Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

UBE3C (ubiquitin protein ligase E3C)

Identity

Alias_symbol (synonym)KIAA0010
KIAA10
Other aliasHECTH2
HGNC (Hugo) UBE3C
LocusID (NCBI) 9690
Atlas_Id 46959
Location 7q36.3  [Link to chromosome band 7q36]
Location_base_pair Starts at 157138961 and ends at 157269372 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANKRD6 (6q15) / UBE3C (7q36.3)ATP1A1 (1p13.1) / UBE3C (7q36.3)DNAJB6 (7q36.3) / UBE3C (7q36.3)
PTBP1 (19p13.3) / UBE3C (7q36.3)RPS27A (2p16.1) / UBE3C (7q36.3)UBE3C (7q36.3) / BAG1 (9p13.3)
UBE3C (7q36.3) / CCND1 (11q13.3)UBE3C (7q36.3) / PTPRN2 (7q36.3)UBE3C (7q36.3) / SEPT11 (4q21.1)
UBE3C (7q36.3) / UBE3C (7q36.3)UBE3C (7q36.3) / UBXN2B (8q12.1)UBE3C (7q36.3) / ZNF667 (19q13.43)
PTBP1 19p13.3 / UBE3C 7q36.3UBE3C 7q36.3 / PTPRN2 7q36.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UBE3C   16803
Cards
Entrez_Gene (NCBI)UBE3C  9690  ubiquitin protein ligase E3C
AliasesHECTH2
GeneCards (Weizmann)UBE3C
Ensembl hg19 (Hinxton)ENSG00000009335 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000009335 [Gene_View]  chr7:157138961-157269372 [Contig_View]  UBE3C [Vega]
ICGC DataPortalENSG00000009335
TCGA cBioPortalUBE3C
AceView (NCBI)UBE3C
Genatlas (Paris)UBE3C
WikiGenes9690
SOURCE (Princeton)UBE3C
Genetics Home Reference (NIH)UBE3C
Genomic and cartography
GoldenPath hg38 (UCSC)UBE3C  -     chr7:157138961-157269372 +  7q36.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UBE3C  -     7q36.3   [Description]    (hg19-Feb_2009)
EnsemblUBE3C - 7q36.3 [CytoView hg19]  UBE3C - 7q36.3 [CytoView hg38]
Mapping of homologs : NCBIUBE3C [Mapview hg19]  UBE3C [Mapview hg38]
OMIM614454   
Gene and transcription
Genbank (Entrez)AA596042 AK127280 AK295138 BC014029 BC026241
RefSeq transcript (Entrez)NM_014671
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UBE3C
Cluster EST : UnigeneHs.118351 [ NCBI ]
CGAP (NCI)Hs.118351
Alternative Splicing GalleryENSG00000009335
Gene ExpressionUBE3C [ NCBI-GEO ]   UBE3C [ EBI - ARRAY_EXPRESS ]   UBE3C [ SEEK ]   UBE3C [ MEM ]
Gene Expression Viewer (FireBrowse)UBE3C [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9690
GTEX Portal (Tissue expression)UBE3C
Human Protein AtlasENSG00000009335-UBE3C [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15386   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15386  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15386
Splice isoforms : SwissVarQ15386
Catalytic activity : Enzyme2.3.2.26 [ Enzyme-Expasy ]   2.3.2.262.3.2.26 [ IntEnz-EBI ]   2.3.2.26 [ BRENDA ]   2.3.2.26 [ KEGG ]   
PhosPhoSitePlusQ15386
Domaine pattern : Prosite (Expaxy)HECT (PS50237)    IQ (PS50096)   
Domains : Interpro (EBI)HECT_dom    IQ_motif_EF-hand-BS   
Domain families : Pfam (Sanger)HECT (PF00632)   
Domain families : Pfam (NCBI)pfam00632   
Domain families : Smart (EMBL)HECTc (SM00119)  IQ (SM00015)  
Conserved Domain (NCBI)UBE3C
DMDM Disease mutations9690
Blocks (Seattle)UBE3C
SuperfamilyQ15386
Human Protein Atlas [tissue]ENSG00000009335-UBE3C [tissue]
Peptide AtlasQ15386
HPRD15604
IPIIPI00604464   IPI00472810   IPI00411748   IPI00925103   
Protein Interaction databases
DIP (DOE-UCLA)Q15386
IntAct (EBI)Q15386
FunCoupENSG00000009335
BioGRIDUBE3C
STRING (EMBL)UBE3C
ZODIACUBE3C
Ontologies - Pathways
QuickGOQ15386
Ontology : AmiGOprotein polyubiquitination  proteasome complex  ubiquitin-protein transferase activity  protein binding  intracellular  nucleus  
Ontology : EGO-EBIprotein polyubiquitination  proteasome complex  ubiquitin-protein transferase activity  protein binding  intracellular  nucleus  
Pathways : KEGGUbiquitin mediated proteolysis   
NDEx NetworkUBE3C
Atlas of Cancer Signalling NetworkUBE3C
Wikipedia pathwaysUBE3C
Orthology - Evolution
OrthoDB9690
GeneTree (enSembl)ENSG00000009335
Phylogenetic Trees/Animal Genes : TreeFamUBE3C
HOVERGENQ15386
HOGENOMQ15386
Homologs : HomoloGeneUBE3C
Homology/Alignments : Family Browser (UCSC)UBE3C
Gene fusions - Rearrangements
Fusion : MitelmanPTBP1/UBE3C [19p13.3/7q36.3]  [t(7;19)(q36;p13)]  
Fusion : MitelmanUBE3C/PTPRN2 [7q36.3/7q36.3]  [t(7;7)(q36;q36)]  
Fusion: TCGA_MDACCPTBP1 19p13.3 UBE3C 7q36.3 PRAD
Fusion: TCGA_MDACCUBE3C 7q36.3 PTPRN2 7q36.3 HNSC
Tumor Fusion PortalUBE3C
Fusion Cancer (Beijing)UBE3C [7q36.3]  -  UBXN2B [8q12.1]  [FUSC004370]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUBE3C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBE3C
dbVarUBE3C
ClinVarUBE3C
1000_GenomesUBE3C 
Exome Variant ServerUBE3C
ExAC (Exome Aggregation Consortium)ENSG00000009335
GNOMAD BrowserENSG00000009335
Genetic variants : HAPMAP9690
Genomic Variants (DGV)UBE3C [DGVbeta]
DECIPHERUBE3C [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUBE3C 
Mutations
ICGC Data PortalUBE3C 
TCGA Data PortalUBE3C 
Broad Tumor PortalUBE3C
OASIS PortalUBE3C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUBE3C  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUBE3C
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UBE3C
DgiDB (Drug Gene Interaction Database)UBE3C
DoCM (Curated mutations)UBE3C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UBE3C (select a term)
intoGenUBE3C
Cancer3DUBE3C(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614454   
Orphanet
DisGeNETUBE3C
MedgenUBE3C
Genetic Testing Registry UBE3C
NextProtQ15386 [Medical]
TSGene9690
GENETestsUBE3C
Target ValidationUBE3C
Huge Navigator UBE3C [HugePedia]
snp3D : Map Gene to Disease9690
BioCentury BCIQUBE3C
ClinGenUBE3C
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9690
Chemical/Pharm GKB GenePA134905339
Clinical trialUBE3C
Miscellaneous
canSAR (ICR)UBE3C (select the gene name)
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUBE3C
EVEXUBE3C
GoPubMedUBE3C
iHOPUBE3C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:40:35 CET 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.