TYMS (thymidylate synthetase)

2003-08-01 Affiliation

Identity

HGNC

TYMS

LOCATION

18p11.32

LOCUSID

7298

ALIAS

HST422,TMS,TS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7298
MIM: 188350
HGNC: 12441
Ensembl: ENSG00000176890

Variants:

dbSNP: 7298
ClinVar: 7298
TCGA: ENSG00000176890
COSMIC: TYMS

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000176890	ENST00000323224	P04818
ENSG00000176890	ENST00000323250	P04818
ENSG00000176890	ENST00000323274	P04818
ENSG00000176890	ENST00000323274	Q53Y97

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Pyrimidine metabolism	KEGG	ko00240
One carbon pool by folate	KEGG	ko00670
Pyrimidine metabolism	KEGG	hsa00240
One carbon pool by folate	KEGG	hsa00670
Metabolic pathways	KEGG	hsa01100
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
Mitotic G1-G1/S phases	REACTOME	R-HSA-453279
G1/S Transition	REACTOME	R-HSA-69206
G1/S-Specific Transcription	REACTOME	R-HSA-69205
E2F mediated regulation of DNA replication	REACTOME	R-HSA-113510
Metabolism	REACTOME	R-HSA-1430728
Metabolism of nucleotides	REACTOME	R-HSA-15869
Pyrimidine metabolism	REACTOME	R-HSA-73848
Pyrimidine biosynthesis	REACTOME	R-HSA-500753
Antifolate resistance	KEGG	ko01523
Antifolate resistance	KEGG	hsa01523

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA10810	pemetrexed	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	11937185, 12651279, 12972956, 14522928, 14647408, 15797993, 16130010, 17203168, 17323057, 17410198, 18322994, 18368069, 19159907, 20386493, 21262916, 22838948, 25246386
PA128406956	fluorouracil	Chemical	ClinicalAnnotation, LabelAnnotation, MultilinkAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	10561213, 10652619, 11102983, 11142426, 11251009, 11913730, 11937185, 11989786, 15115918, 15353299, 16130010, 16267625, 16575011, 16787927, 7577041, 7586009, 7989939, 10373329, 10652619, 11913730, 12782596, 14522928, 15918040, 16182121, 16249645, 16818689, 17203168, 17549067, 20165956, 20385995, 20638924, 20647221, 20665215, 20714149, 20819423, 20932673, 21167658, 21273624, 21325291, 21362378, 21487324, 21919605, 23263912, 25524944, 25677447, 26189437, 27001118, 27557140, 27864592, 27995989
PA131285527	oxaliplatin	Chemical	VariantAnnotation	ambiguous		PD	20385995, 20819423
PA131625240	raltitrexed	Chemical	ClinicalAnnotation, VariantAnnotation, VipGene	associated	PK	PD	11937185, 12651279, 12972956, 14522928, 14647408, 15353299, 15797993, 16130010, 16456808, 17203168, 17323057, 17410198, 18322994, 18368069, 19159907, 20386493, 21262916, 22838948
PA150595617	platinum	Chemical	VariantAnnotation	associated		PD	25677447
PA151917012	dactinomycin	Chemical	VariantAnnotation	not associated		PD	19159907
PA164713220	Pyrimidine analogues	Chemical	ClinicalAnnotation	associated	PK	PD	10652619, 11913730, 12782596, 14522928, 15918040, 16182121, 16249645, 16818689, 17203168, 20165956, 20385995, 20638924, 20647221, 20665215, 20714149, 20819423, 20932673, 21167658, 21273624, 21325291, 21362378, 21919605, 23263912, 25677447, 27001118, 27557140, 27864592, 27995989
PA164777036	hydroxychloroquine	Chemical	VariantAnnotation	associated		PD	18322994
PA164925725	Toxic liver disease	Disease	ClinicalAnnotation	associated		PD	16501586, 17410198, 27992285
PA165966294	Palmar-plantar erythrodysaesthesia syndrome	Disease	VariantAnnotation	associated		PD
PA166114377	hand-foot syndrome	Disease	VariantAnnotation	not associated		PD	21325291
PA166123026	progression-free survival	Disease	VariantAnnotation	associated		PD	25677447
PA166123207	overall survival	Disease	VariantAnnotation	associated		PD	29205204
PA166123366	event-free survival	Disease	VariantAnnotation	not associated		PD	27864592
PA166153403	gastroesophageal cancer	Disease	VariantAnnotation	associated		PD	25677447
PA166155331	rs45445694	Variant	LabelAnnotation, VipGene	associated			10652619, 11102983, 11251009, 11913730, 11937185, 11989786, 7586009, 10373329
PA166180936	rs11280056	Variant	VipGene	associated			15115918, 16130010, 16575011, 16787927, 11142426
PA443265	Adenocarcinoma	Disease	VariantAnnotation	associated		PD	16818689
PA443434	Arthritis, Rheumatoid	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	11937185, 12651279, 12972956, 14522928, 14647408, 15457444, 15797993, 16130010, 17203168, 17323057, 17410198, 18322994, 18368069, 19159907, 19902562, 20386493, 21262916, 22838948
PA443448	Asthenia	Disease	ClinicalAnnotation, VariantAnnotation	associated		PD	16456808, 28347776
PA443560	Breast Neoplasms	Disease	VariantAnnotation	not associated		PD	20638924
PA443622	Carcinoma, Non-Small-Cell Lung	Disease	VariantAnnotation	not associated		PD	18538445, 21605004
PA443756	Colonic Neoplasms	Disease	VariantAnnotation	not associated		PD	20665215
PA443899	Diarrhea	Disease	ClinicalAnnotation, VariantAnnotation	associated		PD	28347776
PA443937	Drug Toxicity	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous		PD	16501586, 16818689, 17323057, 17410198, 20638924, 20647221, 20819423, 22838948, 27864592, 27992285
PA444101	Esophageal Neoplasms	Disease	VariantAnnotation	ambiguous		PD
PA444257	Gastrointestinal Neoplasms	Disease	VariantAnnotation	not associated		PD	27864592
PA444937	Mesothelioma	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous		PD	21262916, 25246386
PA445013	Myelodysplastic Syndromes	Disease	VariantAnnotation	associated		PD	29205204
PA445048	Nausea	Disease	ClinicalAnnotation, VariantAnnotation	associated		PD	28347776
PA445062	Neoplasms	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	10652619, 11913730, 11937185, 12651279, 12782596, 12972956, 14522928, 14647408, 15797993, 15918040, 16130010, 16182121, 16249645, 16818689, 17203168, 17323057, 17410198, 17549067, 18322994, 18368069, 19159907, 20165956, 20385995, 20386493, 20638924, 20647221, 20665215, 20714149, 20819423, 20932673, 21167658, 21262916, 21273624, 21325291, 21362378, 21919605, 22838948, 23263912, 25677447, 26189437, 27001118, 27557140, 27864592, 27995989, 28347776
PA445113	Neutropenia	Disease	VariantAnnotation	associated		PD	26332308
PA445218	Pancreatic Neoplasms	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	10652619, 11913730, 12782596, 14522928, 15918040, 16182121, 16249645, 16818689, 17203168, 20165956, 20385995, 20638924, 20647221, 20665215, 20714149, 20819423, 20932673, 21167658, 21273624, 21325291, 21362378, 21487324, 21919605, 23263912, 25677447, 27001118, 27557140, 27864592, 27995989
PA445451	Psoriasis	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	11937185, 12651279, 12972956, 14522928, 14647408, 15797993, 16130010, 17203168, 17323057, 17410198, 18322994, 18368069, 19159907, 20386493, 21262916, 22838948
PA445503	Rectal Neoplasms	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	10652619, 11913730, 12782596, 14522928, 15918040, 16182121, 16249645, 16818689, 17203168, 20165956, 20385995, 20638924, 20647221, 20665215, 20714149, 20819423, 20932673, 21167658, 21273624, 21325291, 21362378, 21919605, 23263912, 25677447, 27001118, 27557140, 27864592, 27995989
PA445601	Osteosarcoma	Disease	VariantAnnotation	not associated		PD	19159907
PA445742	Stomach Neoplasms	Disease	VariantAnnotation	ambiguous		PD	16249645, 20714149, 23263912
PA445746	Stomatitis	Disease	VariantAnnotation	associated		PD	23652803
PA446051	Vomiting	Disease	ClinicalAnnotation, VariantAnnotation	associated		PD	28347776
PA446108	Colorectal Neoplasms	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	10652619, 11913730, 11937185, 12651279, 12782596, 12972956, 14522928, 14647408, 15797993, 15918040, 16130010, 16182121, 16249645, 16456808, 16818689, 17203168, 17323057, 17410198, 18322994, 18368069, 19159907, 20165956, 20385995, 20386493, 20638924, 20647221, 20665215, 20714149, 20819423, 20932673, 21167658, 21262916, 21273624, 21325291, 21362378, 21919605, 22838948, 23263912, 25677447, 27001118, 27557140, 27864592, 27995989
PA446116	Inflammatory Bowel Diseases	Disease	VariantAnnotation	associated		PD	26332308
PA446155	Precursor Cell Lymphoblastic Leukemia-Lymphoma	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	11937185, 12651279, 12972956, 14522928, 14647408, 15797993, 16130010, 17203168, 17323057, 17410198, 18322994, 18368069, 19159907, 20386493, 21262916, 22838948, 23652803
PA447146	Hyperammonemia	Disease	VariantAnnotation	associated		PD	20714149
PA448492	asparaginase	Chemical	VariantAnnotation	associated		PD
PA448515	azathioprine	Chemical	VariantAnnotation	associated		PD	26332308
PA448771	capecitabine	Chemical	ClinicalAnnotation, DataAnnotation, MultilinkAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	10652619, 11913730, 12782596, 14522928, 15353299, 15918040, 16182121, 16249645, 16818689, 17203168, 17549067, 20165956, 20385995, 20638924, 20647221, 20665215, 20714149, 20819423, 20932673, 21167658, 21273624, 21325291, 21362378, 21919605, 23263912, 25677447, 26189437, 27001118, 27296624, 27557140, 27864592, 27995989, 28347776
PA448803	carboplatin	Chemical	VariantAnnotation	not associated		PD	21262916, 21605004
PA449014	cisplatin	Chemical	VariantAnnotation	ambiguous		PD	16249645, 19159907, 21605004
PA449165	cyclophosphamide	Chemical	VariantAnnotation	not associated		PD	19159907, 20638924
PA449177	cytarabine	Chemical	VariantAnnotation	associated		PD
PA449212	daunorubicin	Chemical	VariantAnnotation	associated		PD
PA449247	dexamethasone	Chemical	VariantAnnotation	associated		PD
PA449383	docetaxel	Chemical	VariantAnnotation	not associated		PD	21605004
PA449412	doxorubicin	Chemical	VariantAnnotation	not associated		PD	19159907
PA449552	etoposide	Chemical	VariantAnnotation	associated		PD
PA449692	folic acid	Chemical	VariantAnnotation	associated		PD	18322994
PA449748	gemcitabine	Chemical	VariantAnnotation, VipGene	ambiguous		PD	15655942, 18538445, 21605004
PA450085	irinotecan	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	16456808, 21273624
PA450198	leucovorin	Chemical	VariantAnnotation	ambiguous	PK	PD	16818689, 20385995, 20647221, 20819423, 21273624
PA450379	mercaptopurine	Chemical	VariantAnnotation	ambiguous		PD	17323057, 22838948
PA450428	methotrexate	Chemical	ClinicalAnnotation, VariantAnnotation, VipGene	ambiguous	PK	PD	10652619, 11102983, 11142426, 11251009, 11913730, 11937185, 11989786, 15115918, 16130010, 16207145, 16575011, 16787927, 7586009, 10373329, 11937185, 12651279, 12972956, 14522928, 14647408, 15457444, 15797993, 16130010, 16501586, 17203168, 17323057, 17410198, 18322994, 18368069, 19159907, 19902562, 20386493, 21262916, 22838948, 23652803, 27992285
PA450761	paclitaxel	Chemical	VariantAnnotation	not associated		PD	21605004, 23263912
PA451100	prednisone	Chemical	VariantAnnotation	associated		PD
PA451547	sulfasalazine	Chemical	VariantAnnotation	associated		PD	18322994
PA451879	vincristine	Chemical	VariantAnnotation	ambiguous		PD	19159907
PA451881	vinorelbine	Chemical	VariantAnnotation	not associated		PD	21605004
PA451996	azacitidine	Chemical	VariantAnnotation	associated		PD	29205204
PA452620	tegafur	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous	PK	PD	10652619, 11913730, 12782596, 14522928, 15918040, 16182121, 16249645, 16818689, 17203168, 20165956, 20385995, 20638924, 20647221, 20665215, 20714149, 20819423, 20932673, 21167658, 21273624, 21325291, 21362378, 21919605, 23263912, 25677447, 26189437, 27001118, 27557140, 27864592, 27995989

References

Pubmed ID	Year	Title	Citations
18677108	2008	Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells.	88
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
18299612	2008	Role of genetic and nongenetic factors for fluorouracil treatment-related severe toxicity: a prospective clinical trial by the German 5-FU Toxicity Study Group.	82
14977639	2004	Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review.	81
12084461	2002	Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism.	76
15213713	2004	A multivariate analysis of genomic polymorphisms: prediction of clinical outcome to 5-FU/oxaliplatin combination chemotherapy in refractory colorectal cancer.	75
15115918	2004	A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels.	65
12782596	2003	A novel single nucleotide polymorphism within the 5' tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity.	64
19493349	2009	118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects.	62
15457444	2004	Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis.	61

Citation

Dessen P

TYMS (thymidylate synthetase)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42737/tyms