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TYK2 (tyrosine kinase 2)

Identity

Alias_symbol (synonym)JTK1
Other aliasIMD35
HGNC (Hugo) TYK2
LocusID (NCBI) 7297
Atlas_Id 446
Location 19p13.2  [Link to chromosome band 19p13]
Location_base_pair Starts at 10350533 and ends at 10380572 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ELAVL1 (19p13.2) / TYK2 (19p13.2)NPM1 (5q35.1) / TYK2 (19p13.2)PLCD3 (17q21.31) / TYK2 (19p13.2)
TBC1D13 (9q34.11) / TYK2 (19p13.2)TYK2 (19p13.2) / ARRB2 (17p13.2)TYK2 (19p13.2) / CDC37 (19p13.2)
TYK2 (19p13.2) / SHC2 (19p13.3)TYK2 (19p13.2) / SHISA4 (1q32.1)ZNF700 (19p13.2) / TYK2 (19p13.2)
TYK2 19p13.2 / CDC37 19p13.2TYK2 19p13.2 / SHC2 19p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 7 ]
  Anaplastic large cell lymphoma, ALK-negative
t(9;14)(p24;q12) STRN3/JAK2
t(1;19)(p34;p13) PABPC4/TYK2
t(5;19)(q35;p13) NPM1/TYK2
t(10;19)(q24;p13) NFKB2/TYK2
t(19;19)(p12;p13) ZNF430/TYK2
t(19;19)(p13;p13) SMARCA4/TYK2

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  TYK2/CDC37 (19p13)
TYK2/SHC2 (19p13)

External links

Nomenclature
HGNC (Hugo)TYK2   12440
LRG (Locus Reference Genomic)LRG_121
Cards
Entrez_Gene (NCBI)TYK2  7297  tyrosine kinase 2
AliasesIMD35; JTK1
GeneCards (Weizmann)TYK2
Ensembl hg19 (Hinxton)ENSG00000105397 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105397 [Gene_View]  ENSG00000105397 [Sequence]  chr19:10350533-10380572 [Contig_View]  TYK2 [Vega]
ICGC DataPortalENSG00000105397
TCGA cBioPortalTYK2
AceView (NCBI)TYK2
Genatlas (Paris)TYK2
WikiGenes7297
SOURCE (Princeton)TYK2
Genetics Home Reference (NIH)TYK2
Genomic and cartography
GoldenPath hg38 (UCSC)TYK2  -     chr19:10350533-10380572 -  19p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TYK2  -     19p13.2   [Description]    (hg19-Feb_2009)
GoldenPathTYK2 - 19p13.2 [CytoView hg19]  TYK2 - 19p13.2 [CytoView hg38]
Genome Data Viewer NCBITYK2 [Mapview hg19]  
OMIM176941   611521   
Gene and transcription
Genbank (Entrez)AK222672 AK303627 AK308360 AK308379 BC014243
RefSeq transcript (Entrez)NM_003331
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TYK2
Alternative Splicing GalleryENSG00000105397
Gene ExpressionTYK2 [ NCBI-GEO ]   TYK2 [ EBI - ARRAY_EXPRESS ]   TYK2 [ SEEK ]   TYK2 [ MEM ]
Gene Expression Viewer (FireBrowse)TYK2 [ Firebrowse - Broad ]
GenevisibleExpression of TYK2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7297
GTEX Portal (Tissue expression)TYK2
Human Protein AtlasENSG00000105397-TYK2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP29597   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP29597  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP29597
Splice isoforms : SwissVarP29597
PhosPhoSitePlusP29597
Domaine pattern : Prosite (Expaxy)FERM_3 (PS50057)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)   
Domains : Interpro (EBI)Band_41_domain    FERM_2    FERM_domain    FERM_F1    FERM_F2    Jak1_PHL_dom    Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    SH2    SH2_dom_sf    Tyr_kinase_AS    Tyr_kinase_cat_dom    Tyr_kinase_non-rcpt_Jak/Tyk2    Tyr_kinase_non-rcpt_TYK2_N   
Domain families : Pfam (Sanger)FERM_F1 (PF18379)    FERM_F2 (PF18377)    Jak1_Phl (PF17887)    Pkinase_Tyr (PF07714)   
Domain families : Pfam (NCBI)pfam18379    pfam18377    pfam17887    pfam07714   
Domain families : Smart (EMBL)B41 (SM00295)  SH2 (SM00252)  TyrKc (SM00219)  
Conserved Domain (NCBI)TYK2
DMDM Disease mutations7297
PDB (RSDB)3LXN    3LXP    3NYX    3NZ0    3ZON    4GFO    4GIH    4GII    4GJ2    4GJ3    4GVJ    4OLI    4PO6    4PY1    4WOV    5C01    5C03    5F1Z    5F20    5TKD    5WAL    6AAM    6DBK    6DBM    6NZE    6NZF    6NZH    6NZP    6NZQ    6NZR   
PDB Europe3LXN    3LXP    3NYX    3NZ0    3ZON    4GFO    4GIH    4GII    4GJ2    4GJ3    4GVJ    4OLI    4PO6    4PY1    4WOV    5C01    5C03    5F1Z    5F20    5TKD    5WAL    6AAM    6DBK    6DBM    6NZE    6NZF    6NZH    6NZP    6NZQ    6NZR   
PDB (PDBSum)3LXN    3LXP    3NYX    3NZ0    3ZON    4GFO    4GIH    4GII    4GJ2    4GJ3    4GVJ    4OLI    4PO6    4PY1    4WOV    5C01    5C03    5F1Z    5F20    5TKD    5WAL    6AAM    6DBK    6DBM    6NZE    6NZF    6NZH    6NZP    6NZQ    6NZR   
PDB (IMB)3LXN    3LXP    3NYX    3NZ0    3ZON    4GFO    4GIH    4GII    4GJ2    4GJ3    4GVJ    4OLI    4PO6    4PY1    4WOV    5C01    5C03    5F1Z    5F20    5TKD    5WAL    6AAM    6DBK    6DBM    6NZE    6NZF    6NZH    6NZP    6NZQ    6NZR   
Structural Biology KnowledgeBase3LXN    3LXP    3NYX    3NZ0    3ZON    4GFO    4GIH    4GII    4GJ2    4GJ3    4GVJ    4OLI    4PO6    4PY1    4WOV    5C01    5C03    5F1Z    5F20    5TKD    5WAL    6AAM    6DBK    6DBM    6NZE    6NZF    6NZH    6NZP    6NZQ    6NZR   
SCOP (Structural Classification of Proteins)3LXN    3LXP    3NYX    3NZ0    3ZON    4GFO    4GIH    4GII    4GJ2    4GJ3    4GVJ    4OLI    4PO6    4PY1    4WOV    5C01    5C03    5F1Z    5F20    5TKD    5WAL    6AAM    6DBK    6DBM    6NZE    6NZF    6NZH    6NZP    6NZQ    6NZR   
CATH (Classification of proteins structures)3LXN    3LXP    3NYX    3NZ0    3ZON    4GFO    4GIH    4GII    4GJ2    4GJ3    4GVJ    4OLI    4PO6    4PY1    4WOV    5C01    5C03    5F1Z    5F20    5TKD    5WAL    6AAM    6DBK    6DBM    6NZE    6NZF    6NZH    6NZP    6NZQ    6NZR   
SuperfamilyP29597
Human Protein Atlas [tissue]ENSG00000105397-TYK2 [tissue]
Peptide AtlasP29597
HPRD01490
IPIIPI00022353   IPI00978964   IPI00981008   IPI00980344   IPI00981671   IPI00979757   IPI00978289   IPI00979674   IPI00976268   
Protein Interaction databases
DIP (DOE-UCLA)P29597
IntAct (EBI)P29597
FunCoupENSG00000105397
BioGRIDTYK2
STRING (EMBL)TYK2
ZODIACTYK2
Ontologies - Pathways
QuickGOP29597
Ontology : AmiGOprotein tyrosine kinase activity  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  growth hormone receptor binding  protein binding  ATP binding  nucleus  cytoplasm  cytosol  cytoskeleton  protein phosphorylation  membrane  peptidyl-tyrosine phosphorylation  cytokine-mediated signaling pathway  type 1 angiotensin receptor binding  intracellular signal transduction  interleukin-12-mediated signaling pathway  interleukin-23-mediated signaling pathway  type I interferon signaling pathway  extracellular exosome  interleukin-27-mediated signaling pathway  
Ontology : EGO-EBIprotein tyrosine kinase activity  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  growth hormone receptor binding  protein binding  ATP binding  nucleus  cytoplasm  cytosol  cytoskeleton  protein phosphorylation  membrane  peptidyl-tyrosine phosphorylation  cytokine-mediated signaling pathway  type 1 angiotensin receptor binding  intracellular signal transduction  interleukin-12-mediated signaling pathway  interleukin-23-mediated signaling pathway  type I interferon signaling pathway  extracellular exosome  interleukin-27-mediated signaling pathway  
Pathways : KEGGOsteoclast differentiation    Jak-STAT signaling pathway    Toxoplasmosis    Hepatitis C    Measles    Influenza A    Herpes simplex infection    Epstein-Barr virus infection   
NDEx NetworkTYK2
Atlas of Cancer Signalling NetworkTYK2
Wikipedia pathwaysTYK2
Orthology - Evolution
OrthoDB7297
GeneTree (enSembl)ENSG00000105397
Phylogenetic Trees/Animal Genes : TreeFamTYK2
HOGENOMP29597
Homologs : HomoloGeneTYK2
Homology/Alignments : Family Browser (UCSC)TYK2
Gene fusions - Rearrangements
Fusion : MitelmanNPM1/TYK2 [5q35.1/19p13.2]  
Fusion : MitelmanTYK2/CDC37 [19p13.2/19p13.2]  
Fusion : MitelmanTYK2/SHC2 [19p13.2/19p13.3]  
Fusion PortalTYK2 19p13.2 CDC37 19p13.2 BRCA
Fusion PortalTYK2 19p13.2 SHC2 19p13.3 BRCA
Fusion : QuiverTYK2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTYK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TYK2
dbVarTYK2
ClinVarTYK2
1000_GenomesTYK2 
Exome Variant ServerTYK2
GNOMAD BrowserENSG00000105397
Varsome BrowserTYK2
Genetic variants : HAPMAP7297
Genomic Variants (DGV)TYK2 [DGVbeta]
DECIPHERTYK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTYK2 
Mutations
ICGC Data PortalTYK2 
TCGA Data PortalTYK2 
Broad Tumor PortalTYK2
OASIS PortalTYK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTYK2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTYK2
Mutations and Diseases : HGMDTYK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutaselect TYK2
DgiDB (Drug Gene Interaction Database)TYK2
DoCM (Curated mutations)TYK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TYK2 (select a term)
intoGenTYK2
Cancer3DTYK2 (select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176941    611521   
Orphanet22001    21147    11710    11709    13859   
DisGeNETTYK2
MedgenTYK2
Genetic Testing Registry TYK2
NextProtP29597 [Medical]
TSGene7297
GENETestsTYK2
Open Targets GeneticsENSG00000105397  [validation]
snp3D : Map Gene to Disease7297
BioCentury BCIQTYK2
ClinGenTYK2
Clinical trials, drugs, therapy
Protein Interactions : CTD7297
Pharm GKB GenePA37094
Pharm GKB PathwaysPA166126086   
Clinical trialTYK2
Miscellaneous
canSAR (ICR)TYK2 (select the gene name)
HarmonizomeTYK2
DataMed IndexTYK2
Probes
Litterature
PubMed194 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTYK2
EVEXTYK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jul 11 20:17:20 CEST 2020
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