Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

TIMELESS (timeless circadian regulator)

Identity

Alias (NCBI)TIM
TIM1
hTIM
HGNC (Hugo) TIMELESS
HGNC Alias symbhTIM
TIM
TIM1
HGNC Alias nameTof1 homolog (S. cerevisiae)
 timeless circadian clock 1
HGNC Previous nametimeless (Drosophila) homolog
 timeless homolog (Drosophila)
LocusID (NCBI) 8914
Atlas_Id 49895
Location 12q13.3  [Link to chromosome band 12q13]
Location_base_pair Starts at 56416363 and ends at 56449426 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
POLA1 (Xp22.11) / TIMELESS (12q13.3)TIMELESS (12q13.3) / RPS15 (19p13.3)POLA1 Xp22.11 / TIMELESS 12q13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TIMELESS   11813
Cards
Entrez_Gene (NCBI)TIMELESS    timeless circadian regulator
AliasesTIM; TIM1; hTIM
GeneCards (Weizmann)TIMELESS
Ensembl hg19 (Hinxton)ENSG00000111602 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111602 [Gene_View]  ENSG00000111602 [Sequence]  chr12:56416363-56449426 [Contig_View]  TIMELESS [Vega]
ICGC DataPortalENSG00000111602
TCGA cBioPortalTIMELESS
AceView (NCBI)TIMELESS
Genatlas (Paris)TIMELESS
SOURCE (Princeton)TIMELESS
Genetics Home Reference (NIH)TIMELESS
Genomic and cartography
GoldenPath hg38 (UCSC)TIMELESS  -     chr12:56416363-56449426 -  12q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TIMELESS  -     12q13.3   [Description]    (hg19-Feb_2009)
GoldenPathTIMELESS - 12q13.3 [CytoView hg19]  TIMELESS - 12q13.3 [CytoView hg38]
ImmunoBaseENSG00000111602
Genome Data Viewer NCBITIMELESS [Mapview hg19]  
OMIM603887   
Gene and transcription
Genbank (Entrez)AB015597 AF098162 AK000721 AK022702 AK296869
RefSeq transcript (Entrez)NM_001330295 NM_003920
Consensus coding sequences : CCDS (NCBI)TIMELESS
Gene ExpressionTIMELESS [ NCBI-GEO ]   TIMELESS [ EBI - ARRAY_EXPRESS ]   TIMELESS [ SEEK ]   TIMELESS [ MEM ]
Gene Expression Viewer (FireBrowse)TIMELESS [ Firebrowse - Broad ]
GenevisibleExpression of TIMELESS in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8914
GTEX Portal (Tissue expression)TIMELESS
Human Protein AtlasENSG00000111602-TIMELESS [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UNS1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UNS1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UNS1
PhosPhoSitePlusQ9UNS1
Domains : Interpro (EBI)TIMELESS_C    Timeless_N   
Domain families : Pfam (Sanger)TIMELESS (PF04821)    TIMELESS_C (PF05029)   
Domain families : Pfam (NCBI)pfam04821    pfam05029   
Conserved Domain (NCBI)TIMELESS
PDB (RSDB)4XHT    4XHU    4XHW    5MQI    6T9Q    6TAZ   
PDB Europe4XHT    4XHU    4XHW    5MQI    6T9Q    6TAZ   
PDB (PDBSum)4XHT    4XHU    4XHW    5MQI    6T9Q    6TAZ   
PDB (IMB)4XHT    4XHU    4XHW    5MQI    6T9Q    6TAZ   
Structural Biology KnowledgeBase4XHT    4XHU    4XHW    5MQI    6T9Q    6TAZ   
SCOP (Structural Classification of Proteins)4XHT    4XHU    4XHW    5MQI    6T9Q    6TAZ   
CATH (Classification of proteins structures)4XHT    4XHU    4XHW    5MQI    6T9Q    6TAZ   
SuperfamilyQ9UNS1
AlphaFold pdb e-kbQ9UNS1   
Human Protein Atlas [tissue]ENSG00000111602-TIMELESS [tissue]
HPRD04864
Protein Interaction databases
DIP (DOE-UCLA)Q9UNS1
IntAct (EBI)Q9UNS1
BioGRIDTIMELESS
STRING (EMBL)TIMELESS
ZODIACTIMELESS
Ontologies - Pathways
QuickGOQ9UNS1
Ontology : AmiGODNA replication checkpoint signaling  chromatin  morphogenesis of an epithelium  DNA binding  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  DNA replication  DNA repair  cellular response to DNA damage stimulus  cellular response to DNA damage stimulus  multicellular organism development  circadian rhythm  detection of abiotic stimulus  replication fork protection complex  site of double-strand break  regulation of cell population proliferation  regulation of circadian rhythm  replication fork arrest  cell cycle phase transition  negative regulation of transcription, DNA-templated  replication fork protection  cell division  cellular response to hydroxyurea  cellular response to cisplatin  cellular response to bleomycin  positive regulation of double-strand break repair via homologous recombination  positive regulation of double-strand break repair  
Ontology : EGO-EBIDNA replication checkpoint signaling  chromatin  morphogenesis of an epithelium  DNA binding  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  DNA replication  DNA repair  cellular response to DNA damage stimulus  cellular response to DNA damage stimulus  multicellular organism development  circadian rhythm  detection of abiotic stimulus  replication fork protection complex  site of double-strand break  regulation of cell population proliferation  regulation of circadian rhythm  replication fork arrest  cell cycle phase transition  negative regulation of transcription, DNA-templated  replication fork protection  cell division  cellular response to hydroxyurea  cellular response to cisplatin  cellular response to bleomycin  positive regulation of double-strand break repair via homologous recombination  positive regulation of double-strand break repair  
NDEx NetworkTIMELESS
Atlas of Cancer Signalling NetworkTIMELESS
Wikipedia pathwaysTIMELESS
Orthology - Evolution
OrthoDB8914
GeneTree (enSembl)ENSG00000111602
Phylogenetic Trees/Animal Genes : TreeFamTIMELESS
Homologs : HomoloGeneTIMELESS
Homology/Alignments : Family Browser (UCSC)TIMELESS
Gene fusions - Rearrangements
Fusion : MitelmanPOLA1/TIMELESS [Xp22.11/12q13.3]  
Fusion : QuiverTIMELESS
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTIMELESS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TIMELESS
dbVarTIMELESS
ClinVarTIMELESS
MonarchTIMELESS
1000_GenomesTIMELESS 
Exome Variant ServerTIMELESS
GNOMAD BrowserENSG00000111602
Varsome BrowserTIMELESS
ACMGTIMELESS variants
VarityQ9UNS1
Genomic Variants (DGV)TIMELESS [DGVbeta]
DECIPHERTIMELESS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTIMELESS 
Mutations
ICGC Data PortalTIMELESS 
TCGA Data PortalTIMELESS 
Broad Tumor PortalTIMELESS
OASIS PortalTIMELESS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTIMELESS  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTIMELESS
Mutations and Diseases : HGMDTIMELESS
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTIMELESS
DgiDB (Drug Gene Interaction Database)TIMELESS
DoCM (Curated mutations)TIMELESS
CIViC (Clinical Interpretations of Variants in Cancer)TIMELESS
Cancer3DTIMELESS
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603887   
Orphanet
DisGeNETTIMELESS
MedgenTIMELESS
Genetic Testing Registry TIMELESS
NextProtQ9UNS1 [Medical]
GENETestsTIMELESS
Target ValidationTIMELESS
Huge Navigator TIMELESS [HugePedia]
ClinGenTIMELESS
Clinical trials, drugs, therapy
MyCancerGenomeTIMELESS
Protein Interactions : CTDTIMELESS
Pharm GKB GenePA36520
PharosQ9UNS1
Clinical trialTIMELESS
Miscellaneous
canSAR (ICR)TIMELESS
HarmonizomeTIMELESS
DataMed IndexTIMELESS
Probes
Litterature
PubMed105 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTIMELESS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:35:06 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.