Atlas of Genetics and Cytogenetics in Oncology and Haematology


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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret jlhuret@AtlasGeneticsOncology.org
Donations are also welcome
If each casual visitor gives 3 Euros or Dollars, the Atlas is saved in a week !
If each professional gives 100 Euros or Dollars once a year (now), the Atlas is saved in 2 weeks !
Don't let the Atlas imminent demise
Note: we send fiscal receipts for donations equal or above 50 Euros or Dollars

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TTR (transthyretin)

Identity

Other namesCTS
CTS1
HEL111
HsT2651
PALB
TBPA
HGNC (Hugo) TTR
LocusID (NCBI) 7276
Location 18q12.1
Location_base_pair Starts at 29171730 and ends at 29178986 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TTR   12405
Cards
Entrez_Gene (NCBI)TTR  7276  transthyretin
GeneCards (Weizmann)TTR
Ensembl hg19 (Hinxton)ENSG00000118271 [Gene_View]  chr18:29171730-29178986 [Contig_View]  TTR [Vega]
Ensembl hg38 (Hinxton)ENSG00000118271 [Gene_View]  chr18:29171730-29178986 [Contig_View]  TTR [Vega]
ICGC DataPortalENSG00000118271
cBioPortalTTR
AceView (NCBI)TTR
Genatlas (Paris)TTR
WikiGenes7276
SOURCE (Princeton)TTR
Genomic and cartography
GoldenPath hg19 (UCSC)TTR  -     chr18:29171730-29178986 +  18q12.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TTR  -     18q12.1   [Description]    (hg38-Dec_2013)
EnsemblTTR - 18q12.1 [CytoView hg19]  TTR - 18q12.1 [CytoView hg38]
Mapping of homologs : NCBITTR [Mapview hg19]  TTR [Mapview hg38]
OMIM105210   115430   145680   176300   
Gene and transcription
Genbank (Entrez)AF162690 AK312051 BC005310 BC020791 BT007189
RefSeq transcript (Entrez)NM_000371
RefSeq genomic (Entrez)NC_000018 NC_018929 NG_009490 NT_010966 NW_004929410
Consensus coding sequences : CCDS (NCBI)TTR
Cluster EST : UnigeneHs.427202 [ NCBI ]
CGAP (NCI)Hs.427202
Alternative Splicing : Fast-db (Paris)GSHG0013981
Alternative Splicing GalleryENSG00000118271
Gene ExpressionTTR [ NCBI-GEO ]     TTR [ SEEK ]   TTR [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP02766 (Uniprot)
NextProtP02766  [Medical]
With graphics : InterProP02766
Splice isoforms : SwissVarP02766 (Swissvar)
Domaine pattern : Prosite (Expaxy)TRANSTHYRETIN_1 (PS00768)    TRANSTHYRETIN_2 (PS00769)   
Domains : Interpro (EBI)Thyroxine_BS    Transthyretin    Transthyretin/HIU_hydrolase    Transthyretin/HIU_hydrolase_SF    Transthyretin_CS   
Related proteins : CluSTrP02766
Domain families : Pfam (Sanger)Transthyretin (PF00576)   
Domain families : Pfam (NCBI)pfam00576   
Domain families : Smart (EMBL)TR_THY (SM00095)  
DMDM Disease mutations7276
Blocks (Seattle)P02766
PDB (SRS)1BM7    1BMZ    1BZ8    1BZD    1BZE    1DVQ    1DVS    1DVT    1DVU    1DVX    1DVY    1DVZ    1E3F    1E4H    1E5A    1ETA    1ETB    1F41    1F64    1F86    1FH2    1FHN    1G1O    1GKO    1ICT    1III    1IIK    1IJN    1QAB    1QWH    1RLB    1SOK    1SOQ    1THA    1THC    1TLM    1TSH    1TT6    1TTA    1TTB    1TTC    1TTR    1TYR    1TZ8    1U21    1X7S    1X7T    1Y1D    1Z7J    1ZCR    1ZD6    2B14    2B15    2B16    2B77    2B9A    2F7I    2F8I    2FBR    2FLM    2G3X    2G3Z    2G4E    2G4G    2G5U    2G9K    2GAB    2H4E    2M5N    2NOY    2PAB    2QEL    2QGB    2QGC    2QGD    2QGE    2ROX    2ROY    2TRH    2TRY    2WQA    3A4D    3A4E    3A4F    3B56    3BSZ    3BT0    3CBR    3CFM    3CFN    3CFQ    3CFT    3CN0    3CN1    3CN2    3CN3    3CN4    3CXF    3D2T    3D7P    3DGD    3DID    3DJR    3DJS    3DJT    3DJZ    3DK0    3DK2    3DO4    3ESN    3ESO    3ESP    3FC8    3FCB    3GLZ    3GPS    3GRB    3GRG    3GS0    3GS4    3GS7    3HJ0    3I9A    3I9I    3I9P    3IMR    3IMS    3IMT    3IMU    3IMV    3IMW    3IPB    3IPE    3KGS    3KGT    3KGU    3M1O    3NEE    3NEO    3NES    3NEX    3NG5    3OZK    3OZL    3P3R    3P3S    3P3T    3P3U    3SSG    3TCT    3TFB    3U2I    3U2J    3W3B    4ABQ    4ABU    4ABV    4ABW    4AC2    4AC4    4ACT    4ANK    4DER    4DES    4DET    4DEU    4DEW    4FI6    4FI7    4FI8    4HIQ    4HIS    4HJS    4HJT    4HJU    4I85    4I87    4I89    4IIZ    4IK6    4IK7    4IKI    4IKJ    4IKK    4IKL    4KY2    4L1S    4L1T    4MAS    4MRB    4MRC    4N85    4N86    4N87    4PM1    4PME    4PMF    4PVL    4PVM    4PVN    4PWE    4PWF    4PWG    4PWH    4PWI    4PWJ    4PWK    4QRF    5TTR   
PDB (PDBSum)1BM7    1BMZ    1BZ8    1BZD    1BZE    1DVQ    1DVS    1DVT    1DVU    1DVX    1DVY    1DVZ    1E3F    1E4H    1E5A    1ETA    1ETB    1F41    1F64    1F86    1FH2    1FHN    1G1O    1GKO    1ICT    1III    1IIK    1IJN    1QAB    1QWH    1RLB    1SOK    1SOQ    1THA    1THC    1TLM    1TSH    1TT6    1TTA    1TTB    1TTC    1TTR    1TYR    1TZ8    1U21    1X7S    1X7T    1Y1D    1Z7J    1ZCR    1ZD6    2B14    2B15    2B16    2B77    2B9A    2F7I    2F8I    2FBR    2FLM    2G3X    2G3Z    2G4E    2G4G    2G5U    2G9K    2GAB    2H4E    2M5N    2NOY    2PAB    2QEL    2QGB    2QGC    2QGD    2QGE    2ROX    2ROY    2TRH    2TRY    2WQA    3A4D    3A4E    3A4F    3B56    3BSZ    3BT0    3CBR    3CFM    3CFN    3CFQ    3CFT    3CN0    3CN1    3CN2    3CN3    3CN4    3CXF    3D2T    3D7P    3DGD    3DID    3DJR    3DJS    3DJT    3DJZ    3DK0    3DK2    3DO4    3ESN    3ESO    3ESP    3FC8    3FCB    3GLZ    3GPS    3GRB    3GRG    3GS0    3GS4    3GS7    3HJ0    3I9A    3I9I    3I9P    3IMR    3IMS    3IMT    3IMU    3IMV    3IMW    3IPB    3IPE    3KGS    3KGT    3KGU    3M1O    3NEE    3NEO    3NES    3NEX    3NG5    3OZK    3OZL    3P3R    3P3S    3P3T    3P3U    3SSG    3TCT    3TFB    3U2I    3U2J    3W3B    4ABQ    4ABU    4ABV    4ABW    4AC2    4AC4    4ACT    4ANK    4DER    4DES    4DET    4DEU    4DEW    4FI6    4FI7    4FI8    4HIQ    4HIS    4HJS    4HJT    4HJU    4I85    4I87    4I89    4IIZ    4IK6    4IK7    4IKI    4IKJ    4IKK    4IKL    4KY2    4L1S    4L1T    4MAS    4MRB    4MRC    4N85    4N86    4N87    4PM1    4PME    4PMF    4PVL    4PVM    4PVN    4PWE    4PWF    4PWG    4PWH    4PWI    4PWJ    4PWK    4QRF    5TTR   
PDB (IMB)1BM7    1BMZ    1BZ8    1BZD    1BZE    1DVQ    1DVS    1DVT    1DVU    1DVX    1DVY    1DVZ    1E3F    1E4H    1E5A    1ETA    1ETB    1F41    1F64    1F86    1FH2    1FHN    1G1O    1GKO    1ICT    1III    1IIK    1IJN    1QAB    1QWH    1RLB    1SOK    1SOQ    1THA    1THC    1TLM    1TSH    1TT6    1TTA    1TTB    1TTC    1TTR    1TYR    1TZ8    1U21    1X7S    1X7T    1Y1D    1Z7J    1ZCR    1ZD6    2B14    2B15    2B16    2B77    2B9A    2F7I    2F8I    2FBR    2FLM    2G3X    2G3Z    2G4E    2G4G    2G5U    2G9K    2GAB    2H4E    2M5N    2NOY    2PAB    2QEL    2QGB    2QGC    2QGD    2QGE    2ROX    2ROY    2TRH    2TRY    2WQA    3A4D    3A4E    3A4F    3B56    3BSZ    3BT0    3CBR    3CFM    3CFN    3CFQ    3CFT    3CN0    3CN1    3CN2    3CN3    3CN4    3CXF    3D2T    3D7P    3DGD    3DID    3DJR    3DJS    3DJT    3DJZ    3DK0    3DK2    3DO4    3ESN    3ESO    3ESP    3FC8    3FCB    3GLZ    3GPS    3GRB    3GRG    3GS0    3GS4    3GS7    3HJ0    3I9A    3I9I    3I9P    3IMR    3IMS    3IMT    3IMU    3IMV    3IMW    3IPB    3IPE    3KGS    3KGT    3KGU    3M1O    3NEE    3NEO    3NES    3NEX    3NG5    3OZK    3OZL    3P3R    3P3S    3P3T    3P3U    3SSG    3TCT    3TFB    3U2I    3U2J    3W3B    4ABQ    4ABU    4ABV    4ABW    4AC2    4AC4    4ACT    4ANK    4DER    4DES    4DET    4DEU    4DEW    4FI6    4FI7    4FI8    4HIQ    4HIS    4HJS    4HJT    4HJU    4I85    4I87    4I89    4IIZ    4IK6    4IK7    4IKI    4IKJ    4IKK    4IKL    4KY2    4L1S    4L1T    4MAS    4MRB    4MRC    4N85    4N86    4N87    4PM1    4PME    4PMF    4PVL    4PVM    4PVN    4PWE    4PWF    4PWG    4PWH    4PWI    4PWJ    4PWK    4QRF    5TTR   
PDB (RSDB)1BM7    1BMZ    1BZ8    1BZD    1BZE    1DVQ    1DVS    1DVT    1DVU    1DVX    1DVY    1DVZ    1E3F    1E4H    1E5A    1ETA    1ETB    1F41    1F64    1F86    1FH2    1FHN    1G1O    1GKO    1ICT    1III    1IIK    1IJN    1QAB    1QWH    1RLB    1SOK    1SOQ    1THA    1THC    1TLM    1TSH    1TT6    1TTA    1TTB    1TTC    1TTR    1TYR    1TZ8    1U21    1X7S    1X7T    1Y1D    1Z7J    1ZCR    1ZD6    2B14    2B15    2B16    2B77    2B9A    2F7I    2F8I    2FBR    2FLM    2G3X    2G3Z    2G4E    2G4G    2G5U    2G9K    2GAB    2H4E    2M5N    2NOY    2PAB    2QEL    2QGB    2QGC    2QGD    2QGE    2ROX    2ROY    2TRH    2TRY    2WQA    3A4D    3A4E    3A4F    3B56    3BSZ    3BT0    3CBR    3CFM    3CFN    3CFQ    3CFT    3CN0    3CN1    3CN2    3CN3    3CN4    3CXF    3D2T    3D7P    3DGD    3DID    3DJR    3DJS    3DJT    3DJZ    3DK0    3DK2    3DO4    3ESN    3ESO    3ESP    3FC8    3FCB    3GLZ    3GPS    3GRB    3GRG    3GS0    3GS4    3GS7    3HJ0    3I9A    3I9I    3I9P    3IMR    3IMS    3IMT    3IMU    3IMV    3IMW    3IPB    3IPE    3KGS    3KGT    3KGU    3M1O    3NEE    3NEO    3NES    3NEX    3NG5    3OZK    3OZL    3P3R    3P3S    3P3T    3P3U    3SSG    3TCT    3TFB    3U2I    3U2J    3W3B    4ABQ    4ABU    4ABV    4ABW    4AC2    4AC4    4ACT    4ANK    4DER    4DES    4DET    4DEU    4DEW    4FI6    4FI7    4FI8    4HIQ    4HIS    4HJS    4HJT    4HJU    4I85    4I87    4I89    4IIZ    4IK6    4IK7    4IKI    4IKJ    4IKK    4IKL    4KY2    4L1S    4L1T    4MAS    4MRB    4MRC    4N85    4N86    4N87    4PM1    4PME    4PMF    4PVL    4PVM    4PVN    4PWE    4PWF    4PWG    4PWH    4PWI    4PWJ    4PWK    4QRF    5TTR   
Human Protein AtlasENSG00000118271
Peptide AtlasP02766
HPRD01447
IPIIPI00022432   IPI00940791   IPI01015306   
Protein Interaction databases
DIP (DOE-UCLA)P02766
IntAct (EBI)P02766
FunCoupENSG00000118271
BioGRIDTTR
IntegromeDBTTR
STRING (EMBL)TTR
Ontologies - Pathways
QuickGOP02766
Ontology : AmiGOretinoid metabolic process  hormone activity  protein binding  extracellular region  extracellular region  extracellular space  cytoplasm  transport  phototransduction, visible light  extracellular matrix organization  retinol metabolic process  identical protein binding  protein complex  protein heterodimerization activity  extracellular exosome  thyroid hormone binding  thyroid hormone transport  
Ontology : EGO-EBIretinoid metabolic process  hormone activity  protein binding  extracellular region  extracellular region  extracellular space  cytoplasm  transport  phototransduction, visible light  extracellular matrix organization  retinol metabolic process  identical protein binding  protein complex  protein heterodimerization activity  extracellular exosome  thyroid hormone binding  thyroid hormone transport  
Protein Interaction DatabaseTTR
DoCM (Curated mutations)TTR
Wikipedia pathwaysTTR
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerTTR [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TTR
dbVarTTR
ClinVarTTR
1000_GenomesTTR 
Exome Variant ServerTTR
SNP (GeneSNP Utah)TTR
SNP : HGBaseTTR
Genetic variants : HAPMAPTTR
Genomic Variants (DGV)TTR [DGVbeta]
Mutations
ICGC Data PortalENSG00000118271 
Somatic Mutations in Cancer : COSMICTTR 
CONAN: Copy Number AnalysisTTR 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)Leiden Muscular Dystrophy pages
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)18:29171730-29178986
Mutations and Diseases : HGMDTTR
OMIM105210    115430    145680    176300   
MedgenTTR
NextProtP02766 [Medical]
GENETestsTTR
Disease Genetic AssociationTTR
Huge Navigator TTR [HugePedia]  TTR [HugeCancerGEM]
snp3D : Map Gene to Disease7276
DGIdb (Drug Gene Interaction db)TTR
General knowledge
Homologs : HomoloGeneTTR
Homology/Alignments : Family Browser (UCSC)TTR
Phylogenetic Trees/Animal Genes : TreeFamTTR
Chemical/Protein Interactions : CTD7276
Chemical/Pharm GKB GenePA37069
Clinical trialTTR
Cancer Resource (Charite)ENSG00000118271
Other databases
Probes
Litterature
PubMed425 Pubmed reference(s) in Entrez
CoreMineTTR
GoPubMedTTR
iHOPTTR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Mar 28 17:44:43 CET 2015

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jlhuret@AtlasGeneticsOncology.org.