Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

TAOK3 (TAO kinase 3)

Identity

Alias (NCBI)DPK
JIK
MAP3K18
hKFC-A
HGNC (Hugo) TAOK3
HGNC Alias symbJIK
DPK
MAP3K18
LocusID (NCBI) 51347
Atlas_Id 43526
Location 12q24.23  [Link to chromosome band 12q24]
Location_base_pair Starts at 118149801 and ends at 118372907 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CTR9 (11p15.3) / TAOK3 (12q24.23)JUP (17q21.2) / TAOK3 (12q24.23)LIMA1 (12q13.12) / TAOK3 (12q24.23)
PCNX2 (1q42.2) / TAOK3 (12q24.23)PTPRK (6q22.33) / TAOK3 (12q24.23)TAOK3 (12q24.23) / DLL3 (19q13.2)
TAOK3 (12q24.23) / TAOK3 (12q24.23)TAOK3 (12q24.23) / TOB1 (17q21.33)LIMA1 12q13.12 / TAOK3 12q24.23
PCNXL2 1q42.2 / TAOK3 12q24.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  dic(9;17)(p13;q11) PAX5/TAOK1


External links

 

Nomenclature
HGNC (Hugo)TAOK3   18133
Cards
Entrez_Gene (NCBI)TAOK3    TAO kinase 3
AliasesDPK; JIK; MAP3K18; hKFC-A
GeneCards (Weizmann)TAOK3
Ensembl hg19 (Hinxton)ENSG00000135090 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000135090 [Gene_View]  ENSG00000135090 [Sequence]  chr12:118149801-118372907 [Contig_View]  TAOK3 [Vega]
ICGC DataPortalENSG00000135090
TCGA cBioPortalTAOK3
AceView (NCBI)TAOK3
Genatlas (Paris)TAOK3
SOURCE (Princeton)TAOK3
Genetics Home Reference (NIH)TAOK3
Genomic and cartography
GoldenPath hg38 (UCSC)TAOK3  -     chr12:118149801-118372907 -  12q24.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TAOK3  -     12q24.23   [Description]    (hg19-Feb_2009)
GoldenPathTAOK3 - 12q24.23 [CytoView hg19]  TAOK3 - 12q24.23 [CytoView hg38]
ImmunoBaseENSG00000135090
Genome Data Viewer NCBITAOK3 [Mapview hg19]  
OMIM616711   
Gene and transcription
Genbank (Entrez)AA744362 AF135158 AF161373 AF179867 AF181985
RefSeq transcript (Entrez)NM_001346487 NM_001346488 NM_001346489 NM_001346490 NM_001346491 NM_001346492 NM_001346493 NM_001346494 NM_001346495 NM_001346496 NM_001346497 NM_016281
Consensus coding sequences : CCDS (NCBI)TAOK3
Gene ExpressionTAOK3 [ NCBI-GEO ]   TAOK3 [ EBI - ARRAY_EXPRESS ]   TAOK3 [ SEEK ]   TAOK3 [ MEM ]
Gene Expression Viewer (FireBrowse)TAOK3 [ Firebrowse - Broad ]
GenevisibleExpression of TAOK3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51347
GTEX Portal (Tissue expression)TAOK3
Human Protein AtlasENSG00000135090-TAOK3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H2K8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H2K8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H2K8
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9H2K8
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)TAOK3
PDB (RSDB)6BDN   
PDB Europe6BDN   
PDB (PDBSum)6BDN   
PDB (IMB)6BDN   
Structural Biology KnowledgeBase6BDN   
SCOP (Structural Classification of Proteins)6BDN   
CATH (Classification of proteins structures)6BDN   
SuperfamilyQ9H2K8
AlphaFold pdb e-kbQ9H2K8   
Human Protein Atlas [tissue]ENSG00000135090-TAOK3 [tissue]
HPRD11620
Protein Interaction databases
DIP (DOE-UCLA)Q9H2K8
IntAct (EBI)Q9H2K8
BioGRIDTAOK3
STRING (EMBL)TAOK3
ZODIACTAOK3
Ontologies - Pathways
QuickGOQ9H2K8
Ontology : AmiGOMAPK cascade  MAPK cascade  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein kinase inhibitor activity  protein binding  ATP binding  cytoplasm  plasma membrane  DNA repair  protein phosphorylation  protein phosphorylation  protein phosphorylation  negative regulation of protein kinase activity  cellular response to DNA damage stimulus  mitotic G2 DNA damage checkpoint signaling  transferase activity  activation of protein kinase activity  positive regulation of stress-activated MAPK cascade  intracellular signal transduction  regulation of MAPK cascade  positive regulation of JUN kinase activity  negative regulation of JNK cascade  positive regulation of JNK cascade  protein autophosphorylation  neuron projection morphogenesis  protein serine kinase activity  protein threonine kinase activity  
Ontology : EGO-EBIMAPK cascade  MAPK cascade  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein kinase inhibitor activity  protein binding  ATP binding  cytoplasm  plasma membrane  DNA repair  protein phosphorylation  protein phosphorylation  protein phosphorylation  negative regulation of protein kinase activity  cellular response to DNA damage stimulus  mitotic G2 DNA damage checkpoint signaling  transferase activity  activation of protein kinase activity  positive regulation of stress-activated MAPK cascade  intracellular signal transduction  regulation of MAPK cascade  positive regulation of JUN kinase activity  negative regulation of JNK cascade  positive regulation of JNK cascade  protein autophosphorylation  neuron projection morphogenesis  protein serine kinase activity  protein threonine kinase activity  
Pathways : KEGGMAPK signaling pathway   
NDEx NetworkTAOK3
Atlas of Cancer Signalling NetworkTAOK3
Wikipedia pathwaysTAOK3
Orthology - Evolution
OrthoDB51347
GeneTree (enSembl)ENSG00000135090
Phylogenetic Trees/Animal Genes : TreeFamTAOK3
Homologs : HomoloGeneTAOK3
Homology/Alignments : Family Browser (UCSC)TAOK3
Gene fusions - Rearrangements
Fusion : MitelmanLIMA1/TAOK3 [12q13.12/12q24.23]  
Fusion : MitelmanPCNXL2/TAOK3 [1q42.2/12q24.23]  
Fusion : QuiverTAOK3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTAOK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TAOK3
dbVarTAOK3
ClinVarTAOK3
MonarchTAOK3
1000_GenomesTAOK3 
Exome Variant ServerTAOK3
GNOMAD BrowserENSG00000135090
Varsome BrowserTAOK3
ACMGTAOK3 variants
VarityQ9H2K8
Genomic Variants (DGV)TAOK3 [DGVbeta]
DECIPHERTAOK3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTAOK3 
Mutations
ICGC Data PortalTAOK3 
TCGA Data PortalTAOK3 
Broad Tumor PortalTAOK3
OASIS PortalTAOK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTAOK3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTAOK3
Mutations and Diseases : HGMDTAOK3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTAOK3
DgiDB (Drug Gene Interaction Database)TAOK3
DoCM (Curated mutations)TAOK3
CIViC (Clinical Interpretations of Variants in Cancer)TAOK3
Cancer3DTAOK3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616711   
Orphanet
DisGeNETTAOK3
MedgenTAOK3
Genetic Testing Registry TAOK3
NextProtQ9H2K8 [Medical]
GENETestsTAOK3
Target ValidationTAOK3
Huge Navigator TAOK3 [HugePedia]
ClinGenTAOK3
Clinical trials, drugs, therapy
MyCancerGenomeTAOK3
Protein Interactions : CTDTAOK3
Pharm GKB GenePA134975064
PharosQ9H2K8
Clinical trialTAOK3
Miscellaneous
canSAR (ICR)TAOK3
HarmonizomeTAOK3
DataMed IndexTAOK3
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTAOK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:34:14 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.