Identity
HGNC
LOCATION
16p13.3
LOCUSID
ALIAS
C358B7.1,P18,UBC9
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7329
MIM: 601661
HGNC: 12485
Ensembl: ENSG00000103275
Variants:
dbSNP: 7329
ClinVar: 7329
TCGA: ENSG00000103275
COSMIC: UBE2I
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443622 | Carcinoma, Non-Small-Cell Lung | Disease | ClinicalAnnotation | associated | PD | 19859084 | |
| PA449014 | cisplatin | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PK | PD | 19859084 |
| PA450085 | irinotecan | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PK | PD | 19859084 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38167292 | 2024 | Stabilization of Pin1 by USP34 promotes Ubc9 isomerization and protein sumoylation in glioma stem cells. | 0 |
| 38465861 | 2024 | Repression of the SUMO-conjugating enzyme UBC9 is associated with lowered double minutes and reduced tumor progression. | 0 |
| 38167292 | 2024 | Stabilization of Pin1 by USP34 promotes Ubc9 isomerization and protein sumoylation in glioma stem cells. | 0 |
| 38465861 | 2024 | Repression of the SUMO-conjugating enzyme UBC9 is associated with lowered double minutes and reduced tumor progression. | 0 |
| 36744815 | 2023 | Upregulation of miRNA-10a-5p promotes tumor progression in cervical cancer by suppressing UBE2I signaling. | 4 |
| 36825757 | 2023 | Knockdown of UBE2I inhibits tumorigenesis and enhances chemosensitivity of cholangiocarcinoma via modulating p27kip1 nuclear export. | 1 |
| 38140545 | 2023 | The Interaction between SARS-CoV-2 Nucleocapsid Protein and UBC9 Inhibits MAVS Ubiquitination by Enhancing Its SUMOylation. | 2 |
| 36744815 | 2023 | Upregulation of miRNA-10a-5p promotes tumor progression in cervical cancer by suppressing UBE2I signaling. | 4 |
| 36825757 | 2023 | Knockdown of UBE2I inhibits tumorigenesis and enhances chemosensitivity of cholangiocarcinoma via modulating p27kip1 nuclear export. | 1 |
| 38140545 | 2023 | The Interaction between SARS-CoV-2 Nucleocapsid Protein and UBC9 Inhibits MAVS Ubiquitination by Enhancing Its SUMOylation. | 2 |
| 36193060 | 2022 | Combined Evaluation of mRNA and Protein Expression, Promoter Methylation, and Immune Infiltration of UBE2I in Pan-Digestive System Tumors. | 1 |
| 36193060 | 2022 | Combined Evaluation of mRNA and Protein Expression, Promoter Methylation, and Immune Infiltration of UBE2I in Pan-Digestive System Tumors. | 1 |
| 33712284 | 2021 | Adipose-specific knockout of ubiquitin-conjugating enzyme E2L6 (Ube2l6) reduces diet-induced obesity, insulin resistance, and hepatic steatosis. | 8 |
| 33712284 | 2021 | Adipose-specific knockout of ubiquitin-conjugating enzyme E2L6 (Ube2l6) reduces diet-induced obesity, insulin resistance, and hepatic steatosis. | 8 |
| 32249212 | 2020 | SUMOylation of the transcription factor ZFHX3 at Lys-2806 requires SAE1, UBC9, and PIAS2 and enhances its stability and function in cell proliferation. | 11 |
Citation
Dessen P
UBE2I (ubiquitin conjugating enzyme E2 I)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/42751/ube2i
