Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TYMS (thymidylate synthetase)

Identity

Alias (NCBI)HST422
TMS
TS
HGNC (Hugo) TYMS
HGNC Alias symbTsase
TMS
HsT422
HGNC Previous nameTS
LocusID (NCBI) 7298
Atlas_Id 42737
Location 18p11.32  [Link to chromosome band 18p11]
Location_base_pair Starts at 657653 and ends at 673577 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TYMS (18p11.32) / AMACR (5p13.2)TYMS (18p11.32) / MORF4L1 (15q25.1)TYMS (18p11.32) / SEPT9 (17q25.2)
TYMS (18p11.32) / TGIF2-C20orf24 (20q11.23)TYMS (18p11.32) / TRAIP (3p21.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TYMS   12441
LRG (Locus Reference Genomic)LRG_783
Cards
Entrez_Gene (NCBI)TYMS    thymidylate synthetase
AliasesHST422; TMS; TS
GeneCards (Weizmann)TYMS
Ensembl hg19 (Hinxton)ENSG00000176890 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000176890 [Gene_View]  ENSG00000176890 [Sequence]  chr18:657653-673577 [Contig_View]  TYMS [Vega]
ICGC DataPortalENSG00000176890
TCGA cBioPortalTYMS
AceView (NCBI)TYMS
Genatlas (Paris)TYMS
SOURCE (Princeton)TYMS
Genetics Home Reference (NIH)TYMS
Genomic and cartography
GoldenPath hg38 (UCSC)TYMS  -     chr18:657653-673577 +  18p11.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TYMS  -     18p11.32   [Description]    (hg19-Feb_2009)
GoldenPathTYMS - 18p11.32 [CytoView hg19]  TYMS - 18p11.32 [CytoView hg38]
ImmunoBaseENSG00000176890
Genome Data Viewer NCBITYMS [Mapview hg19]  
OMIM188350   
Gene and transcription
Genbank (Entrez)AB062290 AB077207 AB077208 AK223372 AK292620
RefSeq transcript (Entrez)NM_001071 NM_001354867 NM_001354868
Consensus coding sequences : CCDS (NCBI)TYMS
Gene ExpressionTYMS [ NCBI-GEO ]   TYMS [ EBI - ARRAY_EXPRESS ]   TYMS [ SEEK ]   TYMS [ MEM ]
Gene Expression Viewer (FireBrowse)TYMS [ Firebrowse - Broad ]
GenevisibleExpression of TYMS in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7298
GTEX Portal (Tissue expression)TYMS
Human Protein AtlasENSG00000176890-TYMS [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04818   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP04818  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP04818
PhosPhoSitePlusP04818
Domaine pattern : Prosite (Expaxy)THYMIDYLATE_SYNTHASE (PS00091)   
Domains : Interpro (EBI)Thymidate_synth/dCMP_Mease    Thymidate_synth/dCMP_Mease_sf    Thymidylate_synthase    Thymidylate_synthase_AS   
Domain families : Pfam (Sanger)Thymidylat_synt (PF00303)   
Domain families : Pfam (NCBI)pfam00303   
Conserved Domain (NCBI)TYMS
PDB (RSDB)1HVY    1HW3    1HW4    1HZW    1I00    1JU6    1JUJ    1YPV    2ONB    2RD8    2RDA    3EAW    3EBU    3ED7    3EDW    3EF9    3EGY    3EHI    3EJL    3GG5    3GH0    3GH2    3H9K    3HB8    3N5E    3N5G    3OB7    4E28    4FGT    4G2O    4G6W    4GD7    4GYH    4H1I    4JEF    4KPW    4O1U    4O1X    4UP1    5HS3    5WRN    5X4W    5X4X    5X4Y    5X5A    5X5D    5X5Q    5X66    5X67    5X69    6OJU    6OJV    6PF3    6PF4    6PF5    6PF6    6QXG    6QXH    6QYQ    6R2E   
PDB Europe1HVY    1HW3    1HW4    1HZW    1I00    1JU6    1JUJ    1YPV    2ONB    2RD8    2RDA    3EAW    3EBU    3ED7    3EDW    3EF9    3EGY    3EHI    3EJL    3GG5    3GH0    3GH2    3H9K    3HB8    3N5E    3N5G    3OB7    4E28    4FGT    4G2O    4G6W    4GD7    4GYH    4H1I    4JEF    4KPW    4O1U    4O1X    4UP1    5HS3    5WRN    5X4W    5X4X    5X4Y    5X5A    5X5D    5X5Q    5X66    5X67    5X69    6OJU    6OJV    6PF3    6PF4    6PF5    6PF6    6QXG    6QXH    6QYQ    6R2E   
PDB (PDBSum)1HVY    1HW3    1HW4    1HZW    1I00    1JU6    1JUJ    1YPV    2ONB    2RD8    2RDA    3EAW    3EBU    3ED7    3EDW    3EF9    3EGY    3EHI    3EJL    3GG5    3GH0    3GH2    3H9K    3HB8    3N5E    3N5G    3OB7    4E28    4FGT    4G2O    4G6W    4GD7    4GYH    4H1I    4JEF    4KPW    4O1U    4O1X    4UP1    5HS3    5WRN    5X4W    5X4X    5X4Y    5X5A    5X5D    5X5Q    5X66    5X67    5X69    6OJU    6OJV    6PF3    6PF4    6PF5    6PF6    6QXG    6QXH    6QYQ    6R2E   
PDB (IMB)1HVY    1HW3    1HW4    1HZW    1I00    1JU6    1JUJ    1YPV    2ONB    2RD8    2RDA    3EAW    3EBU    3ED7    3EDW    3EF9    3EGY    3EHI    3EJL    3GG5    3GH0    3GH2    3H9K    3HB8    3N5E    3N5G    3OB7    4E28    4FGT    4G2O    4G6W    4GD7    4GYH    4H1I    4JEF    4KPW    4O1U    4O1X    4UP1    5HS3    5WRN    5X4W    5X4X    5X4Y    5X5A    5X5D    5X5Q    5X66    5X67    5X69    6OJU    6OJV    6PF3    6PF4    6PF5    6PF6    6QXG    6QXH    6QYQ    6R2E   
Structural Biology KnowledgeBase1HVY    1HW3    1HW4    1HZW    1I00    1JU6    1JUJ    1YPV    2ONB    2RD8    2RDA    3EAW    3EBU    3ED7    3EDW    3EF9    3EGY    3EHI    3EJL    3GG5    3GH0    3GH2    3H9K    3HB8    3N5E    3N5G    3OB7    4E28    4FGT    4G2O    4G6W    4GD7    4GYH    4H1I    4JEF    4KPW    4O1U    4O1X    4UP1    5HS3    5WRN    5X4W    5X4X    5X4Y    5X5A    5X5D    5X5Q    5X66    5X67    5X69    6OJU    6OJV    6PF3    6PF4    6PF5    6PF6    6QXG    6QXH    6QYQ    6R2E   
SCOP (Structural Classification of Proteins)1HVY    1HW3    1HW4    1HZW    1I00    1JU6    1JUJ    1YPV    2ONB    2RD8    2RDA    3EAW    3EBU    3ED7    3EDW    3EF9    3EGY    3EHI    3EJL    3GG5    3GH0    3GH2    3H9K    3HB8    3N5E    3N5G    3OB7    4E28    4FGT    4G2O    4G6W    4GD7    4GYH    4H1I    4JEF    4KPW    4O1U    4O1X    4UP1    5HS3    5WRN    5X4W    5X4X    5X4Y    5X5A    5X5D    5X5Q    5X66    5X67    5X69    6OJU    6OJV    6PF3    6PF4    6PF5    6PF6    6QXG    6QXH    6QYQ    6R2E   
CATH (Classification of proteins structures)1HVY    1HW3    1HW4    1HZW    1I00    1JU6    1JUJ    1YPV    2ONB    2RD8    2RDA    3EAW    3EBU    3ED7    3EDW    3EF9    3EGY    3EHI    3EJL    3GG5    3GH0    3GH2    3H9K    3HB8    3N5E    3N5G    3OB7    4E28    4FGT    4G2O    4G6W    4GD7    4GYH    4H1I    4JEF    4KPW    4O1U    4O1X    4UP1    5HS3    5WRN    5X4W    5X4X    5X4Y    5X5A    5X5D    5X5Q    5X66    5X67    5X69    6OJU    6OJV    6PF3    6PF4    6PF5    6PF6    6QXG    6QXH    6QYQ    6R2E   
SuperfamilyP04818
AlphaFold pdb e-kbP04818   
Human Protein Atlas [tissue]ENSG00000176890-TYMS [tissue]
HPRD01774
Protein Interaction databases
DIP (DOE-UCLA)P04818
IntAct (EBI)P04818
BioGRIDTYMS
STRING (EMBL)TYMS
ZODIACTYMS
Ontologies - Pathways
QuickGOP04818
Ontology : AmiGOregulation of transcription involved in G1/S transition of mitotic cell cycle  translation repressor activity, mRNA regulatory element binding  thymidylate synthase activity  thymidylate synthase activity  thymidylate synthase activity  folic acid binding  nucleus  nucleolus  cytoplasm  mitochondrion  mitochondrion  mitochondrial inner membrane  mitochondrial matrix  cytosol  cytosol  dTMP biosynthetic process  dTMP biosynthetic process  dTTP biosynthetic process  aging  circadian rhythm  response to toxic substance  nucleobase-containing small molecule interconversion  negative regulation of translation  modulation by virus of host process  uracil metabolic process  methylation  response to progesterone  response to vitamin A  response to cytokine  tetrahydrofolate interconversion  response to drug  protein homodimerization activity  response to ethanol  response to organophosphorus  developmental growth  cartilage development  response to glucocorticoid  response to folic acid  intestinal epithelial cell maturation  DNA biosynthetic process  liver regeneration  sequence-specific mRNA binding  
Ontology : EGO-EBIregulation of transcription involved in G1/S transition of mitotic cell cycle  translation repressor activity, mRNA regulatory element binding  thymidylate synthase activity  thymidylate synthase activity  thymidylate synthase activity  folic acid binding  nucleus  nucleolus  cytoplasm  mitochondrion  mitochondrion  mitochondrial inner membrane  mitochondrial matrix  cytosol  cytosol  dTMP biosynthetic process  dTMP biosynthetic process  dTTP biosynthetic process  aging  circadian rhythm  response to toxic substance  nucleobase-containing small molecule interconversion  negative regulation of translation  modulation by virus of host process  uracil metabolic process  methylation  response to progesterone  response to vitamin A  response to cytokine  tetrahydrofolate interconversion  response to drug  protein homodimerization activity  response to ethanol  response to organophosphorus  developmental growth  cartilage development  response to glucocorticoid  response to folic acid  intestinal epithelial cell maturation  DNA biosynthetic process  liver regeneration  sequence-specific mRNA binding  
Pathways : KEGGPyrimidine metabolism    One carbon pool by folate   
NDEx NetworkTYMS
Atlas of Cancer Signalling NetworkTYMS
Wikipedia pathwaysTYMS
Orthology - Evolution
OrthoDB7298
GeneTree (enSembl)ENSG00000176890
Phylogenetic Trees/Animal Genes : TreeFamTYMS
Homologs : HomoloGeneTYMS
Homology/Alignments : Family Browser (UCSC)TYMS
Gene fusions - Rearrangements
Fusion : QuiverTYMS
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTYMS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TYMS
dbVarTYMS
ClinVarTYMS
MonarchTYMS
1000_GenomesTYMS 
Exome Variant ServerTYMS
GNOMAD BrowserENSG00000176890
Varsome BrowserTYMS
ACMGTYMS variants
VarityP04818
Genomic Variants (DGV)TYMS [DGVbeta]
DECIPHERTYMS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTYMS 
Mutations
ICGC Data PortalTYMS 
TCGA Data PortalTYMS 
Broad Tumor PortalTYMS
OASIS PortalTYMS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTYMS  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTYMS
Mutations and Diseases : HGMDTYMS
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTYMS
DgiDB (Drug Gene Interaction Database)TYMS
DoCM (Curated mutations)TYMS
CIViC (Clinical Interpretations of Variants in Cancer)TYMS
Cancer3DTYMS
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM188350   
Orphanet19346   
DisGeNETTYMS
MedgenTYMS
Genetic Testing Registry TYMS
NextProtP04818 [Medical]
GENETestsTYMS
Target ValidationTYMS
Huge Navigator TYMS [HugePedia]
ClinGenTYMS
Clinical trials, drugs, therapy
MyCancerGenomeTYMS
Protein Interactions : CTDTYMS
Pharm GKB GenePA359
Pharm GKB PathwaysPA150653776   PA165291507   PA165291575   PA2039   
PharosP04818
Clinical trialTYMS
Miscellaneous
canSAR (ICR)TYMS
HarmonizomeTYMS
DataMed IndexTYMS
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTYMS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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