Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TCF4 (transcription factor 4)

Identity

Other namesE2-2
ITF-2
ITF2
PTHS
SEF-2
SEF2
SEF2-1
SEF2-1A
SEF2-1B
SEF2-1D
TCF-4
bHLHb19
HGNC (Hugo) TCF4
LocusID (NCBI) 6925
Location 18q21.2
Location_base_pair Starts at 52889562 and ends at 53255860 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TCF4   11634
Cards
Entrez_Gene (NCBI)TCF4  6925  transcription factor 4
GeneCards (Weizmann)TCF4
Ensembl (Hinxton)ENSG00000196628 [Gene_View]  chr18:52889562-53255860 [Contig_View]  TCF4 [Vega]
ICGC DataPortalENSG00000196628
cBioPortalTCF4
AceView (NCBI)TCF4
Genatlas (Paris)TCF4
WikiGenes6925
SOURCE (Princeton)NM_001083962 NM_001243226 NM_001243227 NM_001243228 NM_001243230 NM_001243231 NM_001243232 NM_001243233 NM_001243234 NM_001243235 NM_001243236 NM_003199
Genomic and cartography
GoldenPath (UCSC)TCF4  -  18q21.2   chr18:52889562-53255860 -  18q21.2   [Description]    (hg19-Feb_2009)
EnsemblTCF4 - 18q21.2 [CytoView]
Mapping of homologs : NCBITCF4 [Mapview]
OMIM602272   610954   
Gene and transcription
Genbank (Entrez)AB209741 AK021980 AK026674 AK095041 AK095066
RefSeq transcript (Entrez)NM_001083962 NM_001243226 NM_001243227 NM_001243228 NM_001243230 NM_001243231 NM_001243232 NM_001243233 NM_001243234 NM_001243235 NM_001243236 NM_003199
RefSeq genomic (Entrez)AC_000150 NC_000018 NC_018929 NG_011716 NT_010966 NW_001838469 NW_004929411
Consensus coding sequences : CCDS (NCBI)TCF4
Cluster EST : UnigeneHs.742885 [ NCBI ]
CGAP (NCI)Hs.742885
Alternative Splicing : Fast-db (Paris)GSHG0014319
Alternative Splicing GalleryENSG00000196628
Gene ExpressionTCF4 [ NCBI-GEO ]     TCF4 [ SEEK ]   TCF4 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP15884 (Uniprot)
NextProtP15884  [Medical]
With graphics : InterProP15884
Splice isoforms : SwissVarP15884 (Swissvar)
Domaine pattern : Prosite (Expaxy)BHLH (PS50888)   
Domains : Interpro (EBI)bHLH_dom [organisation]  
Related proteins : CluSTrP15884
Domain families : Pfam (Sanger)HLH (PF00010)   
Domain families : Pfam (NCBI)pfam00010   
Domain families : Smart (EMBL)HLH (SM00353)  
DMDM Disease mutations6925
Blocks (Seattle)P15884
PDB (SRS)2KWF   
PDB (PDBSum)2KWF   
PDB (IMB)2KWF   
PDB (RSDB)2KWF   
Human Protein AtlasENSG00000196628 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP15884
HPRD03780
IPIIPI00013492   IPI00221260   IPI01011844   IPI01015273   IPI01014605   IPI01015919   IPI01013201   IPI00221261   
Protein Interaction databases
DIP (DOE-UCLA)P15884
IntAct (EBI)P15884
FunCoupENSG00000196628
BioGRIDTCF4
InParanoidP15884
Interologous Interaction database P15884
IntegromeDBTCF4
STRING (EMBL)TCF4
Ontologies - Pathways
Ontology : AmiGORNA polymerase II core promoter proximal region sequence-specific DNA binding  sequence-specific DNA binding RNA polymerase recruiting transcription factor activity  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription  TFIIB-class binding transcription factor activity  TFIIB-class transcription factor binding  DNA binding  sequence-specific DNA binding transcription factor activity  protein binding  nucleus  transcription factor complex  DNA-templated transcription, initiation  transcription initiation from RNA polymerase II promoter  protein C-terminus binding  positive regulation of neuron differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  protein heterodimerization activity  protein-DNA complex assembly  E-box binding  
Ontology : EGO-EBIRNA polymerase II core promoter proximal region sequence-specific DNA binding  sequence-specific DNA binding RNA polymerase recruiting transcription factor activity  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription  TFIIB-class binding transcription factor activity  TFIIB-class transcription factor binding  DNA binding  sequence-specific DNA binding transcription factor activity  protein binding  nucleus  transcription factor complex  DNA-templated transcription, initiation  transcription initiation from RNA polymerase II promoter  protein C-terminus binding  positive regulation of neuron differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  protein heterodimerization activity  protein-DNA complex assembly  E-box binding  
Protein Interaction DatabaseTCF4
Wikipedia pathwaysTCF4
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)TCF4
snp3D : Map Gene to Disease6925
SNP (GeneSNP Utah)TCF4
SNP : HGBaseTCF4
Genetic variants : HAPMAPTCF4
Exome VariantTCF4
1000_GenomesTCF4 
ICGC programENSG00000196628 
Somatic Mutations in Cancer : COSMICTCF4 
CONAN: Copy Number AnalysisTCF4 
Mutations and Diseases : HGMDTCF4
Genomic VariantsTCF4  TCF4 [DGVbeta]
dbVarTCF4
ClinVarTCF4
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM602272    610954   
MedgenTCF4
GENETestsTCF4
Disease Genetic AssociationTCF4
Huge Navigator TCF4 [HugePedia]  TCF4 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneTCF4
Homology/Alignments : Family Browser (UCSC)TCF4
Phylogenetic Trees/Animal Genes : TreeFamTCF4
Chemical/Protein Interactions : CTD6925
Chemical/Pharm GKB GenePA164742621
Clinical trialTCF4
Cancer Resource (Charite)ENSG00000196628
Other databases
Probes
Litterature
PubMed157 Pubmed reference(s) in Entrez
CoreMineTCF4
iHOPTCF4
OncoSearchTCF4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jul 30 14:18:18 CEST 2014

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