TACSTD2 (tumor associated calcium signal transducer 2)

2003-05-01  

Identity

HGNC
LOCATION
1p32.1
LOCUSID
ALIAS
EGP-1,EGP1,GA733-1,GA7331,GP50,M1S1,TROP2
FUSION GENES

Other Information

Locus ID:

NCBI: 4070
MIM: 137290
HGNC: 11530
Ensembl: ENSG00000184292

Variants:

dbSNP: 4070
ClinVar: 4070
TCGA: ENSG00000184292
COSMIC: TACSTD2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184292ENST00000371225P09758

Expression (GTEx)

0
500
1000
1500

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
190882042008Trop2 identifies a subpopulation of murine and human prostate basal cells with stem cell characteristics.152
167076022006Clinical significance of TROP2 expression in colorectal cancer.59
194217582009Elevated expressions of MMP7, TROP2, and survivin are associated with survival, disease recurrence, and liver metastasis of colon cancer.57
188133082008High expression of TROP2 correlates with poor prognosis in pancreatic cancer.53
208582812010Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway.51
180842482008TROP2: a novel prognostic marker in squamous cell carcinoma of the oral cavity.49
182815132008Identification of Trop-2 as an oncogene and an attractive therapeutic target in colon cancers.42
188295702008A bicistronic CYCLIN D1-TROP2 mRNA chimera demonstrates a novel oncogenic mechanism in human cancer.39
223498282013Upregulation of Trop-2 quantitatively stimulates human cancer growth.39
261019152015Trop-2 is a novel target for solid cancer therapy with sacituzumab govitecan (IMMU-132), an antibody-drug conjugate (ADC).38

Citation

Dessen P

TACSTD2 (tumor associated calcium signal transducer 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42460/tacstd2