Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TIMELESS (timeless circadian clock)

Identity

Alias_namestimeless (Drosophila) homolog
timeless homolog (Drosophila)
Alias_symbol (synonym)hTIM
TIM
TIM1
Other alias
HGNC (Hugo) TIMELESS
LocusID (NCBI) 8914
Atlas_Id 49895
Location 12q13.3  [Link to chromosome band 12q13]
Location_base_pair Starts at 56416373 and ends at 56449465 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
POLA1 (Xp22.11) / TIMELESS (12q13.3)TIMELESS (12q13.3) / RPS15 (19p13.3)POLA1 Xp22.11 / TIMELESS 12q13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TIMELESS   11813
Cards
Entrez_Gene (NCBI)TIMELESS  8914  timeless circadian clock
AliasesTIM; TIM1; hTIM
GeneCards (Weizmann)TIMELESS
Ensembl hg19 (Hinxton)ENSG00000111602 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111602 [Gene_View]  chr12:56416373-56449465 [Contig_View]  TIMELESS [Vega]
ICGC DataPortalENSG00000111602
TCGA cBioPortalTIMELESS
AceView (NCBI)TIMELESS
Genatlas (Paris)TIMELESS
WikiGenes8914
SOURCE (Princeton)TIMELESS
Genetics Home Reference (NIH)TIMELESS
Genomic and cartography
GoldenPath hg38 (UCSC)TIMELESS  -     chr12:56416373-56449465 -  12q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TIMELESS  -     12q13.3   [Description]    (hg19-Feb_2009)
EnsemblTIMELESS - 12q13.3 [CytoView hg19]  TIMELESS - 12q13.3 [CytoView hg38]
Mapping of homologs : NCBITIMELESS [Mapview hg19]  TIMELESS [Mapview hg38]
OMIM603887   
Gene and transcription
Genbank (Entrez)AB015597 AF098162 AK000721 AK022702 AK296869
RefSeq transcript (Entrez)NM_001330295 NM_003920
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TIMELESS
Cluster EST : UnigeneHs.118631 [ NCBI ]
CGAP (NCI)Hs.118631
Alternative Splicing GalleryENSG00000111602
Gene ExpressionTIMELESS [ NCBI-GEO ]   TIMELESS [ EBI - ARRAY_EXPRESS ]   TIMELESS [ SEEK ]   TIMELESS [ MEM ]
Gene Expression Viewer (FireBrowse)TIMELESS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8914
GTEX Portal (Tissue expression)TIMELESS
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UNS1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UNS1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UNS1
Splice isoforms : SwissVarQ9UNS1
PhosPhoSitePlusQ9UNS1
Domains : Interpro (EBI)Timeless    TIMELESS_C   
Domain families : Pfam (Sanger)TIMELESS (PF04821)    TIMELESS_C (PF05029)   
Domain families : Pfam (NCBI)pfam04821    pfam05029   
Conserved Domain (NCBI)TIMELESS
DMDM Disease mutations8914
Blocks (Seattle)TIMELESS
PDB (SRS)4XHT    4XHU    4XHW   
PDB (PDBSum)4XHT    4XHU    4XHW   
PDB (IMB)4XHT    4XHU    4XHW   
PDB (RSDB)4XHT    4XHU    4XHW   
Structural Biology KnowledgeBase4XHT    4XHU    4XHW   
SCOP (Structural Classification of Proteins)4XHT    4XHU    4XHW   
CATH (Classification of proteins structures)4XHT    4XHU    4XHW   
SuperfamilyQ9UNS1
Human Protein AtlasENSG00000111602
Peptide AtlasQ9UNS1
HPRD04864
IPIIPI00335541   IPI00554678   IPI00816132   IPI00909597   
Protein Interaction databases
DIP (DOE-UCLA)Q9UNS1
IntAct (EBI)Q9UNS1
FunCoupENSG00000111602
BioGRIDTIMELESS
STRING (EMBL)TIMELESS
ZODIACTIMELESS
Ontologies - Pathways
QuickGOQ9UNS1
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  nuclear chromatin  morphogenesis of an epithelium  protein binding  nucleus  nucleus  nucleoplasm  DNA replication  transcription, DNA-templated  cellular response to DNA damage stimulus  cellular response to DNA damage stimulus  circadian rhythm  detection of abiotic stimulus  response to abiotic stimulus  lung development  regulation of cell proliferation  regulation of circadian rhythm  protein homodimerization activity  cell cycle phase transition  negative regulation of transcription, DNA-templated  protein heterodimerization activity  branching morphogenesis of an epithelial tube  cell division  cellular response to hydroxyurea  cellular response to cisplatin  cellular response to bleomycin  positive regulation of double-strand break repair  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  nuclear chromatin  morphogenesis of an epithelium  protein binding  nucleus  nucleus  nucleoplasm  DNA replication  transcription, DNA-templated  cellular response to DNA damage stimulus  cellular response to DNA damage stimulus  circadian rhythm  detection of abiotic stimulus  response to abiotic stimulus  lung development  regulation of cell proliferation  regulation of circadian rhythm  protein homodimerization activity  cell cycle phase transition  negative regulation of transcription, DNA-templated  protein heterodimerization activity  branching morphogenesis of an epithelial tube  cell division  cellular response to hydroxyurea  cellular response to cisplatin  cellular response to bleomycin  positive regulation of double-strand break repair  
NDEx NetworkTIMELESS
Atlas of Cancer Signalling NetworkTIMELESS
Wikipedia pathwaysTIMELESS
Orthology - Evolution
OrthoDB8914
GeneTree (enSembl)ENSG00000111602
Phylogenetic Trees/Animal Genes : TreeFamTIMELESS
HOVERGENQ9UNS1
HOGENOMQ9UNS1
Homologs : HomoloGeneTIMELESS
Homology/Alignments : Family Browser (UCSC)TIMELESS
Gene fusions - Rearrangements
Fusion : MitelmanPOLA1/TIMELESS [Xp22.11/12q13.3]  [t(X;12)(p22;q13)]  
Fusion: TCGAPOLA1 Xp22.11 TIMELESS 12q13.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTIMELESS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TIMELESS
dbVarTIMELESS
ClinVarTIMELESS
1000_GenomesTIMELESS 
Exome Variant ServerTIMELESS
ExAC (Exome Aggregation Consortium)TIMELESS (select the gene name)
Genetic variants : HAPMAP8914
Genomic Variants (DGV)TIMELESS [DGVbeta]
DECIPHERTIMELESS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTIMELESS 
Mutations
ICGC Data PortalTIMELESS 
TCGA Data PortalTIMELESS 
Broad Tumor PortalTIMELESS
OASIS PortalTIMELESS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTIMELESS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTIMELESS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TIMELESS
DgiDB (Drug Gene Interaction Database)TIMELESS
DoCM (Curated mutations)TIMELESS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TIMELESS (select a term)
intoGenTIMELESS
Cancer3DTIMELESS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603887   
Orphanet
MedgenTIMELESS
Genetic Testing Registry TIMELESS
NextProtQ9UNS1 [Medical]
TSGene8914
GENETestsTIMELESS
Target ValidationTIMELESS
Huge Navigator TIMELESS [HugePedia]
snp3D : Map Gene to Disease8914
BioCentury BCIQTIMELESS
ClinGenTIMELESS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8914
Chemical/Pharm GKB GenePA36520
Clinical trialTIMELESS
Miscellaneous
canSAR (ICR)TIMELESS (select the gene name)
Probes
Litterature
PubMed73 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTIMELESS
EVEXTIMELESS
GoPubMedTIMELESS
iHOPTIMELESS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:09:43 CEST 2017

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