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TAOK3 (TAO kinase 3)

Identity

Alias_symbol (synonym)JIK
DPK
MAP3K18
Other aliashKFC-A
HGNC (Hugo) TAOK3
LocusID (NCBI) 51347
Atlas_Id 43526
Location 12q24.23  [Link to chromosome band 12q24]
Location_base_pair Starts at 118149801 and ends at 118372945 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CTR9 (11p15.3) / TAOK3 (12q24.23)JUP (17q21.2) / TAOK3 (12q24.23)LIMA1 (12q13.12) / TAOK3 (12q24.23)
PCNX2 (1q42.2) / TAOK3 (12q24.23)PTPRK (6q22.33) / TAOK3 (12q24.23)TAOK3 (12q24.23) / DLL3 (19q13.2)
TAOK3 (12q24.23) / TAOK3 (12q24.23)TAOK3 (12q24.23) / TOB1 (17q21.33)LIMA1 12q13.12 / TAOK3 12q24.23
PCNXL2 1q42.2 / TAOK3 12q24.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  dic(9;17)(p13;q11) PAX5/TAOK1


External links

Nomenclature
HGNC (Hugo)TAOK3   18133
Cards
Entrez_Gene (NCBI)TAOK3  51347  TAO kinase 3
AliasesDPK; JIK; MAP3K18; hKFC-A
GeneCards (Weizmann)TAOK3
Ensembl hg19 (Hinxton)ENSG00000135090 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000135090 [Gene_View]  chr12:118149801-118372945 [Contig_View]  TAOK3 [Vega]
ICGC DataPortalENSG00000135090
TCGA cBioPortalTAOK3
AceView (NCBI)TAOK3
Genatlas (Paris)TAOK3
WikiGenes51347
SOURCE (Princeton)TAOK3
Genetics Home Reference (NIH)TAOK3
Genomic and cartography
GoldenPath hg38 (UCSC)TAOK3  -     chr12:118149801-118372945 -  12q24.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TAOK3  -     12q24.23   [Description]    (hg19-Feb_2009)
EnsemblTAOK3 - 12q24.23 [CytoView hg19]  TAOK3 - 12q24.23 [CytoView hg38]
Mapping of homologs : NCBITAOK3 [Mapview hg19]  TAOK3 [Mapview hg38]
OMIM616711   
Gene and transcription
Genbank (Entrez)AA744362 AF135158 AF161373 AF179867 AF181985
RefSeq transcript (Entrez)NM_001346487 NM_001346488 NM_001346489 NM_001346490 NM_001346491 NM_001346492 NM_001346493 NM_001346494 NM_001346495 NM_001346496 NM_001346497 NM_016281
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TAOK3
Cluster EST : UnigeneHs.644420 [ NCBI ]
CGAP (NCI)Hs.644420
Alternative Splicing GalleryENSG00000135090
Gene ExpressionTAOK3 [ NCBI-GEO ]   TAOK3 [ EBI - ARRAY_EXPRESS ]   TAOK3 [ SEEK ]   TAOK3 [ MEM ]
Gene Expression Viewer (FireBrowse)TAOK3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51347
GTEX Portal (Tissue expression)TAOK3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H2K8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H2K8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H2K8
Splice isoforms : SwissVarQ9H2K8
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ9H2K8
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)TAOK3
DMDM Disease mutations51347
Blocks (Seattle)TAOK3
SuperfamilyQ9H2K8
Human Protein AtlasENSG00000135090
Peptide AtlasQ9H2K8
HPRD11620
IPIIPI00410485   IPI00478317   IPI01015307   IPI00796238   IPI01012999   IPI01014307   IPI01012124   IPI01013404   IPI01010672   IPI01010321   IPI01009764   IPI01009397   IPI01015785   
Protein Interaction databases
DIP (DOE-UCLA)Q9H2K8
IntAct (EBI)Q9H2K8
FunCoupENSG00000135090
BioGRIDTAOK3
STRING (EMBL)TAOK3
ZODIACTAOK3
Ontologies - Pathways
QuickGOQ9H2K8
Ontology : AmiGOMAPK cascade  protein serine/threonine kinase activity  signal transducer, downstream of receptor, with serine/threonine kinase activity  protein kinase inhibitor activity  protein binding  ATP binding  cytoplasm  plasma membrane  DNA repair  protein phosphorylation  protein phosphorylation  negative regulation of protein kinase activity  cellular response to DNA damage stimulus  mitotic G2 DNA damage checkpoint  transferase activity  positive regulation of stress-activated MAPK cascade  positive regulation of JUN kinase activity  negative regulation of JNK cascade  positive regulation of JNK cascade  protein autophosphorylation  
Ontology : EGO-EBIMAPK cascade  protein serine/threonine kinase activity  signal transducer, downstream of receptor, with serine/threonine kinase activity  protein kinase inhibitor activity  protein binding  ATP binding  cytoplasm  plasma membrane  DNA repair  protein phosphorylation  protein phosphorylation  negative regulation of protein kinase activity  cellular response to DNA damage stimulus  mitotic G2 DNA damage checkpoint  transferase activity  positive regulation of stress-activated MAPK cascade  positive regulation of JUN kinase activity  negative regulation of JNK cascade  positive regulation of JNK cascade  protein autophosphorylation  
Pathways : KEGGMAPK signaling pathway   
NDEx NetworkTAOK3
Atlas of Cancer Signalling NetworkTAOK3
Wikipedia pathwaysTAOK3
Orthology - Evolution
OrthoDB51347
GeneTree (enSembl)ENSG00000135090
Phylogenetic Trees/Animal Genes : TreeFamTAOK3
HOVERGENQ9H2K8
HOGENOMQ9H2K8
Homologs : HomoloGeneTAOK3
Homology/Alignments : Family Browser (UCSC)TAOK3
Gene fusions - Rearrangements
Fusion : MitelmanLIMA1/TAOK3 [12q13.12/12q24.23]  [t(12;12)(q13;q24)]  
Fusion : MitelmanPCNXL2/TAOK3 [1q42.2/12q24.23]  [t(1;12)(q42;q24)]  
Fusion: TCGALIMA1 12q13.12 TAOK3 12q24.23 BLCA
Fusion: TCGAPCNXL2 1q42.2 TAOK3 12q24.23 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTAOK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TAOK3
dbVarTAOK3
ClinVarTAOK3
1000_GenomesTAOK3 
Exome Variant ServerTAOK3
ExAC (Exome Aggregation Consortium)TAOK3 (select the gene name)
Genetic variants : HAPMAP51347
Genomic Variants (DGV)TAOK3 [DGVbeta]
DECIPHERTAOK3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTAOK3 
Mutations
ICGC Data PortalTAOK3 
TCGA Data PortalTAOK3 
Broad Tumor PortalTAOK3
OASIS PortalTAOK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTAOK3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTAOK3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TAOK3
DgiDB (Drug Gene Interaction Database)TAOK3
DoCM (Curated mutations)TAOK3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TAOK3 (select a term)
intoGenTAOK3
Cancer3DTAOK3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616711   
Orphanet
MedgenTAOK3
Genetic Testing Registry TAOK3
NextProtQ9H2K8 [Medical]
TSGene51347
GENETestsTAOK3
Target ValidationTAOK3
Huge Navigator TAOK3 [HugePedia]
snp3D : Map Gene to Disease51347
BioCentury BCIQTAOK3
ClinGenTAOK3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51347
Chemical/Pharm GKB GenePA134975064
Clinical trialTAOK3
Miscellaneous
canSAR (ICR)TAOK3 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTAOK3
EVEXTAOK3
GoPubMedTAOK3
iHOPTAOK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:58:32 CEST 2017

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