Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TOP2B (topoisomerase (DNA) II beta 180kDa)

Identity

Other namesTOPIIB
top2beta
HGNC (Hugo) TOP2B
LocusID (NCBI) 7155
Location 3p24.2
Location_base_pair Starts at 25639396 and ends at 25705863 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TOP2B   11990
Entrez_Gene (NCBI)TOP2B  7155  topoisomerase (DNA) II beta 180kDa
Cards
GeneCards (Weizmann)TOP2B
Ensembl (Hinxton)ENSG00000077097 [Gene_View]  chr3:25639396-25705863 [Contig_View]  TOP2B [Vega]
AceView (NCBI)TOP2B
Genatlas (Paris)TOP2B
SOURCE (Stanford)NM_001068
Genomic and cartography
GoldenPath (UCSC)TOP2B  -  3p24.2   chr3:25639396-25705863 -  3p24.2   [Description]    (hg19-Feb_2009)
EnsemblTOP2B - 3p24.2 [CytoView]
Mapping of homologs : NCBITOP2B [Mapview]
OMIM126431   
Gene and transcription
Genbank (Entrez)AB208879 AK296510 AK297171 AK307450 AK316492
RefSeq transcript (SRS)NM_001068
RefSeq transcript (Entrez)NM_001068
RefSeq genomic (SRS)AC_000135 NC_000003 NC_018914 NT_022517 NW_001838877 NW_004078011
RefSeq genomic (Entrez)AC_000135 NC_000003 NC_018914 NT_022517 NW_001838877 NW_004078011
Consensus coding sequences : CCDS (NCBI)TOP2B
Cluster EST : UnigeneHs.475733 [ SRS ] Hs.475733 [ NCBI ]
CGAP (NCI)Hs.475733
Alternative Splicing : Fast-db (Paris)GSHG0021582
Alternative Splicing GalleryENSG00000077097
Gene ExpressionTOP2B [ NCBI-GEO ]   TOP2B [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02880 (SRS) Q02880 (Uniprot)
NextProtQ02880
With graphics : InterProQ02880
Splice isoforms : SwissVarQ02880(Swissvar)
Domaine pattern : Prosite (SRS)TOPOISOMERASE_II (PS00177)    TOPRIM (PS50880)   
Domaine pattern : Prosite (Expaxy)TOPOISOMERASE_II (PS00177)    TOPRIM (PS50880)   
Domains : Interpro (SRS)Arg_repress_C-like    DTHCT    HATPase_ATP-bd    Ribosomal_S5_D2-typ_fold    Ribosomal_S5_D2-typ_fold_subgr    Topo_IIA    Topo_IIA_A/C    Topo_IIA_A/C_ab    Topo_IIA_A_a    Topo_IIA_bsu_dom2    Topo_IIA_cen_dom    Topo_IIA_like_dom    TopoIIA_CS    Toprim_domain   
Domains : Interpro (EBI)Arg_repress_C-like    DTHCT    HATPase_ATP-bd    Ribosomal_S5_D2-typ_fold    Ribosomal_S5_D2-typ_fold_subgr    Topo_IIA    Topo_IIA_A/C    Topo_IIA_A/C_ab    Topo_IIA_A_a    Topo_IIA_bsu_dom2    Topo_IIA_cen_dom    Topo_IIA_like_dom    TopoIIA_CS    Toprim_domain   
Related proteins : CluSTrQ02880
Domain families : Pfam (SRS)DNA_gyraseB (PF00204)    DNA_topoisoIV (PF00521)    DTHCT (PF08070)    HATPase_c (PF02518)    Toprim (PF01751)   
Domain families : Pfam (Sanger)DNA_gyraseB (PF00204)    DNA_topoisoIV (PF00521)    DTHCT (PF08070)    HATPase_c (PF02518)    Toprim (PF01751)   
Domain families : Pfam (NCBI)pfam00204    pfam00521    pfam08070    pfam02518    pfam01751   
Domain families : Smart (EMBL)HATPase_c (SM00387)  TOP2c (SM00433)  TOP4c (SM00434)  
DMDM7155
Blocks (Seattle)Q02880
PDB (SRS)3QX3   
PDB (PDBSum)3QX3   
PDB (IMB)3QX3   
PDB (RSDB)3QX3   
Human Protein AtlasENSG00000077097
HPRD00537
IPIIPI00027280   IPI00217709   IPI01014228   IPI01011064   IPI00925477   IPI00926182   
Protein Interaction databases
DIP (DOE-UCLA)Q02880
IntAct (EBI)Q02880
FunCoupENSG00000077097
REACTOMETOP2B
Protein Interaction Database7155
BioGRIDTOP2B
InParanoidQ02880
Interologous Interaction database Q02880
IntegromeDBTOP2B
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)TOP2B
SNP (GeneSNP Utah)TOP2B
SNP : HGBaseTOP2B
Genetic variants : HAPMAPTOP2B
Somatic Mutations in Cancer : COSMICTOP2B 
CONAN: Copy Number AnalysisTOP2B 
Mutations and Diseases : HGMDTOP2B
OMIM126431   
GENETests126431   
Disease Genetic AssociationTOP2B
Huge Navigator TOP2B [HugePedia]  TOP2B [HugeCancerGEM]
Genomic VariantsTOP2B  TOP2B [DGVbeta]
ClinVarTOP2B
snp3D : Map Gene to Disease7155
General knowledge
Homologs : HomoloGeneTOP2B
Homology/Alignments : Family Browser (UCSC)TOP2B
Phylogenetic Trees/Animal Genes : TreeFamTOP2B
Catalytic activity : Enzyme5.99.1.3 [ Enzyme-Expasy ]   5.99.1.3 [ Enzyme-SRS ]   5.99.1.3 [ IntEnz-EBI ]   5.99.1.3 [ BRENDA ]   5.99.1.3 [ KEGG ]   
Chemical/Protein Interactions : CTD7155
Chemical/Pharm GKB GenePA36672
Clinical trialTOP2B
Cancer Resource (Charite)ENSG00000077097
Ontology : AmiGOresolution of meiotic recombination intermediates  heterochromatin  synaptonemal complex  sister chromatid segregation  neuron migration  chromatin binding  DNA topoisomerase type II (ATP-hydrolyzing) activity  DNA topoisomerase type II (ATP-hydrolyzing) activity  protein kinase C binding  ATP binding  nucleus  nucleoplasm  nucleolus  cytosol  DNA-dependent DNA replication  DNA topological change  DNA topological change  mitotic recombination  chromosome segregation  axonogenesis  protein C-terminus binding  nucleoid  enzyme binding  forebrain development  histone deacetylase binding  metal ion binding  protein heterodimerization activity  WINAC complex  
Ontology : EGO-EBIresolution of meiotic recombination intermediates  heterochromatin  synaptonemal complex  sister chromatid segregation  neuron migration  chromatin binding  DNA topoisomerase type II (ATP-hydrolyzing) activity  DNA topoisomerase type II (ATP-hydrolyzing) activity  protein kinase C binding  ATP binding  nucleus  nucleoplasm  nucleolus  cytosol  DNA-dependent DNA replication  DNA topological change  DNA topological change  mitotic recombination  chromosome segregation  axonogenesis  protein C-terminus binding  nucleoid  enzyme binding  forebrain development  histone deacetylase binding  metal ion binding  protein heterodimerization activity  WINAC complex  
Pathways : BIOCARTAControl of Gene Expression by Vitamin D Receptor [Genes]    Apoptotic DNA fragmentation and tissue homeostasis [Genes]   
Other databases
Probes
Litterature
PubMed92 Pubmed reference(s) in Entrez
PubGeneTOP2B
iHOPTOP2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 14 17:58:01 CEST 2013
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