Identity
HGNC
LOCATION
3p24.2
LOCUSID
ALIAS
TOPIIB,top2beta
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7155
MIM: 126431
HGNC: 11990
Ensembl: ENSG00000077097
Variants:
dbSNP: 7155
ClinVar: 7155
TCGA: ENSG00000077097
COSMIC: TOP2B
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000077097 | ENST00000264331 | Q02880 |
| ENSG00000077097 | ENST00000413971 | H7BZ82 |
| ENSG00000077097 | ENST00000424225 | E9PCY5 |
| ENSG00000077097 | ENST00000435706 | Q02880 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA449259 | dexrazoxane | Chemical | Pathway | associated | 21048526 | ||
| PA449412 | doxorubicin | Chemical | Pathway | associated | 21048526 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38038260 | 2024 | Using energy to go downhill-a genoprotective role for ATPase activity in DNA topoisomerase II. | 3 |
| 38240344 | 2024 | DNA-PKcs-mediated transcriptional regulation of TOP2B drives chemoresistance in acute myeloid leukemia. | 0 |
| 38263255 | 2024 | MDM2 provides TOP2 poison resistance by promoting proteolysis of TOP2βcc in a p53-independent manner. | 0 |
| 38038260 | 2024 | Using energy to go downhill-a genoprotective role for ATPase activity in DNA topoisomerase II. | 3 |
| 38240344 | 2024 | DNA-PKcs-mediated transcriptional regulation of TOP2B drives chemoresistance in acute myeloid leukemia. | 0 |
| 38263255 | 2024 | MDM2 provides TOP2 poison resistance by promoting proteolysis of TOP2βcc in a p53-independent manner. | 0 |
| 36410793 | 2023 | Effects of hsa-miR-9-3p and hsa-miR-9-5p on Topoisomerase IIβ Expression in Human Leukemia K562 Cells with Acquired Resistance to Etoposide. | 2 |
| 36766705 | 2023 | Taspase1 Facilitates Topoisomerase IIβ-Mediated DNA Double-Strand Breaks Driving Estrogen-Induced Transcription. | 1 |
| 37068767 | 2023 | Revisiting TOP2B-related phenotypes: Three new cases and literature review. | 0 |
| 37834253 | 2023 | To Break or Not to Break: The Role of TOP2B in Transcription. | 3 |
| 36410793 | 2023 | Effects of hsa-miR-9-3p and hsa-miR-9-5p on Topoisomerase IIβ Expression in Human Leukemia K562 Cells with Acquired Resistance to Etoposide. | 2 |
| 36766705 | 2023 | Taspase1 Facilitates Topoisomerase IIβ-Mediated DNA Double-Strand Breaks Driving Estrogen-Induced Transcription. | 1 |
| 37068767 | 2023 | Revisiting TOP2B-related phenotypes: Three new cases and literature review. | 0 |
| 37834253 | 2023 | To Break or Not to Break: The Role of TOP2B in Transcription. | 3 |
| 35660158 | 2022 | A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193. | 5 |
Citation
Dessen P
TOP2B (DNA topoisomerase II beta)
Atlas Genet Cytogenet Oncol Haematol. 2003-06-01
Online version: http://atlasgeneticsoncology.org/gene/42660/top2b
