TREX2 (three prime repair exonuclease 2)

2003-12-01  

Identity

HGNC
LOCATION
Xq28
LOCUSID
FUSION GENES

Other Information

Locus ID:

NCBI: 11219
MIM: 300370
HGNC: 12270
Ensembl: ENSG00000183479

Variants:

dbSNP: 11219
ClinVar: 11219
TCGA: ENSG00000183479
COSMIC: TREX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183479ENST00000330912Q9BQ50
ENSG00000183479ENST00000334497Q9BQ50
ENSG00000183479ENST00000338525Q9BQ50
ENSG00000183479ENST00000370212Q9BQ50
ENSG00000183479ENST00000370231Q9BQ50
ENSG00000183479ENST00000370232Q9BQ50
ENSG00000183479ENST00000393862Q9BQ50

Expression (GTEx)

0
5
10
15
20
25
30

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
248961802014BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2.154
235918202013The human TREX-2 complex is stably associated with the nuclear pore basket.37
156617382005The human TREX2 3' -> 5'-exonuclease structure suggests a mechanism for efficient nonprocessive DNA catalysis.29
174261292007Biochemical and cellular characteristics of the 3' -> 5' exonuclease TREX2.14
185349782008Cooperative DNA binding and communication across the dimer interface in the TREX2 3' --> 5'-exonuclease.11
180921672008TREX1 polymorphisms associated with autoantibodies in patients with systemic lupus erythematosus.8
155814812004Sequence variants in the 3'-->5' deoxyribonuclease TREX2: identification in a genetic screen and effects on catalysis by the recombinant proteins.7
190949982009TREX2 exonuclease defective cells exhibit double-strand breaks and chromosomal fragments but not Robertsonian translocations.7
193214972009DNA binding induces active site conformational change in the human TREX2 3'-exonuclease.7
215465432011Trex2 enables spontaneous sister chromatid exchanges without facilitating DNA double-strand break repair.6

Citation

Dessen P

TREX2 (three prime repair exonuclease 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/42697/trex2