Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TDGF1 (teratocarcinoma-derived growth factor 1)

Identity

Alias_symbol (synonym)CRIPTO
CR
Cripto-1
Other aliasCRGF
HGNC (Hugo) TDGF1
LocusID (NCBI) 6997
Atlas_Id 42507
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 46616045 and ends at 46623952 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
TDGF1P3 (Xq23) / TDGF1 (3p21.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TDGF1   11701
Cards
Entrez_Gene (NCBI)TDGF1  6997  teratocarcinoma-derived growth factor 1
AliasesCR; CRGF; CRIPTO
GeneCards (Weizmann)TDGF1
Ensembl hg19 (Hinxton)ENSG00000241186 [Gene_View]  chr3:46616045-46623952 [Contig_View]  TDGF1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000241186 [Gene_View]  chr3:46616045-46623952 [Contig_View]  TDGF1 [Vega]
ICGC DataPortalENSG00000241186
TCGA cBioPortalTDGF1
AceView (NCBI)TDGF1
Genatlas (Paris)TDGF1
WikiGenes6997
SOURCE (Princeton)TDGF1
Genetics Home Reference (NIH)TDGF1
Genomic and cartography
GoldenPath hg19 (UCSC)TDGF1  -     chr3:46616045-46623952 +  3p21.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TDGF1  -     3p21.31   [Description]    (hg38-Dec_2013)
EnsemblTDGF1 - 3p21.31 [CytoView hg19]  TDGF1 - 3p21.31 [CytoView hg38]
Mapping of homologs : NCBITDGF1 [Mapview hg19]  TDGF1 [Mapview hg38]
OMIM187395   
Gene and transcription
Genbank (Entrez)AK313319 AU125451 BC022393 BC067844 CX755454
RefSeq transcript (Entrez)NM_001174136 NM_003212
RefSeq genomic (Entrez)NC_000003 NC_018914 NG_017049 NG_021214 NT_022517 NW_004929309
Consensus coding sequences : CCDS (NCBI)TDGF1
Cluster EST : UnigeneHs.385870 [ NCBI ]
CGAP (NCI)Hs.385870
Alternative Splicing GalleryENSG00000241186
Gene ExpressionTDGF1 [ NCBI-GEO ]   TDGF1 [ EBI - ARRAY_EXPRESS ]   TDGF1 [ SEEK ]   TDGF1 [ MEM ]
Gene Expression Viewer (FireBrowse)TDGF1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6997
GTEX Portal (Tissue expression)TDGF1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP13385   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP13385  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP13385
Splice isoforms : SwissVarP13385
PhosPhoSitePlusP13385
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_3 (PS50026)   
Domains : Interpro (EBI)Cripto_growth_factor    Cryptic/Cripto_CFC-dom    EGF-like_CS    EGF-like_dom   
Domain families : Pfam (Sanger)CFC (PF09443)   
Domain families : Pfam (NCBI)pfam09443   
Domain families : Smart (EMBL)EGF (SM00181)  
Conserved Domain (NCBI)TDGF1
DMDM Disease mutations6997
Blocks (Seattle)TDGF1
SuperfamilyP13385
Human Protein AtlasENSG00000241186
Peptide AtlasP13385
HPRD01757
IPIIPI00008499   IPI00956535   
Protein Interaction databases
DIP (DOE-UCLA)P13385
IntAct (EBI)P13385
FunCoupENSG00000241186
BioGRIDTDGF1
STRING (EMBL)TDGF1
ZODIACTDGF1
Ontologies - Pathways
QuickGOP13385
Ontology : AmiGOactivation of MAPK activity  morphogenesis of a branching structure  cell migration involved in sprouting angiogenesis  receptor binding  protein binding  extracellular space  plasma membrane  epidermal growth factor receptor signaling pathway  heart development  growth factor activity  positive regulation of cell proliferation  positive regulation of cell proliferation  anterior/posterior axis specification, embryo  embryo development  regulation of signal transduction  cell surface  positive regulation of endothelial cell migration  apical plasma membrane  peptidyl-serine phosphorylation  extrinsic component of plasma membrane  cell differentiation  positive regulation of cell migration  mammary gland development  anchored component of membrane  somatic stem cell population maintenance  cellular response to hepatocyte growth factor stimulus  negative regulation of apoptotic process  cellular response to fibroblast growth factor stimulus  membrane raft  positive regulation of peptidyl-tyrosine phosphorylation  cellular response to interferon-gamma  cellular response to interleukin-6  cellular response to tumor necrosis factor  cellular response to epidermal growth factor stimulus  
Ontology : EGO-EBIactivation of MAPK activity  morphogenesis of a branching structure  cell migration involved in sprouting angiogenesis  receptor binding  protein binding  extracellular space  plasma membrane  epidermal growth factor receptor signaling pathway  heart development  growth factor activity  positive regulation of cell proliferation  positive regulation of cell proliferation  anterior/posterior axis specification, embryo  embryo development  regulation of signal transduction  cell surface  positive regulation of endothelial cell migration  apical plasma membrane  peptidyl-serine phosphorylation  extrinsic component of plasma membrane  cell differentiation  positive regulation of cell migration  mammary gland development  anchored component of membrane  somatic stem cell population maintenance  cellular response to hepatocyte growth factor stimulus  negative regulation of apoptotic process  cellular response to fibroblast growth factor stimulus  membrane raft  positive regulation of peptidyl-tyrosine phosphorylation  cellular response to interferon-gamma  cellular response to interleukin-6  cellular response to tumor necrosis factor  cellular response to epidermal growth factor stimulus  
NDEx NetworkTDGF1
Atlas of Cancer Signalling NetworkTDGF1
Wikipedia pathwaysTDGF1
Orthology - Evolution
OrthoDB6997
GeneTree (enSembl)ENSG00000241186
Phylogenetic Trees/Animal Genes : TreeFamTDGF1
HOVERGENP13385
HOGENOMP13385
Homologs : HomoloGeneTDGF1
Homology/Alignments : Family Browser (UCSC)TDGF1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTDGF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TDGF1
dbVarTDGF1
ClinVarTDGF1
1000_GenomesTDGF1 
Exome Variant ServerTDGF1
ExAC (Exome Aggregation Consortium)TDGF1 (select the gene name)
Genetic variants : HAPMAP6997
Genomic Variants (DGV)TDGF1 [DGVbeta]
DECIPHER (Syndromes)3:46616045-46623952  ENSG00000241186
CONAN: Copy Number AnalysisTDGF1 
Mutations
ICGC Data PortalTDGF1 
TCGA Data PortalTDGF1 
Broad Tumor PortalTDGF1
OASIS PortalTDGF1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTDGF1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTDGF1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TDGF1
DgiDB (Drug Gene Interaction Database)TDGF1
DoCM (Curated mutations)TDGF1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TDGF1 (select a term)
intoGenTDGF1
Cancer3DTDGF1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM187395   
Orphanet20436    20435    18904    12486    12484    12485   
MedgenTDGF1
Genetic Testing Registry TDGF1
NextProtP13385 [Medical]
TSGene6997
GENETestsTDGF1
Huge Navigator TDGF1 [HugePedia]
snp3D : Map Gene to Disease6997
BioCentury BCIQTDGF1
ClinGenTDGF1 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6997
Chemical/Pharm GKB GenePA36420
Clinical trialTDGF1
Miscellaneous
canSAR (ICR)TDGF1 (select the gene name)
Probes
Litterature
PubMed79 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTDGF1
EVEXTDGF1
GoPubMedTDGF1
iHOPTDGF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:22:06 CEST 2017

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