UCP2 (uncoupling protein 2)

2007-02-01  

Identity

HGNC
LOCATION
11q13.4
LOCUSID
ALIAS
BMIQ4,SLC25A8,UCPH
FUSION GENES

Other Information

Locus ID:

NCBI: 7351
MIM: 601693
HGNC: 12518
Ensembl: ENSG00000175567

Variants:

dbSNP: 7351
ClinVar: 7351
TCGA: ENSG00000175567
COSMIC: UCP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175567ENST00000310473P55851
ENSG00000175567ENST00000310473A0A024R5N5
ENSG00000175567ENST00000536983F5GX45
ENSG00000175567ENST00000539764F5H312
ENSG00000175567ENST00000545212H0YFQ0
ENSG00000175567ENST00000663595P55851
ENSG00000175567ENST00000663595A0A024R5N5

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.REACTOMER-HSA-163200
Mitochondrial Uncoupling ProteinsREACTOMER-HSA-166187
The fatty acid cycling modelREACTOMER-HSA-167826
The proton buffering modelREACTOMER-HSA-167827

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
220859322011UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells.184
232661872013The mitochondrial transporter family SLC25: identification, properties and physiopathology.159
128581702003Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma.136
173516412007Uncoupling proteins 2 and 3 are fundamental for mitochondrial Ca2+ uniport.121
243957862014UCP2 transports C4 metabolites out of mitochondria, regulating glucose and glutamine oxidation.112
198894142010Association of telomere length with type 2 diabetes, oxidative stress and UCP2 gene variation.89
198894142010Association of telomere length with type 2 diabetes, oxidative stress and UCP2 gene variation.89
128556742003Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes.85
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
184137492008The mitochondrial uncoupling protein-2 promotes chemoresistance in cancer cells.74

Citation

Dessen P

UCP2 (uncoupling protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45629/ucp2