
Atlas of Cancer Signalling NetworkSUPT16H
Wikipedia pathwaysSUPT16H
Orthology - Evolution
OrthoDB11198
GeneTree (enSembl)ENSG00000092201
Phylogenetic Trees/Animal Genes : TreeFamSUPT16H
HOVERGENQ9Y5B9
HOGENOMQ9Y5B9
Homologs : HomoloGeneSUPT16H
Homology/Alignments : Family Browser (UCSC)SUPT16H
Gene fusions - Rearrangements
Tumor Fusion PortalSUPT16H
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSUPT16H [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SUPT16H
dbVarSUPT16H
ClinVarSUPT16H
1000_GenomesSUPT16H 
Exome Variant ServerSUPT16H
ExAC (Exome Aggregation Consortium)ENSG00000092201
GNOMAD BrowserENSG00000092201
Genetic variants : HAPMAP11198
Genomic Variants (DGV)SUPT16H [DGVbeta]
DECIPHERSUPT16H [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSUPT16H 
Mutations
ICGC Data PortalSUPT16H 
TCGA Data PortalSUPT16H 
Broad Tumor PortalSUPT16H
OASIS PortalSUPT16H [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSUPT16H  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSUPT16H
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SUPT16H
DgiDB (Drug Gene Interaction Database)SUPT16H
DoCM (Curated mutations)SUPT16H (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SUPT16H (select a term)
intoGenSUPT16H
Cancer3DSUPT16H(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605012   
Orphanet
DisGeNETSUPT16H
MedgenSUPT16H
Genetic Testing Registry SUPT16H
NextProtQ9Y5B9 [Medical]
TSGene11198
GENETestsSUPT16H
Target ValidationSUPT16H
Huge Navigator SUPT16H [HugePedia]
snp3D : Map Gene to Disease11198
BioCentury BCIQSUPT16H
ClinGenSUPT16H (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11198
Chemical/Pharm GKB GenePA36251
Clinical trialSUPT16H
Miscellaneous
canSAR (ICR)SUPT16H (select the gene name)
Probes
Litterature
PubMed84 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSUPT16H
EVEXSUPT16H
GoPubMedSUPT16H
iHOPSUPT16H
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:37:15 CET 2017

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