UBE2S (ubiquitin conjugating enzyme E2 S)

2003-08-01  

Identity

HGNC
LOCATION
19q13.42
LOCUSID
ALIAS
E2-EPF,E2EPF,EPF5
FUSION GENES

Other Information

Locus ID:

NCBI: 27338
MIM: 610309
HGNC: 17895
Ensembl: ENSG00000108106

Variants:

dbSNP: 27338
ClinVar: 27338
TCGA: ENSG00000108106
COSMIC: UBE2S

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108106ENST00000264552Q16763
ENSG00000108106ENST00000587845K7EPJ1
ENSG00000108106ENST00000589978K7EM75

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Protein ubiquitinationREACTOMER-HSA-8852135
Synthesis of active ubiquitin: roles of E1 and E2 enzymesREACTOMER-HSA-8866652

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198227572009Identification of a physiological E2 module for the human anaphase-promoting complex.132
248136132014Enhanced protein degradation by branched ubiquitin chains.132
213762372011The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2.123
198207022009UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit.116
200805792010UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex.103
269049402016The Spindle Assembly Checkpoint Is Not Essential for Viability of Human Cells with Genetically Lowered APC/C Activity.21
285257402017RNF8- and Ube2S-Dependent Ubiquitin Lysine 11-Linkage Modification in Response to DNA Damage.13
279108722016SAG/RBX2 E3 ligase complexes with UBCH10 and UBE2S E2s to ubiquitylate β-TrCP1 via K11-linkage for degradation.10
190831922009The predictive role of E2-EPF ubiquitin carrier protein in esophageal squamous cell carcinoma.9
212818172011Deregulation of E2-EPF ubiquitin carrier protein in papillary renal cell carcinoma.9

Citation

Dessen P

UBE2S (ubiquitin conjugating enzyme E2 S)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42753/ube2s