Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TRAF2 (TNF receptor associated factor 2)

Identity

Alias (NCBI)MGC:45012
RNF117
TRAP
TRAP3
HGNC (Hugo) TRAF2
HGNC Alias symbTRAP3
RNF117
LocusID (NCBI) 7186
Atlas_Id 270
Location 9q34.3  [Link to chromosome band 9q34]
Location_base_pair Starts at 136886516 and ends at 136926607 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TRAF2 (9q34.3) / DENND1C (19p13.3)TRAF2 (9q34.3) / EPB41L4B (9q31.3)TRAF2 (9q34.3) / TPRN (9q34.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(2;9)(p23;q33) TRAF1/ALK


External links

 

Nomenclature
HGNC (Hugo)TRAF2   12032
Cards
Entrez_Gene (NCBI)TRAF2    TNF receptor associated factor 2
AliasesMGC:45012; RNF117; TRAP; TRAP3
GeneCards (Weizmann)TRAF2
Ensembl hg19 (Hinxton)ENSG00000127191 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000127191 [Gene_View]  ENSG00000127191 [Sequence]  chr9:136886516-136926607 [Contig_View]  TRAF2 [Vega]
ICGC DataPortalENSG00000127191
TCGA cBioPortalTRAF2
AceView (NCBI)TRAF2
Genatlas (Paris)TRAF2
SOURCE (Princeton)TRAF2
Genetics Home Reference (NIH)TRAF2
Genomic and cartography
GoldenPath hg38 (UCSC)TRAF2  -     chr9:136886516-136926607 +  9q34.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRAF2  -     9q34.3   [Description]    (hg19-Feb_2009)
GoldenPathTRAF2 - 9q34.3 [CytoView hg19]  TRAF2 - 9q34.3 [CytoView hg38]
ImmunoBaseENSG00000127191
Genome Data Viewer NCBITRAF2 [Mapview hg19]  
OMIM601895   
Gene and transcription
Genbank (Entrez)AK054686 AK222961 AK289722 AK294607 AK298370
RefSeq transcript (Entrez)NM_021138
Consensus coding sequences : CCDS (NCBI)TRAF2
Gene ExpressionTRAF2 [ NCBI-GEO ]   TRAF2 [ EBI - ARRAY_EXPRESS ]   TRAF2 [ SEEK ]   TRAF2 [ MEM ]
Gene Expression Viewer (FireBrowse)TRAF2 [ Firebrowse - Broad ]
GenevisibleExpression of TRAF2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7186
GTEX Portal (Tissue expression)TRAF2
Human Protein AtlasENSG00000127191-TRAF2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ12933   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ12933  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ12933
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ12933
Domaine pattern : Prosite (Expaxy)MATH (PS50144)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)    ZF_TRAF (PS50145)   
Domains : Interpro (EBI)MATH/TRAF_dom    TNF_rcpt-assoc_TRAF    TNF_rcpt-assoc_TRAF_met    TRAF-like    TRAF2    TRAF2_MATH    TRAF_BIRC3-bd    Znf_C3HC4_RING-type    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS    Znf_TRAF   
Domain families : Pfam (Sanger)TRAF_BIRC3_bd (PF16673)    zf-C3HC4 (PF00097)    zf-TRAF (PF02176)   
Domain families : Pfam (NCBI)pfam16673    pfam00097    pfam02176   
Domain families : Smart (EMBL)MATH (SM00061)  RING (SM00184)  
Conserved Domain (NCBI)TRAF2
PDB (RSDB)1CA4    1CA9    1CZY    1CZZ    1D00    1D01    1D0A    1D0J    1F3V    1QSC    3KNV    3M06    3M0A    3M0D   
PDB Europe1CA4    1CA9    1CZY    1CZZ    1D00    1D01    1D0A    1D0J    1F3V    1QSC    3KNV    3M06    3M0A    3M0D   
PDB (PDBSum)1CA4    1CA9    1CZY    1CZZ    1D00    1D01    1D0A    1D0J    1F3V    1QSC    3KNV    3M06    3M0A    3M0D   
PDB (IMB)1CA4    1CA9    1CZY    1CZZ    1D00    1D01    1D0A    1D0J    1F3V    1QSC    3KNV    3M06    3M0A    3M0D   
Structural Biology KnowledgeBase1CA4    1CA9    1CZY    1CZZ    1D00    1D01    1D0A    1D0J    1F3V    1QSC    3KNV    3M06    3M0A    3M0D   
SCOP (Structural Classification of Proteins)1CA4    1CA9    1CZY    1CZZ    1D00    1D01    1D0A    1D0J    1F3V    1QSC    3KNV    3M06    3M0A    3M0D   
CATH (Classification of proteins structures)1CA4    1CA9    1CZY    1CZZ    1D00    1D01    1D0A    1D0J    1F3V    1QSC    3KNV    3M06    3M0A    3M0D   
SuperfamilyQ12933
AlphaFold pdb e-kbQ12933   
Human Protein Atlas [tissue]ENSG00000127191-TRAF2 [tissue]
HPRD03538
Protein Interaction databases
DIP (DOE-UCLA)Q12933
IntAct (EBI)Q12933
BioGRIDTRAF2
STRING (EMBL)TRAF2
ZODIACTRAF2
Ontologies - Pathways
QuickGOQ12933
Ontology : AmiGOubiquitin ligase complex  regulation of immunoglobulin production  positive regulation of T cell cytokine production  tumor necrosis factor receptor superfamily complex  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  tumor necrosis factor receptor binding  tumor necrosis factor receptor binding  CD40 receptor binding  protein binding  nucleoplasm  cytosol  cytosol  cell cortex  activation of cysteine-type endopeptidase activity involved in apoptotic process  signal transduction  I-kappaB kinase/NF-kappaB signaling  activation of NF-kappaB-inducing kinase activity  zinc ion binding  cytoplasmic side of plasma membrane  cytoplasmic side of plasma membrane  regulation of tumor necrosis factor-mediated signaling pathway  vesicle membrane  protein deubiquitination  enzyme binding  protein kinase binding  protein phosphatase binding  signal transduction involved in regulation of gene expression  protein catabolic process  protein-macromolecule adaptor activity  mitogen-activated protein kinase kinase kinase binding  ubiquitin protein ligase binding  ubiquitin protein ligase binding  thioesterase binding  positive regulation of interleukin-2 production  tumor necrosis factor-mediated signaling pathway  tumor necrosis factor-mediated signaling pathway  tumor necrosis factor-mediated signaling pathway  negative regulation of glial cell apoptotic process  cellular protein-containing complex assembly  response to endoplasmic reticulum stress  CD40 receptor complex  identical protein binding  regulation of apoptotic process  tumor necrosis factor binding  regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  regulation of protein-containing complex assembly  positive regulation of JUN kinase activity  protein-containing complex binding  membrane raft  positive regulation of JNK cascade  sphingolipid binding  mRNA stabilization  positive regulation of DNA-binding transcription factor activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  protein autoubiquitination  protein autoubiquitination  protein-containing complex assembly  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  protein K63-linked ubiquitination  protein K63-linked ubiquitination  death-inducing signaling complex assembly  cellular response to nitric oxide  TRAF2-GSTP1 complex  programmed necrotic cell death  interleukin-17-mediated signaling pathway  plasma membrane signaling receptor complex  negative regulation of neuron death  regulation of extrinsic apoptotic signaling pathway via death domain receptors  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  positive regulation of tumor necrosis factor-mediated signaling pathway  positive regulation of I-kappaB phosphorylation  IRE1-TRAF2-ASK1 complex  positive regulation of extrinsic apoptotic signaling pathway  
Ontology : EGO-EBIubiquitin ligase complex  regulation of immunoglobulin production  positive regulation of T cell cytokine production  tumor necrosis factor receptor superfamily complex  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  tumor necrosis factor receptor binding  tumor necrosis factor receptor binding  CD40 receptor binding  protein binding  nucleoplasm  cytosol  cytosol  cell cortex  activation of cysteine-type endopeptidase activity involved in apoptotic process  signal transduction  I-kappaB kinase/NF-kappaB signaling  activation of NF-kappaB-inducing kinase activity  zinc ion binding  cytoplasmic side of plasma membrane  cytoplasmic side of plasma membrane  regulation of tumor necrosis factor-mediated signaling pathway  vesicle membrane  protein deubiquitination  enzyme binding  protein kinase binding  protein phosphatase binding  signal transduction involved in regulation of gene expression  protein catabolic process  protein-macromolecule adaptor activity  mitogen-activated protein kinase kinase kinase binding  ubiquitin protein ligase binding  ubiquitin protein ligase binding  thioesterase binding  positive regulation of interleukin-2 production  tumor necrosis factor-mediated signaling pathway  tumor necrosis factor-mediated signaling pathway  tumor necrosis factor-mediated signaling pathway  negative regulation of glial cell apoptotic process  cellular protein-containing complex assembly  response to endoplasmic reticulum stress  CD40 receptor complex  identical protein binding  regulation of apoptotic process  tumor necrosis factor binding  regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  regulation of protein-containing complex assembly  positive regulation of JUN kinase activity  protein-containing complex binding  membrane raft  positive regulation of JNK cascade  sphingolipid binding  mRNA stabilization  positive regulation of DNA-binding transcription factor activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  protein autoubiquitination  protein autoubiquitination  protein-containing complex assembly  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  protein K63-linked ubiquitination  protein K63-linked ubiquitination  death-inducing signaling complex assembly  cellular response to nitric oxide  TRAF2-GSTP1 complex  programmed necrotic cell death  interleukin-17-mediated signaling pathway  plasma membrane signaling receptor complex  negative regulation of neuron death  regulation of extrinsic apoptotic signaling pathway via death domain receptors  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  positive regulation of tumor necrosis factor-mediated signaling pathway  positive regulation of I-kappaB phosphorylation  IRE1-TRAF2-ASK1 complex  positive regulation of extrinsic apoptotic signaling pathway  
Pathways : BIOCARTATNFR1 Signaling Pathway [Genes]    TNFR2 Signaling Pathway [Genes]    SODD/TNFR1 Signaling Pathway [Genes]    MAPKinase Signaling Pathway [Genes]    TACI and BCMA stimulation of B cell immune responses. [Genes]    The 4-1BB-dependent immune response [Genes]    Keratinocyte Differentiation [Genes]    p38 MAPK Signaling Pathway [Genes]    HIV-I Nef: negative effector of Fas and TNF [Genes]    TNF/Stress Related Signaling [Genes]    Induction of apoptosis through DR3 and DR4/5 Death Receptors [Genes]    Ceramide Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    NF-kappa B signaling pathway    Protein processing in endoplasmic reticulum    Apoptosis    Osteoclast differentiation    RIG-I-like receptor signaling pathway    TNF signaling pathway    Adipocytokine signaling pathway    Non-alcoholic fatty liver disease (NAFLD)    Hepatitis C    Herpes simplex infection    Epstein-Barr virus infection    Pathways in cancer    Viral carcinogenesis    Small cell lung cancer   
NDEx NetworkTRAF2
Atlas of Cancer Signalling NetworkTRAF2
Wikipedia pathwaysTRAF2
Orthology - Evolution
OrthoDB7186
GeneTree (enSembl)ENSG00000127191
Phylogenetic Trees/Animal Genes : TreeFamTRAF2
Homologs : HomoloGeneTRAF2
Homology/Alignments : Family Browser (UCSC)TRAF2
Gene fusions - Rearrangements
Fusion : QuiverTRAF2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRAF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRAF2
dbVarTRAF2
ClinVarTRAF2
MonarchTRAF2
1000_GenomesTRAF2 
Exome Variant ServerTRAF2
GNOMAD BrowserENSG00000127191
Varsome BrowserTRAF2
ACMGTRAF2 variants
VarityQ12933
Genomic Variants (DGV)TRAF2 [DGVbeta]
DECIPHERTRAF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRAF2 
Mutations
ICGC Data PortalTRAF2 
TCGA Data PortalTRAF2 
Broad Tumor PortalTRAF2
OASIS PortalTRAF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRAF2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTRAF2
Mutations and Diseases : HGMDTRAF2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTRAF2
DgiDB (Drug Gene Interaction Database)TRAF2
DoCM (Curated mutations)TRAF2
CIViC (Clinical Interpretations of Variants in Cancer)TRAF2
Cancer3DTRAF2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601895   
Orphanet
DisGeNETTRAF2
MedgenTRAF2
Genetic Testing Registry TRAF2
NextProtQ12933 [Medical]
GENETestsTRAF2
Target ValidationTRAF2
Huge Navigator TRAF2 [HugePedia]
ClinGenTRAF2
Clinical trials, drugs, therapy
MyCancerGenomeTRAF2
Protein Interactions : CTDTRAF2
Pharm GKB GenePA164742666
PharosQ12933
Clinical trialTRAF2
Miscellaneous
canSAR (ICR)TRAF2
HarmonizomeTRAF2
DataMed IndexTRAF2
Probes
Litterature
PubMed491 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTRAF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:36:08 CEST 2021

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