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TRPM2 (transient receptor potential cation channel subfamily M member 2)

Identity

Alias_namesTRPC7
transient receptor potential cation channel
Alias_symbol (synonym)KNP3
LTRPC2
NUDT9L1
NUDT9H
EREG1
Other aliasLTrpC-2
HGNC (Hugo) TRPM2
LocusID (NCBI) 7226
Atlas_Id 50540
Location 21q22.3  [Link to chromosome band 21q22]
Location_base_pair Starts at 45773484 and ends at 45862964 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DOPEY2 (21q22.12) / TRPM2 (21q22.3)DOPEY2 21q22.12 / TRPM2 21q22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TRPM2   12339
Cards
Entrez_Gene (NCBI)TRPM2  7226  transient receptor potential cation channel subfamily M member 2
AliasesEREG1; KNP3; LTRPC2; LTrpC-2; 
NUDT9H; NUDT9L1; TRPC7
GeneCards (Weizmann)TRPM2
Ensembl hg19 (Hinxton)ENSG00000142185 [Gene_View]  chr21:45773484-45862964 [Contig_View]  TRPM2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000142185 [Gene_View]  chr21:45773484-45862964 [Contig_View]  TRPM2 [Vega]
ICGC DataPortalENSG00000142185
TCGA cBioPortalTRPM2
AceView (NCBI)TRPM2
Genatlas (Paris)TRPM2
WikiGenes7226
SOURCE (Princeton)TRPM2
Genetics Home Reference (NIH)TRPM2
Genomic and cartography
GoldenPath hg19 (UCSC)TRPM2  -     chr21:45773484-45862964 +  21q22.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TRPM2  -     21q22.3   [Description]    (hg38-Dec_2013)
EnsemblTRPM2 - 21q22.3 [CytoView hg19]  TRPM2 - 21q22.3 [CytoView hg38]
Mapping of homologs : NCBITRPM2 [Mapview hg19]  TRPM2 [Mapview hg38]
OMIM603749   
Gene and transcription
Genbank (Entrez)AB001535 AB017549 AB166745 AB166746 AJ417076
RefSeq transcript (Entrez)NM_001001188 NM_001320350 NM_001320351 NM_001320352 NM_003307
RefSeq genomic (Entrez)NC_000021 NC_018932 NG_022913 NT_011512 NW_004929427
Consensus coding sequences : CCDS (NCBI)TRPM2
Cluster EST : UnigeneHs.369759 [ NCBI ]
CGAP (NCI)Hs.369759
Alternative Splicing GalleryENSG00000142185
Gene ExpressionTRPM2 [ NCBI-GEO ]   TRPM2 [ EBI - ARRAY_EXPRESS ]   TRPM2 [ SEEK ]   TRPM2 [ MEM ]
Gene Expression Viewer (FireBrowse)TRPM2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7226
GTEX Portal (Tissue expression)TRPM2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO94759   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO94759  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO94759
Splice isoforms : SwissVarO94759
Catalytic activity : Enzyme3.6.1.13 [ Enzyme-Expasy ]   3.6.1.133.6.1.13 [ IntEnz-EBI ]   3.6.1.13 [ BRENDA ]   3.6.1.13 [ KEGG ]   
PhosPhoSitePlusO94759
Domaine pattern : Prosite (Expaxy)NUDIX (PS51462)   
Domains : Interpro (EBI)Ion_trans_dom    NUDIX_hydrolase_dom    NUDIX_hydrolase_dom-like    TRPM2   
Domain families : Pfam (Sanger)Ion_trans (PF00520)   
Domain families : Pfam (NCBI)pfam00520   
Conserved Domain (NCBI)TRPM2
DMDM Disease mutations7226
Blocks (Seattle)TRPM2
SuperfamilyO94759
Human Protein AtlasENSG00000142185
Peptide AtlasO94759
HPRD04777
IPIIPI00014911   IPI00412399   IPI00480087   IPI01015334   IPI00952857   IPI00871539   
Protein Interaction databases
DIP (DOE-UCLA)O94759
IntAct (EBI)O94759
FunCoupENSG00000142185
BioGRIDTRPM2
STRING (EMBL)TRPM2
ZODIACTRPM2
Ontologies - Pathways
QuickGOO94759
Ontology : AmiGOcalcium channel activity  sodium channel activity  intracellular  plasma membrane  integral component of plasma membrane  calcium ion transport  response to oxidative stress  metabolic process  positive regulation of insulin secretion  sodium ion transmembrane transport  neuron projection  neuronal cell body  estrous cycle  ADP-ribose diphosphatase activity  calcium ion transmembrane transport  calcium ion import across plasma membrane  positive regulation of oxidative stress-induced neuron death  
Ontology : EGO-EBIcalcium channel activity  sodium channel activity  intracellular  plasma membrane  integral component of plasma membrane  calcium ion transport  response to oxidative stress  metabolic process  positive regulation of insulin secretion  sodium ion transmembrane transport  neuron projection  neuronal cell body  estrous cycle  ADP-ribose diphosphatase activity  calcium ion transmembrane transport  calcium ion import across plasma membrane  positive regulation of oxidative stress-induced neuron death  
NDEx NetworkTRPM2
Atlas of Cancer Signalling NetworkTRPM2
Wikipedia pathwaysTRPM2
Orthology - Evolution
OrthoDB7226
GeneTree (enSembl)ENSG00000142185
Phylogenetic Trees/Animal Genes : TreeFamTRPM2
HOVERGENO94759
HOGENOMO94759
Homologs : HomoloGeneTRPM2
Homology/Alignments : Family Browser (UCSC)TRPM2
Gene fusions - Rearrangements
Fusion : MitelmanDOPEY2/TRPM2 [21q22.12/21q22.3]  [t(21;21)(q22;q22)]  
Fusion: TCGADOPEY2 21q22.12 TRPM2 21q22.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRPM2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRPM2
dbVarTRPM2
ClinVarTRPM2
1000_GenomesTRPM2 
Exome Variant ServerTRPM2
ExAC (Exome Aggregation Consortium)TRPM2 (select the gene name)
Genetic variants : HAPMAP7226
Genomic Variants (DGV)TRPM2 [DGVbeta]
DECIPHER (Syndromes)21:45773484-45862964  ENSG00000142185
CONAN: Copy Number AnalysisTRPM2 
Mutations
ICGC Data PortalTRPM2 
TCGA Data PortalTRPM2 
Broad Tumor PortalTRPM2
OASIS PortalTRPM2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRPM2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTRPM2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TRPM2
DgiDB (Drug Gene Interaction Database)TRPM2
DoCM (Curated mutations)TRPM2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRPM2 (select a term)
intoGenTRPM2
Cancer3DTRPM2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603749   
Orphanet
MedgenTRPM2
Genetic Testing Registry TRPM2
NextProtO94759 [Medical]
TSGene7226
GENETestsTRPM2
Huge Navigator TRPM2 [HugePedia]
snp3D : Map Gene to Disease7226
BioCentury BCIQTRPM2
ClinGenTRPM2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7226
Chemical/Pharm GKB GenePA37012
Clinical trialTRPM2
Miscellaneous
canSAR (ICR)TRPM2 (select the gene name)
Probes
Litterature
PubMed87 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTRPM2
EVEXTRPM2
GoPubMedTRPM2
iHOPTRPM2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Mar 14 13:32:29 CET 2017

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