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UBE2I (ubiquitin conjugating enzyme E2 I)

Identity

Alias (NCBI)C358B7.1
P18
UBC9
HGNC (Hugo) UBE2I
HGNC Alias symbUBC9
HGNC Previous nameubiquitin-conjugating enzyme E2I (homologous to yeast UBC9)
 ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)
 ubiquitin-conjugating enzyme E2I
LocusID (NCBI) 7329
Atlas_Id 42751
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 1309152 and ends at 1327017 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GNGT1 (7q21.3) / UBE2I (16p13.3)MEGF6 (1p36.32) / UBE2I (16p13.3)PDXDC1 (16p13.11) / UBE2I (16p13.3)
TSR3 (16p13.3) / UBE2I (16p13.3)UBE2I (16p13.3) / CACNA1H (16p13.3)UBE2I (16p13.3) / PRSS23 (11q14.2)
UBE2I 16p13.3 / CACNA1H 16p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  inv(2)(p23q13) RANBP2/ALK::t(2;2)(p23;q13) RANBP2/ALK


External links

Nomenclature
HGNC (Hugo)UBE2I   12485
Cards
Entrez_Gene (NCBI)UBE2I    ubiquitin conjugating enzyme E2 I
AliasesC358B7.1; P18; UBC9
GeneCards (Weizmann)UBE2I
Ensembl hg19 (Hinxton)ENSG00000103275 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000103275 [Gene_View]  ENSG00000103275 [Sequence]  chr16:1309152-1327017 [Contig_View]  UBE2I [Vega]
ICGC DataPortalENSG00000103275
TCGA cBioPortalUBE2I
AceView (NCBI)UBE2I
Genatlas (Paris)UBE2I
SOURCE (Princeton)UBE2I
Genetics Home Reference (NIH)UBE2I
Genomic and cartography
GoldenPath hg38 (UCSC)UBE2I  -     chr16:1309152-1327017 +  16p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UBE2I  -     16p13.3   [Description]    (hg19-Feb_2009)
GoldenPathUBE2I - 16p13.3 [CytoView hg19]  UBE2I - 16p13.3 [CytoView hg38]
ImmunoBaseENSG00000103275
genome Data Viewer NCBIUBE2I [Mapview hg19]  
OMIM601661   
Gene and transcription
Genbank (Entrez)AB208988 AJ002385 AK024172 AK093616 AK291118
RefSeq transcript (Entrez)NM_003345 NM_194259 NM_194260 NM_194261
Consensus coding sequences : CCDS (NCBI)UBE2I
Alternative Splicing GalleryENSG00000103275
Gene ExpressionUBE2I [ NCBI-GEO ]   UBE2I [ EBI - ARRAY_EXPRESS ]   UBE2I [ SEEK ]   UBE2I [ MEM ]
Gene Expression Viewer (FireBrowse)UBE2I [ Firebrowse - Broad ]
GenevisibleExpression of UBE2I in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7329
GTEX Portal (Tissue expression)UBE2I
Human Protein AtlasENSG00000103275-UBE2I [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP63279   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP63279  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP63279
PhosPhoSitePlusP63279
Domaine pattern : Prosite (Expaxy)UBC_1 (PS00183)    UBC_2 (PS50127)   
Domains : Interpro (EBI)UBQ-conjugat_E2    UBQ-conjugating_AS    UBQ-conjugating_enzyme/RWD   
Domain families : Pfam (Sanger)UQ_con (PF00179)   
Domain families : Pfam (NCBI)pfam00179   
Conserved Domain (NCBI)UBE2I
PDB (RSDB)1A3S    1KPS    1Z5Q    1Z5S    2GRN    2GRO    2GRP    2GRQ    2GRR    2O25    2PE6    2PX9    2XWU    3A4S    3UIN    3UIO    3UIP    4W5V    4Y1L    5D2M    5F6D    5F6E    5F6U    5F6V    5F6W    5F6X    5F6Y    5FQ2    6SYF   
PDB Europe1A3S    1KPS    1Z5Q    1Z5S    2GRN    2GRO    2GRP    2GRQ    2GRR    2O25    2PE6    2PX9    2XWU    3A4S    3UIN    3UIO    3UIP    4W5V    4Y1L    5D2M    5F6D    5F6E    5F6U    5F6V    5F6W    5F6X    5F6Y    5FQ2    6SYF   
PDB (PDBSum)1A3S    1KPS    1Z5Q    1Z5S    2GRN    2GRO    2GRP    2GRQ    2GRR    2O25    2PE6    2PX9    2XWU    3A4S    3UIN    3UIO    3UIP    4W5V    4Y1L    5D2M    5F6D    5F6E    5F6U    5F6V    5F6W    5F6X    5F6Y    5FQ2    6SYF   
PDB (IMB)1A3S    1KPS    1Z5Q    1Z5S    2GRN    2GRO    2GRP    2GRQ    2GRR    2O25    2PE6    2PX9    2XWU    3A4S    3UIN    3UIO    3UIP    4W5V    4Y1L    5D2M    5F6D    5F6E    5F6U    5F6V    5F6W    5F6X    5F6Y    5FQ2    6SYF   
Structural Biology KnowledgeBase1A3S    1KPS    1Z5Q    1Z5S    2GRN    2GRO    2GRP    2GRQ    2GRR    2O25    2PE6    2PX9    2XWU    3A4S    3UIN    3UIO    3UIP    4W5V    4Y1L    5D2M    5F6D    5F6E    5F6U    5F6V    5F6W    5F6X    5F6Y    5FQ2    6SYF   
SCOP (Structural Classification of Proteins)1A3S    1KPS    1Z5Q    1Z5S    2GRN    2GRO    2GRP    2GRQ    2GRR    2O25    2PE6    2PX9    2XWU    3A4S    3UIN    3UIO    3UIP    4W5V    4Y1L    5D2M    5F6D    5F6E    5F6U    5F6V    5F6W    5F6X    5F6Y    5FQ2    6SYF   
CATH (Classification of proteins structures)1A3S    1KPS    1Z5Q    1Z5S    2GRN    2GRO    2GRP    2GRQ    2GRR    2O25    2PE6    2PX9    2XWU    3A4S    3UIN    3UIO    3UIP    4W5V    4Y1L    5D2M    5F6D    5F6E    5F6U    5F6V    5F6W    5F6X    5F6Y    5FQ2    6SYF   
SuperfamilyP63279
AlphaFold pdb e-kbP63279   
Human Protein Atlas [tissue]ENSG00000103275-UBE2I [tissue]
HPRD09045
Protein Interaction databases
DIP (DOE-UCLA)P63279
IntAct (EBI)P63279
BioGRIDUBE2I
STRING (EMBL)UBE2I
ZODIACUBE2I
Ontologies - Pathways
QuickGOP63279
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  synaptonemal complex  transcription coregulator binding  RNA binding  protein binding  ATP binding  nucleus  nucleus  nucleus  nuclear envelope  nucleoplasm  cytoplasm  cytosol  cellular protein modification process  ubiquitin-dependent protein catabolic process  chromosome segregation  mitotic nuclear membrane reassembly  transcription factor binding  PML body  protein sumoylation  protein sumoylation  protein sumoylation  protein sumoylation  protein sumoylation  viral protein processing  SUMO transferase activity  enzyme binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  HLH domain binding  small protein activating enzyme binding  negative regulation of transcription, DNA-templated  cell division  SUMO conjugating enzyme activity  SUMO conjugating enzyme activity  RING-like zinc finger domain binding  positive regulation of SUMO transferase activity  transferase complex  sumoylated E2 ligase complex  sumoylated E2 ligase complex  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  synaptonemal complex  transcription coregulator binding  RNA binding  protein binding  ATP binding  nucleus  nucleus  nucleus  nuclear envelope  nucleoplasm  cytoplasm  cytosol  cellular protein modification process  ubiquitin-dependent protein catabolic process  chromosome segregation  mitotic nuclear membrane reassembly  transcription factor binding  PML body  protein sumoylation  protein sumoylation  protein sumoylation  protein sumoylation  protein sumoylation  viral protein processing  SUMO transferase activity  enzyme binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  HLH domain binding  small protein activating enzyme binding  negative regulation of transcription, DNA-templated  cell division  SUMO conjugating enzyme activity  SUMO conjugating enzyme activity  RING-like zinc finger domain binding  positive regulation of SUMO transferase activity  transferase complex  sumoylated E2 ligase complex  sumoylated E2 ligase complex  
Pathways : BIOCARTABasic Mechanisms of SUMOylation [Genes]    SUMOylation as a mechanism to modulate CtBP-dependent gene responses [Genes]    ER?associated degradation (ERAD) Pathway [Genes]   
Pathways : KEGGRNA transport    NF-kappa B signaling pathway    Ubiquitin mediated proteolysis    MicroRNAs in cancer   
NDEx NetworkUBE2I
Atlas of Cancer Signalling NetworkUBE2I
Wikipedia pathwaysUBE2I
Orthology - Evolution
OrthoDB7329
GeneTree (enSembl)ENSG00000103275
Phylogenetic Trees/Animal Genes : TreeFamUBE2I
Homologs : HomoloGeneUBE2I
Homology/Alignments : Family Browser (UCSC)UBE2I
Gene fusions - Rearrangements
Fusion : MitelmanUBE2I/CACNA1H [16p13.3/16p13.3]  
Fusion PortalUBE2I 16p13.3 CACNA1H 16p13.3 BRCA
Fusion : QuiverUBE2I
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUBE2I [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBE2I
dbVarUBE2I
ClinVarUBE2I
MonarchUBE2I
1000_GenomesUBE2I 
Exome Variant ServerUBE2I
GNOMAD BrowserENSG00000103275
Varsome BrowserUBE2I
Genomic Variants (DGV)UBE2I [DGVbeta]
DECIPHERUBE2I [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUBE2I 
Mutations
ICGC Data PortalUBE2I 
TCGA Data PortalUBE2I 
Broad Tumor PortalUBE2I
OASIS PortalUBE2I [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUBE2I  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DUBE2I
Mutations and Diseases : HGMDUBE2I
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutasearch UBE2I
DgiDB (Drug Gene Interaction Database)UBE2I
DoCM (Curated mutations)UBE2I (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UBE2I (select a term)
Cancer3DUBE2I(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601661   
Orphanet
DisGeNETUBE2I
MedgenUBE2I
Genetic Testing Registry UBE2I
NextProtP63279 [Medical]
GENETestsUBE2I
Target ValidationUBE2I
Huge Navigator UBE2I [HugePedia]
ClinGenUBE2I
Clinical trials, drugs, therapy
MyCancerGenomeUBE2I
Protein Interactions : CTDUBE2I
Pharm GKB GenePA37134
PharosP63279
Clinical trialUBE2I
Miscellaneous
canSAR (ICR)UBE2I
HarmonizomeUBE2I
DataMed IndexUBE2I
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXUBE2I
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Sep 15 22:42:44 CEST 2021

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