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TRAF2 (TNF receptor associated factor 2)

Identity

Alias_symbol (synonym)TRAP3
Other aliasMGC:45012
TRAP
HGNC (Hugo) TRAF2
LocusID (NCBI) 7186
Atlas_Id 270
Location 9q34.3  [Link to chromosome band 9q34]
Location_base_pair Starts at 136886513 and ends at 136926615 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TRAF2 (9q34.3) / DENND1C (19p13.3)TRAF2 (9q34.3) / EPB41L4B (9q31.3)TRAF2 (9q34.3) / TPRN (9q34.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(2;9)(p23;q33) TRAF1/ALK


External links

Nomenclature
HGNC (Hugo)TRAF2   12032
Cards
Entrez_Gene (NCBI)TRAF2  7186  TNF receptor associated factor 2
AliasesMGC:45012; TRAP; TRAP3
GeneCards (Weizmann)TRAF2
Ensembl hg19 (Hinxton)ENSG00000127191 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000127191 [Gene_View]  chr9:136886513-136926615 [Contig_View]  TRAF2 [Vega]
ICGC DataPortalENSG00000127191
TCGA cBioPortalTRAF2
AceView (NCBI)TRAF2
Genatlas (Paris)TRAF2
WikiGenes7186
SOURCE (Princeton)TRAF2
Genetics Home Reference (NIH)TRAF2
Genomic and cartography
GoldenPath hg38 (UCSC)TRAF2  -     chr9:136886513-136926615 +  9q34.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRAF2  -     9q34.3   [Description]    (hg19-Feb_2009)
EnsemblTRAF2 - 9q34.3 [CytoView hg19]  TRAF2 - 9q34.3 [CytoView hg38]
Mapping of homologs : NCBITRAF2 [Mapview hg19]  TRAF2 [Mapview hg38]
OMIM601895   
Gene and transcription
Genbank (Entrez)AK054686 AK222961 AK289722 AK294607 AK298370
RefSeq transcript (Entrez)NM_021138
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TRAF2
Cluster EST : UnigeneHs.522506 [ NCBI ]
CGAP (NCI)Hs.522506
Alternative Splicing GalleryENSG00000127191
Gene ExpressionTRAF2 [ NCBI-GEO ]   TRAF2 [ EBI - ARRAY_EXPRESS ]   TRAF2 [ SEEK ]   TRAF2 [ MEM ]
Gene Expression Viewer (FireBrowse)TRAF2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7186
GTEX Portal (Tissue expression)TRAF2
Human Protein AtlasENSG00000127191-TRAF2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ12933   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ12933  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ12933
Splice isoforms : SwissVarQ12933
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   
PhosPhoSitePlusQ12933
Domaine pattern : Prosite (Expaxy)MATH (PS50144)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)    ZF_TRAF (PS50145)   
Domains : Interpro (EBI)MATH/TRAF_dom    TNF_rcpt--assoc_TRAF    TRAF-like    TRAF2    TRAF_BIRC3-bd    Znf_C3HC4_RING-type    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS    Znf_TRAF   
Domain families : Pfam (Sanger)TRAF_BIRC3_bd (PF16673)    zf-C3HC4 (PF00097)    zf-TRAF (PF02176)   
Domain families : Pfam (NCBI)pfam16673    pfam00097    pfam02176   
Domain families : Smart (EMBL)MATH (SM00061)  RING (SM00184)  
Conserved Domain (NCBI)TRAF2
DMDM Disease mutations7186
Blocks (Seattle)TRAF2
PDB (SRS)1CA4    1CA9    1CZY    1CZZ    1D00    1D01    1D0A    1D0J    1F3V    1QSC    3KNV    3M06    3M0A    3M0D   
PDB (PDBSum)1CA4    1CA9    1CZY    1CZZ    1D00    1D01    1D0A    1D0J    1F3V    1QSC    3KNV    3M06    3M0A    3M0D   
PDB (IMB)1CA4    1CA9    1CZY    1CZZ    1D00    1D01    1D0A    1D0J    1F3V    1QSC    3KNV    3M06    3M0A    3M0D   
PDB (RSDB)1CA4    1CA9    1CZY    1CZZ    1D00    1D01    1D0A    1D0J    1F3V    1QSC    3KNV    3M06    3M0A    3M0D   
Structural Biology KnowledgeBase1CA4    1CA9    1CZY    1CZZ    1D00    1D01    1D0A    1D0J    1F3V    1QSC    3KNV    3M06    3M0A    3M0D   
SCOP (Structural Classification of Proteins)1CA4    1CA9    1CZY    1CZZ    1D00    1D01    1D0A    1D0J    1F3V    1QSC    3KNV    3M06    3M0A    3M0D   
CATH (Classification of proteins structures)1CA4    1CA9    1CZY    1CZZ    1D00    1D01    1D0A    1D0J    1F3V    1QSC    3KNV    3M06    3M0A    3M0D   
SuperfamilyQ12933
Human Protein Atlas [tissue]ENSG00000127191-TRAF2 [tissue]
Peptide AtlasQ12933
HPRD03538
IPIIPI00030278   IPI00292635   IPI00970911   IPI00970988   IPI00908920   IPI00384922   IPI00647767   IPI00644377   
Protein Interaction databases
DIP (DOE-UCLA)Q12933
IntAct (EBI)Q12933
FunCoupENSG00000127191
BioGRIDTRAF2
STRING (EMBL)TRAF2
ZODIACTRAF2
Ontologies - Pathways
QuickGOQ12933
Ontology : AmiGOubiquitin ligase complex  positive regulation of T cell cytokine production  ubiquitin-protein transferase activity  signal transducer activity  tumor necrosis factor receptor binding  CD40 receptor binding  protein binding  nucleoplasm  cytosol  cytosol  cell cortex  protein complex assembly  activation of cysteine-type endopeptidase activity involved in apoptotic process  signal transduction  I-kappaB kinase/NF-kappaB signaling  activation of NF-kappaB-inducing kinase activity  zinc ion binding  cytoplasmic side of plasma membrane  regulation of tumor necrosis factor-mediated signaling pathway  vesicle membrane  protein deubiquitination  enzyme binding  protein kinase binding  protein phosphatase binding  protein catabolic process  mitogen-activated protein kinase kinase kinase binding  ubiquitin protein ligase binding  thioesterase binding  protein complex binding  positive regulation of interleukin-2 production  tumor necrosis factor-mediated signaling pathway  tumor necrosis factor-mediated signaling pathway  negative regulation of glial cell apoptotic process  response to endoplasmic reticulum stress  CD40 receptor complex  identical protein binding  regulation of apoptotic process  positive regulation of JUN kinase activity  cellular protein complex assembly  membrane raft  sphingolipid binding  positive regulation of T cell activation  regulation of immunoglobulin secretion  positive regulation of sequence-specific DNA binding transcription factor activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  protein heterooligomerization  protein autoubiquitination  protein autoubiquitination  regulation of necroptotic process  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  protein homotrimerization  protein K63-linked ubiquitination  death-inducing signaling complex assembly  cellular response to nitric oxide  positive regulation of protein homodimerization activity  TRAF2-GSTP1 complex  activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  programmed necrotic cell death  negative regulation of neuron death  regulation of extrinsic apoptotic signaling pathway via death domain receptors  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  positive regulation of tumor necrosis factor-mediated signaling pathway  positive regulation of I-kappaB phosphorylation  AIP1-IRE1 complex  IRE1-TRAF2-ASK1 complex  positive regulation of extrinsic apoptotic signaling pathway  
Ontology : EGO-EBIubiquitin ligase complex  positive regulation of T cell cytokine production  ubiquitin-protein transferase activity  signal transducer activity  tumor necrosis factor receptor binding  CD40 receptor binding  protein binding  nucleoplasm  cytosol  cytosol  cell cortex  protein complex assembly  activation of cysteine-type endopeptidase activity involved in apoptotic process  signal transduction  I-kappaB kinase/NF-kappaB signaling  activation of NF-kappaB-inducing kinase activity  zinc ion binding  cytoplasmic side of plasma membrane  regulation of tumor necrosis factor-mediated signaling pathway  vesicle membrane  protein deubiquitination  enzyme binding  protein kinase binding  protein phosphatase binding  protein catabolic process  mitogen-activated protein kinase kinase kinase binding  ubiquitin protein ligase binding  thioesterase binding  protein complex binding  positive regulation of interleukin-2 production  tumor necrosis factor-mediated signaling pathway  tumor necrosis factor-mediated signaling pathway  negative regulation of glial cell apoptotic process  response to endoplasmic reticulum stress  CD40 receptor complex  identical protein binding  regulation of apoptotic process  positive regulation of JUN kinase activity  cellular protein complex assembly  membrane raft  sphingolipid binding  positive regulation of T cell activation  regulation of immunoglobulin secretion  positive regulation of sequence-specific DNA binding transcription factor activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  protein heterooligomerization  protein autoubiquitination  protein autoubiquitination  regulation of necroptotic process  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  protein homotrimerization  protein K63-linked ubiquitination  death-inducing signaling complex assembly  cellular response to nitric oxide  positive regulation of protein homodimerization activity  TRAF2-GSTP1 complex  activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  programmed necrotic cell death  negative regulation of neuron death  regulation of extrinsic apoptotic signaling pathway via death domain receptors  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  positive regulation of tumor necrosis factor-mediated signaling pathway  positive regulation of I-kappaB phosphorylation  AIP1-IRE1 complex  IRE1-TRAF2-ASK1 complex  positive regulation of extrinsic apoptotic signaling pathway  
Pathways : BIOCARTA [Genes]   
Pathways : KEGG   
NDEx NetworkTRAF2
Atlas of Cancer Signalling NetworkTRAF2
Wikipedia pathwaysTRAF2
Orthology - Evolution
OrthoDB7186
GeneTree (enSembl)ENSG00000127191
Phylogenetic Trees/Animal Genes : TreeFamTRAF2
HOVERGENQ12933
HOGENOMQ12933
Homologs : HomoloGeneTRAF2
Homology/Alignments : Family Browser (UCSC)TRAF2
Gene fusions - Rearrangements
Fusion: Tumor Portal TRAF2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRAF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRAF2
dbVarTRAF2
ClinVarTRAF2
1000_GenomesTRAF2 
Exome Variant ServerTRAF2
ExAC (Exome Aggregation Consortium)ENSG00000127191
GNOMAD BrowserENSG00000127191
Genetic variants : HAPMAP7186
Genomic Variants (DGV)TRAF2 [DGVbeta]
DECIPHERTRAF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRAF2 
Mutations
ICGC Data PortalTRAF2 
TCGA Data PortalTRAF2 
Broad Tumor PortalTRAF2
OASIS PortalTRAF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRAF2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTRAF2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TRAF2
DgiDB (Drug Gene Interaction Database)TRAF2
DoCM (Curated mutations)TRAF2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRAF2 (select a term)
intoGenTRAF2
Cancer3DTRAF2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601895   
Orphanet
MedgenTRAF2
Genetic Testing Registry TRAF2
NextProtQ12933 [Medical]
TSGene7186
GENETestsTRAF2
Target ValidationTRAF2
Huge Navigator TRAF2 [HugePedia]
snp3D : Map Gene to Disease7186
BioCentury BCIQTRAF2
ClinGenTRAF2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7186
Chemical/Pharm GKB GenePA164742666
Clinical trialTRAF2
Miscellaneous
canSAR (ICR)TRAF2 (select the gene name)
Probes
Litterature
PubMed385 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTRAF2
EVEXTRAF2
GoPubMedTRAF2
iHOPTRAF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 13:15:31 CET 2017

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