Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TICAM1 (toll-like receptor adaptor molecule 1)

Identity

Other namesIIAE6
PRVTIRB
TICAM-1
TRIF
HGNC (Hugo) TICAM1
LocusID (NCBI) 148022
Location 19p13.3
Location_base_pair Starts at 4815936 and ends at 4831754 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TICAM1   18348
Entrez_Gene (NCBI)TICAM1  148022  toll-like receptor adaptor molecule 1
Cards
GeneCards (Weizmann)TICAM1
Ensembl (Hinxton)ENSG00000127666 [Gene_View]  chr19:4815936-4831754 [Contig_View]  TICAM1 [Vega]
AceView (NCBI)TICAM1
Genatlas (Paris)TICAM1
SOURCE (Stanford)NM_014261 NM_182919
Genomic and cartography
GoldenPath (UCSC)TICAM1  -  19p13.3   chr19:4815936-4831754 -  19p13.3   [Description]    (hg19-Feb_2009)
EnsemblTICAM1 - 19p13.3 [CytoView]
Mapping of homologs : NCBITICAM1 [Mapview]
OMIM607601   614850   
Gene and transcription
Genbank (Entrez)AB086380 AB093555 AB097023 AB446484 AF070530
RefSeq transcript (SRS)NM_014261 NM_182919
RefSeq transcript (Entrez)NM_014261 NM_182919
RefSeq genomic (SRS)AC_000151 NC_000019 NC_018930 NG_031998 NT_011255 NW_001838477 NW_004078096
RefSeq genomic (Entrez)AC_000151 NC_000019 NC_018930 NG_031998 NT_011255 NW_001838477 NW_004078096
Consensus coding sequences : CCDS (NCBI)TICAM1
Cluster EST : UnigeneHs.29344 [ SRS ] Hs.29344 [ NCBI ]
CGAP (NCI)Hs.29344
Alternative Splicing : Fast-db (Paris)GSHG0015389
Alternative Splicing GalleryENSG00000127666
Gene ExpressionTICAM1 [ NCBI-GEO ]   TICAM1 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IUC6 (SRS) Q8IUC6 (Uniprot)
NextProtQ8IUC6
With graphics : InterProQ8IUC6
Splice isoforms : SwissVarQ8IUC6(Swissvar)
Domaine pattern : Prosite (SRS)TIR (PS50104)   
Domaine pattern : Prosite (Expaxy)TIR (PS50104)   
Domains : Interpro (SRS)RHIM_dom    Tol-interleuk_rcpt_adapt_Ticam   
Domains : Interpro (EBI)RHIM_dom    Tol-interleuk_rcpt_adapt_Ticam   
Related proteins : CluSTrQ8IUC6
Domain families : Pfam (SRS)RHIM (PF12721)   
Domain families : Pfam (Sanger)RHIM (PF12721)   
Domain families : Pfam (NCBI)pfam12721   
DMDM148022
Blocks (Seattle)Q8IUC6
PDB (SRS)3RC4   
PDB (PDBSum)3RC4   
PDB (IMB)3RC4   
PDB (RSDB)3RC4   
Human Protein AtlasENSG00000127666
HPRD06350
IPIIPI00216715   
Protein Interaction databases
DIP (DOE-UCLA)Q8IUC6
IntAct (EBI)Q8IUC6
FunCoupENSG00000127666
REACTOMETICAM1
Protein Interaction Database148022
BioGRIDTICAM1
InParanoidQ8IUC6
Interologous Interaction database Q8IUC6
IntegromeDBTICAM1
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)TICAM1
SNP (GeneSNP Utah)TICAM1
SNP : HGBaseTICAM1
Genetic variants : HAPMAPTICAM1
Somatic Mutations in Cancer : COSMICTICAM1 
CONAN: Copy Number AnalysisTICAM1 
Mutations and Diseases : HGMDTICAM1
OMIM607601    614850   
GENETests607601    614850   
Disease Genetic AssociationTICAM1
Huge Navigator TICAM1 [HugePedia]  TICAM1 [HugeCancerGEM]
Genomic VariantsTICAM1  TICAM1 [DGVbeta]
snp3D : Map Gene to Disease148022
General knowledge
Homologs : HomoloGeneTICAM1
Homology/Alignments : Family Browser (UCSC)TICAM1
Phylogenetic Trees/Animal Genes : TreeFamTICAM1
Chemical/Protein Interactions : CTD148022
Chemical/Pharm GKB GenePA142670812
Clinical trialTICAM1
Cancer Resource (Charite)ENSG00000127666
Ontology : AmiGOmacrophage activation involved in immune response  MyD88-independent toll-like receptor signaling pathway  signal transducer activity  protein binding  cytosol  apoptotic process  inflammatory response  I-kappaB kinase/NF-kappaB cascade  Toll signaling pathway  endosome membrane  protein kinase binding  positive regulation of B cell proliferation  positive regulation of protein ubiquitination  lipopolysaccharide-mediated signaling pathway  positive regulation of protein binding  positive regulation of type I interferon production  positive regulation of interleukin-6 production  positive regulation of tumor necrosis factor production  toll-like receptor 3 signaling pathway  toll-like receptor 4 signaling pathway  TRIF-dependent toll-like receptor signaling pathway  positive regulation of I-kappaB kinase/NF-kappaB cascade  response to exogenous dsRNA  regulation of protein homodimerization activity  positive regulation of chemokine biosynthetic process  innate immune response  positive regulation of interferon-beta biosynthetic process  positive regulation of nitric oxide biosynthetic process  positive regulation of NF-kappaB transcription factor activity  defense response to virus  
Ontology : EGO-EBImacrophage activation involved in immune response  MyD88-independent toll-like receptor signaling pathway  signal transducer activity  protein binding  cytosol  apoptotic process  inflammatory response  I-kappaB kinase/NF-kappaB cascade  Toll signaling pathway  endosome membrane  protein kinase binding  positive regulation of B cell proliferation  positive regulation of protein ubiquitination  lipopolysaccharide-mediated signaling pathway  positive regulation of protein binding  positive regulation of type I interferon production  positive regulation of interleukin-6 production  positive regulation of tumor necrosis factor production  toll-like receptor 3 signaling pathway  toll-like receptor 4 signaling pathway  TRIF-dependent toll-like receptor signaling pathway  positive regulation of I-kappaB kinase/NF-kappaB cascade  response to exogenous dsRNA  regulation of protein homodimerization activity  positive regulation of chemokine biosynthetic process  innate immune response  positive regulation of interferon-beta biosynthetic process  positive regulation of nitric oxide biosynthetic process  positive regulation of NF-kappaB transcription factor activity  defense response to virus  
Pathways : KEGGToll-like receptor signaling pathway
Other databases
Probes
Litterature
PubMed82 Pubmed reference(s) in Entrez
PubGeneTICAM1
iHOPTICAM1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:22:53 CEST 2013
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