Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TDGF1 (teratocarcinoma-derived growth factor 1)

Identity

Alias (NCBI)CR
CR-1
CRGF
CRIPTO
HGNC (Hugo) TDGF1
HGNC Alias symbCRIPTO
CR
Cripto-1
CR-1
LocusID (NCBI) 6997
Atlas_Id 42507
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 46577788 and ends at 46582457 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TDGF1P3 (Xq23) / TDGF1 (3p21.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TDGF1   11701
Cards
Entrez_Gene (NCBI)TDGF1    teratocarcinoma-derived growth factor 1
AliasesCR; CR-1; CRGF; CRIPTO
GeneCards (Weizmann)TDGF1
Ensembl hg19 (Hinxton)ENSG00000241186 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000241186 [Gene_View]  ENSG00000241186 [Sequence]  chr3:46577788-46582457 [Contig_View]  TDGF1 [Vega]
ICGC DataPortalENSG00000241186
TCGA cBioPortalTDGF1
AceView (NCBI)TDGF1
Genatlas (Paris)TDGF1
SOURCE (Princeton)TDGF1
Genetics Home Reference (NIH)TDGF1
Genomic and cartography
GoldenPath hg38 (UCSC)TDGF1  -     chr3:46577788-46582457 +  3p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TDGF1  -     3p21.31   [Description]    (hg19-Feb_2009)
GoldenPathTDGF1 - 3p21.31 [CytoView hg19]  TDGF1 - 3p21.31 [CytoView hg38]
ImmunoBaseENSG00000241186
Genome Data Viewer NCBITDGF1 [Mapview hg19]  
OMIM187395   
Gene and transcription
Genbank (Entrez)AK313319 AU125451 BC022393 BC067844 CX755454
RefSeq transcript (Entrez)NM_001174136 NM_003212
Consensus coding sequences : CCDS (NCBI)TDGF1
Gene ExpressionTDGF1 [ NCBI-GEO ]   TDGF1 [ EBI - ARRAY_EXPRESS ]   TDGF1 [ SEEK ]   TDGF1 [ MEM ]
Gene Expression Viewer (FireBrowse)TDGF1 [ Firebrowse - Broad ]
GenevisibleExpression of TDGF1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6997
GTEX Portal (Tissue expression)TDGF1
Human Protein AtlasENSG00000241186-TDGF1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP13385   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP13385  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP13385
PhosPhoSitePlusP13385
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_3 (PS50026)   
Domains : Interpro (EBI)Cripto_growth_factor    Cryptic/Cripto_CFC-dom    EGF-like_dom   
Domain families : Pfam (Sanger)CFC (PF09443)   
Domain families : Pfam (NCBI)pfam09443   
Conserved Domain (NCBI)TDGF1
SuperfamilyP13385
AlphaFold pdb e-kbP13385   
Human Protein Atlas [tissue]ENSG00000241186-TDGF1 [tissue]
HPRD01757
Protein Interaction databases
DIP (DOE-UCLA)P13385
IntAct (EBI)P13385
BioGRIDTDGF1
STRING (EMBL)TDGF1
ZODIACTDGF1
Ontologies - Pathways
QuickGOP13385
Ontology : AmiGOactivation of MAPK activity  activation of MAPK activity  blood vessel development  morphogenesis of a branching structure  cell migration involved in sprouting angiogenesis  signaling receptor binding  signaling receptor binding  protein binding  extracellular region  extracellular space  plasma membrane  epidermal growth factor receptor signaling pathway  determination of left/right symmetry  heart development  heart development  growth factor activity  positive regulation of cell population proliferation  positive regulation of cell population proliferation  anterior/posterior axis specification, embryo  embryo development ending in birth or egg hatching  anterior/posterior pattern specification  regulation of signal transduction  cell surface  cell surface  positive regulation of endothelial cell migration  apical plasma membrane  peptidyl-serine phosphorylation  extrinsic component of plasma membrane  cell differentiation  positive regulation of cell migration  mammary gland development  anchored component of membrane  somatic stem cell population maintenance  cellular response to hepatocyte growth factor stimulus  nodal signaling pathway  nodal binding  negative regulation of apoptotic process  cellular response to fibroblast growth factor stimulus  membrane raft  anatomical structure development  positive regulation of peptidyl-tyrosine phosphorylation  activin receptor binding  cellular response to interferon-gamma  cellular response to interleukin-6  cellular response to tumor necrosis factor  cellular response to epidermal growth factor stimulus  
Ontology : EGO-EBIactivation of MAPK activity  activation of MAPK activity  blood vessel development  morphogenesis of a branching structure  cell migration involved in sprouting angiogenesis  signaling receptor binding  signaling receptor binding  protein binding  extracellular region  extracellular space  plasma membrane  epidermal growth factor receptor signaling pathway  determination of left/right symmetry  heart development  heart development  growth factor activity  positive regulation of cell population proliferation  positive regulation of cell population proliferation  anterior/posterior axis specification, embryo  embryo development ending in birth or egg hatching  anterior/posterior pattern specification  regulation of signal transduction  cell surface  cell surface  positive regulation of endothelial cell migration  apical plasma membrane  peptidyl-serine phosphorylation  extrinsic component of plasma membrane  cell differentiation  positive regulation of cell migration  mammary gland development  anchored component of membrane  somatic stem cell population maintenance  cellular response to hepatocyte growth factor stimulus  nodal signaling pathway  nodal binding  negative regulation of apoptotic process  cellular response to fibroblast growth factor stimulus  membrane raft  anatomical structure development  positive regulation of peptidyl-tyrosine phosphorylation  activin receptor binding  cellular response to interferon-gamma  cellular response to interleukin-6  cellular response to tumor necrosis factor  cellular response to epidermal growth factor stimulus  
NDEx NetworkTDGF1
Atlas of Cancer Signalling NetworkTDGF1
Wikipedia pathwaysTDGF1
Orthology - Evolution
OrthoDB6997
GeneTree (enSembl)ENSG00000241186
Phylogenetic Trees/Animal Genes : TreeFamTDGF1
Homologs : HomoloGeneTDGF1
Homology/Alignments : Family Browser (UCSC)TDGF1
Gene fusions - Rearrangements
Fusion : QuiverTDGF1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTDGF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TDGF1
dbVarTDGF1
ClinVarTDGF1
MonarchTDGF1
1000_GenomesTDGF1 
Exome Variant ServerTDGF1
GNOMAD BrowserENSG00000241186
Varsome BrowserTDGF1
ACMGTDGF1 variants
VarityP13385
Genomic Variants (DGV)TDGF1 [DGVbeta]
DECIPHERTDGF1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTDGF1 
Mutations
ICGC Data PortalTDGF1 
TCGA Data PortalTDGF1 
Broad Tumor PortalTDGF1
OASIS PortalTDGF1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTDGF1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTDGF1
Mutations and Diseases : HGMDTDGF1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTDGF1
DgiDB (Drug Gene Interaction Database)TDGF1
DoCM (Curated mutations)TDGF1
CIViC (Clinical Interpretations of Variants in Cancer)TDGF1
Cancer3DTDGF1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM187395   
Orphanet20436    20435    18904    12486    12484    12485   
DisGeNETTDGF1
MedgenTDGF1
Genetic Testing Registry TDGF1
NextProtP13385 [Medical]
GENETestsTDGF1
Target ValidationTDGF1
Huge Navigator TDGF1 [HugePedia]
ClinGenTDGF1 (curated)
Clinical trials, drugs, therapy
MyCancerGenomeTDGF1
Protein Interactions : CTDTDGF1
Pharm GKB GenePA36420
PharosP13385
Clinical trialTDGF1
Miscellaneous
canSAR (ICR)TDGF1
HarmonizomeTDGF1
DataMed IndexTDGF1
Probes
Litterature
PubMed111 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTDGF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:34:39 CEST 2021

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