TNRC6A (trinucleotide repeat containing adaptor 6A)

2009-03-01  

Identity

HGNC
LOCATION
16p12.1
LOCUSID
ALIAS
CAGH26,FAME6,GW1,GW182,TNRC6
FUSION GENES

Other Information

Locus ID:

NCBI: 27327
MIM: 610739
HGNC: 11969
Ensembl: ENSG00000090905

Variants:

dbSNP: 27327
ClinVar: 27327
TCGA: ENSG00000090905
COSMIC: TNRC6A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000090905ENST00000315183Q8NDV7
ENSG00000090905ENST00000395799Q8NDV7
ENSG00000090905ENST00000450465H7C269
ENSG00000090905ENST00000491718I3L3S5
ENSG00000090905ENST00000568750H3BTQ1
ENSG00000090905ENST00000569098H3BRT3
ENSG00000090905ENST00000569376I3L218

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Signaling by the B Cell Receptor (BCR)REACTOMER-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)REACTOMER-HSA-1168372
PIP3 activates AKT signalingREACTOMER-HSA-1257604
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
Role of LAT2/NTAL/LAB on calcium mobilizationREACTOMER-HSA-2730905
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
GAB1 signalosomeREACTOMER-HSA-180292
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
PI3K/AKT activationREACTOMER-HSA-198203
Signaling by PDGFREACTOMER-HSA-186797
Downstream signal transductionREACTOMER-HSA-186763
Signaling by SCF-KITREACTOMER-HSA-1433557
MAPK family signaling cascadesREACTOMER-HSA-5683057
MAPK6/MAPK4 signalingREACTOMER-HSA-5687128
Signaling by NOTCHREACTOMER-HSA-157118
Pre-NOTCH Expression and ProcessingREACTOMER-HSA-1912422
Pre-NOTCH Transcription and TranslationREACTOMER-HSA-1912408
Signaling by WntREACTOMER-HSA-195721
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
Ca2+ pathwayREACTOMER-HSA-4086398
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Metabolic GenesREACTOMER-HSA-5628897
Gene Silencing by RNAREACTOMER-HSA-211000
Post-transcriptional silencing by small RNAsREACTOMER-HSA-426496
Transcriptional regulation by small RNAsREACTOMER-HSA-5578749
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Oncogene Induced SenescenceREACTOMER-HSA-2559585
Oxidative Stress Induced SenescenceREACTOMER-HSA-2559580

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443309AlcoholismDiseaseClinicalAnnotationassociatedPD32451486
PA448073ethanolChemicalClinicalAnnotationassociatedPD32451486

References

Pubmed IDYearTitleCitations
162846232005A role for the P-body component GW182 in microRNA function.264
183450152008GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay.176
162846222005Disruption of GW bodies impairs mammalian RNA interference.162
219841842011miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs.146
119509432002A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles.144
219841852011miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT.133
154943742004GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation.86
193837682009The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins.73
193249642009The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing.56
231508742013Human TNRC6A is an Argonaute-navigator protein for microRNA-mediated gene silencing in the nucleus.52

Citation

Dessen P

TNRC6A (trinucleotide repeat containing adaptor 6A)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50817/tnrc6a