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TPM2 (tropomyosin 2 (beta))

Identity

Other namesAMCD1
DA1
DA2B
HEL-S-273
NEM4
TMSB
HGNC (Hugo) TPM2
LocusID (NCBI) 7169
Atlas_Id 50293
Location 9p13.3
Location_base_pair Starts at 35681990 and ends at 35690053 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
EIF4G1 (3q27.1) / TPM2 (9p13.3)LOC441242 () / TPM2 (9p13.3)MYBPC1 (12q23.2) / TPM2 (9p13.3)
PDIA6 (2p25.1) / TPM2 (9p13.3)TPM1 (15q22.2) / TPM2 (9p13.3)TPM2 (9p13.3) / CIT (12q24.23)
TPM2 (9p13.3) / ECHDC2 (1p32.3)TPM2 (9p13.3) / FAH (15q25.1)TPM2 (9p13.3) / MUC2 (11p15.5)
TPM2 (9p13.3) / MYBPC1 (12q23.2)TPM2 (9p13.3) / MYH9 (22q12.3)TPM2 (9p13.3) / TPM2 (9p13.3)
TPM2 (9p13.3) / TPM3 (1q21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TPM2   12011
Cards
Entrez_Gene (NCBI)TPM2  7169  tropomyosin 2 (beta)
GeneCards (Weizmann)TPM2
Ensembl hg19 (Hinxton)ENSG00000198467 [Gene_View]  chr9:35681990-35690053 [Contig_View]  TPM2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000198467 [Gene_View]  chr9:35681990-35690053 [Contig_View]  TPM2 [Vega]
ICGC DataPortalENSG00000198467
TCGA cBioPortalTPM2
AceView (NCBI)TPM2
Genatlas (Paris)TPM2
WikiGenes7169
SOURCE (Princeton)TPM2
Genomic and cartography
GoldenPath hg19 (UCSC)TPM2  -     chr9:35681990-35690053 -  9p13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TPM2  -     9p13.3   [Description]    (hg38-Dec_2013)
EnsemblTPM2 - 9p13.3 [CytoView hg19]  TPM2 - 9p13.3 [CytoView hg38]
Mapping of homologs : NCBITPM2 [Mapview hg19]  TPM2 [Mapview hg38]
OMIM108120   190990   255310   601680   609285   
Gene and transcription
Genbank (Entrez)AA394062 AI360640 AI660199 AJ572605 AK130045
RefSeq transcript (Entrez)NM_001145822 NM_001301226 NM_001301227 NM_003289 NM_213674
RefSeq genomic (Entrez)NC_000009 NC_018920 NG_011620 NT_008413 NW_004929342
Consensus coding sequences : CCDS (NCBI)TPM2
Cluster EST : UnigeneHs.300772 [ NCBI ]
CGAP (NCI)Hs.300772
Alternative Splicing : Fast-db (Paris)GSHG0030790
Alternative Splicing GalleryENSG00000198467
Gene ExpressionTPM2 [ NCBI-GEO ]   TPM2 [ EBI - ARRAY_EXPRESS ]   TPM2 [ SEEK ]   TPM2 [ MEM ]
Gene Expression Viewer (FireBrowse)TPM2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)7169
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07951 (Uniprot)
NextProtP07951  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP07951
Splice isoforms : SwissVarP07951 (Swissvar)
PhosPhoSitePlusP07951
Domaine pattern : Prosite (Expaxy)TROPOMYOSIN (PS00326)   
Domains : Interpro (EBI)Tropomyosin   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
DMDM Disease mutations7169
Blocks (Seattle)TPM2
SuperfamilyP07951
Human Protein AtlasENSG00000198467
Peptide AtlasP07951
HPRD11768
IPIIPI00013991   IPI00220709   IPI00218820   IPI00910712   IPI00513698   IPI00646748   
Protein Interaction databases
DIP (DOE-UCLA)P07951
IntAct (EBI)P07951
FunCoupENSG00000198467
BioGRIDTPM2
STRING (EMBL)TPM2
ZODIACTPM2
Ontologies - Pathways
QuickGOP07951
Ontology : AmiGOactin binding  cytosol  muscle thin filament tropomyosin  muscle contraction  structural constituent of muscle  muscle filament sliding  regulation of ATPase activity  
Ontology : EGO-EBIactin binding  cytosol  muscle thin filament tropomyosin  muscle contraction  structural constituent of muscle  muscle filament sliding  regulation of ATPase activity  
Pathways : KEGGCardiac muscle contraction    Adrenergic signaling in cardiomyocytes    Hypertrophic cardiomyopathy (HCM)    Dilated cardiomyopathy   
NDEx Network
Atlas of Cancer Signalling NetworkTPM2
Wikipedia pathwaysTPM2
Orthology - Evolution
OrthoDB7169
GeneTree (enSembl)ENSG00000198467
Phylogenetic Trees/Animal Genes : TreeFamTPM2
Homologs : HomoloGeneTPM2
Homology/Alignments : Family Browser (UCSC)TPM2
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerTPM2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TPM2
dbVarTPM2
ClinVarTPM2
1000_GenomesTPM2 
Exome Variant ServerTPM2
ExAC (Exome Aggregation Consortium)TPM2 (select the gene name)
SNP (GeneSNP Utah)TPM2
SNP : HGBaseTPM2
Genetic variants : HAPMAPTPM2
Genomic Variants (DGV)TPM2 [DGVbeta]
Mutations
ICGC Data PortalTPM2 
TCGA Data PortalTPM2 
Broad Tumor PortalTPM2
OASIS PortalTPM2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTPM2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)Leiden Muscular Dystrophy pages
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch TPM2
DgiDB (Drug Gene Interaction Database)TPM2
DoCM (Curated mutations)TPM2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TPM2 (select a term)
intoGenTPM2
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)9:35681990-35690053
CONAN: Copy Number AnalysisTPM2 
Mutations and Diseases : HGMDTPM2
OMIM108120    190990    255310    601680    609285   
MedgenTPM2
Genetic Testing Registry TPM2
NextProtP07951 [Medical]
TSGene7169
GENETestsTPM2
Huge Navigator TPM2 [HugePedia]  TPM2 [HugeCancerGEM]
snp3D : Map Gene to Disease7169
BioCentury BCIQTPM2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7169
Chemical/Pharm GKB GenePA36691
Clinical trialTPM2
Miscellaneous
canSAR (ICR)TPM2 (select the gene name)
Probes
Litterature
PubMed82 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTPM2
GoPubMedTPM2
iHOPTPM2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Sat Apr 16 18:08:06 CEST 2016

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