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UBE2I (ubiquitin conjugating enzyme E2 I)

Identity

Other namesC358B7.1
P18
UBC9
HGNC (Hugo) UBE2I
LocusID (NCBI) 7329
Atlas_Id 42751
Location 16p13.3
Location_base_pair Starts at 1359628 and ends at 1377019 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
GNGT1 (7q21.3) / UBE2I (16p13.3)MEGF6 (1p36.32) / UBE2I (16p13.3)PDXDC1 (16p13.11) / UBE2I (16p13.3)
TSR3 (16p13.3) / UBE2I (16p13.3)UBE2I (16p13.3) / CACNA1H (16p13.3)UBE2I (16p13.3) / PRSS23 (11q14.2)
UBE2I 16p13.3 / CACNA1H 16p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  inv(2)(p23q13) RANBP2/ALK;t(2;2)(p23;q13) RANBP2/ALK

External links

Nomenclature
HGNC (Hugo)UBE2I   12485
Cards
Entrez_Gene (NCBI)UBE2I  7329  ubiquitin conjugating enzyme E2 I
AliasesC358B7.1; P18; UBC9
GeneCards (Weizmann)UBE2I
Ensembl hg19 (Hinxton)ENSG00000103275 [Gene_View]  chr16:1359628-1377019 [Contig_View]  UBE2I [Vega]
Ensembl hg38 (Hinxton)ENSG00000103275 [Gene_View]  chr16:1359628-1377019 [Contig_View]  UBE2I [Vega]
ICGC DataPortalENSG00000103275
TCGA cBioPortalUBE2I
AceView (NCBI)UBE2I
Genatlas (Paris)UBE2I
WikiGenes7329
SOURCE (Princeton)UBE2I
Genomic and cartography
GoldenPath hg19 (UCSC)UBE2I  -     chr16:1359628-1377019 +  16p13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)UBE2I  -     16p13.3   [Description]    (hg38-Dec_2013)
EnsemblUBE2I - 16p13.3 [CytoView hg19]  UBE2I - 16p13.3 [CytoView hg38]
Mapping of homologs : NCBIUBE2I [Mapview hg19]  UBE2I [Mapview hg38]
OMIM601661   
Gene and transcription
Genbank (Entrez)AB208988 AJ002385 AK024172 AK093616 AK291118
RefSeq transcript (Entrez)NM_003345 NM_194259 NM_194260 NM_194261
RefSeq genomic (Entrez)NC_000016 NC_018927 NT_010393 NW_004929400
Consensus coding sequences : CCDS (NCBI)UBE2I
Cluster EST : UnigeneHs.302903 [ NCBI ]
CGAP (NCI)Hs.302903
Alternative Splicing GalleryENSG00000103275
Gene ExpressionUBE2I [ NCBI-GEO ]   UBE2I [ EBI - ARRAY_EXPRESS ]   UBE2I [ SEEK ]   UBE2I [ MEM ]
Gene Expression Viewer (FireBrowse)UBE2I [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7329
GTEX Portal (Tissue expression)UBE2I
Protein : pattern, domain, 3D structure
UniProt/SwissProtP63279 (Uniprot)
NextProtP63279  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP63279
Splice isoforms : SwissVarP63279 (Swissvar)
PhosPhoSitePlusP63279
Domaine pattern : Prosite (Expaxy)UBIQUITIN_CONJUGAT_1 (PS00183)    UBIQUITIN_CONJUGAT_2 (PS50127)   
Domains : Interpro (EBI)Ubc9    UBQ-conjugat_E2    UBQ-conjugating_AS    UBQ-conjugating_enzyme/RWD   
Domain families : Pfam (Sanger)UQ_con (PF00179)   
Domain families : Pfam (NCBI)pfam00179   
DMDM Disease mutations7329
Blocks (Seattle)UBE2I
PDB (SRS)1A3S    1KPS    1Z5Q    1Z5S    2GRN    2GRO    2GRP    2GRQ    2GRR    2O25    2PE6    2PX9    2XWU    3A4S    3UIN    3UIO    3UIP    4W5V    4Y1L    5D2M   
PDB (PDBSum)1A3S    1KPS    1Z5Q    1Z5S    2GRN    2GRO    2GRP    2GRQ    2GRR    2O25    2PE6    2PX9    2XWU    3A4S    3UIN    3UIO    3UIP    4W5V    4Y1L    5D2M   
PDB (IMB)1A3S    1KPS    1Z5Q    1Z5S    2GRN    2GRO    2GRP    2GRQ    2GRR    2O25    2PE6    2PX9    2XWU    3A4S    3UIN    3UIO    3UIP    4W5V    4Y1L    5D2M   
PDB (RSDB)1A3S    1KPS    1Z5Q    1Z5S    2GRN    2GRO    2GRP    2GRQ    2GRR    2O25    2PE6    2PX9    2XWU    3A4S    3UIN    3UIO    3UIP    4W5V    4Y1L    5D2M   
Structural Biology KnowledgeBase1A3S    1KPS    1Z5Q    1Z5S    2GRN    2GRO    2GRP    2GRQ    2GRR    2O25    2PE6    2PX9    2XWU    3A4S    3UIN    3UIO    3UIP    4W5V    4Y1L    5D2M   
SCOP (Structural Classification of Proteins)1A3S    1KPS    1Z5Q    1Z5S    2GRN    2GRO    2GRP    2GRQ    2GRR    2O25    2PE6    2PX9    2XWU    3A4S    3UIN    3UIO    3UIP    4W5V    4Y1L    5D2M   
CATH (Classification of proteins structures)1A3S    1KPS    1Z5Q    1Z5S    2GRN    2GRO    2GRP    2GRQ    2GRR    2O25    2PE6    2PX9    2XWU    3A4S    3UIN    3UIO    3UIP    4W5V    4Y1L    5D2M   
SuperfamilyP63279
Human Protein AtlasENSG00000103275
Peptide AtlasP63279
HPRD09045
IPIIPI00032957   IPI00975499   IPI00450472   
Protein Interaction databases
DIP (DOE-UCLA)P63279
IntAct (EBI)P63279
FunCoupENSG00000103275
BioGRIDUBE2I
STRING (EMBL)UBE2I
ZODIACUBE2I
Ontologies - Pathways
QuickGOP63279
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  synaptonemal complex  protein binding  ATP binding  nucleus  nuclear envelope  nucleoplasm  cytoplasm  cytosol  cellular protein modification process  ubiquitin-dependent protein catabolic process  chromosome segregation  mitotic nuclear division  transcription factor binding  viral process  PML body  ligase activity  protein sumoylation  protein sumoylation  protein sumoylation  SUMO transferase activity  SUMO transferase activity  enzyme binding  ubiquitin protein ligase binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  HLH domain binding  poly(A) RNA binding  negative regulation of transcription, DNA-templated  cell division  ubiquitin protein ligase activity  SUMO conjugating enzyme activity  global genome nucleotide-excision repair  RING-like zinc finger domain binding  positive regulation of SUMO transferase activity  transferase complex  sumoylated E2 ligase complex  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  synaptonemal complex  protein binding  ATP binding  nucleus  nuclear envelope  nucleoplasm  cytoplasm  cytosol  cellular protein modification process  ubiquitin-dependent protein catabolic process  chromosome segregation  mitotic nuclear division  transcription factor binding  viral process  PML body  ligase activity  protein sumoylation  protein sumoylation  protein sumoylation  SUMO transferase activity  SUMO transferase activity  enzyme binding  ubiquitin protein ligase binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  HLH domain binding  poly(A) RNA binding  negative regulation of transcription, DNA-templated  cell division  ubiquitin protein ligase activity  SUMO conjugating enzyme activity  global genome nucleotide-excision repair  RING-like zinc finger domain binding  positive regulation of SUMO transferase activity  transferase complex  sumoylated E2 ligase complex  
Pathways : BIOCARTABasic Mechanisms of SUMOylation [Genes]    SUMOylation as a mechanism to modulate CtBP-dependent gene responses [Genes]    ER┐associated degradation (ERAD) Pathway [Genes]   
Pathways : KEGGRNA transport    NF-kappa B signaling pathway    Ubiquitin mediated proteolysis    MicroRNAs in cancer   
NDEx Network
Atlas of Cancer Signalling NetworkUBE2I
Wikipedia pathwaysUBE2I
Orthology - Evolution
OrthoDB7329
GeneTree (enSembl)ENSG00000103275
Phylogenetic Trees/Animal Genes : TreeFamUBE2I
Homologs : HomoloGeneUBE2I
Homology/Alignments : Family Browser (UCSC)UBE2I
Gene fusions - Rearrangements
Fusion: TCGAUBE2I 16p13.3 CACNA1H 16p13.3 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerUBE2I [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBE2I
dbVarUBE2I
ClinVarUBE2I
1000_GenomesUBE2I 
Exome Variant ServerUBE2I
ExAC (Exome Aggregation Consortium)UBE2I (select the gene name)
Genetic variants : HAPMAP7329
Genomic Variants (DGV)UBE2I [DGVbeta]
Mutations
ICGC Data PortalUBE2I 
TCGA Data PortalUBE2I 
Broad Tumor PortalUBE2I
OASIS PortalUBE2I [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUBE2I 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UBE2I
DgiDB (Drug Gene Interaction Database)UBE2I
DoCM (Curated mutations)UBE2I (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UBE2I (select a term)
intoGenUBE2I
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)16:1359628-1377019  ENSG00000103275
CONAN: Copy Number AnalysisUBE2I 
Mutations and Diseases : HGMDUBE2I
OMIM601661   
MedgenUBE2I
Genetic Testing Registry UBE2I
NextProtP63279 [Medical]
TSGene7329
GENETestsUBE2I
Huge Navigator UBE2I [HugePedia]
snp3D : Map Gene to Disease7329
BioCentury BCIQUBE2I
ClinGenUBE2I
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7329
Chemical/Pharm GKB GenePA37134
Clinical trialUBE2I
Miscellaneous
canSAR (ICR)UBE2I (select the gene name)
Probes
Litterature
PubMed412 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUBE2I
EVEXUBE2I
GoPubMedUBE2I
iHOPUBE2I
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat May 28 11:26:19 CEST 2016

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