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UBE2K (ubiquitin conjugating enzyme E2 K)

Identity

Alias_namesHIP2
huntingtin interacting protein 2
ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)
ubiquitin-conjugating enzyme E2K
Alias_symbol (synonym)HYPG
UBC1
Other aliasE2-25K
LIG
HGNC (Hugo) UBE2K
LocusID (NCBI) 3093
Atlas_Id 75418
Location 4p14  [Link to chromosome band 4p14]
Location_base_pair Starts at 39698044 and ends at 39782790 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
UBE2K (4p14) / CCDC149 (4p15.2)UBE2K (4p14) / FAM216B (13q14.11)UBE2K (4p14) / PDS5A (4p14)
UBE2K (4p14) / UBE2K (4p14)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(4;13)(p14;q14) UBE2K/FAM216B


External links

Nomenclature
HGNC (Hugo)UBE2K   4914
Cards
Entrez_Gene (NCBI)UBE2K  3093  ubiquitin conjugating enzyme E2 K
AliasesE2-25K; HIP2; HYPG; LIG; 
UBC1
GeneCards (Weizmann)UBE2K
Ensembl hg19 (Hinxton)ENSG00000078140 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000078140 [Gene_View]  chr4:39698044-39782790 [Contig_View]  UBE2K [Vega]
ICGC DataPortalENSG00000078140
TCGA cBioPortalUBE2K
AceView (NCBI)UBE2K
Genatlas (Paris)UBE2K
WikiGenes3093
SOURCE (Princeton)UBE2K
Genetics Home Reference (NIH)UBE2K
Genomic and cartography
GoldenPath hg38 (UCSC)UBE2K  -     chr4:39698044-39782790 +  4p14   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UBE2K  -     4p14   [Description]    (hg19-Feb_2009)
EnsemblUBE2K - 4p14 [CytoView hg19]  UBE2K - 4p14 [CytoView hg38]
Mapping of homologs : NCBIUBE2K [Mapview hg19]  UBE2K [Mapview hg38]
OMIM602846   
Gene and transcription
Genbank (Entrez)AB022435 AB022436 AK093533 AK291454 AK295846
RefSeq transcript (Entrez)NM_001111112 NM_001111113 NM_001312646 NM_001312647 NM_001312648 NM_005339
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UBE2K
Cluster EST : UnigeneHs.50308 [ NCBI ]
CGAP (NCI)Hs.50308
Alternative Splicing GalleryENSG00000078140
Gene ExpressionUBE2K [ NCBI-GEO ]   UBE2K [ EBI - ARRAY_EXPRESS ]   UBE2K [ SEEK ]   UBE2K [ MEM ]
Gene Expression Viewer (FireBrowse)UBE2K [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3093
GTEX Portal (Tissue expression)UBE2K
Human Protein AtlasENSG00000078140-UBE2K [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61086   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP61086  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP61086
Splice isoforms : SwissVarP61086
PhosPhoSitePlusP61086
Domaine pattern : Prosite (Expaxy)UBA (PS50030)    UBIQUITIN_CONJUGAT_1 (PS00183)    UBIQUITIN_CONJUGAT_2 (PS50127)   
Domains : Interpro (EBI)UBA    UBA-like    UBQ-conjugat_E2    UBQ-conjugating_AS    UBQ-conjugating_enzyme/RWD   
Domain families : Pfam (Sanger)UBA (PF00627)    UQ_con (PF00179)   
Domain families : Pfam (NCBI)pfam00627    pfam00179   
Domain families : Smart (EMBL)UBA (SM00165)  
Conserved Domain (NCBI)UBE2K
DMDM Disease mutations3093
Blocks (Seattle)UBE2K
PDB (SRS)1YLA    2O25    3E46    3F92    3K9O    3K9P    5DFL   
PDB (PDBSum)1YLA    2O25    3E46    3F92    3K9O    3K9P    5DFL   
PDB (IMB)1YLA    2O25    3E46    3F92    3K9O    3K9P    5DFL   
PDB (RSDB)1YLA    2O25    3E46    3F92    3K9O    3K9P    5DFL   
Structural Biology KnowledgeBase1YLA    2O25    3E46    3F92    3K9O    3K9P    5DFL   
SCOP (Structural Classification of Proteins)1YLA    2O25    3E46    3F92    3K9O    3K9P    5DFL   
CATH (Classification of proteins structures)1YLA    2O25    3E46    3F92    3K9O    3K9P    5DFL   
SuperfamilyP61086
Human Protein Atlas [tissue]ENSG00000078140-UBE2K [tissue]
Peptide AtlasP61086
HPRD04165
IPIIPI00021370   IPI00019894   IPI00910176   IPI00878126   IPI00967679   
Protein Interaction databases
DIP (DOE-UCLA)P61086
IntAct (EBI)P61086
FunCoupENSG00000078140
BioGRIDUBE2K
STRING (EMBL)UBE2K
ZODIACUBE2K
Ontologies - Pathways
QuickGOP61086
Ontology : AmiGO###############################################################################################################################################################################################################################################################                                        
Ontology : EGO-EBI###############################################################################################################################################################################################################################################################                                        
Pathways : KEGGHuntington's disease   
NDEx NetworkUBE2K
Atlas of Cancer Signalling NetworkUBE2K
Wikipedia pathwaysUBE2K
Orthology - Evolution
OrthoDB3093
GeneTree (enSembl)ENSG00000078140
Phylogenetic Trees/Animal Genes : TreeFamUBE2K
HOVERGENP61086
HOGENOMP61086
Homologs : HomoloGeneUBE2K
Homology/Alignments : Family Browser (UCSC)UBE2K
Gene fusions - Rearrangements
Fusion : QuiverUBE2K
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUBE2K [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBE2K
dbVarUBE2K
ClinVarUBE2K
1000_GenomesUBE2K 
Exome Variant ServerUBE2K
ExAC (Exome Aggregation Consortium)ENSG00000078140
GNOMAD BrowserENSG00000078140
Genetic variants : HAPMAP3093
Genomic Variants (DGV)UBE2K [DGVbeta]
DECIPHERUBE2K [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUBE2K 
Mutations
ICGC Data PortalUBE2K 
TCGA Data PortalUBE2K 
Broad Tumor PortalUBE2K
OASIS PortalUBE2K [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUBE2K  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUBE2K
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UBE2K
DgiDB (Drug Gene Interaction Database)UBE2K
DoCM (Curated mutations)UBE2K (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UBE2K (select a term)
intoGenUBE2K
Cancer3DUBE2K(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602846   
Orphanet
DisGeNETUBE2K
MedgenUBE2K
Genetic Testing Registry UBE2K
NextProtP61086 [Medical]
TSGene3093
GENETestsUBE2K
Target ValidationUBE2K
Huge Navigator UBE2K [HugePedia]
snp3D : Map Gene to Disease3093
BioCentury BCIQUBE2K
ClinGenUBE2K
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3093
Chemical/Pharm GKB GenePA162407874
Clinical trialUBE2K
Miscellaneous
canSAR (ICR)UBE2K (select the gene name)
Probes
Litterature
PubMed1 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUBE2K
EVEXUBE2K
GoPubMedUBE2K
iHOPUBE2K
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Fri Feb 23 18:57:30 CET 2018

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