TYMS (thymidylate synthetase)

Identity

Other names	HsT422
	MGC88736
	TMS
	TS
	TSase
HGNC	TYMS
Location	18p11.31-p11.21
Location_base_pair	Starts at 647604 and ends at 663499 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	TYMS   12441
Entrez_Gene	TYMS  7298  thymidylate synthetase
	Cards
GeneCards	TYMS
Ensembl	ENSG00000176890 [Gene_View]  TYMS [Vega]
Genatlas	TYMS
	Genomic and cartography
GoldenPath	TYMS  -     chr18:647604-663499 +  18p11.32   [Description]    (hg18-March_2006)
Ensembl	TYMS - 18p11.32 [CytoView]
NCBI	Mapview
OMIM	188350 Disease map [OMIM]
HomoloGene	TYMS
	Gene and transcription
Genbank	AB062290 [ ENTREZ ]
Genbank	AB077207 [ ENTREZ ]
Genbank	AB077208 [ ENTREZ ]
Genbank	AK223372 [ ENTREZ ]
Genbank	AK292620 [ ENTREZ ]
RefSeq	NM_001071 [ SRS ]    NM_001071 [ ENTREZ ]
RefSeq	AC_000061 [ SRS ]    AC_000061 [ ENTREZ ]
RefSeq	AC_000150 [ SRS ]    AC_000150 [ ENTREZ ]
RefSeq	NC_000018 [ SRS ]    NC_000018 [ ENTREZ ]
RefSeq	NT_010859 [ SRS ]    NT_010859 [ ENTREZ ]
RefSeq	NW_001838461 [ SRS ]    NW_001838461 [ ENTREZ ]
RefSeq	NW_926940 [ SRS ]    NW_926940 [ ENTREZ ]
CCDS	TYMS CCDS - NCBI
AceView	TYMS AceView - NCBI
Unigene	Hs.592338 [ SRS ]    Hs.592338 [ NCBI ]
Fast-db	459 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P04818 [ SRS]    P04818 [ EXPASY ]     P04818 [ INTERPRO ]     P04818 [ UNIPROT ] P04818 [ VarSplice FASTA ]
Prosite	PS00091 THYMIDYLATE_SYNTHASE [ SRS ]    PS00091 THYMIDYLATE_SYNTHASE [ Expasy ]
Interpro	IPR000398 Thymidylat_synth_C [ SRS ]    IPR000398 Thymidylat_synth_C [ EBI ]
CluSTr	P04818
Pfam	PF00303 Thymidylat_synt [ SRS ]    PF00303 Thymidylat_synt [ Sanger ]    pfam00303 [ NCBI-CDD ]
Prodom	PD001180 Thymidylat_synth[INRA-Toulouse]
Prodom	P04818 TYSY_HUMAN [ Domain structure ]   P04818 TYSY_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P04818
PDB	1HVY [ SRS ]    1HVY [ PdbSum ],   1HVY [ IMB ]   1HVY [ RSDB ]
PDB	1HW3 [ SRS ]    1HW3 [ PdbSum ],   1HW3 [ IMB ]   1HW3 [ RSDB ]
PDB	1HW4 [ SRS ]    1HW4 [ PdbSum ],   1HW4 [ IMB ]   1HW4 [ RSDB ]
PDB	1HZW [ SRS ]    1HZW [ PdbSum ],   1HZW [ IMB ]   1HZW [ RSDB ]
PDB	1I00 [ SRS ]    1I00 [ PdbSum ],   1I00 [ IMB ]   1I00 [ RSDB ]
PDB	1JU6 [ SRS ]    1JU6 [ PdbSum ],   1JU6 [ IMB ]   1JU6 [ RSDB ]
PDB	1JUJ [ SRS ]    1JUJ [ PdbSum ],   1JUJ [ IMB ]   1JUJ [ RSDB ]
PDB	2ONB [ SRS ]    2ONB [ PdbSum ],   2ONB [ IMB ]   2ONB [ RSDB ]
HPRD	01774
	Protein Interaction databases
DIP	P04818
IntAct	P04818
	Polymorphism : SNP, mutations, diseases
OMIM	188350    [ map ]
GENETests	188350
SNP	TYMS [dbSNP-NCBI]
SNP	NM_001071 [SNP-NCI]
SNP	TYMS [GeneSNPs - Utah]  TYMS] [HGBASE - SRS]
HAPMAP	TYMS [HAPMAP]
COSMIC	TYMS [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	TYMS
Genetic Association	TYMS
CDC HuGE	TYMS
	General knowledge
Family Browser	TYMS [UCSC Family Browser]
SOURCE	NM_001071
SMD	Hs.592338
SAGE	Hs.592338
GO	thymidylate synthase activity [Amigo]  thymidylate synthase activity
GO	thymidylate synthase activity [Amigo]  thymidylate synthase activity
GO	cytosol [Amigo]  cytosol
GO	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process [Amigo]  nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
GO	dTMP biosynthetic process [Amigo]  dTMP biosynthetic process
GO	DNA replication [Amigo]  DNA replication
GO	DNA repair [Amigo]  DNA repair
GO	methyltransferase activity [Amigo]  methyltransferase activity
GO	deoxyribonucleoside monophosphate biosynthetic process [Amigo]  deoxyribonucleoside monophosphate biosynthetic process
GO	nucleotide biosynthetic process [Amigo]  nucleotide biosynthetic process
GO	transferase activity [Amigo]  transferase activity
GO	phosphoinositide-mediated signaling [Amigo]  phosphoinositide-mediated signaling
KEGG	Pyrimidine metabolism
KEGG	One carbon pool by folate
PubGene	TYMS
TreeFam	TYMS
CTD	7298 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	TYMS Related clones (RZPD - Berlin)
	PubMed
PubMed	207 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Thu Nov 27 14:17:55 2008