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TACSTD2 (tumor associated calcium signal transducer 2)

Identity

Alias (NCBI)EGP-1
EGP1
GA733-1
GA7331
GP50
M1S1
TROP2
HGNC (Hugo) TACSTD2
HGNC Alias symbTROP2
GA733-1
EGP-1
HGNC Alias nameepithelial glycoprotein-1
 trophoblast cell surface antigen 2
HGNC Previous nameM1S1
HGNC Previous namemembrane component chromosome 1 surface marker 1
LocusID (NCBI) 4070
Atlas_Id 42460
Location 1p32.1  [Link to chromosome band 1p32]
Location_base_pair Starts at 58575433 and ends at 58577252 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCND1 (11q13.3)::TACSTD2 (1p32.1)TACSTD2 (1p32.1)::OMA1 (1p32.2)TACSTD2 (1p32.1)::TACSTD2 (1p32.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TACSTD2   11530
Cards
Entrez_Gene (NCBI)TACSTD2    tumor associated calcium signal transducer 2
AliasesEGP-1; EGP1; GA733-1; GA7331; 
GP50; M1S1; TROP2
GeneCards (Weizmann)TACSTD2
Ensembl hg19 (Hinxton)ENSG00000184292 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000184292 [Gene_View]  ENSG00000184292 [Sequence]  chr1:58575433-58577252 [Contig_View]  TACSTD2 [Vega]
ICGC DataPortalENSG00000184292
TCGA cBioPortalTACSTD2
AceView (NCBI)TACSTD2
Genatlas (Paris)TACSTD2
SOURCE (Princeton)TACSTD2
Genetics Home Reference (NIH)TACSTD2
Genomic and cartography
GoldenPath hg38 (UCSC)TACSTD2  -     chr1:58575433-58577252 -  1p32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TACSTD2  -     1p32.1   [Description]    (hg19-Feb_2009)
GoldenPathTACSTD2 - 1p32.1 [CytoView hg19]  TACSTD2 - 1p32.1 [CytoView hg38]
ImmunoBaseENSG00000184292
Genome Data Viewer NCBITACSTD2 [Mapview hg19]  
OMIM137290   204870   
Gene and transcription
Genbank (Entrez)AI201870 AW052118 BC009409 BM765888 BT007255
RefSeq transcript (Entrez)NM_002353
Consensus coding sequences : CCDS (NCBI)TACSTD2
Gene ExpressionTACSTD2 [ NCBI-GEO ]   TACSTD2 [ EBI - ARRAY_EXPRESS ]   TACSTD2 [ SEEK ]   TACSTD2 [ MEM ]
Gene Expression Viewer (FireBrowse)TACSTD2 [ Firebrowse - Broad ]
GenevisibleExpression of TACSTD2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4070
GTEX Portal (Tissue expression)TACSTD2
Human Protein AtlasENSG00000184292-TACSTD2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP09758   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP09758  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP09758
PhosPhoSitePlusP09758
Domaine pattern : Prosite (Expaxy)THYROGLOBULIN_1_1 (PS00484)    THYROGLOBULIN_1_2 (PS51162)   
Domains : Interpro (EBI)EPCAM/Trop-2    Thyroglobulin_1    Thyroglobulin_1_sf   
Domain families : Pfam (Sanger)Thyroglobulin_1 (PF00086)   
Domain families : Pfam (NCBI)pfam00086   
Domain families : Smart (EMBL)TY (SM00211)  
Conserved Domain (NCBI)TACSTD2
PDB (RSDB)2MAE    2MVK    2MVL   
PDB Europe2MAE    2MVK    2MVL   
PDB (PDBSum)2MAE    2MVK    2MVL   
PDB (IMB)2MAE    2MVK    2MVL   
Structural Biology KnowledgeBase2MAE    2MVK    2MVL   
SCOP (Structural Classification of Proteins)2MAE    2MVK    2MVL   
CATH (Classification of proteins structures)2MAE    2MVK    2MVL   
SuperfamilyP09758
AlphaFold pdb e-kbP09758   
Human Protein Atlas [tissue]ENSG00000184292-TACSTD2 [tissue]
HPRD00672
Protein Interaction databases
DIP (DOE-UCLA)P09758
IntAct (EBI)P09758
BioGRIDTACSTD2
STRING (EMBL)TACSTD2
ZODIACTACSTD2
Ontologies - Pathways
QuickGOP09758
Ontology : AmiGOprotein binding  extracellular space  nucleus  cytosol  visual perception  basal plasma membrane  negative regulation of epithelial cell migration  membrane  integral component of membrane  lateral plasma membrane  regulation of epithelial cell proliferation  response to stimulus  negative regulation of stress fiber assembly  ureteric bud morphogenesis  extracellular exosome  negative regulation of branching involved in ureteric bud morphogenesis  negative regulation of substrate adhesion-dependent cell spreading  negative regulation of ruffle assembly  negative regulation of cell motility  positive regulation of stem cell differentiation  
Ontology : EGO-EBIprotein binding  extracellular space  nucleus  cytosol  visual perception  basal plasma membrane  negative regulation of epithelial cell migration  membrane  integral component of membrane  lateral plasma membrane  regulation of epithelial cell proliferation  response to stimulus  negative regulation of stress fiber assembly  ureteric bud morphogenesis  extracellular exosome  negative regulation of branching involved in ureteric bud morphogenesis  negative regulation of substrate adhesion-dependent cell spreading  negative regulation of ruffle assembly  negative regulation of cell motility  positive regulation of stem cell differentiation  
NDEx NetworkTACSTD2
Atlas of Cancer Signalling NetworkTACSTD2
Wikipedia pathwaysTACSTD2
Orthology - Evolution
OrthoDB4070
GeneTree (enSembl)ENSG00000184292
Phylogenetic Trees/Animal Genes : TreeFamTACSTD2
Homologs : HomoloGeneTACSTD2
Homology/Alignments : Family Browser (UCSC)TACSTD2
Gene fusions - Rearrangements
Fusion : MitelmanCCND1::TACSTD2 [11q13.3/1p32.1]  
Fusion : QuiverTACSTD2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTACSTD2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TACSTD2
dbVarTACSTD2
ClinVarTACSTD2
MonarchTACSTD2
1000_GenomesTACSTD2 
Exome Variant ServerTACSTD2
GNOMAD BrowserENSG00000184292
Varsome BrowserTACSTD2
ACMGTACSTD2 variants
VarityP09758
Genomic Variants (DGV)TACSTD2 [DGVbeta]
DECIPHERTACSTD2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTACSTD2 
Mutations
ICGC Data PortalTACSTD2 
TCGA Data PortalTACSTD2 
Broad Tumor PortalTACSTD2
OASIS PortalTACSTD2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTACSTD2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTACSTD2
Mutations and Diseases : HGMDTACSTD2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTACSTD2
DgiDB (Drug Gene Interaction Database)TACSTD2
DoCM (Curated mutations)TACSTD2
CIViC (Clinical Interpretations of Variants in Cancer)TACSTD2
Cancer3DTACSTD2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM137290    204870   
Orphanet13974   
DisGeNETTACSTD2
MedgenTACSTD2
Genetic Testing Registry TACSTD2
NextProtP09758 [Medical]
GENETestsTACSTD2
Target ValidationTACSTD2
Huge Navigator TACSTD2 [HugePedia]
ClinGenTACSTD2
Clinical trials, drugs, therapy
MyCancerGenomeTACSTD2
Protein Interactions : CTDTACSTD2
Pharm GKB GenePA36305
PharosP09758
Clinical trialTACSTD2
Miscellaneous
canSAR (ICR)TACSTD2
HarmonizomeTACSTD2
ARCHS4TACSTD2
DataMed IndexTACSTD2
Probes
Litterature
PubMed145 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTACSTD2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 13:01:53 CET 2022

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