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UBE2K (ubiquitin-conjugating enzyme E2K)

Identity

Alias_namesHIP2
huntingtin interacting protein 2
ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)
ubiquitin-conjugating enzyme E2K
Alias_symbol (synonym)HYPG
UBC1
Other aliasE2-25K
LIG
HGNC (Hugo) UBE2K
LocusID (NCBI) 3093
Atlas_Id 75418
Location 4p14  [Link to chromosome band 4p14]
Location_base_pair Starts at 39699664 and ends at 39784410 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
UBE2K (4p14) / CCDC149 (4p15.2)UBE2K (4p14) / FAM216B (13q14.11)UBE2K (4p14) / PDS5A (4p14)
UBE2K (4p14) / UBE2K (4p14)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UBE2K   4914
Cards
Entrez_Gene (NCBI)UBE2K  3093  ubiquitin-conjugating enzyme E2K
AliasesE2-25K; HIP2; HYPG; LIG; 
UBC1
GeneCards (Weizmann)UBE2K
Ensembl hg19 (Hinxton)ENSG00000078140 [Gene_View]  chr4:39699664-39784410 [Contig_View]  UBE2K [Vega]
Ensembl hg38 (Hinxton)ENSG00000078140 [Gene_View]  chr4:39699664-39784410 [Contig_View]  UBE2K [Vega]
ICGC DataPortalENSG00000078140
TCGA cBioPortalUBE2K
AceView (NCBI)UBE2K
Genatlas (Paris)UBE2K
WikiGenes3093
SOURCE (Princeton)UBE2K
Genetics Home Reference (NIH)UBE2K
Genomic and cartography
GoldenPath hg19 (UCSC)UBE2K  -     chr4:39699664-39784410 +  4p14   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)UBE2K  -     4p14   [Description]    (hg38-Dec_2013)
EnsemblUBE2K - 4p14 [CytoView hg19]  UBE2K - 4p14 [CytoView hg38]
Mapping of homologs : NCBIUBE2K [Mapview hg19]  UBE2K [Mapview hg38]
OMIM602846   
Gene and transcription
Genbank (Entrez)AB022435 AB022436 AK093533 AK291454 AK295846
RefSeq transcript (Entrez)NM_001111112 NM_001111113 NM_005339
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_006238 NW_004929317
Consensus coding sequences : CCDS (NCBI)UBE2K
Cluster EST : UnigeneHs.50308 [ NCBI ]
CGAP (NCI)Hs.50308
Alternative Splicing GalleryENSG00000078140
Gene ExpressionUBE2K [ NCBI-GEO ]   UBE2K [ EBI - ARRAY_EXPRESS ]   UBE2K [ SEEK ]   UBE2K [ MEM ]
Gene Expression Viewer (FireBrowse)UBE2K [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3093
GTEX Portal (Tissue expression)UBE2K
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61086   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP61086  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP61086
Splice isoforms : SwissVarP61086
Catalytic activity : Enzyme6.3.2.19 [ Enzyme-Expasy ]   6.3.2.196.3.2.19 [ IntEnz-EBI ]   6.3.2.19 [ BRENDA ]   6.3.2.19 [ KEGG ]   
PhosPhoSitePlusP61086
Domaine pattern : Prosite (Expaxy)UBA (PS50030)    UBIQUITIN_CONJUGAT_1 (PS00183)    UBIQUITIN_CONJUGAT_2 (PS50127)   
Domains : Interpro (EBI)UBA-like    UBA/transl_elong_EF1B_N_euk    UBA/Ts_N    UBQ-conjugat_E2    UBQ-conjugating_AS    UBQ-conjugating_enzyme/RWD   
Domain families : Pfam (Sanger)UBA (PF00627)    UQ_con (PF00179)   
Domain families : Pfam (NCBI)pfam00627    pfam00179   
Domain families : Smart (EMBL)UBA (SM00165)  
Conserved Domain (NCBI)UBE2K
DMDM Disease mutations3093
Blocks (Seattle)UBE2K
PDB (SRS)1YLA    2O25    3E46    3F92    3K9O    3K9P   
PDB (PDBSum)1YLA    2O25    3E46    3F92    3K9O    3K9P   
PDB (IMB)1YLA    2O25    3E46    3F92    3K9O    3K9P   
PDB (RSDB)1YLA    2O25    3E46    3F92    3K9O    3K9P   
Structural Biology KnowledgeBase1YLA    2O25    3E46    3F92    3K9O    3K9P   
SCOP (Structural Classification of Proteins)1YLA    2O25    3E46    3F92    3K9O    3K9P   
CATH (Classification of proteins structures)1YLA    2O25    3E46    3F92    3K9O    3K9P   
SuperfamilyP61086
Human Protein AtlasENSG00000078140
Peptide AtlasP61086
HPRD04165
IPIIPI00021370   IPI00019894   IPI00910176   IPI00878126   IPI00967679   
Protein Interaction databases
DIP (DOE-UCLA)P61086
IntAct (EBI)P61086
FunCoupENSG00000078140
BioGRIDUBE2K
STRING (EMBL)UBE2K
ZODIACUBE2K
Ontologies - Pathways
QuickGOP61086
Ontology : AmiGOubiquitin-protein transferase activity  protein binding  ATP binding  nucleus  cytoplasm  ubiquitin-dependent protein catabolic process  actin cytoskeleton  ligase activity  ubiquitin protein ligase binding  regulation of proteasomal ubiquitin-dependent protein catabolic process  ubiquitin-ubiquitin ligase activity  proteasome-mediated ubiquitin-dependent protein catabolic process  intermediate filament cytoskeleton  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  extracellular exosome  protein K48-linked ubiquitination  
Ontology : EGO-EBIubiquitin-protein transferase activity  protein binding  ATP binding  nucleus  cytoplasm  ubiquitin-dependent protein catabolic process  actin cytoskeleton  ligase activity  ubiquitin protein ligase binding  regulation of proteasomal ubiquitin-dependent protein catabolic process  ubiquitin-ubiquitin ligase activity  proteasome-mediated ubiquitin-dependent protein catabolic process  intermediate filament cytoskeleton  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  extracellular exosome  protein K48-linked ubiquitination  
Pathways : KEGGUbiquitin mediated proteolysis   
NDEx NetworkUBE2K
Atlas of Cancer Signalling NetworkUBE2K
Wikipedia pathwaysUBE2K
Orthology - Evolution
OrthoDB3093
GeneTree (enSembl)ENSG00000078140
Phylogenetic Trees/Animal Genes : TreeFamUBE2K
HOVERGENP61086
HOGENOMP61086
Homologs : HomoloGeneUBE2K
Homology/Alignments : Family Browser (UCSC)UBE2K
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUBE2K [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBE2K
dbVarUBE2K
ClinVarUBE2K
1000_GenomesUBE2K 
Exome Variant ServerUBE2K
ExAC (Exome Aggregation Consortium)UBE2K (select the gene name)
Genetic variants : HAPMAP3093
Genomic Variants (DGV)UBE2K [DGVbeta]
DECIPHER (Syndromes)4:39699664-39784410  ENSG00000078140
CONAN: Copy Number AnalysisUBE2K 
Mutations
ICGC Data PortalUBE2K 
TCGA Data PortalUBE2K 
Broad Tumor PortalUBE2K
OASIS PortalUBE2K [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUBE2K  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUBE2K
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UBE2K
DgiDB (Drug Gene Interaction Database)UBE2K
DoCM (Curated mutations)UBE2K (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UBE2K (select a term)
intoGenUBE2K
Cancer3DUBE2K(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602846   
Orphanet
MedgenUBE2K
Genetic Testing Registry UBE2K
NextProtP61086 [Medical]
TSGene3093
GENETestsUBE2K
Huge Navigator UBE2K [HugePedia]
snp3D : Map Gene to Disease3093
BioCentury BCIQUBE2K
ClinGenUBE2K
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3093
Chemical/Pharm GKB GenePA162407874
Clinical trialUBE2K
Miscellaneous
canSAR (ICR)UBE2K (select the gene name)
Probes
Litterature
PubMed77 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUBE2K
EVEXUBE2K
GoPubMedUBE2K
iHOPUBE2K
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:50:37 CET 2017

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