Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TRPM2 (transient receptor potential cation channel subfamily M member 2)

Identity

Alias (NCBI)EREG1
KNP3
LTRPC2
LTrpC-2
NUDT9H
NUDT9L1
TRPC7
HGNC (Hugo) TRPM2
HGNC Alias symbKNP3
LTRPC2
NUDT9L1
NUDT9H
EREG1
HGNC Previous nameTRPC7
HGNC Previous nametransient receptor potential cation channel, subfamily M, member 2
LocusID (NCBI) 7226
Atlas_Id 50540
Location 21q22.3  [Link to chromosome band 21q22]
Location_base_pair Starts at 44353601 and ends at 44443081 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DOPEY2 (21q22.12) / TRPM2 (21q22.3)DOPEY2 21q22.12 / TRPM2 21q22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TRPM2   12339
Cards
Entrez_Gene (NCBI)TRPM2    transient receptor potential cation channel subfamily M member 2
AliasesEREG1; KNP3; LTRPC2; LTrpC-2; 
NUDT9H; NUDT9L1; TRPC7
GeneCards (Weizmann)TRPM2
Ensembl hg19 (Hinxton)ENSG00000142185 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000142185 [Gene_View]  ENSG00000142185 [Sequence]  chr21:44353601-44443081 [Contig_View]  TRPM2 [Vega]
ICGC DataPortalENSG00000142185
TCGA cBioPortalTRPM2
AceView (NCBI)TRPM2
Genatlas (Paris)TRPM2
SOURCE (Princeton)TRPM2
Genetics Home Reference (NIH)TRPM2
Genomic and cartography
GoldenPath hg38 (UCSC)TRPM2  -     chr21:44353601-44443081 +  21q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRPM2  -     21q22.3   [Description]    (hg19-Feb_2009)
GoldenPathTRPM2 - 21q22.3 [CytoView hg19]  TRPM2 - 21q22.3 [CytoView hg38]
ImmunoBaseENSG00000142185
Genome Data Viewer NCBITRPM2 [Mapview hg19]  
OMIM603749   
Gene and transcription
Genbank (Entrez)AB001535 AB017549 AB166745 AB166746 AJ417076
RefSeq transcript (Entrez)NM_001001188 NM_001320350 NM_001320351 NM_001320352 NM_003307
Consensus coding sequences : CCDS (NCBI)TRPM2
Gene ExpressionTRPM2 [ NCBI-GEO ]   TRPM2 [ EBI - ARRAY_EXPRESS ]   TRPM2 [ SEEK ]   TRPM2 [ MEM ]
Gene Expression Viewer (FireBrowse)TRPM2 [ Firebrowse - Broad ]
GenevisibleExpression of TRPM2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7226
GTEX Portal (Tissue expression)TRPM2
Human Protein AtlasENSG00000142185-TRPM2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO94759   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO94759  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO94759
PhosPhoSitePlusO94759
Domaine pattern : Prosite (Expaxy)NUDIX (PS51462)   
Domains : Interpro (EBI)Ion_trans_dom    NUDIX_hydrolase-like_dom_sf    NUDIX_hydrolase_dom    TRPM2    TRPM_SLOG   
Domain families : Pfam (Sanger)Ion_trans (PF00520)    LSDAT_euk (PF18139)   
Domain families : Pfam (NCBI)pfam00520    pfam18139   
Conserved Domain (NCBI)TRPM2
PDB (RSDB)6MIX    6MIZ    6MJ2    6PUO    6PUR    6PUS    6PUU   
PDB Europe6MIX    6MIZ    6MJ2    6PUO    6PUR    6PUS    6PUU   
PDB (PDBSum)6MIX    6MIZ    6MJ2    6PUO    6PUR    6PUS    6PUU   
PDB (IMB)6MIX    6MIZ    6MJ2    6PUO    6PUR    6PUS    6PUU   
Structural Biology KnowledgeBase6MIX    6MIZ    6MJ2    6PUO    6PUR    6PUS    6PUU   
SCOP (Structural Classification of Proteins)6MIX    6MIZ    6MJ2    6PUO    6PUR    6PUS    6PUU   
CATH (Classification of proteins structures)6MIX    6MIZ    6MJ2    6PUO    6PUR    6PUS    6PUU   
SuperfamilyO94759
AlphaFold pdb e-kbO94759   
Human Protein Atlas [tissue]ENSG00000142185-TRPM2 [tissue]
HPRD04777
Protein Interaction databases
DIP (DOE-UCLA)O94759
IntAct (EBI)O94759
BioGRIDTRPM2
STRING (EMBL)TRPM2
ZODIACTRPM2
Ontologies - Pathways
QuickGOO94759
Ontology : AmiGOtemperature homeostasis  dendritic cell chemotaxis  cation channel activity  cation channel activity  calcium channel activity  sodium channel activity  manganese ion transmembrane transporter activity  calcium ion binding  calcium ion binding  lysosome  lysosomal membrane  plasma membrane  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  integral component of plasma membrane  integral component of plasma membrane  calcium ion transport  response to heat  response to purine-containing compound  calcium-release channel activity  hydrolase activity  cytoplasmic vesicle membrane  positive regulation of insulin secretion  response to hydroperoxide  specific granule membrane  calcium-mediated signaling using intracellular calcium source  sodium ion transmembrane transport  neuron projection  perikaryon  neutrophil degranulation  estrous cycle  ADP-ribose diphosphatase activity  release of sequestered calcium ion into cytosol  release of sequestered calcium ion into cytosol  release of sequestered calcium ion into cytosol  protein homotetramerization  regulation of filopodium assembly  cellular response to hydrogen peroxide  calcium ion transmembrane transport  calcium ion transmembrane transport  calcium ion transmembrane transport  tertiary granule membrane  cellular response to calcium ion  cellular response to purine-containing compound  manganese ion transmembrane transport  cellular response to temperature stimulus  zinc ion transmembrane transport  mono-ADP-D-ribose binding  dendritic cell differentiation  calcium ion transmembrane import into cytosol  cation transmembrane transport  calcium ion import across plasma membrane  ligand-gated calcium channel activity  ligand-gated calcium channel activity  ficolin-1-rich granule membrane  positive regulation of oxidative stress-induced neuron death  regulation of actin cytoskeleton reorganization  
Ontology : EGO-EBItemperature homeostasis  dendritic cell chemotaxis  cation channel activity  cation channel activity  calcium channel activity  sodium channel activity  manganese ion transmembrane transporter activity  calcium ion binding  calcium ion binding  lysosome  lysosomal membrane  plasma membrane  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  integral component of plasma membrane  integral component of plasma membrane  calcium ion transport  response to heat  response to purine-containing compound  calcium-release channel activity  hydrolase activity  cytoplasmic vesicle membrane  positive regulation of insulin secretion  response to hydroperoxide  specific granule membrane  calcium-mediated signaling using intracellular calcium source  sodium ion transmembrane transport  neuron projection  perikaryon  neutrophil degranulation  estrous cycle  ADP-ribose diphosphatase activity  release of sequestered calcium ion into cytosol  release of sequestered calcium ion into cytosol  release of sequestered calcium ion into cytosol  protein homotetramerization  regulation of filopodium assembly  cellular response to hydrogen peroxide  calcium ion transmembrane transport  calcium ion transmembrane transport  calcium ion transmembrane transport  tertiary granule membrane  cellular response to calcium ion  cellular response to purine-containing compound  manganese ion transmembrane transport  cellular response to temperature stimulus  zinc ion transmembrane transport  mono-ADP-D-ribose binding  dendritic cell differentiation  calcium ion transmembrane import into cytosol  cation transmembrane transport  calcium ion import across plasma membrane  ligand-gated calcium channel activity  ligand-gated calcium channel activity  ficolin-1-rich granule membrane  positive regulation of oxidative stress-induced neuron death  regulation of actin cytoskeleton reorganization  
NDEx NetworkTRPM2
Atlas of Cancer Signalling NetworkTRPM2
Wikipedia pathwaysTRPM2
Orthology - Evolution
OrthoDB7226
GeneTree (enSembl)ENSG00000142185
Phylogenetic Trees/Animal Genes : TreeFamTRPM2
Homologs : HomoloGeneTRPM2
Homology/Alignments : Family Browser (UCSC)TRPM2
Gene fusions - Rearrangements
Fusion : MitelmanDOPEY2/TRPM2 [21q22.12/21q22.3]  
Fusion : QuiverTRPM2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRPM2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRPM2
dbVarTRPM2
ClinVarTRPM2
MonarchTRPM2
1000_GenomesTRPM2 
Exome Variant ServerTRPM2
GNOMAD BrowserENSG00000142185
Varsome BrowserTRPM2
ACMGTRPM2 variants
VarityO94759
Genomic Variants (DGV)TRPM2 [DGVbeta]
DECIPHERTRPM2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRPM2 
Mutations
ICGC Data PortalTRPM2 
TCGA Data PortalTRPM2 
Broad Tumor PortalTRPM2
OASIS PortalTRPM2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRPM2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTRPM2
Mutations and Diseases : HGMDTRPM2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTRPM2
DgiDB (Drug Gene Interaction Database)TRPM2
DoCM (Curated mutations)TRPM2
CIViC (Clinical Interpretations of Variants in Cancer)TRPM2
Cancer3DTRPM2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603749   
Orphanet
DisGeNETTRPM2
MedgenTRPM2
Genetic Testing Registry TRPM2
NextProtO94759 [Medical]
GENETestsTRPM2
Target ValidationTRPM2
Huge Navigator TRPM2 [HugePedia]
ClinGenTRPM2
Clinical trials, drugs, therapy
MyCancerGenomeTRPM2
Protein Interactions : CTDTRPM2
Pharm GKB GenePA37012
PharosO94759
Clinical trialTRPM2
Miscellaneous
canSAR (ICR)TRPM2
HarmonizomeTRPM2
DataMed IndexTRPM2
Probes
Litterature
PubMed130 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTRPM2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:36:31 CEST 2021

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