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TACSTD2 (tumor associated calcium signal transducer 2)

Identity

Alias_namesM1S1
Alias_symbol (synonym)TROP2
GA733-1
EGP-1
Other aliasEGP1
GA7331
GP50
HGNC (Hugo) TACSTD2
LocusID (NCBI) 4070
Atlas_Id 42460
Location 1p32.1  [Link to chromosome band 1p32]
Location_base_pair Starts at 58575423 and ends at 58577494 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCND1 (11q13.3) / TACSTD2 (1p32.1)TACSTD2 (1p32.1) / OMA1 (1p32.2)TACSTD2 (1p32.1) / TACSTD2 (1p32.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TACSTD2   11530
Cards
Entrez_Gene (NCBI)TACSTD2  4070  tumor associated calcium signal transducer 2
AliasesEGP-1; EGP1; GA733-1; GA7331; 
GP50; M1S1; TROP2
GeneCards (Weizmann)TACSTD2
Ensembl hg19 (Hinxton)ENSG00000184292 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000184292 [Gene_View]  chr1:58575423-58577494 [Contig_View]  TACSTD2 [Vega]
ICGC DataPortalENSG00000184292
TCGA cBioPortalTACSTD2
AceView (NCBI)TACSTD2
Genatlas (Paris)TACSTD2
WikiGenes4070
SOURCE (Princeton)TACSTD2
Genetics Home Reference (NIH)TACSTD2
Genomic and cartography
GoldenPath hg38 (UCSC)TACSTD2  -     chr1:58575423-58577494 -  1p32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TACSTD2  -     1p32.1   [Description]    (hg19-Feb_2009)
EnsemblTACSTD2 - 1p32.1 [CytoView hg19]  TACSTD2 - 1p32.1 [CytoView hg38]
Mapping of homologs : NCBITACSTD2 [Mapview hg19]  TACSTD2 [Mapview hg38]
OMIM137290   204870   
Gene and transcription
Genbank (Entrez)AI201870 AW052118 BC009409 BM765888 BT007255
RefSeq transcript (Entrez)NM_002353
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TACSTD2
Cluster EST : UnigeneHs.23582 [ NCBI ]
CGAP (NCI)Hs.23582
Alternative Splicing GalleryENSG00000184292
Gene ExpressionTACSTD2 [ NCBI-GEO ]   TACSTD2 [ EBI - ARRAY_EXPRESS ]   TACSTD2 [ SEEK ]   TACSTD2 [ MEM ]
Gene Expression Viewer (FireBrowse)TACSTD2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4070
GTEX Portal (Tissue expression)TACSTD2
Human Protein AtlasENSG00000184292-TACSTD2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP09758   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP09758  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP09758
Splice isoforms : SwissVarP09758
PhosPhoSitePlusP09758
Domaine pattern : Prosite (Expaxy)THYROGLOBULIN_1_1 (PS00484)    THYROGLOBULIN_1_2 (PS51162)   
Domains : Interpro (EBI)Thyroglobulin_1   
Domain families : Pfam (Sanger)Thyroglobulin_1 (PF00086)   
Domain families : Pfam (NCBI)pfam00086   
Domain families : Smart (EMBL)TY (SM00211)  
Conserved Domain (NCBI)TACSTD2
DMDM Disease mutations4070
Blocks (Seattle)TACSTD2
PDB (SRS)2MAE    2MVK    2MVL   
PDB (PDBSum)2MAE    2MVK    2MVL   
PDB (IMB)2MAE    2MVK    2MVL   
PDB (RSDB)2MAE    2MVK    2MVL   
Structural Biology KnowledgeBase2MAE    2MVK    2MVL   
SCOP (Structural Classification of Proteins)2MAE    2MVK    2MVL   
CATH (Classification of proteins structures)2MAE    2MVK    2MVL   
SuperfamilyP09758
Human Protein Atlas [tissue]ENSG00000184292-TACSTD2 [tissue]
Peptide AtlasP09758
HPRD00672
IPIIPI00297910   
Protein Interaction databases
DIP (DOE-UCLA)P09758
IntAct (EBI)P09758
FunCoupENSG00000184292
BioGRIDTACSTD2
STRING (EMBL)TACSTD2
ZODIACTACSTD2
Ontologies - Pathways
QuickGOP09758
Ontology : AmiGOreceptor activity  protein binding  extracellular space  nucleus  cytosol  integral component of plasma membrane  cell surface receptor signaling pathway  visual perception  cell proliferation  basal plasma membrane  negative regulation of epithelial cell migration  membrane  lateral plasma membrane  regulation of epithelial cell proliferation  negative regulation of stress fiber assembly  ureteric bud morphogenesis  extracellular exosome  negative regulation of branching involved in ureteric bud morphogenesis  cell-cell adhesion  negative regulation of substrate adhesion-dependent cell spreading  negative regulation of ruffle assembly  negative regulation of cell motility  positive regulation of stem cell differentiation  
Ontology : EGO-EBIreceptor activity  protein binding  extracellular space  nucleus  cytosol  integral component of plasma membrane  cell surface receptor signaling pathway  visual perception  cell proliferation  basal plasma membrane  negative regulation of epithelial cell migration  membrane  lateral plasma membrane  regulation of epithelial cell proliferation  negative regulation of stress fiber assembly  ureteric bud morphogenesis  extracellular exosome  negative regulation of branching involved in ureteric bud morphogenesis  cell-cell adhesion  negative regulation of substrate adhesion-dependent cell spreading  negative regulation of ruffle assembly  negative regulation of cell motility  positive regulation of stem cell differentiation  
NDEx NetworkTACSTD2
Atlas of Cancer Signalling NetworkTACSTD2
Wikipedia pathwaysTACSTD2
Orthology - Evolution
OrthoDB4070
GeneTree (enSembl)ENSG00000184292
Phylogenetic Trees/Animal Genes : TreeFamTACSTD2
HOVERGENP09758
HOGENOMP09758
Homologs : HomoloGeneTACSTD2
Homology/Alignments : Family Browser (UCSC)TACSTD2
Gene fusions - Rearrangements
Fusion : MitelmanCCND1/TACSTD2 [11q13.3/1p32.1]  [t(1;11)(p32;q13)]  
Tumor Fusion PortalTACSTD2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTACSTD2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TACSTD2
dbVarTACSTD2
ClinVarTACSTD2
1000_GenomesTACSTD2 
Exome Variant ServerTACSTD2
ExAC (Exome Aggregation Consortium)ENSG00000184292
GNOMAD BrowserENSG00000184292
Genetic variants : HAPMAP4070
Genomic Variants (DGV)TACSTD2 [DGVbeta]
DECIPHERTACSTD2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTACSTD2 
Mutations
ICGC Data PortalTACSTD2 
TCGA Data PortalTACSTD2 
Broad Tumor PortalTACSTD2
OASIS PortalTACSTD2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTACSTD2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTACSTD2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TACSTD2
DgiDB (Drug Gene Interaction Database)TACSTD2
DoCM (Curated mutations)TACSTD2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TACSTD2 (select a term)
intoGenTACSTD2
Cancer3DTACSTD2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM137290    204870   
Orphanet13974   
DisGeNETTACSTD2
MedgenTACSTD2
Genetic Testing Registry TACSTD2
NextProtP09758 [Medical]
TSGene4070
GENETestsTACSTD2
Target ValidationTACSTD2
Huge Navigator TACSTD2 [HugePedia]
snp3D : Map Gene to Disease4070
BioCentury BCIQTACSTD2
ClinGenTACSTD2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4070
Chemical/Pharm GKB GenePA36305
Clinical trialTACSTD2
Miscellaneous
canSAR (ICR)TACSTD2 (select the gene name)
Probes
Litterature
PubMed95 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTACSTD2
EVEXTACSTD2
GoPubMedTACSTD2
iHOPTACSTD2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:37:33 CET 2017

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