TAOK3 (TAO kinase 3)

2006-10-01  

Identity

HGNC
LOCATION
12q24.23
LOCUSID
ALIAS
DPK,JIK,MAP3K18,hKFC-A
FUSION GENES

Other Information

Locus ID:

NCBI: 51347
MIM: 616711
HGNC: 18133
Ensembl: ENSG00000135090

Variants:

dbSNP: 51347
ClinVar: 51347
TCGA: ENSG00000135090
COSMIC: TAOK3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135090ENST00000392533Q9H2K8
ENSG00000135090ENST00000419821Q9H2K8
ENSG00000135090ENST00000535570F5H5E0
ENSG00000135090ENST00000536979F5GWV8
ENSG00000135090ENST00000537822F5H1I2
ENSG00000135090ENST00000537952G3V1Q8
ENSG00000135090ENST00000538601H0YF68
ENSG00000135090ENST00000539872F5H0M3
ENSG00000135090ENST00000540561F5H5C7
ENSG00000135090ENST00000541186F5H3L7
ENSG00000135090ENST00000541786F5H7G4
ENSG00000135090ENST00000541878F5H005
ENSG00000135090ENST00000542532F5GX96
ENSG00000135090ENST00000542902F5GY38

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
MAPK signaling pathwayKEGGhsa04010
MAPK (JNK) signalingKEGGhsa_M00688
MAPK (p38) signalingKEGGhsa_M00689
MAPK (JNK) signalingKEGGM00688
MAPK (p38) signalingKEGGM00689

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA445208PainDiseaseClinicalAnnotationassociatedPD30031856
PA445210Pain, PostoperativeDiseaseClinicalAnnotationassociatedPD
PA450550morphineChemicalClinicalAnnotationassociatedPD
PA452618opioidsChemicalClinicalAnnotationassociatedPD30031856

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
266468992015Genome-wide methylation analysis identifies differentially methylated CpG loci associated with severe obesity in childhood.23
300318562018Single-Nucleotide Polymorphisms in TAOK3 Are Associated With High Opioid Requirement for Pain Management in Patients With Advanced Cancer Admitted to a Tertiary Palliative Care Unit.2
303738502018TAOK3 Regulates Canonical TCR Signaling by Preventing Early SHP-1-Mediated Inactivation of LCK.0

Citation

Dessen P

TAOK3 (TAO kinase 3)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43526/taok3