TYK2 (tyrosine kinase 2)

2003-02-01  

Identity

HGNC
LOCATION
19p13.2
LOCUSID
ALIAS
IMD35,JTK1
FUSION GENES

Other Information

Locus ID:

NCBI: 7297
MIM: 176941
HGNC: 12440
Ensembl: ENSG00000105397

Variants:

dbSNP: 7297
ClinVar: 7297
TCGA: ENSG00000105397
COSMIC: TYK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105397ENST00000264818P29597
ENSG00000105397ENST00000264818A0A024R7E4
ENSG00000105397ENST00000524462E9PM19
ENSG00000105397ENST00000525220H0YE41
ENSG00000105397ENST00000525621P29597
ENSG00000105397ENST00000525621A0A024R7E4
ENSG00000105397ENST00000525976H0YE24
ENSG00000105397ENST00000527481K7EM33
ENSG00000105397ENST00000529370E9PPF2
ENSG00000105397ENST00000530560K7EJR6
ENSG00000105397ENST00000530829E9PQE9
ENSG00000105397ENST00000531836E9PQL2
ENSG00000105397ENST00000533334H0YCT7

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Jak-STAT signaling pathwayKEGGko04630
Jak-STAT signaling pathwayKEGGhsa04630
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
JAK-STAT signalingKEGGhsa_M00684
JAK-STAT signalingKEGGM00684
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733
Regulation of IFNA signalingREACTOMER-HSA-912694
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-6 signalingREACTOMER-HSA-1059683
Signal TransductionREACTOMER-HSA-162582
MAPK family signaling cascadesREACTOMER-HSA-5683057
MAPK1/MAPK3 signalingREACTOMER-HSA-5684996
RAF-independent MAPK1/3 activationREACTOMER-HSA-112409
MAPK3 (ERK1) activationREACTOMER-HSA-110056
MAPK1 (ERK2) activationREACTOMER-HSA-112411
Interleukin-6 family signalingREACTOMER-HSA-6783589
IL-6-type cytokine receptor ligand interactionsREACTOMER-HSA-6788467
Th1 and Th2 cell differentiationKEGGko04658
Th1 and Th2 cell differentiationKEGGhsa04658
Th17 cell differentiationKEGGko04659
Th17 cell differentiationKEGGhsa04659
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807
Interleukin-10 signalingREACTOMER-HSA-6783783

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
209531902010A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.309
195259552009Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.185
156578752005Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.182
199668052010The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes.112
192490082009Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease.109
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
229610002012Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis.93
182703282008Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia.90
220461412011Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus.90
125546542003The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression.66

Citation

Dessen P

TYK2 (tyrosine kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/446/tyk2