Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

TYMS (thymidylate synthetase)

Identity

Alias_namesTS
Alias_symbol (synonym)Tsase
TMS
HsT422
Other aliasHST422
HGNC (Hugo) TYMS
LocusID (NCBI) 7298
Atlas_Id 42737
Location 18p11.32  [Link to chromosome band 18p11]
Location_base_pair Starts at 657604 and ends at 673499 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TYMS (18p11.32) / AMACR (5p13.2)TYMS (18p11.32) / MORF4L1 (15q25.1)TYMS (18p11.32) / SEPT9 (17q25.2)
TYMS (18p11.32) / TGIF2-C20orf24 (20q11.23)TYMS (18p11.32) / TRAIP (3p21.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TYMS   12441
LRG (Locus Reference Genomic)LRG_783
Cards
Entrez_Gene (NCBI)TYMS  7298  thymidylate synthetase
AliasesHST422; TMS; TS
GeneCards (Weizmann)TYMS
Ensembl hg19 (Hinxton)ENSG00000176890 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000176890 [Gene_View]  chr18:657604-673499 [Contig_View]  TYMS [Vega]
ICGC DataPortalENSG00000176890
TCGA cBioPortalTYMS
AceView (NCBI)TYMS
Genatlas (Paris)TYMS
WikiGenes7298
SOURCE (Princeton)TYMS
Genetics Home Reference (NIH)TYMS
Genomic and cartography
GoldenPath hg38 (UCSC)TYMS  -     chr18:657604-673499 +  18p11.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TYMS  -     18p11.32   [Description]    (hg19-Feb_2009)
EnsemblTYMS - 18p11.32 [CytoView hg19]  TYMS - 18p11.32 [CytoView hg38]
Mapping of homologs : NCBITYMS [Mapview hg19]  TYMS [Mapview hg38]
OMIM188350   
Gene and transcription
Genbank (Entrez)AB062290 AB077207 AB077208 AK223372 AK292620
RefSeq transcript (Entrez)NM_001071
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TYMS
Cluster EST : UnigeneHs.369762 [ NCBI ]
CGAP (NCI)Hs.369762
Alternative Splicing GalleryENSG00000176890
Gene ExpressionTYMS [ NCBI-GEO ]   TYMS [ EBI - ARRAY_EXPRESS ]   TYMS [ SEEK ]   TYMS [ MEM ]
Gene Expression Viewer (FireBrowse)TYMS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7298
GTEX Portal (Tissue expression)TYMS
Human Protein AtlasENSG00000176890-TYMS [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04818   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP04818  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP04818
Splice isoforms : SwissVarP04818
PhosPhoSitePlusP04818
Domaine pattern : Prosite (Expaxy)THYMIDYLATE_SYNTHASE (PS00091)   
Domains : Interpro (EBI)Thymidate_synth/dCMP_Mease    Thymidylate_synthase    Thymidylate_synthase_AS   
Domain families : Pfam (Sanger)Thymidylat_synt (PF00303)   
Domain families : Pfam (NCBI)pfam00303   
Conserved Domain (NCBI)TYMS
DMDM Disease mutations7298
Blocks (Seattle)TYMS
PDB (SRS)1HVY    1HW3    1HW4    1HZW    1I00    1JU6    1JUJ    1YPV    2ONB    2RD8    2RDA    3EAW    3EBU    3ED7    3EDW    3EF9    3EGY    3EHI    3EJL    3GG5    3GH0    3GH2    3H9K    3HB8    3N5E    3N5G    3OB7    4E28    4FGT    4G2O    4G6W    4GD7    4GYH    4H1I    4JEF    4KPW    4O1U    4O1X    4UP1    5HS3    5WRN   
PDB (PDBSum)1HVY    1HW3    1HW4    1HZW    1I00    1JU6    1JUJ    1YPV    2ONB    2RD8    2RDA    3EAW    3EBU    3ED7    3EDW    3EF9    3EGY    3EHI    3EJL    3GG5    3GH0    3GH2    3H9K    3HB8    3N5E    3N5G    3OB7    4E28    4FGT    4G2O    4G6W    4GD7    4GYH    4H1I    4JEF    4KPW    4O1U    4O1X    4UP1    5HS3    5WRN   
PDB (IMB)1HVY    1HW3    1HW4    1HZW    1I00    1JU6    1JUJ    1YPV    2ONB    2RD8    2RDA    3EAW    3EBU    3ED7    3EDW    3EF9    3EGY    3EHI    3EJL    3GG5    3GH0    3GH2    3H9K    3HB8    3N5E    3N5G    3OB7    4E28    4FGT    4G2O    4G6W    4GD7    4GYH    4H1I    4JEF    4KPW    4O1U    4O1X    4UP1    5HS3    5WRN   
PDB (RSDB)1HVY    1HW3    1HW4    1HZW    1I00    1JU6    1JUJ    1YPV    2ONB    2RD8    2RDA    3EAW    3EBU    3ED7    3EDW    3EF9    3EGY    3EHI    3EJL    3GG5    3GH0    3GH2    3H9K    3HB8    3N5E    3N5G    3OB7    4E28    4FGT    4G2O    4G6W    4GD7    4GYH    4H1I    4JEF    4KPW    4O1U    4O1X    4UP1    5HS3    5WRN   
Structural Biology KnowledgeBase1HVY    1HW3    1HW4    1HZW    1I00    1JU6    1JUJ    1YPV    2ONB    2RD8    2RDA    3EAW    3EBU    3ED7    3EDW    3EF9    3EGY    3EHI    3EJL    3GG5    3GH0    3GH2    3H9K    3HB8    3N5E    3N5G    3OB7    4E28    4FGT    4G2O    4G6W    4GD7    4GYH    4H1I    4JEF    4KPW    4O1U    4O1X    4UP1    5HS3    5WRN   
SCOP (Structural Classification of Proteins)1HVY    1HW3    1HW4    1HZW    1I00    1JU6    1JUJ    1YPV    2ONB    2RD8    2RDA    3EAW    3EBU    3ED7    3EDW    3EF9    3EGY    3EHI    3EJL    3GG5    3GH0    3GH2    3H9K    3HB8    3N5E    3N5G    3OB7    4E28    4FGT    4G2O    4G6W    4GD7    4GYH    4H1I    4JEF    4KPW    4O1U    4O1X    4UP1    5HS3    5WRN   
CATH (Classification of proteins structures)1HVY    1HW3    1HW4    1HZW    1I00    1JU6    1JUJ    1YPV    2ONB    2RD8    2RDA    3EAW    3EBU    3ED7    3EDW    3EF9    3EGY    3EHI    3EJL    3GG5    3GH0    3GH2    3H9K    3HB8    3N5E    3N5G    3OB7    4E28    4FGT    4G2O    4G6W    4GD7    4GYH    4H1I    4JEF    4KPW    4O1U    4O1X    4UP1    5HS3    5WRN   
SuperfamilyP04818
Human Protein Atlas [tissue]ENSG00000176890-TYMS [tissue]
Peptide AtlasP04818
HPRD01774
IPIIPI00221108   IPI00103732   IPI00103733   
Protein Interaction databases
DIP (DOE-UCLA)P04818
IntAct (EBI)P04818
FunCoupENSG00000176890
BioGRIDTYMS
STRING (EMBL)TYMS
ZODIACTYMS
Ontologies - Pathways
QuickGOP04818
Ontology : AmiGOG1/S transition of mitotic cell cycle  regulation of transcription involved in G1/S transition of mitotic cell cycle  nucleotide binding  translation repressor activity, nucleic acid binding  thymidylate synthase activity  thymidylate synthase activity  folic acid binding  nucleus  nucleoplasm  nucleolus  cytoplasm  mitochondrion  mitochondrial inner membrane  mitochondrial matrix  cytosol  dTMP biosynthetic process  dTTP biosynthetic process  aging  circadian rhythm  drug binding  cell proliferation  response to toxic substance  cell growth  negative regulation of translation  immortalization of host cell by virus  uracil metabolic process  methylation  response to progesterone  response to vitamin A  response to cytokine  tetrahydrofolate interconversion  response to drug  protein homodimerization activity  response to ethanol  dUMP metabolic process  pyrimidine nucleoside biosynthetic process  response to organophosphorus  cofactor binding  developmental growth  cartilage development  response to glucocorticoid  response to folic acid  intestinal epithelial cell maturation  DNA biosynthetic process  liver regeneration  sequence-specific mRNA binding  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  regulation of transcription involved in G1/S transition of mitotic cell cycle  nucleotide binding  translation repressor activity, nucleic acid binding  thymidylate synthase activity  thymidylate synthase activity  folic acid binding  nucleus  nucleoplasm  nucleolus  cytoplasm  mitochondrion  mitochondrial inner membrane  mitochondrial matrix  cytosol  dTMP biosynthetic process  dTTP biosynthetic process  aging  circadian rhythm  drug binding  cell proliferation  response to toxic substance  cell growth  negative regulation of translation  immortalization of host cell by virus  uracil metabolic process  methylation  response to progesterone  response to vitamin A  response to cytokine  tetrahydrofolate interconversion  response to drug  protein homodimerization activity  response to ethanol  dUMP metabolic process  pyrimidine nucleoside biosynthetic process  response to organophosphorus  cofactor binding  developmental growth  cartilage development  response to glucocorticoid  response to folic acid  intestinal epithelial cell maturation  DNA biosynthetic process  liver regeneration  sequence-specific mRNA binding  
Pathways : KEGGPyrimidine metabolism    One carbon pool by folate   
NDEx NetworkTYMS
Atlas of Cancer Signalling NetworkTYMS
Wikipedia pathwaysTYMS
Orthology - Evolution
OrthoDB7298
GeneTree (enSembl)ENSG00000176890
Phylogenetic Trees/Animal Genes : TreeFamTYMS
HOVERGENP04818
HOGENOMP04818
Homologs : HomoloGeneTYMS
Homology/Alignments : Family Browser (UCSC)TYMS
Gene fusions - Rearrangements
Tumor Fusion PortalTYMS
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTYMS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TYMS
dbVarTYMS
ClinVarTYMS
1000_GenomesTYMS 
Exome Variant ServerTYMS
ExAC (Exome Aggregation Consortium)ENSG00000176890
GNOMAD BrowserENSG00000176890
Genetic variants : HAPMAP7298
Genomic Variants (DGV)TYMS [DGVbeta]
DECIPHERTYMS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTYMS 
Mutations
ICGC Data PortalTYMS 
TCGA Data PortalTYMS 
Broad Tumor PortalTYMS
OASIS PortalTYMS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTYMS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTYMS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TYMS
DgiDB (Drug Gene Interaction Database)TYMS
DoCM (Curated mutations)TYMS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TYMS (select a term)
intoGenTYMS
Cancer3DTYMS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM188350   
Orphanet19346   
DisGeNETTYMS
MedgenTYMS
Genetic Testing Registry TYMS
NextProtP04818 [Medical]
TSGene7298
GENETestsTYMS
Target ValidationTYMS
Huge Navigator TYMS [HugePedia]
snp3D : Map Gene to Disease7298
BioCentury BCIQTYMS
ClinGenTYMS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7298
Chemical/Pharm GKB GenePA359
Clinical trialTYMS
Miscellaneous
canSAR (ICR)TYMS (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTYMS
EVEXTYMS
GoPubMedTYMS
iHOPTYMS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:40:22 CET 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.