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UCP2 (uncoupling protein 2)

Identity

Alias_namesBMIQ4
body mass index QTL 4
body mass index quantitative trait 4
uncoupling protein 2 (mitochondrial, proton carrier)
Alias_symbol (synonym)SLC25A8
Other aliasUCPH
HGNC (Hugo) UCP2
LocusID (NCBI) 7351
Atlas_Id 45629
Location 11q13.4  [Link to chromosome band 11q13]
Location_base_pair Starts at 73974671 and ends at 73982844 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
C2orf61 (2p21) / UCP2 (11q13.4)EIF3D (22q12.3) / UCP2 (11q13.4)EP400 (12q24.33) / UCP2 (11q13.4)
GABBR1 (6p22.1) / UCP2 (11q13.4)KCNQ1 (11p15.5) / UCP2 (11q13.4)UCP2 (11q13.4) / EIF4G1 (3q27.1)
UCP2 (11q13.4) / TCF20 (22q13.2)UCP2 (11q13.4) / UCP2 (11q13.4)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UCP2   12518
Cards
Entrez_Gene (NCBI)UCP2  7351  uncoupling protein 2
AliasesBMIQ4; SLC25A8; UCPH
GeneCards (Weizmann)UCP2
Ensembl hg19 (Hinxton)ENSG00000175567 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000175567 [Gene_View]  chr11:73974671-73982844 [Contig_View]  UCP2 [Vega]
ICGC DataPortalENSG00000175567
TCGA cBioPortalUCP2
AceView (NCBI)UCP2
Genatlas (Paris)UCP2
WikiGenes7351
SOURCE (Princeton)UCP2
Genetics Home Reference (NIH)UCP2
Genomic and cartography
GoldenPath hg38 (UCSC)UCP2  -     chr11:73974671-73982844 -  11q13.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UCP2  -     11q13.4   [Description]    (hg19-Feb_2009)
EnsemblUCP2 - 11q13.4 [CytoView hg19]  UCP2 - 11q13.4 [CytoView hg38]
Mapping of homologs : NCBIUCP2 [Mapview hg19]  UCP2 [Mapview hg38]
OMIM601693   607447   
Gene and transcription
Genbank (Entrez)AK025742 AK222540 AK222557 BC011737 DQ893298
RefSeq transcript (Entrez)NM_003355
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UCP2
Cluster EST : UnigeneHs.80658 [ NCBI ]
CGAP (NCI)Hs.80658
Alternative Splicing GalleryENSG00000175567
Gene ExpressionUCP2 [ NCBI-GEO ]   UCP2 [ EBI - ARRAY_EXPRESS ]   UCP2 [ SEEK ]   UCP2 [ MEM ]
Gene Expression Viewer (FireBrowse)UCP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7351
GTEX Portal (Tissue expression)UCP2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP55851   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP55851  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP55851
Splice isoforms : SwissVarP55851
PhosPhoSitePlusP55851
Domaine pattern : Prosite (Expaxy)SOLCAR (PS50920)   
Domains : Interpro (EBI)Mit_uncoupling    Mitochondrial_sb/sol_carrier    Mt_carrier_dom   
Domain families : Pfam (Sanger)Mito_carr (PF00153)   
Domain families : Pfam (NCBI)pfam00153   
Conserved Domain (NCBI)UCP2
DMDM Disease mutations7351
Blocks (Seattle)UCP2
SuperfamilyP55851
Human Protein AtlasENSG00000175567
Peptide AtlasP55851
HPRD03410
IPIIPI00026573   IPI00884209   IPI01010814   IPI01015276   IPI01015349   
Protein Interaction databases
DIP (DOE-UCLA)P55851
IntAct (EBI)P55851
FunCoupENSG00000175567
BioGRIDUCP2
STRING (EMBL)UCP2
ZODIACUCP2
Ontologies - Pathways
QuickGOP55851
Ontology : AmiGOresponse to superoxide  response to hypoxia  protein binding  mitochondrial inner membrane  mitochondrial inner membrane  transport  female pregnancy  aging  response to cold  positive regulation of cell death  proton transport  integral component of membrane  oxidative phosphorylation uncoupler activity  cellular response to insulin stimulus  cellular response to amino acid starvation  negative regulation of apoptotic process  regulation of mitochondrial membrane potential  negative regulation of insulin secretion involved in cellular response to glucose stimulus  response to fatty acid  cellular response to glucose stimulus  liver regeneration  mitochondrial transmembrane transport  adaptive thermogenesis  
Ontology : EGO-EBIresponse to superoxide  response to hypoxia  protein binding  mitochondrial inner membrane  mitochondrial inner membrane  transport  female pregnancy  aging  response to cold  positive regulation of cell death  proton transport  integral component of membrane  oxidative phosphorylation uncoupler activity  cellular response to insulin stimulus  cellular response to amino acid starvation  negative regulation of apoptotic process  regulation of mitochondrial membrane potential  negative regulation of insulin secretion involved in cellular response to glucose stimulus  response to fatty acid  cellular response to glucose stimulus  liver regeneration  mitochondrial transmembrane transport  adaptive thermogenesis  
NDEx NetworkUCP2
Atlas of Cancer Signalling NetworkUCP2
Wikipedia pathwaysUCP2
Orthology - Evolution
OrthoDB7351
GeneTree (enSembl)ENSG00000175567
Phylogenetic Trees/Animal Genes : TreeFamUCP2
HOVERGENP55851
HOGENOMP55851
Homologs : HomoloGeneUCP2
Homology/Alignments : Family Browser (UCSC)UCP2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUCP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UCP2
dbVarUCP2
ClinVarUCP2
1000_GenomesUCP2 
Exome Variant ServerUCP2
ExAC (Exome Aggregation Consortium)UCP2 (select the gene name)
Genetic variants : HAPMAP7351
Genomic Variants (DGV)UCP2 [DGVbeta]
DECIPHERUCP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUCP2 
Mutations
ICGC Data PortalUCP2 
TCGA Data PortalUCP2 
Broad Tumor PortalUCP2
OASIS PortalUCP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUCP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUCP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch UCP2
DgiDB (Drug Gene Interaction Database)UCP2
DoCM (Curated mutations)UCP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UCP2 (select a term)
intoGenUCP2
Cancer3DUCP2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601693    607447   
Orphanet20383   
MedgenUCP2
Genetic Testing Registry UCP2
NextProtP55851 [Medical]
TSGene7351
GENETestsUCP2
Target ValidationUCP2
Huge Navigator UCP2 [HugePedia]
snp3D : Map Gene to Disease7351
BioCentury BCIQUCP2
ClinGenUCP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7351
Chemical/Pharm GKB GenePA37165
Clinical trialUCP2
Miscellaneous
canSAR (ICR)UCP2 (select the gene name)
Probes
Litterature
PubMed295 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUCP2
EVEXUCP2
GoPubMedUCP2
iHOPUCP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:11:06 CEST 2017

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