Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TYK2 (tyrosine kinase 2)

Identity

Alias (NCBI)IMD35
JTK1
HGNC (Hugo) TYK2
HGNC Alias symbJTK1
LocusID (NCBI) 7297
Atlas_Id 446
Location 19p13.2  [Link to chromosome band 19p13]
Location_base_pair Starts at 10350533 and ends at 10380572 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ELAVL1 (19p13.2) / TYK2 (19p13.2)NPM1 (5q35.1) / TYK2 (19p13.2)PLCD3 (17q21.31) / TYK2 (19p13.2)
TBC1D13 (9q34.11) / TYK2 (19p13.2)TYK2 (19p13.2) / ARRB2 (17p13.2)TYK2 (19p13.2) / CDC37 (19p13.2)
TYK2 (19p13.2) / SHC2 (19p13.3)TYK2 (19p13.2) / SHISA4 (1q32.1)ZNF700 (19p13.2) / TYK2 (19p13.2)
TYK2 19p13.2 / CDC37 19p13.2TYK2 19p13.2 / SHC2 19p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 7 ]
  Anaplastic large cell lymphoma, ALK-negative
t(9;14)(p24;q12) STRN3/JAK2
t(1;19)(p34;p13) PABPC4/TYK2
t(5;19)(q35;p13) NPM1/TYK2
t(10;19)(q24;p13) NFKB2/TYK2
t(19;19)(p12;p13) ZNF430/TYK2
t(19;19)(p13;p13) SMARCA4/TYK2

External links

 

Nomenclature
HGNC (Hugo)TYK2   12440
LRG (Locus Reference Genomic)LRG_121
Cards
Entrez_Gene (NCBI)TYK2    tyrosine kinase 2
AliasesIMD35; JTK1
GeneCards (Weizmann)TYK2
Ensembl hg19 (Hinxton)ENSG00000105397 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105397 [Gene_View]  ENSG00000105397 [Sequence]  chr19:10350533-10380572 [Contig_View]  TYK2 [Vega]
ICGC DataPortalENSG00000105397
TCGA cBioPortalTYK2
AceView (NCBI)TYK2
Genatlas (Paris)TYK2
SOURCE (Princeton)TYK2
Genetics Home Reference (NIH)TYK2
Genomic and cartography
GoldenPath hg38 (UCSC)TYK2  -     chr19:10350533-10380572 -  19p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TYK2  -     19p13.2   [Description]    (hg19-Feb_2009)
GoldenPathTYK2 - 19p13.2 [CytoView hg19]  TYK2 - 19p13.2 [CytoView hg38]
ImmunoBaseENSG00000105397
Genome Data Viewer NCBITYK2 [Mapview hg19]  
OMIM176941   611521   
Gene and transcription
Genbank (Entrez)AK222672 AK303627 AK308360 AK308379 BC014243
RefSeq transcript (Entrez)NM_001385197 NM_001385198 NM_001385199 NM_001385200 NM_001385201 NM_001385202 NM_001385203 NM_001385204 NM_001385205 NM_001385206 NM_001385207 NM_003331
Consensus coding sequences : CCDS (NCBI)TYK2
Gene ExpressionTYK2 [ NCBI-GEO ]   TYK2 [ EBI - ARRAY_EXPRESS ]   TYK2 [ SEEK ]   TYK2 [ MEM ]
Gene Expression Viewer (FireBrowse)TYK2 [ Firebrowse - Broad ]
GenevisibleExpression of TYK2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7297
GTEX Portal (Tissue expression)TYK2
Human Protein AtlasENSG00000105397-TYK2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP29597   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP29597  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP29597
PhosPhoSitePlusP29597
Domaine pattern : Prosite (Expaxy)FERM_3 (PS50057)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)   
Domains : Interpro (EBI)Band_41_domain    FERM_2    FERM_domain    FERM_F1    FERM_F2    Jak1_PHL_dom    Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    SH2    SH2_dom_sf    Tyr_kinase_AS    Tyr_kinase_cat_dom    Tyr_kinase_non-rcpt_Jak/Tyk2    Tyr_kinase_non-rcpt_TYK2_N   
Domain families : Pfam (Sanger)FERM_F1 (PF18379)    FERM_F2 (PF18377)    Jak1_Phl (PF17887)    PK_Tyr_Ser-Thr (PF07714)   
Domain families : Pfam (NCBI)pfam18379    pfam18377    pfam17887    pfam07714   
Domain families : Smart (EMBL)B41 (SM00295)  SH2 (SM00252)  TyrKc (SM00219)  
Conserved Domain (NCBI)TYK2
PDB (RSDB)3LXN    3LXP    3NYX    3NZ0    3ZON    4GFO    4GIH    4GII    4GJ2    4GJ3    4GVJ    4OLI    4PO6    4PY1    4WOV    5C01    5C03    5F1Z    5F20    5TKD    5WAL    6AAM    6DBK    6DBM    6NSL    6NZE    6NZF    6NZH    6NZP    6NZQ    6NZR    6OVA    6VNS    6VNV    6VNX    6VNY   
PDB Europe3LXN    3LXP    3NYX    3NZ0    3ZON    4GFO    4GIH    4GII    4GJ2    4GJ3    4GVJ    4OLI    4PO6    4PY1    4WOV    5C01    5C03    5F1Z    5F20    5TKD    5WAL    6AAM    6DBK    6DBM    6NSL    6NZE    6NZF    6NZH    6NZP    6NZQ    6NZR    6OVA    6VNS    6VNV    6VNX    6VNY   
PDB (PDBSum)3LXN    3LXP    3NYX    3NZ0    3ZON    4GFO    4GIH    4GII    4GJ2    4GJ3    4GVJ    4OLI    4PO6    4PY1    4WOV    5C01    5C03    5F1Z    5F20    5TKD    5WAL    6AAM    6DBK    6DBM    6NSL    6NZE    6NZF    6NZH    6NZP    6NZQ    6NZR    6OVA    6VNS    6VNV    6VNX    6VNY   
PDB (IMB)3LXN    3LXP    3NYX    3NZ0    3ZON    4GFO    4GIH    4GII    4GJ2    4GJ3    4GVJ    4OLI    4PO6    4PY1    4WOV    5C01    5C03    5F1Z    5F20    5TKD    5WAL    6AAM    6DBK    6DBM    6NSL    6NZE    6NZF    6NZH    6NZP    6NZQ    6NZR    6OVA    6VNS    6VNV    6VNX    6VNY   
Structural Biology KnowledgeBase3LXN    3LXP    3NYX    3NZ0    3ZON    4GFO    4GIH    4GII    4GJ2    4GJ3    4GVJ    4OLI    4PO6    4PY1    4WOV    5C01    5C03    5F1Z    5F20    5TKD    5WAL    6AAM    6DBK    6DBM    6NSL    6NZE    6NZF    6NZH    6NZP    6NZQ    6NZR    6OVA    6VNS    6VNV    6VNX    6VNY   
SCOP (Structural Classification of Proteins)3LXN    3LXP    3NYX    3NZ0    3ZON    4GFO    4GIH    4GII    4GJ2    4GJ3    4GVJ    4OLI    4PO6    4PY1    4WOV    5C01    5C03    5F1Z    5F20    5TKD    5WAL    6AAM    6DBK    6DBM    6NSL    6NZE    6NZF    6NZH    6NZP    6NZQ    6NZR    6OVA    6VNS    6VNV    6VNX    6VNY   
CATH (Classification of proteins structures)3LXN    3LXP    3NYX    3NZ0    3ZON    4GFO    4GIH    4GII    4GJ2    4GJ3    4GVJ    4OLI    4PO6    4PY1    4WOV    5C01    5C03    5F1Z    5F20    5TKD    5WAL    6AAM    6DBK    6DBM    6NSL    6NZE    6NZF    6NZH    6NZP    6NZQ    6NZR    6OVA    6VNS    6VNV    6VNX    6VNY   
SuperfamilyP29597
AlphaFold pdb e-kbP29597   
Human Protein Atlas [tissue]ENSG00000105397-TYK2 [tissue]
HPRD01490
Protein Interaction databases
DIP (DOE-UCLA)P29597
IntAct (EBI)P29597
BioGRIDTYK2
STRING (EMBL)TYK2
ZODIACTYK2
Ontologies - Pathways
QuickGOP29597
Ontology : AmiGOprotein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  growth hormone receptor binding  protein binding  ATP binding  nucleus  cytoplasm  cytosol  cytoskeleton  protein phosphorylation  membrane  peptidyl-tyrosine phosphorylation  cytokine-mediated signaling pathway  type 1 angiotensin receptor binding  intracellular signal transduction  interleukin-12-mediated signaling pathway  interleukin-23-mediated signaling pathway  type I interferon signaling pathway  extracellular exosome  interleukin-27-mediated signaling pathway  
Ontology : EGO-EBIprotein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  growth hormone receptor binding  protein binding  ATP binding  nucleus  cytoplasm  cytosol  cytoskeleton  protein phosphorylation  membrane  peptidyl-tyrosine phosphorylation  cytokine-mediated signaling pathway  type 1 angiotensin receptor binding  intracellular signal transduction  interleukin-12-mediated signaling pathway  interleukin-23-mediated signaling pathway  type I interferon signaling pathway  extracellular exosome  interleukin-27-mediated signaling pathway  
Pathways : BIOCARTAStat3 Signaling Pathway [Genes]    IFN alpha signaling pathway [Genes]    NO2-dependent IL 12 Pathway in NK cells [Genes]    IL12 and Stat4 Dependent Signaling Pathway in Th1 Development [Genes]    IL22 Soluble Receptor Signaling Pathway [Genes]   
Pathways : KEGGOsteoclast differentiation    Jak-STAT signaling pathway    Toxoplasmosis    Hepatitis C    Measles    Influenza A    Herpes simplex infection    Epstein-Barr virus infection   
NDEx NetworkTYK2
Atlas of Cancer Signalling NetworkTYK2
Wikipedia pathwaysTYK2
Orthology - Evolution
OrthoDB7297
GeneTree (enSembl)ENSG00000105397
Phylogenetic Trees/Animal Genes : TreeFamTYK2
Homologs : HomoloGeneTYK2
Homology/Alignments : Family Browser (UCSC)TYK2
Gene fusions - Rearrangements
Fusion : MitelmanNPM1/TYK2 [5q35.1/19p13.2]  
Fusion : MitelmanTYK2/CDC37 [19p13.2/19p13.2]  
Fusion : MitelmanTYK2/SHC2 [19p13.2/19p13.3]  
Fusion : QuiverTYK2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTYK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TYK2
dbVarTYK2
ClinVarTYK2
MonarchTYK2
1000_GenomesTYK2 
Exome Variant ServerTYK2
GNOMAD BrowserENSG00000105397
Varsome BrowserTYK2
ACMGTYK2 variants
VarityP29597
Genomic Variants (DGV)TYK2 [DGVbeta]
DECIPHERTYK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTYK2 
Mutations
ICGC Data PortalTYK2 
TCGA Data PortalTYK2 
Broad Tumor PortalTYK2
OASIS PortalTYK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTYK2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTYK2
Mutations and Diseases : HGMDTYK2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTYK2
DgiDB (Drug Gene Interaction Database)TYK2
DoCM (Curated mutations)TYK2
CIViC (Clinical Interpretations of Variants in Cancer)TYK2
Cancer3DTYK2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176941    611521   
Orphanet22001    21147    11710    11709    13859   
DisGeNETTYK2
MedgenTYK2
Genetic Testing Registry TYK2
NextProtP29597 [Medical]
GENETestsTYK2
Target ValidationTYK2
Huge Navigator TYK2 [HugePedia]
ClinGenTYK2
Clinical trials, drugs, therapy
MyCancerGenomeTYK2
Protein Interactions : CTDTYK2
Pharm GKB GenePA37094
Pharm GKB PathwaysPA166126086   
PharosP29597
Clinical trialTYK2
Miscellaneous
canSAR (ICR)TYK2
HarmonizomeTYK2
DataMed IndexTYK2
Probes
Litterature
PubMed204 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTYK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:36:59 CEST 2021
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