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TOP2B (topoisomerase (DNA) II beta)

Identity

Other namesTOPIIB
top2beta
HGNC (Hugo) TOP2B
LocusID (NCBI) 7155
Atlas_Id 42660
Location 3p24.2  [Link to chromosome band 3p24]
Location_base_pair Starts at 25639396 and ends at 25705863 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AD_1 () / TOP2B (3p24.2)AP3D1 (19p13.3) / TOP2B (3p24.2)COX7A1 (19q13.12) / TOP2B (3p24.2)
GCNT2 (6p24.3) / TOP2B (3p24.2)NUP98 (11p15.4) / TOP2B (3p24.2)OLFM4 (13q14.3) / TOP2B (3p24.2)
TBC1D5 (3p24.3) / TOP2B (3p24.2)TOP2B (3p24.2) / FBN1 (15q21.1)TOP2B (3p24.2) / NUP98 (11p15.4)
TOP2B (3p24.2) / TOP2B (3p24.2)TPI1 (12p13.31) / TOP2B (3p24.2)OLFM4 13q14.3 / TOP2B 3p24.2
TBC1D5 3p24.3 / TOP2B 3p24.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TOP2B   11990
Cards
Entrez_Gene (NCBI)TOP2B  7155  topoisomerase (DNA) II beta
AliasesTOPIIB; top2beta
GeneCards (Weizmann)TOP2B
Ensembl hg19 (Hinxton)ENSG00000077097 [Gene_View]  chr3:25639396-25705863 [Contig_View]  TOP2B [Vega]
Ensembl hg38 (Hinxton)ENSG00000077097 [Gene_View]  chr3:25639396-25705863 [Contig_View]  TOP2B [Vega]
ICGC DataPortalENSG00000077097
TCGA cBioPortalTOP2B
AceView (NCBI)TOP2B
Genatlas (Paris)TOP2B
WikiGenes7155
SOURCE (Princeton)TOP2B
Genomic and cartography
GoldenPath hg19 (UCSC)TOP2B  -     chr3:25639396-25705863 -  3p24.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TOP2B  -     3p24.2   [Description]    (hg38-Dec_2013)
EnsemblTOP2B - 3p24.2 [CytoView hg19]  TOP2B - 3p24.2 [CytoView hg38]
Mapping of homologs : NCBITOP2B [Mapview hg19]  TOP2B [Mapview hg38]
OMIM126431   
Gene and transcription
Genbank (Entrez)AB208879 AK296510 AK297171 AK307450 AK316492
RefSeq transcript (Entrez)NM_001068
RefSeq genomic (Entrez)NC_000003 NC_018914 NT_022517 NW_004929309
Consensus coding sequences : CCDS (NCBI)TOP2B
Cluster EST : UnigeneHs.475733 [ NCBI ]
CGAP (NCI)Hs.475733
Alternative Splicing GalleryENSG00000077097
Gene ExpressionTOP2B [ NCBI-GEO ]   TOP2B [ EBI - ARRAY_EXPRESS ]   TOP2B [ SEEK ]   TOP2B [ MEM ]
Gene Expression Viewer (FireBrowse)TOP2B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7155
GTEX Portal (Tissue expression)TOP2B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02880 (Uniprot)
NextProtQ02880  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ02880
Splice isoforms : SwissVarQ02880 (Swissvar)
Catalytic activity : Enzyme5.99.1.3 [ Enzyme-Expasy ]   5.99.1.35.99.1.3 [ IntEnz-EBI ]   5.99.1.3 [ BRENDA ]   5.99.1.3 [ KEGG ]   
PhosPhoSitePlusQ02880
Domaine pattern : Prosite (Expaxy)TOPOISOMERASE_II (PS00177)    TOPRIM (PS50880)   
Domains : Interpro (EBI)Arg_repress_C-like    DTHCT    HATPase_C    Ribosomal_S5_D2-typ_fold    Ribosomal_S5_D2-typ_fold_subgr    Top2b    Topo_IIA    Topo_IIA-like_dom    Topo_IIA_A/C    Topo_IIA_A/C_ab    Topo_IIA_A_a    Topo_IIA_bsu_dom2    Topo_IIA_cen_dom    TopoIIA_CS    TOPRIM_C    Toprim_domain   
Domain families : Pfam (Sanger)DNA_gyraseB (PF00204)    DNA_topoisoIV (PF00521)    DTHCT (PF08070)    HATPase_c (PF02518)    Toprim (PF01751)    TOPRIM_C (PF16898)   
Domain families : Pfam (NCBI)pfam00204    pfam00521    pfam08070    pfam02518    pfam01751    pfam16898   
Domain families : Smart (EMBL)HATPase_c (SM00387)  TOP2c (SM00433)  TOP4c (SM00434)  
DMDM Disease mutations7155
Blocks (Seattle)TOP2B
PDB (SRS)3QX3    4G0U    4G0V    4G0W    4J3N   
PDB (PDBSum)3QX3    4G0U    4G0V    4G0W    4J3N   
PDB (IMB)3QX3    4G0U    4G0V    4G0W    4J3N   
PDB (RSDB)3QX3    4G0U    4G0V    4G0W    4J3N   
Structural Biology KnowledgeBase3QX3    4G0U    4G0V    4G0W    4J3N   
SCOP (Structural Classification of Proteins)3QX3    4G0U    4G0V    4G0W    4J3N   
CATH (Classification of proteins structures)3QX3    4G0U    4G0V    4G0W    4J3N   
SuperfamilyQ02880
Human Protein AtlasENSG00000077097
Peptide AtlasQ02880
HPRD00537
IPIIPI00027280   IPI00217709   IPI01014228   IPI01011064   IPI00925477   IPI00926182   
Protein Interaction databases
DIP (DOE-UCLA)Q02880
IntAct (EBI)Q02880
FunCoupENSG00000077097
BioGRIDTOP2B
STRING (EMBL)TOP2B
ZODIACTOP2B
Ontologies - Pathways
QuickGOQ02880
Ontology : AmiGOresolution of meiotic recombination intermediates  heterochromatin  sister chromatid segregation  neuron migration  chromatin binding  DNA topoisomerase type II (ATP-hydrolyzing) activity  protein kinase C binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  nucleolus  cytoplasm  cytosol  DNA topological change  DNA unwinding involved in DNA replication  mitotic recombination  axonogenesis  protein C-terminus binding  DNA binding, bending  nucleoid  DNA topoisomerase complex (ATP-hydrolyzing)  protein sumoylation  enzyme binding  forebrain development  histone deacetylase binding  mitotic DNA integrity checkpoint  metal ion binding  protein heterodimerization activity  
Ontology : EGO-EBIresolution of meiotic recombination intermediates  heterochromatin  sister chromatid segregation  neuron migration  chromatin binding  DNA topoisomerase type II (ATP-hydrolyzing) activity  protein kinase C binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  nucleolus  cytoplasm  cytosol  DNA topological change  DNA unwinding involved in DNA replication  mitotic recombination  axonogenesis  protein C-terminus binding  DNA binding, bending  nucleoid  DNA topoisomerase complex (ATP-hydrolyzing)  protein sumoylation  enzyme binding  forebrain development  histone deacetylase binding  mitotic DNA integrity checkpoint  metal ion binding  protein heterodimerization activity  
Pathways : BIOCARTAControl of Gene Expression by Vitamin D Receptor [Genes]    Apoptotic DNA fragmentation and tissue homeostasis [Genes]   
NDEx NetworkTOP2B
Atlas of Cancer Signalling NetworkTOP2B
Wikipedia pathwaysTOP2B
Orthology - Evolution
OrthoDB7155
GeneTree (enSembl)ENSG00000077097
Phylogenetic Trees/Animal Genes : TreeFamTOP2B
Homologs : HomoloGeneTOP2B
Homology/Alignments : Family Browser (UCSC)TOP2B
Gene fusions - Rearrangements
Fusion: TCGAOLFM4 13q14.3 TOP2B 3p24.2 PRAD
Fusion: TCGATBC1D5 3p24.3 TOP2B 3p24.2 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerTOP2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TOP2B
dbVarTOP2B
ClinVarTOP2B
1000_GenomesTOP2B 
Exome Variant ServerTOP2B
ExAC (Exome Aggregation Consortium)TOP2B (select the gene name)
Genetic variants : HAPMAP7155
Genomic Variants (DGV)TOP2B [DGVbeta]
Mutations
ICGC Data PortalTOP2B 
TCGA Data PortalTOP2B 
Broad Tumor PortalTOP2B
OASIS PortalTOP2B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTOP2B 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TOP2B
DgiDB (Drug Gene Interaction Database)TOP2B
DoCM (Curated mutations)TOP2B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TOP2B (select a term)
intoGenTOP2B
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)3:25639396-25705863  ENSG00000077097
CONAN: Copy Number AnalysisTOP2B 
Mutations and Diseases : HGMDTOP2B
OMIM126431   
MedgenTOP2B
Genetic Testing Registry TOP2B
NextProtQ02880 [Medical]
TSGene7155
GENETestsTOP2B
Huge Navigator TOP2B [HugePedia]
snp3D : Map Gene to Disease7155
BioCentury BCIQTOP2B
ClinGenTOP2B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7155
Chemical/Pharm GKB GenePA36672
Clinical trialTOP2B
Miscellaneous
canSAR (ICR)TOP2B (select the gene name)
Probes
Litterature
PubMed102 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTOP2B
EVEXTOP2B
GoPubMedTOP2B
iHOPTOP2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 19 19:17:26 CEST 2016

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