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TREX2 (three prime repair exonuclease 2)

Identity

Alias (NCBI)-
HGNC (Hugo) TREX2
LocusID (NCBI) 11219
Atlas_Id 42697
Location Xq28  [Link to chromosome band Xq28]
Location_base_pair Starts at 153444720 and ends at 153446487 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TREX2 (Xq28) / NRXN1 (2p16.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TREX2   12270
Cards
Entrez_Gene (NCBI)TREX2    three prime repair exonuclease 2
Aliases
GeneCards (Weizmann)TREX2
Ensembl hg19 (Hinxton)ENSG00000183479 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000183479 [Gene_View]  ENSG00000183479 [Sequence]  chrX:153444720-153446487 [Contig_View]  TREX2 [Vega]
ICGC DataPortalENSG00000183479
TCGA cBioPortalTREX2
AceView (NCBI)TREX2
Genatlas (Paris)TREX2
SOURCE (Princeton)TREX2
Genetics Home Reference (NIH)TREX2
Genomic and cartography
GoldenPath hg38 (UCSC)TREX2  -     chrX:153444720-153446487 -  Xq28   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TREX2  -     Xq28   [Description]    (hg19-Feb_2009)
GoldenPathTREX2 - Xq28 [CytoView hg19]  TREX2 - Xq28 [CytoView hg38]
ImmunoBaseENSG00000183479
Genome Data Viewer NCBITREX2 [Mapview hg19]  
OMIM300370   
Gene and transcription
Genbank (Entrez)AF151107 AW296654
RefSeq transcript (Entrez)NM_080699 NM_080700 NM_080701
Consensus coding sequences : CCDS (NCBI)TREX2
Gene ExpressionTREX2 [ NCBI-GEO ]   TREX2 [ EBI - ARRAY_EXPRESS ]   TREX2 [ SEEK ]   TREX2 [ MEM ]
Gene Expression Viewer (FireBrowse)TREX2 [ Firebrowse - Broad ]
GenevisibleExpression of TREX2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11219
GTEX Portal (Tissue expression)TREX2
Human Protein AtlasENSG00000183479-TREX2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BQ50   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BQ50  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BQ50
Catalytic activity : Enzyme3.1.11.2 [ Enzyme-Expasy ]   3.1.11.23.1.11.2 [ IntEnz-EBI ]   3.1.11.2 [ BRENDA ]   3.1.11.2 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9BQ50
Domains : Interpro (EBI)Exonuclease_RNaseT/DNA_pol3    RNaseH-like_sf    RNaseH_sf    TREX2   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)EXOIII (SM00479)  
Conserved Domain (NCBI)TREX2
PDB (RSDB)1Y97   
PDB Europe1Y97   
PDB (PDBSum)1Y97   
PDB (IMB)1Y97   
Structural Biology KnowledgeBase1Y97   
SCOP (Structural Classification of Proteins)1Y97   
CATH (Classification of proteins structures)1Y97   
SuperfamilyQ9BQ50
AlphaFold pdb e-kbQ9BQ50   
Human Protein Atlas [tissue]ENSG00000183479-TREX2 [tissue]
HPRD02299
Protein Interaction databases
DIP (DOE-UCLA)Q9BQ50
IntAct (EBI)Q9BQ50
BioGRIDTREX2
STRING (EMBL)TREX2
ZODIACTREX2
Ontologies - Pathways
QuickGOQ9BQ50
Ontology : AmiGOmagnesium ion binding  DNA catabolic process, exonucleolytic  nucleic acid binding  protein binding  nucleus  cytoplasm  DNA metabolic process  DNA repair  3'-5'-exodeoxyribonuclease activity  3'-5'-exodeoxyribonuclease activity  exodeoxyribonuclease III activity  protein homodimerization activity  
Ontology : EGO-EBImagnesium ion binding  DNA catabolic process, exonucleolytic  nucleic acid binding  protein binding  nucleus  cytoplasm  DNA metabolic process  DNA repair  3'-5'-exodeoxyribonuclease activity  3'-5'-exodeoxyribonuclease activity  exodeoxyribonuclease III activity  protein homodimerization activity  
NDEx NetworkTREX2
Atlas of Cancer Signalling NetworkTREX2
Wikipedia pathwaysTREX2
Orthology - Evolution
OrthoDB11219
GeneTree (enSembl)ENSG00000183479
Phylogenetic Trees/Animal Genes : TreeFamTREX2
Homologs : HomoloGeneTREX2
Homology/Alignments : Family Browser (UCSC)TREX2
Gene fusions - Rearrangements
Fusion : QuiverTREX2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTREX2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TREX2
dbVarTREX2
ClinVarTREX2
MonarchTREX2
1000_GenomesTREX2 
Exome Variant ServerTREX2
GNOMAD BrowserENSG00000183479
Varsome BrowserTREX2
ACMGTREX2 variants
VarityQ9BQ50
Genomic Variants (DGV)TREX2 [DGVbeta]
DECIPHERTREX2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTREX2 
Mutations
ICGC Data PortalTREX2 
TCGA Data PortalTREX2 
Broad Tumor PortalTREX2
OASIS PortalTREX2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTREX2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTREX2
Mutations and Diseases : HGMDTREX2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTREX2
DgiDB (Drug Gene Interaction Database)TREX2
DoCM (Curated mutations)TREX2
CIViC (Clinical Interpretations of Variants in Cancer)TREX2
Cancer3DTREX2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300370   
Orphanet
DisGeNETTREX2
MedgenTREX2
Genetic Testing Registry TREX2
NextProtQ9BQ50 [Medical]
GENETestsTREX2
Target ValidationTREX2
Huge Navigator TREX2 [HugePedia]
ClinGenTREX2
Clinical trials, drugs, therapy
MyCancerGenomeTREX2
Protein Interactions : CTDTREX2
Pharm GKB GenePA36950
PharosQ9BQ50
Clinical trialTREX2
Miscellaneous
canSAR (ICR)TREX2
HarmonizomeTREX2
DataMed IndexTREX2
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTREX2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:36:15 CEST 2021

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