Atlas of Genetics and Cytogenetics in Oncology and Haematology


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UBE2I (ubiquitin-conjugating enzyme E2I)

Identity

Other namesC358B7.1
P18
UBC9
HGNC (Hugo) UBE2I
LocusID (NCBI) 7329
Location 16p13.3
Location_base_pair Starts at 1359628 and ends at 1377019 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)UBE2I   12485
Cards
Entrez_Gene (NCBI)UBE2I  7329  ubiquitin-conjugating enzyme E2I
GeneCards (Weizmann)UBE2I
Ensembl (Hinxton)ENSG00000103275 [Gene_View]  chr16:1359628-1377019 [Contig_View]  UBE2I [Vega]
ICGC DataPortalENSG00000103275
cBioPortalUBE2I
AceView (NCBI)UBE2I
Genatlas (Paris)UBE2I
WikiGenes7329
SOURCE (Princeton)NM_003345 NM_194259 NM_194260 NM_194261
Genomic and cartography
GoldenPath (UCSC)UBE2I  -  16p13.3   chr16:1359628-1377019 +  16p13.3   [Description]    (hg19-Feb_2009)
EnsemblUBE2I - 16p13.3 [CytoView]
Mapping of homologs : NCBIUBE2I [Mapview]
OMIM601661   
Gene and transcription
Genbank (Entrez)AB208988 AJ002385 AK024172 AK093616 AK291118
RefSeq transcript (Entrez)NM_003345 NM_194259 NM_194260 NM_194261
RefSeq genomic (Entrez)AC_000148 NC_000016 NC_018927 NT_010393 NW_001838339 NW_004929400
Consensus coding sequences : CCDS (NCBI)UBE2I
Cluster EST : UnigeneHs.302903 [ NCBI ]
CGAP (NCI)Hs.302903
Alternative Splicing : Fast-db (Paris)GSHG0010832
Alternative Splicing GalleryENSG00000103275
Gene ExpressionUBE2I [ NCBI-GEO ]     UBE2I [ SEEK ]   UBE2I [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP63279 (Uniprot)
NextProtP63279  [Medical]
With graphics : InterProP63279
Splice isoforms : SwissVarP63279 (Swissvar)
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.-6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
Domaine pattern : Prosite (Expaxy)UBIQUITIN_CONJUGAT_1 (PS00183)    UBIQUITIN_CONJUGAT_2 (PS50127)   
Domains : Interpro (EBI)Ubc9 [organisation]   UBQ-conjugat_E2 [organisation]   UBQ-conjugating_AS [organisation]   UBQ-conjugating_enzyme/RWD [organisation]  
Related proteins : CluSTrP63279
Domain families : Pfam (Sanger)UQ_con (PF00179)   
Domain families : Pfam (NCBI)pfam00179   
DMDM Disease mutations7329
Blocks (Seattle)P63279
PDB (SRS)1A3S    1KPS    1Z5Q    1Z5S    2GRN    2GRO    2GRP    2GRQ    2GRR    2O25    2PE6    2PX9    2XWU    3A4S    3UIN    3UIO    3UIP   
PDB (PDBSum)1A3S    1KPS    1Z5Q    1Z5S    2GRN    2GRO    2GRP    2GRQ    2GRR    2O25    2PE6    2PX9    2XWU    3A4S    3UIN    3UIO    3UIP   
PDB (IMB)1A3S    1KPS    1Z5Q    1Z5S    2GRN    2GRO    2GRP    2GRQ    2GRR    2O25    2PE6    2PX9    2XWU    3A4S    3UIN    3UIO    3UIP   
PDB (RSDB)1A3S    1KPS    1Z5Q    1Z5S    2GRN    2GRO    2GRP    2GRQ    2GRR    2O25    2PE6    2PX9    2XWU    3A4S    3UIN    3UIO    3UIP   
Human Protein AtlasENSG00000103275 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP63279
HPRD09045
IPIIPI00032957   IPI00975499   IPI00450472   
Protein Interaction databases
DIP (DOE-UCLA)P63279
IntAct (EBI)P63279
FunCoupENSG00000103275
BioGRIDUBE2I
InParanoidP63279
Interologous Interaction database P63279
IntegromeDBUBE2I
STRING (EMBL)UBE2I
Ontologies - Pathways
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  synaptonemal complex  fibrillar center  ubiquitin-protein transferase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  cellular protein modification process  ubiquitin-dependent protein catabolic process  chromosome segregation  mitotic nuclear division  protein C-terminus binding  transcription factor binding  regulation of receptor activity  viral process  protein ubiquitination  PML body  protein sumoylation  protein sumoylation  protein sumoylation  SUMO ligase activity  enzyme binding  dendrite  positive regulation of intracellular steroid hormone receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  HLH domain binding  bHLH transcription factor binding  post-translational protein modification  cellular protein metabolic process  poly(A) RNA binding  synapse  negative regulation of transcription, DNA-templated  positive regulation of sequence-specific DNA binding transcription factor activity  RING-like zinc finger domain binding  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  synaptonemal complex  fibrillar center  ubiquitin-protein transferase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  cellular protein modification process  ubiquitin-dependent protein catabolic process  chromosome segregation  mitotic nuclear division  protein C-terminus binding  transcription factor binding  regulation of receptor activity  viral process  protein ubiquitination  PML body  protein sumoylation  protein sumoylation  protein sumoylation  SUMO ligase activity  enzyme binding  dendrite  positive regulation of intracellular steroid hormone receptor signaling pathway  proteasome-mediated ubiquitin-dependent protein catabolic process  HLH domain binding  bHLH transcription factor binding  post-translational protein modification  cellular protein metabolic process  poly(A) RNA binding  synapse  negative regulation of transcription, DNA-templated  positive regulation of sequence-specific DNA binding transcription factor activity  RING-like zinc finger domain binding  
Pathways : BIOCARTABasic Mechanisms of SUMOylation [Genes]    SUMOylation as a mechanism to modulate CtBP-dependent gene responses [Genes]    ER?associated degradation (ERAD) Pathway [Genes]   
Pathways : KEGGRNA transport    NF-kappa B signaling pathway    Ubiquitin mediated proteolysis    MicroRNAs in cancer   
Protein Interaction DatabaseUBE2I
Wikipedia pathwaysUBE2I
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)UBE2I
snp3D : Map Gene to Disease7329
SNP (GeneSNP Utah)UBE2I
SNP : HGBaseUBE2I
Genetic variants : HAPMAPUBE2I
Exome VariantUBE2I
1000_GenomesUBE2I 
ICGC programENSG00000103275 
Somatic Mutations in Cancer : COSMICUBE2I 
CONAN: Copy Number AnalysisUBE2I 
Mutations and Diseases : HGMDUBE2I
Mutations and Diseases : intOGenUBE2I
Genomic VariantsUBE2I  UBE2I [DGVbeta]
dbVarUBE2I
ClinVarUBE2I
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM601661   
MedgenUBE2I
GENETestsUBE2I
Disease Genetic AssociationUBE2I
Huge Navigator UBE2I [HugePedia]  UBE2I [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneUBE2I
Homology/Alignments : Family Browser (UCSC)UBE2I
Phylogenetic Trees/Animal Genes : TreeFamUBE2I
Chemical/Protein Interactions : CTD7329
Chemical/Pharm GKB GenePA37134
Clinical trialUBE2I
Cancer Resource (Charite)ENSG00000103275
Other databases
Probes
Litterature
PubMed325 Pubmed reference(s) in Entrez
CoreMineUBE2I
iHOPUBE2I
OncoSearchUBE2I
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 17:09:20 CEST 2014

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