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TREX2 (three prime repair exonuclease 2)

Identity

Other alias-
HGNC (Hugo) TREX2
LocusID (NCBI) 11219
Atlas_Id 42697
Location Xq28  [Link to chromosome band Xq28]
Location_base_pair Starts at 152710178 and ends at 152711945 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
TREX2 (Xq28) / NRXN1 (2p16.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TREX2   12270
Cards
Entrez_Gene (NCBI)TREX2  11219  three prime repair exonuclease 2
Aliases
GeneCards (Weizmann)TREX2
Ensembl hg19 (Hinxton)ENSG00000183479 [Gene_View]  chrX:152710178-152711945 [Contig_View]  TREX2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000183479 [Gene_View]  chrX:152710178-152711945 [Contig_View]  TREX2 [Vega]
ICGC DataPortalENSG00000183479
TCGA cBioPortalTREX2
AceView (NCBI)TREX2
Genatlas (Paris)TREX2
WikiGenes11219
SOURCE (Princeton)TREX2
Genetics Home Reference (NIH)TREX2
Genomic and cartography
GoldenPath hg19 (UCSC)TREX2  -     chrX:152710178-152711945 -  Xq28   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TREX2  -     Xq28   [Description]    (hg38-Dec_2013)
EnsemblTREX2 - Xq28 [CytoView hg19]  TREX2 - Xq28 [CytoView hg38]
Mapping of homologs : NCBITREX2 [Mapview hg19]  TREX2 [Mapview hg38]
OMIM300370   
Gene and transcription
Genbank (Entrez)AF151107 AW296654 BC156244 BC157021 DQ891762
RefSeq transcript (Entrez)NM_080699 NM_080700 NM_080701
RefSeq genomic (Entrez)NC_000023 NC_018934 NG_029986 NT_011681 NW_004929448
Consensus coding sequences : CCDS (NCBI)TREX2
Cluster EST : UnigeneHs.644635 [ NCBI ]
CGAP (NCI)Hs.644635
Alternative Splicing GalleryENSG00000183479
Gene ExpressionTREX2 [ NCBI-GEO ]   TREX2 [ EBI - ARRAY_EXPRESS ]   TREX2 [ SEEK ]   TREX2 [ MEM ]
Gene Expression Viewer (FireBrowse)TREX2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11219
GTEX Portal (Tissue expression)TREX2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BQ50   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BQ50  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BQ50
Splice isoforms : SwissVarQ9BQ50
Catalytic activity : Enzyme3.1.11.2 [ Enzyme-Expasy ]   3.1.11.23.1.11.2 [ IntEnz-EBI ]   3.1.11.2 [ BRENDA ]   3.1.11.2 [ KEGG ]   
PhosPhoSitePlusQ9BQ50
Domains : Interpro (EBI)Exonuclease_RNaseT/DNA_pol3    RNaseH-like_dom   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)EXOIII (SM00479)  
Conserved Domain (NCBI)TREX2
DMDM Disease mutations11219
Blocks (Seattle)TREX2
PDB (SRS)1Y97   
PDB (PDBSum)1Y97   
PDB (IMB)1Y97   
PDB (RSDB)1Y97   
Structural Biology KnowledgeBase1Y97   
SCOP (Structural Classification of Proteins)1Y97   
CATH (Classification of proteins structures)1Y97   
SuperfamilyQ9BQ50
Human Protein AtlasENSG00000183479
Peptide AtlasQ9BQ50
HPRD02299
IPIIPI00383247   IPI00939474   IPI00414167   
Protein Interaction databases
DIP (DOE-UCLA)Q9BQ50
IntAct (EBI)Q9BQ50
FunCoupENSG00000183479
BioGRIDTREX2
STRING (EMBL)TREX2
ZODIACTREX2
Ontologies - Pathways
QuickGOQ9BQ50
Ontology : AmiGOmagnesium ion binding  nucleic acid binding  nucleus  DNA metabolic process  DNA repair  3'-5'-exodeoxyribonuclease activity  exodeoxyribonuclease III activity  protein homodimerization activity  nucleic acid phosphodiester bond hydrolysis  nucleic acid phosphodiester bond hydrolysis  nucleic acid phosphodiester bond hydrolysis  
Ontology : EGO-EBImagnesium ion binding  nucleic acid binding  nucleus  DNA metabolic process  DNA repair  3'-5'-exodeoxyribonuclease activity  exodeoxyribonuclease III activity  protein homodimerization activity  nucleic acid phosphodiester bond hydrolysis  nucleic acid phosphodiester bond hydrolysis  nucleic acid phosphodiester bond hydrolysis  
NDEx NetworkTREX2
Atlas of Cancer Signalling NetworkTREX2
Wikipedia pathwaysTREX2
Orthology - Evolution
OrthoDB11219
GeneTree (enSembl)ENSG00000183479
Phylogenetic Trees/Animal Genes : TreeFamTREX2
HOVERGENQ9BQ50
HOGENOMQ9BQ50
Homologs : HomoloGeneTREX2
Homology/Alignments : Family Browser (UCSC)TREX2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTREX2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TREX2
dbVarTREX2
ClinVarTREX2
1000_GenomesTREX2 
Exome Variant ServerTREX2
ExAC (Exome Aggregation Consortium)TREX2 (select the gene name)
Genetic variants : HAPMAP11219
Genomic Variants (DGV)TREX2 [DGVbeta]
DECIPHER (Syndromes)X:152710178-152711945  ENSG00000183479
CONAN: Copy Number AnalysisTREX2 
Mutations
ICGC Data PortalTREX2 
TCGA Data PortalTREX2 
Broad Tumor PortalTREX2
OASIS PortalTREX2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTREX2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTREX2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TREX2
DgiDB (Drug Gene Interaction Database)TREX2
DoCM (Curated mutations)TREX2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TREX2 (select a term)
intoGenTREX2
Cancer3DTREX2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300370   
Orphanet
MedgenTREX2
Genetic Testing Registry TREX2
NextProtQ9BQ50 [Medical]
TSGene11219
GENETestsTREX2
Huge Navigator TREX2 [HugePedia]
snp3D : Map Gene to Disease11219
BioCentury BCIQTREX2
ClinGenTREX2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11219
Chemical/Pharm GKB GenePA36950
Clinical trialTREX2
Miscellaneous
canSAR (ICR)TREX2 (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTREX2
EVEXTREX2
GoPubMedTREX2
iHOPTREX2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:23:23 CEST 2017

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