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TICAM1 (toll-like receptor adaptor molecule 1)

Identity

Other namesIIAE6
MyD88-3
PRVTIRB
TICAM-1
TRIF
HGNC (Hugo) TICAM1
LocusID (NCBI) 148022
Location 19p13.3
Location_base_pair Starts at 4815936 and ends at 4831754 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TICAM1   18348
Cards
Entrez_Gene (NCBI)TICAM1  148022  toll-like receptor adaptor molecule 1
GeneCards (Weizmann)TICAM1
Ensembl (Hinxton)ENSG00000127666 [Gene_View]  chr19:4815936-4831754 [Contig_View]  TICAM1 [Vega]
AceView (NCBI)TICAM1
Genatlas (Paris)TICAM1
WikiGenes148022
SOURCE (Princeton)NM_014261 NM_182919
Genomic and cartography
GoldenPath (UCSC)TICAM1  -  19p13.3   chr19:4815936-4831754 -  19p13.3   [Description]    (hg19-Feb_2009)
EnsemblTICAM1 - 19p13.3 [CytoView]
Mapping of homologs : NCBITICAM1 [Mapview]
OMIM607601   614850   
Gene and transcription
Genbank (Entrez)AB086380 AB093555 AB097023 AB446484 AF070530
RefSeq transcript (Entrez)NM_014261 NM_182919
RefSeq genomic (Entrez)AC_000151 NC_000019 NC_018930 NG_031998 NT_011255 NW_001838477 NW_004929412
Consensus coding sequences : CCDS (NCBI)TICAM1
Cluster EST : UnigeneHs.29344 [ NCBI ]
CGAP (NCI)Hs.29344
Alternative Splicing : Fast-db (Paris)GSHG0015389
Alternative Splicing GalleryENSG00000127666
Gene ExpressionTICAM1 [ NCBI-GEO ]     TICAM1 [ SEEK ]   TICAM1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IUC6 (Uniprot)
NextProtQ8IUC6  [Medical]
With graphics : InterProQ8IUC6
Splice isoforms : SwissVarQ8IUC6 (Swissvar)
Domaine pattern : Prosite (Expaxy)TIR (PS50104)   
Domains : Interpro (EBI)RHIM_dom    TICAM1    TIR_dom   
Related proteins : CluSTrQ8IUC6
Domain families : Pfam (Sanger)RHIM (PF12721)   
Domain families : Pfam (NCBI)pfam12721   
DMDM Disease mutations148022
Blocks (Seattle)Q8IUC6
PDB (SRS)3RC4   
PDB (PDBSum)3RC4   
PDB (IMB)3RC4   
PDB (RSDB)3RC4   
Human Protein AtlasENSG00000127666
Peptide AtlasQ8IUC6
HPRD06350
IPIIPI00216715   
Protein Interaction databases
DIP (DOE-UCLA)Q8IUC6
IntAct (EBI)Q8IUC6
FunCoupENSG00000127666
BioGRIDTICAM1
InParanoidQ8IUC6
Interologous Interaction database Q8IUC6
IntegromeDBTICAM1
STRING (EMBL)TICAM1
Ontologies - Pathways
Ontology : AmiGOtoll-like receptor signaling pathway  macrophage activation involved in immune response  MyD88-independent toll-like receptor signaling pathway  signal transducer activity  protein binding  cytosol  inflammatory response  I-kappaB kinase/NF-kappaB cascade  endosome membrane  protein kinase binding  positive regulation of B cell proliferation  positive regulation of protein ubiquitination  lipopolysaccharide-mediated signaling pathway  positive regulation of protein binding  positive regulation of type I interferon production  positive regulation of interleukin-6 production  positive regulation of tumor necrosis factor production  toll-like receptor 3 signaling pathway  toll-like receptor 4 signaling pathway  TRIF-dependent toll-like receptor signaling pathway  positive regulation of I-kappaB kinase/NF-kappaB cascade  response to exogenous dsRNA  regulation of protein homodimerization activity  positive regulation of chemokine biosynthetic process  innate immune response  positive regulation of interferon-beta biosynthetic process  positive regulation of nitric oxide biosynthetic process  positive regulation of NF-kappaB transcription factor activity  defense response to virus  apoptotic signaling pathway  ripoptosome  
Ontology : EGO-EBItoll-like receptor signaling pathway  macrophage activation involved in immune response  MyD88-independent toll-like receptor signaling pathway  signal transducer activity  protein binding  cytosol  inflammatory response  I-kappaB kinase/NF-kappaB cascade  endosome membrane  protein kinase binding  positive regulation of B cell proliferation  positive regulation of protein ubiquitination  lipopolysaccharide-mediated signaling pathway  positive regulation of protein binding  positive regulation of type I interferon production  positive regulation of interleukin-6 production  positive regulation of tumor necrosis factor production  toll-like receptor 3 signaling pathway  toll-like receptor 4 signaling pathway  TRIF-dependent toll-like receptor signaling pathway  positive regulation of I-kappaB kinase/NF-kappaB cascade  response to exogenous dsRNA  regulation of protein homodimerization activity  positive regulation of chemokine biosynthetic process  innate immune response  positive regulation of interferon-beta biosynthetic process  positive regulation of nitric oxide biosynthetic process  positive regulation of NF-kappaB transcription factor activity  defense response to virus  apoptotic signaling pathway  ripoptosome  
Pathways : KEGGNF-kappa B signaling pathway    Toll-like receptor signaling pathway    Pertussis    Chagas disease (American trypanosomiasis)    Hepatitis C    Hepatitis B    Influenza A    Herpes simplex infection   
REACTOMETICAM1
Protein Interaction DatabaseTICAM1
Wikipedia pathwaysTICAM1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)TICAM1
SNP (GeneSNP Utah)TICAM1
SNP : HGBaseTICAM1
Genetic variants : HAPMAPTICAM1
1000_GenomesTICAM1 
ICGC programENSG00000127666 
Somatic Mutations in Cancer : COSMICTICAM1 
CONAN: Copy Number AnalysisTICAM1 
Mutations and Diseases : HGMDTICAM1
OMIM607601    614850   
GENETestsTICAM1
Disease Genetic AssociationTICAM1
Huge Navigator TICAM1 [HugePedia]  TICAM1 [HugeCancerGEM]
Genomic VariantsTICAM1  TICAM1 [DGVbeta]
Exome VariantTICAM1
dbVarTICAM1
ClinVarTICAM1
snp3D : Map Gene to Disease148022
General knowledge
Homologs : HomoloGeneTICAM1
Homology/Alignments : Family Browser (UCSC)TICAM1
Phylogenetic Trees/Animal Genes : TreeFamTICAM1
Chemical/Protein Interactions : CTD148022
Chemical/Pharm GKB GenePA142670812
Clinical trialTICAM1
Cancer Resource (Charite)ENSG00000127666
Other databases
Probes
Litterature
PubMed88 Pubmed reference(s) in Entrez
CoreMineTICAM1
iHOPTICAM1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Mar 31 09:11:51 CEST 2014

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