Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

TBK1 (TANK binding kinase 1)

Identity

Alias_namesTANK-binding kinase 1
Alias_symbol (synonym)NAK
Other aliasFTDALS4
T2K
HGNC (Hugo) TBK1
LocusID (NCBI) 29110
Atlas_Id 42480
Location 12q14.2  [Link to chromosome band 12q14]
Location_base_pair Starts at 64452060 and ends at 64502119 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TBK1 (12q14.2) / ARHGAP5 (14q12)TBK1 (12q14.2) / C12orf56 (12q14.2)TBK1 (12q14.2) / OS9 (12q13.3)
TBK1 12q14.2 / ARHGAP5 14q12TBK1 12q14.2 / C12orf56 12q14.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TBK1   11584
Cards
Entrez_Gene (NCBI)TBK1  29110  TANK binding kinase 1
AliasesFTDALS4; NAK; T2K
GeneCards (Weizmann)TBK1
Ensembl hg19 (Hinxton)ENSG00000183735 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000183735 [Gene_View]  chr12:64452060-64502119 [Contig_View]  TBK1 [Vega]
ICGC DataPortalENSG00000183735
TCGA cBioPortalTBK1
AceView (NCBI)TBK1
Genatlas (Paris)TBK1
WikiGenes29110
SOURCE (Princeton)TBK1
Genetics Home Reference (NIH)TBK1
Genomic and cartography
GoldenPath hg38 (UCSC)TBK1  -     chr12:64452060-64502119 +  12q14.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TBK1  -     12q14.2   [Description]    (hg19-Feb_2009)
EnsemblTBK1 - 12q14.2 [CytoView hg19]  TBK1 - 12q14.2 [CytoView hg38]
Mapping of homologs : NCBITBK1 [Mapview hg19]  TBK1 [Mapview hg38]
OMIM604834   616439   
Gene and transcription
Genbank (Entrez)AA970899 AF174536 AF191838 AK002192 AK291039
RefSeq transcript (Entrez)NM_013254
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TBK1
Cluster EST : UnigeneHs.505874 [ NCBI ]
CGAP (NCI)Hs.505874
Alternative Splicing GalleryENSG00000183735
Gene ExpressionTBK1 [ NCBI-GEO ]   TBK1 [ EBI - ARRAY_EXPRESS ]   TBK1 [ SEEK ]   TBK1 [ MEM ]
Gene Expression Viewer (FireBrowse)TBK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29110
GTEX Portal (Tissue expression)TBK1
Human Protein AtlasENSG00000183735-TBK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UHD2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UHD2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UHD2
Splice isoforms : SwissVarQ9UHD2
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ9UHD2
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)TBK1
DMDM Disease mutations29110
Blocks (Seattle)TBK1
PDB (SRS)4EFO    4EUT    4EUU    4IM0    4IM2    4IM3    4IW0    4IWO    4IWP    4IWQ    5EOA    5EOF    5EP6   
PDB (PDBSum)4EFO    4EUT    4EUU    4IM0    4IM2    4IM3    4IW0    4IWO    4IWP    4IWQ    5EOA    5EOF    5EP6   
PDB (IMB)4EFO    4EUT    4EUU    4IM0    4IM2    4IM3    4IW0    4IWO    4IWP    4IWQ    5EOA    5EOF    5EP6   
PDB (RSDB)4EFO    4EUT    4EUU    4IM0    4IM2    4IM3    4IW0    4IWO    4IWP    4IWQ    5EOA    5EOF    5EP6   
Structural Biology KnowledgeBase4EFO    4EUT    4EUU    4IM0    4IM2    4IM3    4IW0    4IWO    4IWP    4IWQ    5EOA    5EOF    5EP6   
SCOP (Structural Classification of Proteins)4EFO    4EUT    4EUU    4IM0    4IM2    4IM3    4IW0    4IWO    4IWP    4IWQ    5EOA    5EOF    5EP6   
CATH (Classification of proteins structures)4EFO    4EUT    4EUU    4IM0    4IM2    4IM3    4IW0    4IWO    4IWP    4IWQ    5EOA    5EOF    5EP6   
SuperfamilyQ9UHD2
Human Protein Atlas [tissue]ENSG00000183735-TBK1 [tissue]
Peptide AtlasQ9UHD2
HPRD05322
IPIIPI00293613   IPI00740001   IPI01014214   IPI01013748   IPI01013407   
Protein Interaction databases
DIP (DOE-UCLA)Q9UHD2
IntAct (EBI)Q9UHD2
FunCoupENSG00000183735
BioGRIDTBK1
STRING (EMBL)TBK1
ZODIACTBK1
Ontologies - Pathways
QuickGOQ9UHD2
Ontology : AmiGOnucleic acid binding  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  cytosol  protein phosphorylation  inflammatory response  I-kappaB kinase/NF-kappaB signaling  response to virus  endosome membrane  negative regulation of gene expression  positive regulation of macroautophagy  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  regulation of type I interferon production  negative regulation of type I interferon production  positive regulation of type I interferon production  type I interferon production  positive regulation of interferon-alpha production  positive regulation of interferon-beta production  positive regulation of peptidyl-serine phosphorylation  TRIF-dependent toll-like receptor signaling pathway  positive regulation of I-kappaB kinase/NF-kappaB signaling  dendritic cell proliferation  innate immune response  positive regulation of interferon-beta biosynthetic process  positive regulation of transcription from RNA polymerase II promoter  defense response to Gram-positive bacterium  phosphoprotein binding  defense response to virus  regulation of neuron death  positive regulation of xenophagy  
Ontology : EGO-EBInucleic acid binding  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  cytosol  protein phosphorylation  inflammatory response  I-kappaB kinase/NF-kappaB signaling  response to virus  endosome membrane  negative regulation of gene expression  positive regulation of macroautophagy  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  regulation of type I interferon production  negative regulation of type I interferon production  positive regulation of type I interferon production  type I interferon production  positive regulation of interferon-alpha production  positive regulation of interferon-beta production  positive regulation of peptidyl-serine phosphorylation  TRIF-dependent toll-like receptor signaling pathway  positive regulation of I-kappaB kinase/NF-kappaB signaling  dendritic cell proliferation  innate immune response  positive regulation of interferon-beta biosynthetic process  positive regulation of transcription from RNA polymerase II promoter  defense response to Gram-positive bacterium  phosphoprotein binding  defense response to virus  regulation of neuron death  positive regulation of xenophagy  
Pathways : KEGG   
NDEx NetworkTBK1
Atlas of Cancer Signalling NetworkTBK1
Wikipedia pathwaysTBK1
Orthology - Evolution
OrthoDB29110
GeneTree (enSembl)ENSG00000183735
Phylogenetic Trees/Animal Genes : TreeFamTBK1
HOVERGENQ9UHD2
HOGENOMQ9UHD2
Homologs : HomoloGeneTBK1
Homology/Alignments : Family Browser (UCSC)TBK1
Gene fusions - Rearrangements
Fusion : MitelmanTBK1/ARHGAP5 [12q14.2/14q12]  
Fusion : MitelmanTBK1/C12orf56 [12q14.2/12q14.2]  [t(12;12)(q14;q14)]  
Fusion: TCGATBK1 12q14.2 ARHGAP5 14q12 BRCA
Fusion: TCGATBK1 12q14.2 C12orf56 12q14.2 BRCA
Fusion: Tumor Portal TBK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTBK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TBK1
dbVarTBK1
ClinVarTBK1
1000_GenomesTBK1 
Exome Variant ServerTBK1
ExAC (Exome Aggregation Consortium)ENSG00000183735
GNOMAD BrowserENSG00000183735
Genetic variants : HAPMAP29110
Genomic Variants (DGV)TBK1 [DGVbeta]
DECIPHERTBK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTBK1 
Mutations
ICGC Data PortalTBK1 
TCGA Data PortalTBK1 
Broad Tumor PortalTBK1
OASIS PortalTBK1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDTBK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch TBK1
DgiDB (Drug Gene Interaction Database)TBK1
DoCM (Curated mutations)TBK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TBK1 (select a term)
intoGenTBK1
Cancer3DTBK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604834    616439   
Orphanet106    20341    3275   
MedgenTBK1
Genetic Testing Registry TBK1
NextProtQ9UHD2 [Medical]
TSGene29110
GENETestsTBK1
Target ValidationTBK1
Huge Navigator TBK1 [HugePedia]
snp3D : Map Gene to Disease29110
BioCentury BCIQTBK1
ClinGenTBK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD29110
Chemical/Pharm GKB GenePA36348
Clinical trialTBK1
Miscellaneous
canSAR (ICR)TBK1 (select the gene name)
Probes
Litterature
PubMed212 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTBK1
EVEXTBK1
GoPubMedTBK1
iHOPTBK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 13:13:56 CET 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.