Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TLR4 (toll like receptor 4)

Identity

Alias_namestoll-like receptor 4
Alias_symbol (synonym)hToll
CD284
TLR-4
ARMD10
Other aliasTOLL
HGNC (Hugo) TLR4
LocusID (NCBI) 7099
Atlas_Id 46368
Location 9q33.1  [Link to chromosome band 9q33]
Location_base_pair Starts at 117704175 and ends at 117717491 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TLR4   11850
Cards
Entrez_Gene (NCBI)TLR4  7099  toll like receptor 4
AliasesARMD10; CD284; TLR-4; TOLL
GeneCards (Weizmann)TLR4
Ensembl hg19 (Hinxton)ENSG00000136869 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136869 [Gene_View]  chr9:117704175-117717491 [Contig_View]  TLR4 [Vega]
ICGC DataPortalENSG00000136869
TCGA cBioPortalTLR4
AceView (NCBI)TLR4
Genatlas (Paris)TLR4
WikiGenes7099
SOURCE (Princeton)TLR4
Genetics Home Reference (NIH)TLR4
Genomic and cartography
GoldenPath hg38 (UCSC)TLR4  -     chr9:117704175-117717491 +  9q33.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TLR4  -     9q33.1   [Description]    (hg19-Feb_2009)
EnsemblTLR4 - 9q33.1 [CytoView hg19]  TLR4 - 9q33.1 [CytoView hg38]
Mapping of homologs : NCBITLR4 [Mapview hg19]  TLR4 [Mapview hg38]
OMIM603030   611488   
Gene and transcription
Genbank (Entrez)AA598398 AB445638 AK226155 AK290053 AK293068
RefSeq transcript (Entrez)NM_003266 NM_138554 NM_138556 NM_138557
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TLR4
Cluster EST : UnigeneHs.174312 [ NCBI ]
CGAP (NCI)Hs.174312
Alternative Splicing GalleryENSG00000136869
Gene ExpressionTLR4 [ NCBI-GEO ]   TLR4 [ EBI - ARRAY_EXPRESS ]   TLR4 [ SEEK ]   TLR4 [ MEM ]
Gene Expression Viewer (FireBrowse)TLR4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7099
GTEX Portal (Tissue expression)TLR4
Human Protein AtlasENSG00000136869-TLR4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00206   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00206  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00206
Splice isoforms : SwissVarO00206
PhosPhoSitePlusO00206
Domaine pattern : Prosite (Expaxy)LRR (PS51450)    TIR (PS50104)   
Domains : Interpro (EBI)Cys-rich_flank_reg_C    L_dom-like    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp    TIR_dom    TLR4   
Domain families : Pfam (Sanger)LRR_6 (PF13516)    LRR_8 (PF13855)    TIR (PF01582)   
Domain families : Pfam (NCBI)pfam13516    pfam13855    pfam01582   
Domain families : Smart (EMBL)LRR_TYP (SM00369)  LRRCT (SM00082)  TIR (SM00255)  
Conserved Domain (NCBI)TLR4
DMDM Disease mutations7099
Blocks (Seattle)TLR4
PDB (SRS)2Z62    2Z63    2Z65    2Z66    3FXI    3UL7    3UL8    3UL9    3ULA    4G8A   
PDB (PDBSum)2Z62    2Z63    2Z65    2Z66    3FXI    3UL7    3UL8    3UL9    3ULA    4G8A   
PDB (IMB)2Z62    2Z63    2Z65    2Z66    3FXI    3UL7    3UL8    3UL9    3ULA    4G8A   
PDB (RSDB)2Z62    2Z63    2Z65    2Z66    3FXI    3UL7    3UL8    3UL9    3ULA    4G8A   
Structural Biology KnowledgeBase2Z62    2Z63    2Z65    2Z66    3FXI    3UL7    3UL8    3UL9    3ULA    4G8A   
SCOP (Structural Classification of Proteins)2Z62    2Z63    2Z65    2Z66    3FXI    3UL7    3UL8    3UL9    3ULA    4G8A   
CATH (Classification of proteins structures)2Z62    2Z63    2Z65    2Z66    3FXI    3UL7    3UL8    3UL9    3ULA    4G8A   
SuperfamilyO00206
Human Protein Atlas [tissue]ENSG00000136869-TLR4 [tissue]
Peptide AtlasO00206
HPRD04325
IPIIPI00008673   IPI00374265   IPI00914904   IPI00954813   IPI00969398   
Protein Interaction databases
DIP (DOE-UCLA)O00206
IntAct (EBI)O00206
FunCoupENSG00000136869
BioGRIDTLR4
STRING (EMBL)TLR4
ZODIACTLR4
Ontologies - Pathways
QuickGOO00206
Ontology : AmiGOactivation of MAPK activity  lipopolysaccharide binding  lipopolysaccharide binding  lipopolysaccharide receptor activity  toll-like receptor signaling pathway  toll-like receptor signaling pathway  B cell proliferation involved in immune response  nitric oxide production involved in inflammatory response  regulation of dendritic cell cytokine production  MyD88-dependent toll-like receptor signaling pathway  MyD88-independent toll-like receptor signaling pathway  receptor activity  transmembrane signaling receptor activity  protein binding  cytoplasm  plasma membrane  plasma membrane  integral component of plasma membrane  inflammatory response  immune response  I-kappaB kinase/NF-kappaB signaling  I-kappaB phosphorylation  external side of plasma membrane  cell surface  endosome membrane  positive regulation of platelet activation  positive regulation of gene expression  astrocyte development  detection of fungus  positive regulation of B cell proliferation  intrinsic component of plasma membrane  lipopolysaccharide-mediated signaling pathway  lipopolysaccharide-mediated signaling pathway  response to lipopolysaccharide  response to lipopolysaccharide  detection of lipopolysaccharide  interferon-gamma production  negative regulation of interferon-gamma production  negative regulation of interleukin-17 production  negative regulation of interleukin-23 production  negative regulation of interleukin-6 production  negative regulation of tumor necrosis factor production  positive regulation of chemokine production  positive regulation of interferon-alpha production  positive regulation of interferon-beta production  positive regulation of interferon-gamma production  positive regulation of interleukin-1 production  positive regulation of interleukin-10 production  positive regulation of interleukin-12 production  positive regulation of interleukin-6 production  positive regulation of interleukin-8 production  positive regulation of tumor necrosis factor production  negative regulation of MyD88-independent toll-like receptor signaling pathway  toll-like receptor 4 signaling pathway  TRIF-dependent toll-like receptor signaling pathway  T-helper 1 type immune response  macrophage activation  positive regulation of NF-kappaB import into nucleus  positive regulation of tumor necrosis factor biosynthetic process  defense response to bacterium  positive regulation of interleukin-12 biosynthetic process  innate immune response  positive regulation of MHC class II biosynthetic process  positive regulation of interferon-beta biosynthetic process  positive regulation of interleukin-8 biosynthetic process  positive regulation of nitric oxide biosynthetic process  negative regulation of osteoclast differentiation  positive regulation of transcription from RNA polymerase II promoter  positive regulation of JNK cascade  lipopolysaccharide receptor complex  perinuclear region of cytoplasm  interleukin-1 beta secretion  regulation of cytokine secretion  positive regulation of inflammatory response  defense response to Gram-negative bacterium  defense response to Gram-negative bacterium  positive regulation of NF-kappaB transcription factor activity  positive regulation of nitric-oxide synthase biosynthetic process  intestinal epithelial structure maintenance  positive regulation of macrophage cytokine production  necroptotic process  negative regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway  positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  cellular response to lipopolysaccharide  cellular response to lipoteichoic acid  cellular response to mechanical stimulus  apoptotic signaling pathway  positive regulation of NLRP3 inflammasome complex assembly  
Ontology : EGO-EBIactivation of MAPK activity  lipopolysaccharide binding  lipopolysaccharide binding  lipopolysaccharide receptor activity  toll-like receptor signaling pathway  toll-like receptor signaling pathway  B cell proliferation involved in immune response  nitric oxide production involved in inflammatory response  regulation of dendritic cell cytokine production  MyD88-dependent toll-like receptor signaling pathway  MyD88-independent toll-like receptor signaling pathway  receptor activity  transmembrane signaling receptor activity  protein binding  cytoplasm  plasma membrane  plasma membrane  integral component of plasma membrane  inflammatory response  immune response  I-kappaB kinase/NF-kappaB signaling  I-kappaB phosphorylation  external side of plasma membrane  cell surface  endosome membrane  positive regulation of platelet activation  positive regulation of gene expression  astrocyte development  detection of fungus  positive regulation of B cell proliferation  intrinsic component of plasma membrane  lipopolysaccharide-mediated signaling pathway  lipopolysaccharide-mediated signaling pathway  response to lipopolysaccharide  response to lipopolysaccharide  detection of lipopolysaccharide  interferon-gamma production  negative regulation of interferon-gamma production  negative regulation of interleukin-17 production  negative regulation of interleukin-23 production  negative regulation of interleukin-6 production  negative regulation of tumor necrosis factor production  positive regulation of chemokine production  positive regulation of interferon-alpha production  positive regulation of interferon-beta production  positive regulation of interferon-gamma production  positive regulation of interleukin-1 production  positive regulation of interleukin-10 production  positive regulation of interleukin-12 production  positive regulation of interleukin-6 production  positive regulation of interleukin-8 production  positive regulation of tumor necrosis factor production  negative regulation of MyD88-independent toll-like receptor signaling pathway  toll-like receptor 4 signaling pathway  TRIF-dependent toll-like receptor signaling pathway  T-helper 1 type immune response  macrophage activation  positive regulation of NF-kappaB import into nucleus  positive regulation of tumor necrosis factor biosynthetic process  defense response to bacterium  positive regulation of interleukin-12 biosynthetic process  innate immune response  positive regulation of MHC class II biosynthetic process  positive regulation of interferon-beta biosynthetic process  positive regulation of interleukin-8 biosynthetic process  positive regulation of nitric oxide biosynthetic process  negative regulation of osteoclast differentiation  positive regulation of transcription from RNA polymerase II promoter  positive regulation of JNK cascade  lipopolysaccharide receptor complex  perinuclear region of cytoplasm  interleukin-1 beta secretion  regulation of cytokine secretion  positive regulation of inflammatory response  defense response to Gram-negative bacterium  defense response to Gram-negative bacterium  positive regulation of NF-kappaB transcription factor activity  positive regulation of nitric-oxide synthase biosynthetic process  intestinal epithelial structure maintenance  positive regulation of macrophage cytokine production  necroptotic process  negative regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway  positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  cellular response to lipopolysaccharide  cellular response to lipoteichoic acid  cellular response to mechanical stimulus  apoptotic signaling pathway  positive regulation of NLRP3 inflammasome complex assembly  
Pathways : KEGG   
NDEx NetworkTLR4
Atlas of Cancer Signalling NetworkTLR4
Wikipedia pathwaysTLR4
Orthology - Evolution
OrthoDB7099
GeneTree (enSembl)ENSG00000136869
Phylogenetic Trees/Animal Genes : TreeFamTLR4
HOVERGENO00206
HOGENOMO00206
Homologs : HomoloGeneTLR4
Homology/Alignments : Family Browser (UCSC)TLR4
Gene fusions - Rearrangements
Tumor Fusion PortalTLR4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTLR4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TLR4
dbVarTLR4
ClinVarTLR4
1000_GenomesTLR4 
Exome Variant ServerTLR4
ExAC (Exome Aggregation Consortium)ENSG00000136869
GNOMAD BrowserENSG00000136869
Genetic variants : HAPMAP7099
Genomic Variants (DGV)TLR4 [DGVbeta]
DECIPHERTLR4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTLR4 
Mutations
ICGC Data PortalTLR4 
TCGA Data PortalTLR4 
Broad Tumor PortalTLR4
OASIS PortalTLR4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTLR4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTLR4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)TBsLVD Tuberculosis susceptibility Locus Variation Database
LOVD (Leiden Open Variation Database)Pharmacogenomics of Infectious Diseases (PGx_IfD )
BioMutasearch TLR4
DgiDB (Drug Gene Interaction Database)TLR4
DoCM (Curated mutations)TLR4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TLR4 (select a term)
intoGenTLR4
Cancer3DTLR4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603030    611488   
Orphanet703   
DisGeNETTLR4
MedgenTLR4
Genetic Testing Registry TLR4
NextProtO00206 [Medical]
TSGene7099
GENETestsTLR4
Target ValidationTLR4
Huge Navigator TLR4 [HugePedia]
snp3D : Map Gene to Disease7099
BioCentury BCIQTLR4
ClinGenTLR4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7099
Chemical/Pharm GKB GenePA36552
Clinical trialTLR4
Miscellaneous
canSAR (ICR)TLR4 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTLR4
EVEXTLR4
GoPubMedTLR4
iHOPTLR4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:38:35 CET 2017

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