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UBE2V2 (ubiquitin conjugating enzyme E2 V2)

Identity

Alias_namesubiquitin-conjugating enzyme E2 variant 2
Alias_symbol (synonym)UEV-2
DDVit-1
EDPF-1
MMS2
Other aliasDDVIT1
EDAF-1
EDPF1
UEV2
HGNC (Hugo) UBE2V2
LocusID (NCBI) 7336
Atlas_Id 42755
Location 8q11.21  [Link to chromosome band 8q11]
Location_base_pair Starts at 48920995 and ends at 48974454 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PRKDC (8q11.21) / UBE2V2 (8q11.21)UBE2V2 (8q11.21) / NRIP1 (21q11.2)UBE2V2 (8q11.21) / PRKAA1 (5p13.1)
UBE2V2 (8q11.21) / UBE2V2 (8q11.21)PRKDC 8q11.21 / UBE2V2 8q11.21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)UBE2V2   12495
Cards
Entrez_Gene (NCBI)UBE2V2  7336  ubiquitin conjugating enzyme E2 V2
AliasesDDVIT1; DDVit-1; EDAF-1; EDPF-1; 
EDPF1; MMS2; UEV-2; UEV2
GeneCards (Weizmann)UBE2V2
Ensembl hg19 (Hinxton)ENSG00000169139 [Gene_View]  chr8:48920995-48974454 [Contig_View]  UBE2V2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000169139 [Gene_View]  chr8:48920995-48974454 [Contig_View]  UBE2V2 [Vega]
ICGC DataPortalENSG00000169139
TCGA cBioPortalUBE2V2
AceView (NCBI)UBE2V2
Genatlas (Paris)UBE2V2
WikiGenes7336
SOURCE (Princeton)UBE2V2
Genetics Home Reference (NIH)UBE2V2
Genomic and cartography
GoldenPath hg19 (UCSC)UBE2V2  -     chr8:48920995-48974454 +  8q11.21   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)UBE2V2  -     8q11.21   [Description]    (hg38-Dec_2013)
EnsemblUBE2V2 - 8q11.21 [CytoView hg19]  UBE2V2 - 8q11.21 [CytoView hg38]
Mapping of homologs : NCBIUBE2V2 [Mapview hg19]  UBE2V2 [Mapview hg38]
OMIM603001   
Gene and transcription
Genbank (Entrez)AF049140 AK094617 AK123928 AK313447 BC007051
RefSeq transcript (Entrez)NM_003350
RefSeq genomic (Entrez)NC_000008 NC_018919 NT_008183 NW_004929339
Consensus coding sequences : CCDS (NCBI)UBE2V2
Cluster EST : UnigeneHs.595400 [ NCBI ]
CGAP (NCI)Hs.595400
Alternative Splicing GalleryENSG00000169139
Gene ExpressionUBE2V2 [ NCBI-GEO ]   UBE2V2 [ EBI - ARRAY_EXPRESS ]   UBE2V2 [ SEEK ]   UBE2V2 [ MEM ]
Gene Expression Viewer (FireBrowse)UBE2V2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7336
GTEX Portal (Tissue expression)UBE2V2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15819   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15819  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15819
Splice isoforms : SwissVarQ15819
PhosPhoSitePlusQ15819
Domaine pattern : Prosite (Expaxy)UBIQUITIN_CONJUGAT_2 (PS50127)   
Domains : Interpro (EBI)UBQ-conjugat_E2    UBQ-conjugating_enzyme/RWD   
Domain families : Pfam (Sanger)UQ_con (PF00179)   
Domain families : Pfam (NCBI)pfam00179   
Conserved Domain (NCBI)UBE2V2
DMDM Disease mutations7336
Blocks (Seattle)UBE2V2
PDB (SRS)1J74    1J7D    1ZGU    3VON    4NR3    4NRG    4NRI    4ONL    4ONM    4ONN    4ORH    5AIT   
PDB (PDBSum)1J74    1J7D    1ZGU    3VON    4NR3    4NRG    4NRI    4ONL    4ONM    4ONN    4ORH    5AIT   
PDB (IMB)1J74    1J7D    1ZGU    3VON    4NR3    4NRG    4NRI    4ONL    4ONM    4ONN    4ORH    5AIT   
PDB (RSDB)1J74    1J7D    1ZGU    3VON    4NR3    4NRG    4NRI    4ONL    4ONM    4ONN    4ORH    5AIT   
Structural Biology KnowledgeBase1J74    1J7D    1ZGU    3VON    4NR3    4NRG    4NRI    4ONL    4ONM    4ONN    4ORH    5AIT   
SCOP (Structural Classification of Proteins)1J74    1J7D    1ZGU    3VON    4NR3    4NRG    4NRI    4ONL    4ONM    4ONN    4ORH    5AIT   
CATH (Classification of proteins structures)1J74    1J7D    1ZGU    3VON    4NR3    4NRG    4NRI    4ONL    4ONM    4ONN    4ORH    5AIT   
SuperfamilyQ15819
Human Protein AtlasENSG00000169139
Peptide AtlasQ15819
HPRD04300
IPIIPI00019600   IPI00981344   IPI01015099   IPI01015529   IPI01012867   IPI00980777   
Protein Interaction databases
DIP (DOE-UCLA)Q15819
IntAct (EBI)Q15819
FunCoupENSG00000169139
BioGRIDUBE2V2
STRING (EMBL)UBE2V2
ZODIACUBE2V2
Ontologies - Pathways
QuickGOQ15819
Ontology : AmiGOprotein polyubiquitination  DNA double-strand break processing  protein binding  nucleus  nucleoplasm  cytoplasm  regulation of DNA repair  postreplication repair  double-strand break repair via nonhomologous end joining  cell proliferation  positive regulation of neuron projection development  protein ubiquitination  UBC13-MMS2 complex  ubiquitin protein ligase binding  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  error-free postreplication DNA repair  negative regulation of neuron apoptotic process  positive regulation of DNA repair  positive regulation of synapse assembly  ubiquitin protein ligase activity  ubiquitin conjugating enzyme activity  extracellular exosome  protein K63-linked ubiquitination  global genome nucleotide-excision repair  
Ontology : EGO-EBIprotein polyubiquitination  DNA double-strand break processing  protein binding  nucleus  nucleoplasm  cytoplasm  regulation of DNA repair  postreplication repair  double-strand break repair via nonhomologous end joining  cell proliferation  positive regulation of neuron projection development  protein ubiquitination  UBC13-MMS2 complex  ubiquitin protein ligase binding  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  error-free postreplication DNA repair  negative regulation of neuron apoptotic process  positive regulation of DNA repair  positive regulation of synapse assembly  ubiquitin protein ligase activity  ubiquitin conjugating enzyme activity  extracellular exosome  protein K63-linked ubiquitination  global genome nucleotide-excision repair  
NDEx NetworkUBE2V2
Atlas of Cancer Signalling NetworkUBE2V2
Wikipedia pathwaysUBE2V2
Orthology - Evolution
OrthoDB7336
GeneTree (enSembl)ENSG00000169139
Phylogenetic Trees/Animal Genes : TreeFamUBE2V2
HOVERGENQ15819
HOGENOMQ15819
Homologs : HomoloGeneUBE2V2
Homology/Alignments : Family Browser (UCSC)UBE2V2
Gene fusions - Rearrangements
Fusion : MitelmanPRKDC/UBE2V2 [8q11.21/8q11.21]  [t(8;8)(q11;q11)]  
Fusion : MitelmanUBE2V2/NRIP1 [8q11.21/21q11.2]  [t(8;21)(q11;q21)]  
Fusion: TCGAPRKDC 8q11.21 UBE2V2 8q11.21 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUBE2V2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBE2V2
dbVarUBE2V2
ClinVarUBE2V2
1000_GenomesUBE2V2 
Exome Variant ServerUBE2V2
ExAC (Exome Aggregation Consortium)UBE2V2 (select the gene name)
Genetic variants : HAPMAP7336
Genomic Variants (DGV)UBE2V2 [DGVbeta]
DECIPHER (Syndromes)8:48920995-48974454  ENSG00000169139
CONAN: Copy Number AnalysisUBE2V2 
Mutations
ICGC Data PortalUBE2V2 
TCGA Data PortalUBE2V2 
Broad Tumor PortalUBE2V2
OASIS PortalUBE2V2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUBE2V2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUBE2V2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UBE2V2
DgiDB (Drug Gene Interaction Database)UBE2V2
DoCM (Curated mutations)UBE2V2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UBE2V2 (select a term)
intoGenUBE2V2
Cancer3DUBE2V2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603001   
Orphanet
MedgenUBE2V2
Genetic Testing Registry UBE2V2
NextProtQ15819 [Medical]
TSGene7336
GENETestsUBE2V2
Huge Navigator UBE2V2 [HugePedia]
snp3D : Map Gene to Disease7336
BioCentury BCIQUBE2V2
ClinGenUBE2V2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7336
Chemical/Pharm GKB GenePA37143
Clinical trialUBE2V2
Miscellaneous
canSAR (ICR)UBE2V2 (select the gene name)
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUBE2V2
EVEXUBE2V2
GoPubMedUBE2V2
iHOPUBE2V2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:24:08 CEST 2017

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